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Reactive cysteine residues in the oxidative dimerization and Cu2+ induced aggregation of human γD-crystallin: Implications for age-related cataract.

Ramkumar S, Fan X, Wang B, Yang S, Monnier VM.

Biochim Biophys Acta Mol Basis Dis. 2018 Nov;1864(11):3595-3604. doi: 10.1016/j.bbadis.2018.08.021. Epub 2018 Aug 18.


Evidence of glucuronidation of the glycation product LW-1: tentative structure and implications for the long-term complications of diabetes.

Sell DR, Nemet I, Liang Z, Monnier VM.

Glycoconj J. 2018 Apr;35(2):177-190. doi: 10.1007/s10719-017-9810-7. Epub 2018 Jan 5.


Proteomic analysis of the glutathione-deficient LEGSKO mouse lens reveals activation of EMT signaling, loss of lens specific markers, and changes in stress response proteins.

Whitson JA, Wilmarth PA, Klimek J, Monnier VM, David L, Fan X.

Free Radic Biol Med. 2017 Dec;113:84-96. doi: 10.1016/j.freeradbiomed.2017.09.019. Epub 2017 Sep 22.


Hand, shoulder and back stiffness in long-term type 1 diabetes; cross-sectional association with skin collagen advanced glycation end-products. The Dialong study.

Holte KB, Juel NG, Brox JI, Hanssen KF, Fosmark DS, Sell DR, Monnier VM, Berg TJ.

J Diabetes Complications. 2017 Sep;31(9):1408-1414. doi: 10.1016/j.jdiacomp.2017.06.007. Epub 2017 Jun 22.


Transcriptome of the GSH-Depleted Lens Reveals Changes in Detoxification and EMT Signaling Genes, Transport Systems, and Lipid Homeostasis.

Whitson JA, Zhang X, Medvedovic M, Chen J, Wei Z, Monnier VM, Fan X.

Invest Ophthalmol Vis Sci. 2017 May 1;58(5):2666-2684. doi: 10.1167/iovs.16-21398.


The oxidized thiol proteome in aging and cataractous mouse and human lens revealed by ICAT labeling.

Wang B, Hom G, Zhou S, Guo M, Li B, Yang J, Monnier VM, Fan X.

Aging Cell. 2017 Apr;16(2):244-261. doi: 10.1111/acel.12548. Epub 2016 Nov 13.


Gclc deficiency in mouse CNS causes mitochondrial damage and neurodegeneration.

Feng W, Rosca M, Fan Y, Hu Y, Feng P, Lee HG, Monnier VM, Fan X.

Hum Mol Genet. 2017 Apr 1;26(7):1376-1390. doi: 10.1093/hmg/ddx040.


Evidence of Dual Mechanisms of Glutathione Uptake in the Rodent Lens: A Novel Role for Vitreous Humor in Lens Glutathione Homeostasis.

Whitson JA, Sell DR, Goodman MC, Monnier VM, Fan X.

Invest Ophthalmol Vis Sci. 2016 Jul 1;57(8):3914-25. doi: 10.1167/iovs.16-19592.


Advanced glycation in diabetes, aging and age-related diseases: conclusions.

Monnier VM, Taniguchi N.

Glycoconj J. 2016 Aug;33(4):691-2. doi: 10.1007/s10719-016-9711-1. No abstract available.


Advanced glycation in diabetes, aging and age-related diseases: editorial and dedication.

Monnier VM, Taniguchi N.

Glycoconj J. 2016 Aug;33(4):483-6. doi: 10.1007/s10719-016-9704-0. Epub 2016 Jul 15. No abstract available.


Lens glutathione homeostasis: Discrepancies and gaps in knowledge standing in the way of novel therapeutic approaches.

Fan X, Monnier VM, Whitson J.

Exp Eye Res. 2017 Mar;156:103-111. doi: 10.1016/j.exer.2016.06.018. Epub 2016 Jun 29. Review.


New Locus for Skin Intrinsic Fluorescence in Type 1 Diabetes Also Associated With Blood and Skin Glycated Proteins.

Roshandel D, Klein R, Klein BE, Wolffenbuttel BH, van der Klauw MM, van Vliet-Ostaptchouk JV, Atzmon G, Ben-Avraham D, Crandall JP, Barzilai N, Bull SB, Canty AJ, Hosseini SM, Hiraki LT, Maynard J, Sell DR, Monnier VM, Cleary PA, Braffett BH; DCCT/EDIC Research Group, Paterson AD.

Diabetes. 2016 Jul;65(7):2060-71. doi: 10.2337/db15-1484. Epub 2016 Apr 12.


Skin collagen fluorophore LW-1 versus skin fluorescence as markers for the long-term progression of subclinical macrovascular disease in type 1 diabetes.

