Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 62

1.

Characterisation of healthy donor-derived T-cell responses specific to telaprevir diastereomers.

Alhilali KA, Al-Attar Z, Gibson A, Tailor A, Meng X, Monshouwer M, Snoeys J, Park BK, Naisbitt DJ.

Toxicol Sci. 2019 Jan 12. doi: 10.1093/toxsci/kfz007. [Epub ahead of print]

PMID:
30649540
2.

Effect of Plasma Protein Binding on the Anti-Hepatitis B Virus Activity and Pharmacokinetic Properties of NVR 3-778.

Helsen N, Vervoort T, Vandenbossche J, Lenz O, Monshouwer M, Pauwels F, Snoeys J.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01497-18. doi: 10.1128/AAC.01497-18. Print 2018 Nov.

PMID:
30181376
3.

Finding synergies for 3Rs - Toxicokinetics and read-across: Report from an EPAA partners' Forum.

Laroche C, Aggarwal M, Bender H, Benndorf P, Birk B, Crozier J, Dal Negro G, De Gaetano F, Desaintes C, Gardner I, Hubesch B, Irizar A, John D, Kumar V, Lostia A, Manou I, Monshouwer M, Müller BP, Paini A, Reid K, Rowan T, Sachana M, Schutte K, Stirling C, Taalman R, van Aerts L, Weissenhorn R, Sauer UG.

Regul Toxicol Pharmacol. 2018 Nov;99:5-21. doi: 10.1016/j.yrtph.2018.08.006. Epub 2018 Aug 23.

4.

Establishing a systematic framework to characterise in vitro methods for human hepatic metabolic clearance.

Gouliarmou V, Lostia AM, Coecke S, Bernasconi C, Bessems J, Dorne JL, Ferguson S, Testai E, Remy UG, Brian Houston J, Monshouwer M, Nong A, Pelkonen O, Morath S, Wetmore BA, Worth A, Zanelli U, Zorzoli MC, Whelan M.

Toxicol In Vitro. 2018 Dec;53:233-244. doi: 10.1016/j.tiv.2018.08.004. Epub 2018 Aug 9.

PMID:
30099088
5.

The utility of HepaRG cells for bioenergetic investigation and detection of drug-induced mitochondrial toxicity.

Kamalian L, Douglas O, Jolly CE, Snoeys J, Simic D, Monshouwer M, Williams DP, Kevin Park B, Chadwick AE.

Toxicol In Vitro. 2018 Dec;53:136-147. doi: 10.1016/j.tiv.2018.08.001. Epub 2018 Aug 7.

6.

Clinical Investigation of Coproporphyrins as Sensitive Biomarkers to Predict Mild to Strong OATP1B-Mediated Drug-Drug Interactions.

Kunze A, Ediage EN, Dillen L, Monshouwer M, Snoeys J.

Clin Pharmacokinet. 2018 Dec;57(12):1559-1570. doi: 10.1007/s40262-018-0648-3.

PMID:
29663259
7.

Effects of Co-Culture Media on Hepatic Differentiation of hiPSC with or without HUVEC Co-Culture.

Freyer N, Greuel S, Knöspel F, Strahl N, Amini L, Jacobs F, Monshouwer M, Zeilinger K.

Int J Mol Sci. 2017 Aug 7;18(8). pii: E1724. doi: 10.3390/ijms18081724.

8.

Elucidating the Plasma and Liver Pharmacokinetics of Simeprevir in Special Populations Using Physiologically Based Pharmacokinetic Modelling.

Snoeys J, Beumont M, Monshouwer M, Ouwerkerk-Mahadevan S.

Clin Pharmacokinet. 2017 Jul;56(7):781-792. doi: 10.1007/s40262-016-0476-2.

PMID:
27896690
9.

Hepatic Differentiation of Human Induced Pluripotent Stem Cells in a Perfused Three-Dimensional Multicompartment Bioreactor.

Freyer N, Knöspel F, Strahl N, Amini L, Schrade P, Bachmann S, Damm G, Seehofer D, Jacobs F, Monshouwer M, Zeilinger K.

Biores Open Access. 2016 Aug 1;5(1):235-48. doi: 10.1089/biores.2016.0027. eCollection 2016.

10.

Ibrutinib Dosing Strategies Based on Interaction Potential of CYP3A4 Perpetrators Using Physiologically Based Pharmacokinetic Modeling.

de Zwart L, Snoeys J, De Jong J, Sukbuntherng J, Mannaert E, Monshouwer M.

Clin Pharmacol Ther. 2016 Nov;100(5):548-557. doi: 10.1002/cpt.419. Epub 2016 Aug 27.

PMID:
27367453
11.

In Vitro Model for Hepatotoxicity Studies Based on Primary Human Hepatocyte Cultivation in a Perfused 3D Bioreactor System.

