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Toxicoproteomic Analysis of Poly(ADP-ribose)-associated Proteins Induced by Oxidative Stress in Human Proximal Tubule Cells.

Islas-Robles A, Yedlapudi D, Lau SS, Monks TJ.

Toxicol Sci. 2019 Jun 4. pii: kfz131. doi: 10.1093/toxsci/kfz131. [Epub ahead of print]


Concurrent Inhibition of Vesicular Monoamine Transporter 2 Does Not Protect Against 3,4-Methylenedioxymethamphetamine (Ecstasy) Induced Neurotoxicity.

Cholanians AB, Phan AV, Lau SS, Monks TJ.

Toxicol Sci. 2019 Jul 1;170(1):157-166. doi: 10.1093/toxsci/kfz085.


Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes.

Li H, O'Meara M, Zhang X, Zhang K, Seyoum B, Yi Z, Kaufman RJ, Monks TJ, Wang JM.

Diabetes. 2019 Jun;68(6):1287-1302. doi: 10.2337/db18-0933. Epub 2019 Mar 18.


Cell-specific regulation of Nrf2 during ROS-Dependent cell death caused by 2,3,5-tris(glutathion-S-yl)hydroquinone (TGHQ).

Zhang F, Munoz FM, Sun L, Zhang S, Lau SS, Monks TJ.

Chem Biol Interact. 2019 Apr 1;302:1-10. doi: 10.1016/j.cbi.2019.01.027. Epub 2019 Jan 28.


All-trans-retinoic acid-mediated cytoprotection in LLC-PK1 renal epithelial cells is coupled to p-ERK activation in a ROS-independent manner.

Sapiro JM, Monks TJ, Lau SS.

Am J Physiol Renal Physiol. 2017 Dec 1;313(6):F1200-F1208. doi: 10.1152/ajprenal.00085.2017. Epub 2017 Aug 2.


MiR-27b augments bone marrow progenitor cell survival via suppressing the mitochondrial apoptotic pathway in Type 2 diabetes.

Li H, Liu J, Wang Y, Fu Z, Hüttemann M, Monks TJ, Chen AF, Wang JM.

Am J Physiol Endocrinol Metab. 2017 Oct 1;313(4):E391-E401. doi: 10.1152/ajpendo.00073.2017. Epub 2017 Jul 11.


From the Cover: ROS-Induced Store-Operated Ca2+ Entry Coupled to PARP-1 Hyperactivation Is Independent of PARG Activity in Necrotic Cell Death.

Munoz FM, Zhang F, Islas-Robles A, Lau SS, Monks TJ.

Toxicol Sci. 2017 Aug 1;158(2):444-453. doi: 10.1093/toxsci/kfx106.


Report of the 2014-2016 AACP Research and Graduate Affairs Committee.

Eddington Chair ND, Aubé J, Das SK, Ellingrod VL, Hansen R, Madhavan SS, Monks TJ, Morris ME, Lakoski Staff Liaison JM.

Am J Pharm Educ. 2016 Nov 25;80(9):S21. doi: 10.5688/ajpe809S21. No abstract available.


Exploration of early-life candidate biomarkers for childhood asthma using antibody arrays.

Xu H, Radabaugh T, Lu Z, Galligan M, Billheimer D, Vercelli D, Wright AL, Monks TJ, Halonen M, Lau SS.

Pediatr Allergy Immunol. 2016 Nov;27(7):696-701. doi: 10.1111/pai.12613. Epub 2016 Sep 12.


In situ, dual-mode monitoring of organ-on-a-chip with smartphone-based fluorescence microscope.

Cho S, Islas-Robles A, Nicolini AM, Monks TJ, Yoon JY.

Biosens Bioelectron. 2016 Dec 15;86:697-705. doi: 10.1016/j.bios.2016.07.015. Epub 2016 Jul 7.


From the Cover: Arsenic Induces Accumulation of α-Synuclein: Implications for Synucleinopathies and Neurodegeneration.

