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Items: 37


Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation.

Primiano MJ, Lefker BA, Bowman MR, Bree AG, Hubeau C, Bonin PD, Mangan M, Dower K, Monks BG, Cushing L, Wang S, Guzova J, Jiao A, Lin LL, Latz E, Hepworth D, Hall JP.

J Immunol. 2016 Sep 15;197(6):2421-33. doi: 10.4049/jimmunol.1600035. Epub 2016 Aug 12.


A Novel Factor H-Fc Chimeric Immunotherapeutic Molecule against Neisseria gonorrhoeae.

Shaughnessy J, Gulati S, Agarwal S, Unemo M, Ohnishi M, Su XH, Monks BG, Visintin A, Madico G, Lewis LA, Golenbock DT, Reed GW, Rice PA, Ram S.

J Immunol. 2016 Feb 15;196(4):1732-40. doi: 10.4049/jimmunol.1500292. Epub 2016 Jan 15.


A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.

Coll RC, Robertson AA, Chae JJ, Higgins SC, Muñoz-Planillo R, Inserra MC, Vetter I, Dungan LS, Monks BG, Stutz A, Croker DE, Butler MS, Haneklaus M, Sutton CE, Núñez G, Latz E, Kastner DL, Mills KH, Masters SL, Schroder K, Cooper MA, O'Neill LA.

Nat Med. 2015 Mar;21(3):248-55. doi: 10.1038/nm.3806. Epub 2015 Feb 16.


The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.

Franklin BS, Bossaller L, De Nardo D, Ratter JM, Stutz A, Engels G, Brenker C, Nordhoff M, Mirandola SR, Al-Amoudi A, Mangan MS, Zimmer S, Monks BG, Fricke M, Schmidt RE, Espevik T, Jones B, Jarnicki AG, Hansbro PM, Busto P, Marshak-Rothstein A, Hornemann S, Aguzzi A, Kastenmüller W, Latz E.

Nat Immunol. 2014 Aug;15(8):727-37. doi: 10.1038/ni.2913. Epub 2014 Jun 22.


ASC speck formation as a readout for inflammasome activation.

Stutz A, Horvath GL, Monks BG, Latz E.

Methods Mol Biol. 2013;1040:91-101. doi: 10.1007/978-1-62703-523-1_8.


Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis.

Hett EC, Slater LH, Mark KG, Kawate T, Monks BG, Stutz A, Latz E, Hung DT.

Nat Chem Biol. 2013 Jun;9(6):398-405. doi: 10.1038/nchembio.1236. Epub 2013 Apr 21. Erratum in: Nat Chem Biol. 2013 Jul;9(7):466.


Natural loss-of-function mutation of myeloid differentiation protein 88 disrupts its ability to form Myddosomes.

Nagpal K, Plantinga TS, Sirois CM, Monks BG, Latz E, Netea MG, Golenbock DT.

J Biol Chem. 2011 Apr 1;286(13):11875-82. doi: 10.1074/jbc.M110.199653. Epub 2011 Feb 16.


MD-2 residues tyrosine 42, arginine 69, aspartic acid 122, and leucine 125 provide species specificity for lipid IVA.

Meng J, Drolet JR, Monks BG, Golenbock DT.

J Biol Chem. 2010 Sep 3;285(36):27935-43. doi: 10.1074/jbc.M110.134668. Epub 2010 Jun 30.


The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.

Rathinam VA, Jiang Z, Waggoner SN, Sharma S, Cole LE, Waggoner L, Vanaja SK, Monks BG, Ganesan S, Latz E, Hornung V, Vogel SN, Szomolanyi-Tsuda E, Fitzgerald KA.

Nat Immunol. 2010 May;11(5):395-402. doi: 10.1038/ni.1864. Epub 2010 Mar 28.


Cell type-specific recognition of human metapneumoviruses (HMPVs) by retinoic acid-inducible gene I (RIG-I) and TLR7 and viral interference of RIG-I ligand recognition by HMPV-B1 phosphoprotein.