Sell DR, Sun W, Gao X, Strauch C, Lachin JM, Cleary PA, Genuth S; DCCT/EDIC Research Group, Monnier VM.

Cardiovasc Diabetol. 2016 Feb 11;15:30. doi: 10.1186/s12933-016-0343-3.


Evidence of Highly Conserved β-Crystallin Disulfidome that Can be Mimicked by In Vitro Oxidation in Age-related Human Cataract and Glutathione Depleted Mouse Lens.

Fan X, Zhou S, Wang B, Hom G, Guo M, Li B, Yang J, Vaysburg D, Monnier VM.

Mol Cell Proteomics. 2015 Dec;14(12):3211-23. doi: 10.1074/mcp.M115.050948. Epub 2015 Oct 9.


Erratum to: Skin collagen advanced glycation endproducts (AGEs) and the long-term progression of sub-clinical cardiovascular disease in type 1 diabetes.

Monnier VM, Sun W, Gao X, Sell DR, Cleary PA, Lachin JM, Genuth S; DCCT/EDIC Research Group.

Cardiovasc Diabetol. 2015 Oct 9;14:138. doi: 10.1186/s12933-015-0295-z. No abstract available.


Skin collagen advanced glycation endproducts (AGEs) and the long-term progression of sub-clinical cardiovascular disease in type 1 diabetes.

Monnier VM, Sun W, Gao X, Sell DR, Cleary PA, Lachin JM, Genuth S; DCCT/EDIC Research Group.

Cardiovasc Diabetol. 2015 Sep 5;14:118. doi: 10.1186/s12933-015-0266-4. Erratum in: Cardiovasc Diabetol. 2015;14:138.


Biological Effects Induced by Specific Advanced Glycation End Products in the Reconstructed Skin Model of Aging.

Pageon H, Zucchi H, Dai Z, Sell DR, Strauch CM, Monnier VM, Asselineau D.

Biores Open Access. 2015 Jan 1;4(1):54-64. doi: 10.1089/biores.2014.0053. eCollection 2015.


Bleach in the diabetic kidney destabilizes basement membrane collagen.

Monnier VM.

Diabetes. 2015 Jun;64(6):1910-1. doi: 10.2337/db15-0293. No abstract available.


Effect of chronic hypoxia on RAGE and its soluble forms in lungs and plasma of mice.

Gopal P, Gosker HR, Theije CC, Eurlings IM, Sell DR, Monnier VM, Reynaert NL.

Biochim Biophys Acta. 2015 May;1852(5):992-1000. doi: 10.1016/j.bbadis.2015.02.003. Epub 2015 Feb 19.


Glucosepane and oxidative markers in skin collagen correlate with intima media thickness and arterial stiffness in long-term type 1 diabetes.

Sveen KA, Dahl-Jørgensen K, Stensaeth KH, Angel K, Seljeflot I, Sell DR, Monnier VM, Hanssen KF.

J Diabetes Complications. 2015 Apr;29(3):407-12. doi: 10.1016/j.jdiacomp.2014.12.011. Epub 2014 Dec 29.


Advanced glycation end-products reduce collagen molecular sliding to affect collagen fibril damage mechanisms but not stiffness.

Fessel G, Li Y, Diederich V, Guizar-Sicairos M, Schneider P, Sell DR, Monnier VM, Snedeker JG.

PLoS One. 2014 Nov 3;9(11):e110948. doi: 10.1371/journal.pone.0110948. eCollection 2014.


Skin advanced glycation end products glucosepane and methylglyoxal hydroimidazolone are independently associated with long-term microvascular complication progression of type 1 diabetes.

Genuth S, Sun W, Cleary P, Gao X, Sell DR, Lachin J; DCCT/EDIC Research Group, Monnier VM.

Diabetes. 2015 Jan;64(1):266-78. doi: 10.2337/db14-0215. Epub 2014 Sep 3.


GWAS identifies an NAT2 acetylator status tag single nucleotide polymorphism to be a major locus for skin fluorescence.

Eny KM, Lutgers HL, Maynard J, Klein BE, Lee KE, Atzmon G, Monnier VM, van Vliet-Ostaptchouk JV, Graaff R, van der Harst P, Snieder H, van der Klauw MM, Sell DR, Hosseini SM, Cleary PA, Braffett BH, Orchard TJ, Lyons TJ, Howard K, Klein R, Crandall JP, Barzilai N, Milman S, Ben-Avraham D; LifeLines Cohort Study Group; DCCT/EDIC Research Group, Wolffenbuttel BH, Paterson AD.

Diabetologia. 2014 Aug;57(8):1623-34. doi: 10.1007/s00125-014-3286-9. Epub 2014 Jun 17.