Cholanians AB, Phan AV, Ditzel EJ, Camenisch TD, Lau SS, Monks TJ.

Toxicol Sci. 2016 Oct;153(2):271-81. doi: 10.1093/toxsci/kfw117. Epub 2016 Jul 13.


Metformin Scavenges Methylglyoxal To Form a Novel Imidazolinone Metabolite in Humans.

Kinsky OR, Hargraves TL, Anumol T, Jacobsen NE, Dai J, Snyder SA, Monks TJ, Lau SS.

Chem Res Toxicol. 2016 Feb 15;29(2):227-34. doi: 10.1021/acs.chemrestox.5b00497. Epub 2016 Jan 27.


Site specific modification of the human plasma proteome by methylglyoxal.

Kimzey MJ, Kinsky OR, Yassine HN, Tsaprailis G, Stump CS, Monks TJ, Lau SS.

Toxicol Appl Pharmacol. 2015 Dec 1;289(2):155-62. doi: 10.1016/j.taap.2015.09.029. Epub 2015 Oct 3.


Transcriptional and post-translational modifications of B-Raf in quinol-thioether induced tuberous sclerosis renal cell carcinoma.

Cohen JD, Labenski M, Mastrandrea NJ, Canatsey RD, Monks TJ, Lau SS.

Mol Carcinog. 2016 Aug;55(8):1243-50. doi: 10.1002/mc.22366. Epub 2015 Aug 31.


Vesicular monoamine transporter 2 and the acute and long-term response to 3,4-(±)-methylenedioxymethamphetamine.

Lizarraga LE, Cholanians AB, Phan AV, Herndon JM, Lau SS, Monks TJ.

Toxicol Sci. 2015 Jan;143(1):209-19. doi: 10.1093/toxsci/kfu222. Epub 2014 Nov 4.


PARP-1 hyperactivation and reciprocal elevations in intracellular Ca2+ during ROS-induced nonapoptotic cell death.

Zhang F, Xie R, Munoz FM, Lau SS, Monks TJ.

Toxicol Sci. 2014 Jul;140(1):118-34. doi: 10.1093/toxsci/kfu073. Epub 2014 Apr 20.


Catechol-o-methyltransferase and 3,4-({+/-})-methylenedioxymethamphetamine toxicity.

Herndon JM, Cholanians AB, Lizarraga LE, Lau SS, Monks TJ.

Toxicol Sci. 2014 May;139(1):162-73. doi: 10.1093/toxsci/kfu035. Epub 2014 Mar 3.


Glial cell response to 3,4-(+/-)-methylenedioxymethamphetamine and its metabolites.

Herndon JM, Cholanians AB, Lau SS, Monks TJ.

Toxicol Sci. 2014 Mar;138(1):130-8. doi: 10.1093/toxsci/kft275. Epub 2013 Dec 3.


Reactive intermediates: molecular and MS-based approaches to assess the functional significance of chemical-protein adducts.

Monks TJ, Lau SS.

Toxicol Pathol. 2013 Feb;41(2):315-21. doi: 10.1177/0192623312467399. Epub 2012 Dec 6.


A dual role for poly(ADP-ribose) polymerase-1 during caspase-dependent apoptosis.

Zhang F, Lau SS, Monks TJ.

Toxicol Sci. 2012 Jul;128(1):103-14. doi: 10.1093/toxsci/kfs142. Epub 2012 Apr 20.


ERK crosstalks with 4EBP1 to activate cyclin D1 translation during quinol-thioether-induced tuberous sclerosis renal cell carcinoma.

Cohen JD, Gard JM, Nagle RB, Dietrich JD, Monks TJ, Lau SS.

Toxicol Sci. 2011 Nov;124(1):75-87. doi: 10.1093/toxsci/kfr203. Epub 2011 Aug 2.


cAMP-dependent cytosolic mislocalization of p27(kip)-cyclin D1 during quinol-thioether-induced tuberous sclerosis renal cell carcinoma.