Knöspel F, Jacobs F, Freyer N, Damm G, De Bondt A, van den Wyngaert I, Snoeys J, Monshouwer M, Richter M, Strahl N, Seehofer D, Zeilinger K.

Int J Mol Sci. 2016 Apr 16;17(4):584. doi: 10.3390/ijms17040584.

12.

Mechanistic understanding of the nonlinear pharmacokinetics and intersubject variability of simeprevir: A PBPK-guided drug development approach.

Snoeys J, Beumont M, Monshouwer M, Ouwerkerk-Mahadevan S.

Clin Pharmacol Ther. 2016 Feb;99(2):224-34. doi: 10.1002/cpt.206. Epub 2015 Nov 10.

PMID:
26259716
13.

The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death.

Kamalian L, Chadwick AE, Bayliss M, French NS, Monshouwer M, Snoeys J, Park BK.

Toxicol In Vitro. 2015 Jun;29(4):732-40. doi: 10.1016/j.tiv.2015.02.011. Epub 2015 Mar 5.

14.

Synthesis, in Vitro Covalent Binding Evaluation, and Metabolism of (14)C-Labeled Inhibitors of 11β-HSD1.

Sun D, Ye Q, Yan X, Rew Y, Fan P, He X, Jiang M, McMinn DL, Monshouwer M, Tu H, Powers JP.

ACS Med Chem Lett. 2014 Sep 23;5(11):1245-50. doi: 10.1021/ml500331y. eCollection 2014 Nov 13.

15.

Mechanistic understanding of brain drug disposition to optimize the selection of potential neurotherapeutics in drug discovery.

Loryan I, Sinha V, Mackie C, Van Peer A, Drinkenburg W, Vermeulen A, Morrison D, Monshouwer M, Heald D, Hammarlund-Udenaes M.

Pharm Res. 2014 Aug;31(8):2203-19. doi: 10.1007/s11095-014-1319-1. Epub 2014 Mar 13.

PMID:
24623476
16.

Drug-drug interactions between rosuvastatin and oral antidiabetic drugs occurring at the level of OATP1B1.

van de Steeg E, Greupink R, Schreurs M, Nooijen IH, Verhoeckx KC, Hanemaaijer R, Ripken D, Monshouwer M, Vlaming ML, DeGroot J, Verwei M, Russel FG, Huisman MT, Wortelboer HM.

Drug Metab Dispos. 2013 Mar;41(3):592-601. doi: 10.1124/dmd.112.049023. Epub 2012 Dec 17.

PMID:
23248200
17.

In silico identification of potential cholestasis-inducing agents via modeling of Na(+)-dependent taurocholate cotransporting polypeptide substrate specificity.

Greupink R, Nabuurs SB, Zarzycka B, Verweij V, Monshouwer M, Huisman MT, Russel FG.

Toxicol Sci. 2012 Sep;129(1):35-48. doi: 10.1093/toxsci/kfs188. Epub 2012 May 28.

PMID:
22641618
18.

Interaction of fluvastatin with the liver-specific Na+ -dependent taurocholate cotransporting polypeptide (NTCP).

Greupink R, Dillen L, Monshouwer M, Huisman MT, Russel FG.

Eur J Pharm Sci. 2011 Nov 20;44(4):487-96. doi: 10.1016/j.ejps.2011.09.009. Epub 2011 Sep 16.

PMID:
21945488
19.

Determination of time-dependent inactivation of CYP3A4 in cryopreserved human hepatocytes and assessment of human drug-drug interactions.

Chen Y, Liu L, Monshouwer M, Fretland AJ.

Drug Metab Dispos. 2011 Nov;39(11):2085-92. doi: 10.1124/dmd.111.040634. Epub 2011 Aug 11.

PMID:
21835977
20.

Effect of hepatitis C virus infection on the mRNA expression of drug transporters and cytochrome p450 enzymes in chimeric mice with humanized liver.

Kikuchi R, McCown M, Olson P, Tateno C, Morikawa Y, Katoh Y, Bourdet DL, Monshouwer M, Fretland AJ.

Drug Metab Dispos. 2010 Nov;38(11):1954-61. doi: 10.1124/dmd.109.031732. Epub 2010 Aug 6.

PMID:
20693416
21.

In silico and in vitro pharmacogenetics: aldehyde oxidase rapidly metabolizes a p38 kinase inhibitor.

Zhang X, Liu HH, Weller P, Zheng M, Tao W, Wang J, Liao G, Monshouwer M, Peltz G.

Pharmacogenomics J. 2011 Feb;11(1):15-24. doi: 10.1038/tpj.2010.8. Epub 2010 Feb 23.

PMID:
20177421
22.