Goutagny N, Jiang Z, Tian J, Parroche P, Schickli J, Monks BG, Ulbrandt N, Ji H, Kiener PA, Coyle AJ, Fitzgerald KA.

J Immunol. 2010 Feb 1;184(3):1168-79. doi: 10.4049/jimmunol.0902750. Epub 2009 Dec 30.


Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.

Bauernfeind FG, Horvath G, Stutz A, Alnemri ES, MacDonald K, Speert D, Fernandes-Alnemri T, Wu J, Monks BG, Fitzgerald KA, Hornung V, Latz E.

J Immunol. 2009 Jul 15;183(2):787-91. doi: 10.4049/jimmunol.0901363. Epub 2009 Jul 1.


A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling.

Nagpal K, Plantinga TS, Wong J, Monks BG, Gay NJ, Netea MG, Fitzgerald KA, Golenbock DT.

J Biol Chem. 2009 Sep 18;284(38):25742-8. doi: 10.1074/jbc.M109.014886. Epub 2009 Jun 9.


The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.

Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, Reinheckel T, Fitzgerald KA, Latz E, Moore KJ, Golenbock DT.

Nat Immunol. 2008 Aug;9(8):857-65. doi: 10.1038/ni.1636. Epub 2008 Jul 11.


Ligand-induced conformational changes allosterically activate Toll-like receptor 9.

Latz E, Verma A, Visintin A, Gong M, Sirois CM, Klein DC, Monks BG, McKnight CJ, Lamphier MS, Duprex WP, Espevik T, Golenbock DT.

Nat Immunol. 2007 Jul;8(7):772-9. Epub 2007 Jun 17.


Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9.

Parroche P, Lauw FN, Goutagny N, Latz E, Monks BG, Visintin A, Halmen KA, Lamphier M, Olivier M, Bartholomeu DC, Gazzinelli RT, Golenbock DT.

Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1919-24. Epub 2007 Jan 29.


MD-2 expression is not required for cell surface targeting of Toll-like receptor 4 (TLR4).

Visintin A, Halmen KA, Khan N, Monks BG, Golenbock DT, Lien E.

J Leukoc Biol. 2006 Dec;80(6):1584-92. Epub 2006 Aug 31.



Visintin A, Iliev DB, Monks BG, Halmen KA, Golenbock DT.

Immunobiology. 2006;211(6-8):437-47. Epub 2006 Jul 18. Review.


The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.

Rowe DC, McGettrick AF, Latz E, Monks BG, Gay NJ, Yamamoto M, Akira S, O'Neill LA, Fitzgerald KA, Golenbock DT.

Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6299-304. Epub 2006 Apr 7.


Pharmacological inhibition of endotoxin responses is achieved by targeting the TLR4 coreceptor, MD-2.

Visintin A, Halmen KA, Latz E, Monks BG, Golenbock DT.

J Immunol. 2005 Nov 15;175(10):6465-72.


The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.

Rothenfusser S, Goutagny N, DiPerna G, Gong M, Monks BG, Schoenemeyer A, Yamamoto M, Akira S, Fitzgerald KA.

J Immunol. 2005 Oct 15;175(8):5260-8.


TLR9 signals after translocating from the ER to CpG DNA in the lysosome.

Latz E, Schoenemeyer A, Visintin A, Fitzgerald KA, Monks BG, Knetter CF, Lien E, Nilsen NJ, Espevik T, Golenbock DT.

Nat Immunol. 2004 Feb;5(2):190-8. Epub 2004 Jan 11.


Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction.

Visintin A, Latz E, Monks BG, Espevik T, Golenbock DT.

J Biol Chem. 2003 Nov 28;278(48):48313-20. Epub 2003 Sep 5.


Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction.

Latz E, Visintin A, Lien E, Fitzgerald KA, Monks BG, Kurt-Jones EA, Golenbock DT, Espevik T.

J Biol Chem. 2002 Dec 6;277(49):47834-43. Epub 2002 Sep 24.


Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers.