Cohen JD, Tham KY, Mastrandrea NJ, Gallegos AC, Monks TJ, Lau SS.

Toxicol Sci. 2011 Aug;122(2):361-71. doi: 10.1093/toxsci/kfr118. Epub 2011 Jun 20.


The frequency of 1,4-benzoquinone-lysine adducts in cytochrome c correlate with defects in apoptosome activation.

Fisher AA, Labenski MT, Malladi S, Chapman JD, Bratton SB, Monks TJ, Lau SS.

Toxicol Sci. 2011 Jul;122(1):64-72. doi: 10.1093/toxsci/kfr085. Epub 2011 Apr 28.


Introduction to the proceedings of the 8th international Symposium on Biological Reactive Intermediates.

Monks TJ, de la Torre R.

Chem Biol Interact. 2011 Jun 30;192(1-2):1-2. doi: 10.1016/j.cbi.2011.03.003. Epub 2011 Mar 12. No abstract available.


The cytoprotective effect of N-acetyl-L-cysteine against ROS-induced cytotoxicity is independent of its ability to enhance glutathione synthesis.

Zhang F, Lau SS, Monks TJ.

Toxicol Sci. 2011 Mar;120(1):87-97. doi: 10.1093/toxsci/kfq364. Epub 2010 Dec 6.


Identification of chemical-adducted proteins in urine by multi-dimensional protein identification technology (LC/LC-MS/MS).

Labenski MT, Fisher AA, Monks TJ, Lau SS.

Methods Mol Biol. 2011;691:339-47. doi: 10.1007/978-1-60761-849-2_21.


One-dimensional western blotting coupled to LC-MS/MS analysis to identify chemical-adducted proteins in rat urine.

Labenski MT, Fisher AA, Monks TJ, Lau SS.

Methods Mol Biol. 2011;691:327-38. doi: 10.1007/978-1-60761-849-2_20.


Utilization of LC-MS/MS analyses to identify site-specific chemical protein adducts in vitro.

Fisher AA, Labenski MT, Monks TJ, Lau SS.

Methods Mol Biol. 2011;691:317-26. doi: 10.1007/978-1-60761-849-2_19.


Utilization of MALDI-TOF to determine chemical-protein adduct formation in vitro.

Fisher AA, Labenski MT, Monks TJ, Lau SS.

Methods Mol Biol. 2011;691:303-16. doi: 10.1007/978-1-60761-849-2_18.


New site(s) of methylglyoxal-modified human serum albumin, identified by multiple reaction monitoring, alter warfarin binding and prostaglandin metabolism.

Kimzey MJ, Yassine HN, Riepel BM, Tsaprailis G, Monks TJ, Lau SS.

Chem Biol Interact. 2011 Jun 30;192(1-2):122-8. doi: 10.1016/j.cbi.2010.09.032. Epub 2010 Oct 8.


The fate of benzene-oxide.

Monks TJ, Butterworth M, Lau SS.

Chem Biol Interact. 2010 Mar 19;184(1-2):201-6. doi: 10.1016/j.cbi.2009.12.025. Epub 2009 Dec 29.


Role of hydroquinone-thiol conjugates in benzene-mediated toxicity.

Lau SS, Kuhlman CL, Bratton SB, Monks TJ.

Chem Biol Interact. 2010 Mar 19;184(1-2):212-7. doi: 10.1016/j.cbi.2009.12.016. Epub 2009 Dec 23.


Serotonergic neurotoxic thioether metabolites of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"): synthesis, isolation, and characterization of diastereoisomers.

Pizarro N, de la Torre R, Joglar J, Okumura N, Perfetti X, Lau SS, Monks TJ.

Chem Res Toxicol. 2008 Dec;21(12):2272-9. doi: 10.1021/tx8002017.


Neurotoxic thioether adducts of 3,4-methylenedioxymethamphetamine identified in human urine after ecstasy ingestion.