Enzyme induction: translating multiple approaches, assays, endpoints, and opinions into a valuable induction screening strategy.

Fretland A, Monshouwer M.

Comb Chem High Throughput Screen. 2010 Feb;13(2):135-44. Review.

PMID:
20053161
23.

Comparison of in vitro bioactivation of flutamide and its cyano analogue: evidence for reductive activation by human NADPH:cytochrome P450 reductase.

Wen B, Coe KJ, Rademacher P, Fitch WL, Monshouwer M, Nelson SD.

Chem Res Toxicol. 2008 Dec;21(12):2393-406. doi: 10.1021/tx800281h.

24.

Unbound drug concentration in brain homogenate and cerebral spinal fluid at steady state as a surrogate for unbound concentration in brain interstitial fluid.

Liu X, Van Natta K, Yeo H, Vilenski O, Weller PE, Worboys PD, Monshouwer M.

Drug Metab Dispos. 2009 Apr;37(4):787-93. doi: 10.1124/dmd.108.024125. Epub 2008 Dec 30.

PMID:
19116265
25.

Discovery of novel, potent benzamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) exhibiting oral activity in an enzyme inhibition ex vivo model.

Julian LD, Wang Z, Bostick T, Caille S, Choi R, DeGraffenreid M, Di Y, He X, Hungate RW, Jaen JC, Liu J, Monshouwer M, McMinn D, Rew Y, Sudom A, Sun D, Tu H, Ursu S, Walker N, Yan X, Ye Q, Powers JP.

J Med Chem. 2008 Jul 10;51(13):3953-60. doi: 10.1021/jm800310g. Epub 2008 Jun 14.

PMID:
18553955
26.

In silico and in vitro pharmacogenetic analysis in mice.

Guo Y, Lu P, Farrell E, Zhang X, Weller P, Monshouwer M, Wang J, Liao G, Zhang Z, Hu S, Allard J, Shafer S, Usuka J, Peltz G.

Proc Natl Acad Sci U S A. 2007 Nov 6;104(45):17735-40. Epub 2007 Oct 31.

27.

Analytical tools and approaches for metabolite identification in early drug discovery.

Chen Y, Monshouwer M, Fitch WL.

Pharm Res. 2007 Feb;24(2):248-57. Epub 2006 Oct 18. Review.

PMID:
17048114
28.

Metabolism: a bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54.

Coecke S, Ahr H, Blaauboer BJ, Bremer S, Casati S, Castell J, Combes R, Corvi R, Crespi CL, Cunningham ML, Elaut G, Eletti B, Freidig A, Gennari A, Ghersi-Egea JF, Guillouzo A, Hartung T, Hoet P, Ingelman-Sundberg M, Munn S, Janssens W, Ladstetter B, Leahy D, Long A, Meneguz A, Monshouwer M, Morath S, Nagelkerke F, Pelkonen O, Ponti J, Prieto P, Richert L, Sabbioni E, Schaack B, Steiling W, Testai E, Vericat JA, Worth A.

Altern Lab Anim. 2006 Feb;34(1):49-84. No abstract available.

PMID:
16522150
29.

Toxicokinetics and metabolism.

Coecke S, Blaauboer BJ, Elaut G, Freeman S, Freidig A, Gensmantel N, Hoet P, Kapoulas VM, Ladstetter B, Langley G, Leahy D, Mannens G, Meneguz A, Monshouwer M, Nemery B, Pelkonen O, Pfaller W, Prieto P, Proctor N, Rogiers V, Rostami-Hodjegan A, Sabbioni E, Steiling W, van de Sandt JJ.

Altern Lab Anim. 2005 Jul;33 Suppl 1:147-75. No abstract available.

PMID:
16194147
30.

An in vitro approach to detect metabolite toxicity due to CYP3A4-dependent bioactivation of xenobiotics.

Vignati L, Turlizzi E, Monaci S, Grossi P, Kanter Rd, Monshouwer M.

Toxicology. 2005 Dec 15;216(2-3):154-67. Epub 2005 Sep 19.

PMID:
16169652
31.

An in vivo and in vitro comparison of CYP gene induction in mice using liver slices and quantitative RT-PCR.

Martignoni M, de Kanter R, Grossi P, Saturno G, Barbaria E, Monshouwer M.

Toxicol In Vitro. 2006 Feb;20(1):125-31. Epub 2005 Aug 10.

PMID:
16098711
32.

Substrate specific metabolism by polymorphic cytochrome P450 2D6 alleles.

Bogni A, Monshouwer M, Moscone A, Hidestrand M, Ingelman-Sundberg M, Hartung T, Coecke S.

Toxicol In Vitro. 2005 Aug;19(5):621-9.

PMID:
15893449
33.

