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Items: 44


Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes.

Elyahu Y, Hekselman I, Eizenberg-Magar I, Berner O, Strominger I, Schiller M, Mittal K, Nemirovsky A, Eremenko E, Vital A, Simonovsky E, Chalifa-Caspi V, Friedman N, Yeger-Lotem E, Monsonego A.

Sci Adv. 2019 Aug 21;5(8):eaaw8330. doi: 10.1126/sciadv.aaw8330. eCollection 2019 Aug.


CD4 T Cells Induce A Subset of MHCII-Expressing Microglia that Attenuates Alzheimer Pathology.

Mittal K, Eremenko E, Berner O, Elyahu Y, Strominger I, Apelblat D, Nemirovsky A, Spiegel I, Monsonego A.

iScience. 2019 Jun 28;16:298-311. doi: 10.1016/j.isci.2019.05.039. Epub 2019 May 30.


BDNF-producing, amyloid β-specific CD4 T cells as targeted drug-delivery vehicles in Alzheimer's disease.

Eremenko E, Mittal K, Berner O, Kamenetsky N, Nemirovsky A, Elyahu Y, Monsonego A.

EBioMedicine. 2019 May;43:424-434. doi: 10.1016/j.ebiom.2019.04.019. Epub 2019 May 11.


Co-assembled Ca2+ Alginate-Sulfate Nanoparticles for Intracellular Plasmid DNA Delivery.

Goldshtein M, Shamir S, Vinogradov E, Monsonego A, Cohen S.

Mol Ther Nucleic Acids. 2019 Jun 7;16:378-390. doi: 10.1016/j.omtn.2019.03.006. Epub 2019 Mar 28.


The Choroid Plexus Functions as a Niche for T-Cell Stimulation Within the Central Nervous System.

Strominger I, Elyahu Y, Berner O, Reckhow J, Mittal K, Nemirovsky A, Monsonego A.

Front Immunol. 2018 May 16;9:1066. doi: 10.3389/fimmu.2018.01066. eCollection 2018.


Old Mice Accumulate Activated Effector CD4 T Cells Refractory to Regulatory T Cell-Induced Immunosuppression.

Harpaz I, Bhattacharya U, Elyahu Y, Strominger I, Monsonego A.

Front Immunol. 2017 Mar 22;8:283. doi: 10.3389/fimmu.2017.00283. eCollection 2017.


TGF-β affinity-bound to a macroporous alginate scaffold generates local and peripheral immunotolerant responses and improves allocell transplantation.

Orr S, Strominger I, Eremenko E, Vinogradov E, Ruvinov E, Monsonego A, Cohen S.

Acta Biomater. 2016 Nov;45:196-209. doi: 10.1016/j.actbio.2016.08.015. Epub 2016 Aug 11.


Targeting innate immunity for neurodegenerative disorders of the central nervous system.

Andreasson KI, Bachstetter AD, Colonna M, Ginhoux F, Holmes C, Lamb B, Landreth G, Lee DC, Low D, Lynch MA, Monsonego A, O'Banion MK, Pekny M, Puschmann T, Russek-Blum N, Sandusky LA, Selenica ML, Takata K, Teeling J, Town T, Van Eldik LJ.

J Neurochem. 2016 Sep;138(5):653-93. doi: 10.1111/jnc.13667. Review. Erratum in: J Neurochem. 2017 Apr;141(1):151.


Differential TGF-β Signaling in Glial Subsets Underlies IL-6-Mediated Epileptogenesis in Mice.

Levy N, Milikovsky DZ, Baranauskas G, Vinogradov E, David Y, Ketzef M, Abutbul S, Weissberg I, Kamintsky L, Fleidervish I, Friedman A, Monsonego A.

J Immunol. 2015 Aug 15;195(4):1713-22. doi: 10.4049/jimmunol.1401446. Epub 2015 Jul 1.


Accelerated microglial pathology is associated with Aβ plaques in mouse models of Alzheimer's disease.

Baron R, Babcock AA, Nemirovsky A, Finsen B, Monsonego A.

Aging Cell. 2014 Aug;13(4):584-95. doi: 10.1111/acel.12210. Epub 2014 Mar 18.


Th1 polarization of T cells injected into the cerebrospinal fluid induces brain immunosurveillance.

Fisher Y, Strominger I, Biton S, Nemirovsky A, Baron R, Monsonego A.

J Immunol. 2014 Jan 1;192(1):92-102. doi: 10.4049/jimmunol.1301707. Epub 2013 Dec 4.


Preferential lentiviral targeting of astrocytes in the central nervous system.

Fassler M, Weissberg I, Levy N, Diaz-Griffero F, Monsonego A, Friedman A, Taube R.

PLoS One. 2013 Oct 2;8(10):e76092. doi: 10.1371/journal.pone.0076092. eCollection 2013.