An advanced glycation end product (AGE)-rich diet promotes Nε-carboxymethyl-lysine accumulation in the cardiac tissue and tendons of rats.

Roncero-Ramos I, Niquet-Léridon C, Strauch C, Monnier VM, Tessier FJ, Navarro MP, Delgado-Andrade C.

J Agric Food Chem. 2014 Jun 25;62(25):6001-6. doi: 10.1021/jf501005n. Epub 2014 Jun 10.


UVA light-excited kynurenines oxidize ascorbate and modify lens proteins through the formation of advanced glycation end products: implications for human lens aging and cataract formation.

Linetsky M, Raghavan CT, Johar K, Fan X, Monnier VM, Vasavada AR, Nagaraj RH.

J Biol Chem. 2014 Jun 13;289(24):17111-23. doi: 10.1074/jbc.M114.554410. Epub 2014 May 5.


Impaired left ventricular function and myocardial blood flow reserve in patients with long-term type 1 diabetes and no significant coronary artery disease: associations with protein glycation.

Sveen KA, Nerdrum T, Hanssen KF, Brekke M, Torjesen PA, Strauch CM, Sell DR, Monnier VM, Dahl-Jørgensen K, Steine K.

Diab Vasc Dis Res. 2014 Mar;11(2):84-91. doi: 10.1177/1479164113518805. Epub 2014 Jan 17.


Deletion of Mecom in mouse results in early-onset spinal deformity and osteopenia.

Juneja SC, Vonica A, Zeiss C, Lezon-Geyda K, Yatsula B, Sell DR, Monnier VM, Lin S, Ardito T, Eyre D, Reynolds D, Yao Z, Awad HA, Yu H, Wilson M, Honnons S, Boyce BF, Xing L, Zhang Y, Perkins AS.

Bone. 2014 Mar;60:148-61. doi: 10.1016/j.bone.2013.11.020. Epub 2013 Dec 4.


The impact of salsalate treatment on serum levels of advanced glycation end products in type 2 diabetes.

Barzilay JI, Jablonski KA, Fonseca V, Shoelson SE, Goldfine AB, Strauch C, Monnier VM; TINSAL-T2D Research Consortium.

Diabetes Care. 2014 Apr;37(4):1083-91. doi: 10.2337/dc13-1527. Epub 2013 Nov 19.


Small- and large-fiber neuropathy after 40 years of type 1 diabetes: associations with glycemic control and advanced protein glycation: the Oslo Study.

Sveen KA, Karimé B, Jørum E, Mellgren SI, Fagerland MW, Monnier VM, Dahl-Jørgensen K, Hanssen KF.

Diabetes Care. 2013 Nov;36(11):3712-7. doi: 10.2337/dc13-0788. Epub 2013 Sep 11.


Glucosepane: a poorly understood advanced glycation end product of growing importance for diabetes and its complications.

Monnier VM, Sun W, Sell DR, Fan X, Nemet I, Genuth S.

Clin Chem Lab Med. 2014 Jan 1;52(1):21-32. doi: 10.1515/cclm-2013-0174. Review.


Skin aging by glycation: lessons from the reconstructed skin model.

Pageon H, Zucchi H, Rousset F, Monnier VM, Asselineau D.

Clin Chem Lab Med. 2014 Jan 1;52(1):169-74. doi: 10.1515/cclm-2013-0091.


Metabolic transit of N(ε)-carboxymethyl-lysine after consumption of AGEs from bread crust.

Roncero-Ramos I, Delgado-Andrade C, Tessier FJ, Niquet-Léridon C, Strauch C, Monnier VM, Navarro MP.

Food Funct. 2013 Jul;4(7):1032-9. doi: 10.1039/c3fo30351a. Epub 2013 Feb 25.


The LEGSKO mouse: a mouse model of age-related nuclear cataract based on genetic suppression of lens glutathione synthesis.

Fan X, Liu X, Hao S, Wang B, Robinson ML, Monnier VM.

PLoS One. 2012;7(11):e50832. doi: 10.1371/journal.pone.0050832. Epub 2012 Nov 30.


The association between skin collagen glucosepane and past progression of microvascular and neuropathic complications in type 1 diabetes.

Monnier VM, Sell DR, Strauch C, Sun W, Lachin JM, Cleary PA, Genuth S; DCCT Research Group.

J Diabetes Complications. 2013 Mar-Apr;27(2):141-9. doi: 10.1016/j.jdiacomp.2012.10.004. Epub 2012 Nov 12.


Molecular basis of arterial stiffening: role of glycation - a mini-review.

Sell DR, Monnier VM.

Gerontology. 2012;58(3):227-37. doi: 10.1159/000334668. Epub 2012 Jan 4. Review.