An in vivo and in vitro comparison of CYP induction in rat liver and intestine using slices and quantitative RT-PCR.

Martignoni M, de Kanter R, Grossi P, Mahnke A, Saturno G, Monshouwer M.

Chem Biol Interact. 2004 Dec 30;151(1):1-11.

PMID:
15607757
34.

Lack of strain-related differences in drug metabolism and efflux transporter characteristics between CD-1 and athymic nude mice.

Martignoni M, de Kanter R, Moscone A, Grossi P, Monshouwer M.

Cancer Chemother Pharmacol. 2005 Feb;55(2):129-35. Epub 2004 Sep 22.

PMID:
15592720
35.

Prediction of whole-body metabolic clearance of drugs through the combined use of slices from rat liver, lung, kidney, small intestine and colon.

De Kanter R, Monshouwer M, Draaisma AL, De Jager MH, de Graaf IA, Proost JH, Meijer DK, Groothuis GM.

Xenobiotica. 2004 Mar;34(3):229-41.

PMID:
15204696
36.
37.

Phase I and phase II metabolic activities are retained in liver slices from mouse, rat, dog, monkey and human after cryopreservation.

Martignoni M, Monshouwer M, de Kanter R, Pezzetta D, Moscone A, Grossi P.

Toxicol In Vitro. 2004 Feb;18(1):121-8.

PMID:
14630070
38.

Hepatic (dys-)function during inflammation.

Monshouwer M, Hoebe KH.

Toxicol In Vitro. 2003 Oct-Dec;17(5-6):681-6. Review.

PMID:
14599463
39.

Precision-cut organ slices as a tool to study toxicity and metabolism of xenobiotics with special reference to non-hepatic tissues.

de Kanter R, Monshouwer M, Meijer DK, Groothuis GM.

Curr Drug Metab. 2002 Feb;3(1):39-59. Review.

PMID:
11878310
40.

The use of genetically engineered cells for assessing CYP2D6-related polymorphic effects.

Coecke S, Bogni A, Langezaal I, Worth A, Hartung T, Monshouwer M.

Toxicol In Vitro. 2001 Aug-Oct;15(4-5):553-6.

PMID:
11566590
41.

Differential effects of pentoxifylline on the hepatic inflammatory response in porcine liver cell cultures. Increase in inducible nitric oxide synthase expression.

Hoebe KH, Gonzalez-Ramon N, Nijmeijer SM, Witkamp RF, van Leengoed LA, van Miert AS, Monshouwer M.

Biochem Pharmacol. 2001 May 1;61(9):1137-44.

PMID:
11301047
42.

Direct cell-to-cell contact between Kupffer cells and hepatocytes augments endotoxin-induced hepatic injury.

Hoebe KH, Witkamp RF, Fink-Gremmels J, Van Miert AS, Monshouwer M.

Am J Physiol Gastrointest Liver Physiol. 2001 Apr;280(4):G720-8.

43.

Decrease in brain cytochrome P450 enzyme activities during infection and inflammation of the central nervous system.

Monshouwer M, Agnello D, Ghezzi P, Villa P.

Neuroimmunomodulation. 2000;8(3):142-7.

PMID:
11124580
44.

Suppression of the acute inflammatory response of porcine alveolar- and liver macrophages.

Izeboud CA, Monshouwer M, Witkamp RF, van Miert AS.

Vet Q. 2000 Jan;22(1):26-30.

PMID:
10682384
45.

Cocultures of porcine hepatocytes and Kupffer cells as an improved in vitro model for the study of hepatotoxic compounds.

Hoebe KH, Monshouwer M, Witkamp RF, Fink-Gremmels J, van Miert AS.

Vet Q. 2000 Jan;22(1):21-5.

PMID:
10682383
46.
47.
48.

The beta-adrenoceptor agonist clenbuterol is a potent inhibitor of the LPS-induced production of TNF-alpha and IL-6 in vitro and in vivo.

Izeboud CA, Monshouwer M, van Miert AS, Witkamp RF.

Inflamm Res. 1999 Sep;48(9):497-502.

PMID:
10522805
49.

Participation of beta-adrenergic receptors on macrophages in modulation of LPS-induced cytokine release.

Izeboud CA, Mocking JA, Monshouwer M, van Miert AS, Witkamp RF.

J Recept Signal Transduct Res. 1999 Jan-Jul;19(1-4):191-202.

PMID:
10071758
50.

Characterization of cytochrome P450 isoenzymes in primary cultures of pig hepatocytes.

Monshouwer M, Van't Klooster GA, Nijmeijer SM, Witkamp RF, van Miert AS.

Toxicol In Vitro. 1998 Dec;12(6):715-23.

PMID:
20654461

Supplemental Content

Loading ...
Support Center