Perfetti X, O'Mathúna B, Pizarro N, Cuyàs E, Khymenets O, Almeida B, Pellegrini M, Pichini S, Lau SS, Monks TJ, Farré M, Pascual JA, Joglar J, de la Torre R.

Drug Metab Dispos. 2009 Jul;37(7):1448-55. doi: 10.1124/dmd.108.026393. Epub 2009 Apr 6.


Protein electrophile-binding motifs: lysine-rich proteins are preferential targets of quinones.

Labenski MT, Fisher AA, Lo HH, Monks TJ, Lau SS.

Drug Metab Dispos. 2009 Jun;37(6):1211-8. doi: 10.1124/dmd.108.026211. Epub 2009 Feb 27.


Improved MALDI-TOF imaging yields increased protein signals at high molecular mass.

Leinweber BD, Tsaprailis G, Monks TJ, Lau SS.

J Am Soc Mass Spectrom. 2009 Jan;20(1):89-95. doi: 10.1016/j.jasms.2008.09.008. Epub 2008 Sep 12.


Accumulation of neurotoxic thioether metabolites of 3,4-(+/-)-methylenedioxymethamphetamine in rat brain.

Erives GV, Lau SS, Monks TJ.

J Pharmacol Exp Ther. 2008 Jan;324(1):284-91. Epub 2007 Sep 28.


Quinone electrophiles selectively adduct "electrophile binding motifs" within cytochrome c.

Fisher AA, Labenski MT, Malladi S, Gokhale V, Bowen ME, Milleron RS, Bratton SB, Monks TJ, Lau SS.

Biochemistry. 2007 Oct 2;46(39):11090-100. Epub 2007 Sep 7.


Ros-induced histone modifications and their role in cell survival and cell death.

Monks TJ, Xie R, Tikoo K, Lau SS.

Drug Metab Rev. 2006;38(4):755-67. Review.



Monks TJ.

Drug Metab Rev. 2006;38(4):599-600. No abstract available.


Age-dependent (+)MDMA-mediated neurotoxicity in mice.

Reveron ME, Monks TJ, Duvauchelle CL.

Neurotoxicology. 2005 Dec;26(6):1031-40. Epub 2005 Jul 5.


Alkylation of cytochrome c by (glutathion-S-yl)-1,4-benzoquinone and iodoacetamide demonstrates compound-dependent site specificity.

Person MD, Mason DE, Liebler DC, Monks TJ, Lau SS.

Chem Res Toxicol. 2005 Jan;18(1):41-50.


Serotonergic neurotoxic metabolites of ecstasy identified in rat brain.

Jones DC, Duvauchelle C, Ikegami A, Olsen CM, Lau SS, de la Torre R, Monks TJ.

J Pharmacol Exp Ther. 2005 Apr;313(1):422-31. Epub 2005 Jan 5.


Estradiol metabolites as isoform-specific inhibitors of human glutathione S-transferases.

Abel EL, Lyon RP, Bammler TK, Verlinde CL, Lau SS, Monks TJ, Eaton DL.

Chem Biol Interact. 2004 Dec 30;151(1):21-32.


Menadione metabolism to thiodione in hepatoblastoma by scanning electrochemical microscopy.

Mauzeroll J, Bard AJ, Owhadian O, Monks TJ.

Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17582-7. Epub 2004 Dec 15.


The role of metabolism in 3,4-(+)-methylenedioxyamphetamine and 3,4-(+)-methylenedioxymethamphetamine (ecstasy) toxicity.

Monks TJ, Jones DC, Bai F, Lau SS.

Ther Drug Monit. 2004 Apr;26(2):132-6. Review.


Grp78 is essential for 11-deoxy-16,16-dimethyl PGE2-mediated cytoprotection in renal epithelial cells.

Jia Z, Person MD, Dong J, Shen J, Hensley SC, Stevens JL, Monks TJ, Lau SS.

Am J Physiol Renal Physiol. 2004 Dec;287(6):F1113-22. Epub 2004 Jun 29.

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