Flo TH, Ryan L, Latz E, Takeuchi O, Monks BG, Lien E, Halaas Ø, Akira S, Skjåk-Braek G, Golenbock DT, Espevik T.

J Biol Chem. 2002 Sep 20;277(38):35489-95. Epub 2002 Jun 27.


Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling.

Schromm AB, Lien E, Henneke P, Chow JC, Yoshimura A, Heine H, Latz E, Monks BG, Schwartz DA, Miyake K, Golenbock DT.

J Exp Med. 2001 Jul 2;194(1):79-88.


C4bp binding to porin mediates stable serum resistance of Neisseria gonorrhoeae.

Ram S, Cullinane M, Blom AM, Gulati S, McQuillen DP, Boden R, Monks BG, O'Connell C, Elkins C, Pangburn MK, Dahlbäck B, Rice PA.

Int Immunopharmacol. 2001 Mar;1(3):423-32. Review.


Binding of C4b-binding protein to porin: a molecular mechanism of serum resistance of Neisseria gonorrhoeae.

Ram S, Cullinane M, Blom AM, Gulati S, McQuillen DP, Monks BG, O'Connell C, Boden R, Elkins C, Pangburn MK, Dahlbäck B, Rice PA.

J Exp Med. 2001 Feb 5;193(3):281-95.


Divergent response to LPS and bacteria in CD14-deficient murine macrophages.

Moore KJ, Andersson LP, Ingalls RR, Monks BG, Li R, Arnaout MA, Golenbock DT, Freeman MW.

J Immunol. 2000 Oct 15;165(8):4272-80.


Bacterial lipopolysaccharide induces expression of the stress response genes hop and H411.

Heine H, Delude RL, Monks BG, Espevik T, Golenbock DT.

J Biol Chem. 1999 Jul 23;274(30):21049-55.


Cutting edge: cells that carry A null allele for toll-like receptor 2 are capable of responding to endotoxin.

Heine H, Kirschning CJ, Lien E, Monks BG, Rothe M, Golenbock DT.

J Immunol. 1999 Jun 15;162(12):6971-5.


Membrane expression of soluble endotoxin-binding proteins permits lipopolysaccharide signaling in Chinese hamster ovary fibroblasts independently of CD14.

Ingalls RR, Monks BG, Golenbock DT.

J Biol Chem. 1999 May 14;274(20):13993-8. Erratum in: J Biol Chem 1999 Jul 23;274(30):21490.


CD11/CD18 and CD14 share a common lipid A signaling pathway.

Ingalls RR, Monks BG, Savedra R Jr, Christ WJ, Delude RL, Medvedev AE, Espevik T, Golenbock DT.

J Immunol. 1998 Nov 15;161(10):5413-20.


Targeted deletion of the lipopolysaccharide (LPS)-binding protein gene leads to profound suppression of LPS responses ex vivo, whereas in vivo responses remain intact.

Wurfel MM, Monks BG, Ingalls RR, Dedrick RL, Delude R, Zhou D, Lamping N, Schumann RR, Thieringer R, Fenton MJ, Wright SD, Golenbock D.

J Exp Med. 1997 Dec 15;186(12):2051-6.


Dual effects of LPS antibodies on cellular uptake of LPS and LPS-induced proinflammatory functions.

Pollack M, Ohl CA, Golenbock DT, Di Padova F, Wahl LM, Koles NL, Guelde G, Monks BG.

J Immunol. 1997 Oct 1;159(7):3519-30.


An upstream protein interacts with a distinct protein that binds to the cap site of the human interleukin 1 beta gene.

Monks BG, Martell BA, Buras JA, Fenton MJ.

Mol Immunol. 1994 Feb;31(2):139-51.


The functional importance of a cap site-proximal region of the human prointerleukin 1 beta gene is defined by viral protein trans-activation.

Hunninghake GW, Monks BG, Geist LJ, Monick MM, Monroy MA, Stinski MF, Webb AC, Dayer JM, Auron PE, Fenton MJ.

Mol Cell Biol. 1992 Aug;12(8):3439-48.

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