Advanced glycation end-products as markers of aging and longevity in the long-lived Ansell's mole-rat (Fukomys anselli).

Dammann P, Sell DR, Begall S, Strauch C, Monnier VM.

J Gerontol A Biol Sci Med Sci. 2012 Jun;67(6):573-83. doi: 10.1093/gerona/glr208. Epub 2011 Dec 9.


Oxygen reactivity in flavoenzymes: context matters.

McDonald CA, Fagan RL, Collard F, Monnier VM, Palfey BA.

J Am Chem Soc. 2011 Oct 26;133(42):16809-11. doi: 10.1021/ja2081873. Epub 2011 Oct 4.


Topical application of L-arginine blocks advanced glycation by ascorbic acid in the lens of hSVCT2 transgenic mice.

Fan X, Xiaoqin L, Potts B, Strauch CM, Nemet I, Monnier VM.

Mol Vis. 2011;17:2221-7. Epub 2011 Aug 18.


Vitamin C degradation products and pathways in the human lens.

Nemet I, Monnier VM.

J Biol Chem. 2011 Oct 28;286(43):37128-36. doi: 10.1074/jbc.M111.245100. Epub 2011 Aug 31.


The cation-π interaction between Lys53 and the flavin of fructosamine oxidase (FAOX-II) is critical for activity.

Collard F, Fagan RL, Zhang J, Nemet I, Palfey BA, Monnier VM.

Biochemistry. 2011 Sep 20;50(37):7977-86. doi: 10.1021/bi1020666. Epub 2011 Aug 25.


Protection from retinopathy and other complications in patients with type 1 diabetes of extreme duration: the joslin 50-year medalist study.

Sun JK, Keenan HA, Cavallerano JD, Asztalos BF, Schaefer EJ, Sell DR, Strauch CM, Monnier VM, Doria A, Aiello LP, King GL.

Diabetes Care. 2011 Apr;34(4):968-74. doi: 10.2337/dc10-1675.


Pudendal nerve injury reduces urethral outlet resistance in diabetic rats.

Pan HQ, Lin DL, Strauch C, Butler RS, Monnier VM, Daneshgari F, Damaser MS.

Am J Physiol Renal Physiol. 2010 Dec;299(6):F1443-50. doi: 10.1152/ajprenal.00341.2009. Epub 2010 Sep 29.


Multiplex analysis of age-related protein and lipid modifications in human Bruch's membrane.

Beattie JR, Pawlak AM, Boulton ME, Zhang J, Monnier VM, McGarvey JJ, Stitt AW.

FASEB J. 2010 Dec;24(12):4816-24. doi: 10.1096/fj.10-166090. Epub 2010 Aug 4.


Favored and disfavored pathways of protein crosslinking by glucose: glucose lysine dimer (GLUCOLD) and crossline versus glucosepane.

Nemet I, Strauch CM, Monnier VM.

Amino Acids. 2011 Jan;40(1):167-81. doi: 10.1007/s00726-010-0631-2. Epub 2010 Jul 4.


Anaerobic vs aerobic pathways of carbonyl and oxidant stress in human lens and skin during aging and in diabetes: A comparative analysis.

Fan X, Sell DR, Zhang J, Nemet I, Theves M, Lu J, Strauch C, Halushka MK, Monnier VM.

Free Radic Biol Med. 2010 Sep 1;49(5):847-56. doi: 10.1016/j.freeradbiomed.2010.06.003. Epub 2010 Jun 9.


Partial characterization of the molecular nature of collagen-linked fluorescence: role of diabetes and end-stage renal disease.

Sell DR, Nemet I, Monnier VM.

Arch Biochem Biophys. 2010 Jan 15;493(2):192-206. doi: 10.1016/ Epub 2009 Oct 30.


Mechanism of lysine oxidation in human lens crystallins during aging and in diabetes.

Fan X, Zhang J, Theves M, Strauch C, Nemet I, Liu X, Qian J, Giblin FJ, Monnier VM.

J Biol Chem. 2009 Dec 11;284(50):34618-27. doi: 10.1074/jbc.M109.032094. Epub 2009 Oct 23.


Crystal structure of the deglycating enzyme fructosamine oxidase (amadoriase II).

Collard F, Zhang J, Nemet I, Qanungo KR, Monnier VM, Yee VC.

J Biol Chem. 2008 Oct 3;283(40):27007-16. doi: 10.1074/jbc.M804885200. Epub 2008 Jul 30.


Identification of glucose-derived cross-linking sites in ribonuclease A.

Dai Z, Wang B, Sun G, Fan X, Anderson VE, Monnier VM.

J Proteome Res. 2008 Jul;7(7):2756-68. doi: 10.1021/pr700874a. Epub 2008 May 24.

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