CD4 T cells in immunity and immunotherapy of Alzheimer's disease.

Monsonego A, Nemirovsky A, Harpaz I.

Immunology. 2013 Aug;139(4):438-46. doi: 10.1111/imm.12103. Review.


Inflammatory events at blood-brain barrier in neuroinflammatory and neurodegenerative disorders: implications for clinical disease.

de Vries HE, Kooij G, Frenkel D, Georgopoulos S, Monsonego A, Janigro D.

Epilepsia. 2012 Nov;53 Suppl 6:45-52. doi: 10.1111/j.1528-1167.2012.03702.x. Review.


Chronic exposure to stress predisposes to higher autoimmune susceptibility in C57BL/6 mice: glucocorticoids as a double-edged sword.

Harpaz I, Abutbul S, Nemirovsky A, Gal R, Cohen H, Monsonego A.

Eur J Immunol. 2013 Mar;43(3):758-69. doi: 10.1002/eji.201242613. Epub 2013 Jan 31. Erratum in: Eur J Immunol. 2013 Nov;43(11):3076.


TGF-β signaling through SMAD2/3 induces the quiescent microglial phenotype within the CNS environment.

Abutbul S, Shapiro J, Szaingurten-Solodkin I, Levy N, Carmy Y, Baron R, Jung S, Monsonego A.

Glia. 2012 Jul;60(7):1160-71. doi: 10.1002/glia.22343. Epub 2012 Apr 17.


Active Aβ vaccination fails to enhance amyloid clearance in a mouse model of Alzheimer's disease with Aβ42-driven pathology.

Nemirovsky A, Shapiro J, Baron R, Kompaniets A, Monsonego A.

J Neuroimmunol. 2012 Jun 15;247(1-2):95-9. doi: 10.1016/j.jneuroim.2012.03.017. Epub 2012 Apr 10.


Dendritic cells regulate amyloid-β-specific T-cell entry into the brain: the role of perivascular amyloid-β.

Fisher Y, Nemirovsky A, Baron R, Monsonego A.

J Alzheimers Dis. 2011;27(1):99-111. doi: 10.3233/JAD-2011-102034.


Amyloid beta-HSP60 peptide conjugate vaccine treats a mouse model of Alzheimer's disease.

Nemirovsky A, Fisher Y, Baron R, Cohen IR, Monsonego A.

Vaccine. 2011 May 23;29(23):4043-50. doi: 10.1016/j.vaccine.2011.03.033. Epub 2011 Apr 5.


Stromal cell-induced immune regulation in a transplantable lymphoid-like cell constructs.

Kaminer-Israeli Y, Shapiro J, Cohen S, Monsonego A.

Biomaterials. 2010 Dec;31(35):9273-84. doi: 10.1016/j.biomaterials.2010.08.070. Epub 2010 Sep 24.


The Neural/Immune Gene Ontology: clipping the Gene Ontology for neurological and immunological systems.

Geifman N, Monsonego A, Rubin E.

BMC Bioinformatics. 2010 Sep 12;11:458. doi: 10.1186/1471-2105-11-458.


T cells specifically targeted to amyloid plaques enhance plaque clearance in a mouse model of Alzheimer's disease.

Fisher Y, Nemirovsky A, Baron R, Monsonego A.

PLoS One. 2010 May 26;5(5):e10830. doi: 10.1371/journal.pone.0010830.


Silencing of proinflammatory genes targeted to peritoneal-residing macrophages using siRNA encapsulated in biodegradable microspheres.

Brunner T, Cohen S, Monsonego A.

Biomaterials. 2010 Mar;31(9):2627-36. doi: 10.1016/j.biomaterials.2009.12.011. Epub 2009 Dec 24.


Signal regulatory protein-beta1: a microglial modulator of phagocytosis in Alzheimer's disease.

Gaikwad S, Larionov S, Wang Y, Dannenberg H, Matozaki T, Monsonego A, Thal DR, Neumann H.

Am J Pathol. 2009 Dec;175(6):2528-39. doi: 10.2353/ajpath.2009.090147. Epub 2009 Nov 5.


HLA-DR alleles in amyloid beta-peptide autoimmunity: a highly immunogenic role for the DRB1*1501 allele.

Zota V, Nemirovsky A, Baron R, Fisher Y, Selkoe DJ, Altmann DM, Weiner HL, Monsonego A.

J Immunol. 2009 Sep 1;183(5):3522-30. doi: 10.4049/jimmunol.0900620. Epub 2009 Aug 12.


IFN-gamma enhances neurogenesis in wild-type mice and in a mouse model of Alzheimer's disease.

Baron R, Nemirovsky A, Harpaz I, Cohen H, Owens T, Monsonego A.

FASEB J. 2008 Aug;22(8):2843-52. doi: 10.1096/fj.08-105866. Epub 2008 Apr 7.


Reversal of axonal loss and disability in a mouse model of progressive multiple sclerosis.

Basso AS, Frenkel D, Quintana FJ, Costa-Pinto FA, Petrovic-Stojkovic S, Puckett L, Monsonego A, Bar-Shir A, Engel Y, Gozin M, Weiner HL.

J Clin Invest. 2008 Apr;118(4):1532-43. doi: 10.1172/JCI33464.


Immunity and neuronal repair in the progression of Alzheimer's disease: a brief overview.

Baron R, Harpaz I, Nemirovsky A, Cohen H, Monsonego A.

Exp Gerontol. 2007 Jan-Feb;42(1-2):64-9. Epub 2006 Oct 30. Review.


Innate immunity in multiple sclerosis: myeloid dendritic cells in secondary progressive multiple sclerosis are activated and drive a proinflammatory immune response.

Karni A, Abraham M, Monsonego A, Cai G, Freeman GJ, Hafler D, Khoury SJ, Weiner HL.

J Immunol. 2006 Sep 15;177(6):4196-202.


Immunization therapy in Alzheimer's disease.

Mor F, Monsonego A.

Expert Rev Neurother. 2006 May;6(5):653-9. Review.


Abeta-induced meningoencephalitis is IFN-gamma-dependent and is associated with T cell-dependent clearance of Abeta in a mouse model of Alzheimer's disease.

Monsonego A, Imitola J, Petrovic S, Zota V, Nemirovsky A, Baron R, Fisher Y, Owens T, Weiner HL.

Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5048-53. Epub 2006 Mar 20.


The mechanism of nasal tolerance in lupus prone mice is T-cell anergy induced by immature B cells that lack B7 expression.

Wu HY, Monsonego A, Weiner HL.

J Autoimmun. 2006 Mar;26(2):116-26. Epub 2006 Jan 19.


Development of a safe oral Abeta vaccine using recombinant adeno-associated virus vector for Alzheimer's disease.

Hara H, Monsonego A, Yuasa K, Adachi K, Xiao X, Takeda S, Takahashi K, Weiner HL, Tabira T.

J Alzheimers Dis. 2004 Oct;6(5):483-8.


Immunotherapeutic approaches to Alzheimer's disease.

Monsonego A, Weiner HL.

Science. 2003 Oct 31;302(5646):834-8. Review.


Beneficial effect of orally administered myelin basic protein in EAE-susceptible Lewis rats in a model of acute CNS degeneration.

Monsonego A, Beserman ZP, Kipnis J, Yoles E, Weiner HL, Schwartz M.

J Autoimmun. 2003 Sep;21(2):131-8.


Microglia-mediated nitric oxide cytotoxicity of T cells following amyloid beta-peptide presentation to Th1 cells.

Monsonego A, Imitola J, Zota V, Oida T, Weiner HL.

J Immunol. 2003 Sep 1;171(5):2216-24. Erratum in: J Immunol. 2004 Jan 1;172(1):717.


Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease.

Monsonego A, Zota V, Karni A, Krieger JI, Bar-Or A, Bitan G, Budson AE, Sperling R, Selkoe DJ, Weiner HL.

J Clin Invest. 2003 Aug;112(3):415-22.


Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimer's disease.

Monsonego A, Maron R, Zota V, Selkoe DJ, Weiner HL.

Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10273-8. Epub 2001 Aug 21.


Differential T cell response in central and peripheral nerve injury: connection with immune privilege.

Moalem G, Monsonego A, Shani Y, Cohen IR, Schwartz M.

FASEB J. 1999 Jul;13(10):1207-17.


Factor XIIIa as a nerve-associated transglutaminase.

Monsonego A, Mizrahi T, Eitan S, Moalem G, Bárdos H, Adány R, Schwartz M.

FASEB J. 1998 Sep;12(12):1163-71.


Expression of GTP-dependent and GTP-independent tissue-type transglutaminase in cytokine-treated rat brain astrocytes.

Monsonego A, Shani Y, Friedmann I, Paas Y, Eizenberg O, Schwartz M.

J Biol Chem. 1997 Feb 7;272(6):3724-32. Erratum in: J Biol Chem 1997 Mar 14;272(11):7565.


Complete transection of rat optic nerve while sparing the meninges and the vasculature: an experimental model for optic nerve neuropathy and trauma.

Solomon AS, Lavie V, Hauben U, Monsonego A, Yoles E, Schwartz M.

J Neurosci Methods. 1996 Dec;70(1):21-5.


The fumR gene encoding fumarase in the filamentous fungus Rhizopus oryzae: cloning, structure and expression.

Friedberg D, Peleg Y, Monsonego A, Maissi S, Battat E, Rokem JS, Goldberg I.

Gene. 1995 Sep 22;163(1):139-44.


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