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Healthy attachments: Cell adhesion molecules collectively control myelin integrity.

Li J, Monk KR.

J Cell Biol. 2019 Sep 2;218(9):2824-2825. doi: 10.1083/jcb.201907077. Epub 2019 Aug 26.


Glia in the skin activate pain responses.

Doan RA, Monk KR.

Science. 2019 Aug 16;365(6454):641-642. doi: 10.1126/science.aay6144. No abstract available.


Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7.

Harty BL, Coelho F, Pease-Raissi SE, Mogha A, Ackerman SD, Herbert AL, Gereau RW 4th, Golden JP, Lyons DA, Chan JR, Monk KR.

Nat Commun. 2019 Jul 5;10(1):2976. doi: 10.1038/s41467-019-10881-y.


The expanding functional roles and signaling mechanisms of adhesion G protein-coupled receptors.

Morgan RK, Anderson GR, Araç D, Aust G, Balenga N, Boucard A, Bridges JP, Engel FB, Formstone CJ, Glitsch MD, Gray RS, Hall RA, Hsiao CC, Kim HY, Knierim AB, Kusuluri DK, Leon K, Liebscher I, Piao X, Prömel S, Scholz N, Srivastava S, Thor D, Tolias KF, Ushkaryov YA, Vallon M, Van Meir EG, Vanhollebeke B, Wolfrum U, Wright KM, Monk KR, Mogha A.

Ann N Y Acad Sci. 2019 Jun 6. doi: 10.1111/nyas.14094. [Epub ahead of print]


Mutations in dock1 disrupt early Schwann cell development.

Cunningham RL, Herbert AL, Harty BL, Ackerman SD, Monk KR.

Neural Dev. 2018 Aug 8;13(1):17. doi: 10.1186/s13064-018-0114-9.


Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells.

Giera S, Luo R, Ying Y, Ackerman SD, Jeong SJ, Stoveken HM, Folts CJ, Welsh CA, Tall GG, Stevens B, Monk KR, Piao X.

Elife. 2018 May 29;7. pii: e33385. doi: 10.7554/eLife.33385.


Deletion of Tsc2 in Nociceptors Reduces Target Innervation, Ion Channel Expression, and Sensitivity to Heat.

Carlin D, Golden JP, Mogha A, Samineni VK, Monk KR, Gereau RW 4th, Cavalli V.

eNeuro. 2018 May 3;5(2). pii: ENEURO.0436-17.2018. doi: 10.1523/ENEURO.0436-17.2018. eCollection 2018 Mar-Apr.


Live Imaging of Schwann Cell Development in Zebrafish.

Cunningham RL, Monk KR.

Methods Mol Biol. 2018;1739:401-405. doi: 10.1007/978-1-4939-7649-2_27.


Transmission Electron Microscopy for Zebrafish Larvae and Adult Lateral Line Nerve.

Cunningham RL, Monk KR.

Methods Mol Biol. 2018;1739:385-400. doi: 10.1007/978-1-4939-7649-2_26.


Whole Mount In Situ Hybridization and Immunohistochemistry for Zebrafish Larvae.

Cunningham RL, Monk KR.

Methods Mol Biol. 2018;1739:371-384. doi: 10.1007/978-1-4939-7649-2_25.


GPR56/ADGRG1 regulates development and maintenance of peripheral myelin.

Ackerman SD, Luo R, Poitelon Y, Mogha A, Harty BL, D'Rozario M, Sanchez NE, Lakkaraju AKK, Gamble P, Li J, Qu J, MacEwan MR, Ray WZ, Aguzzi A, Feltri ML, Piao X, Monk KR.

J Exp Med. 2018 Mar 5;215(3):941-961. doi: 10.1084/jem.20161714. Epub 2018 Jan 24.


Unwrapping the unappreciated: recent progress in Remak Schwann cell biology.

Harty BL, Monk KR.

Curr Opin Neurobiol. 2017 Dec;47:131-137. doi: 10.1016/j.conb.2017.10.003. Epub 2017 Nov 6. Review.


Dynein/dynactin is necessary for anterograde transport of Mbp mRNA in oligodendrocytes and for myelination in vivo.

Herbert AL, Fu MM, Drerup CM, Gray RS, Harty BL, Ackerman SD, O'Reilly-Pol T, Johnson SL, Nechiporuk AV, Barres BA, Monk KR.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9153-E9162. doi: 10.1073/pnas.1711088114. Epub 2017 Oct 12.


Whole Genome Sequencing-Based Mapping and Candidate Identification of Mutations from Fixed Zebrafish Tissue.

Sanchez NE, Harty BL, O'Reilly-Pol T, Ackerman SD, Herbert AL, Holmgren M, Johnson SL, Gray RS, Monk KR.

G3 (Bethesda). 2017 Oct 5;7(10):3415-3425. doi: 10.1534/g3.117.300212.


Regulation of mitochondria-dynactin interaction and mitochondrial retrograde transport in axons.

Drerup CM, Herbert AL, Monk KR, Nechiporuk AV.

Elife. 2017 Apr 17;6. pii: e22234. doi: 10.7554/eLife.22234.


Analysis of myelinated axon formation in zebrafish.

D'Rozario M, Monk KR, Petersen SC.

Methods Cell Biol. 2017;138:383-414. doi: 10.1016/bs.mcb.2016.08.001. Epub 2016 Sep 29. Review.


G Protein-Coupled Receptors in Myelinating Glia: (Trends in Pharmacological Sciences 37, 977-987; 2016).

Mogha A, D'Rozario M, Monk KR.

Trends Pharmacol Sci. 2017 Mar;38(3):316. doi: 10.1016/ Epub 2017 Jan 22. No abstract available.


Advances in myelinating glial cell development.

Herbert AL, Monk KR.

Curr Opin Neurobiol. 2017 Feb;42:53-60. doi: 10.1016/j.conb.2016.11.003. Epub 2016 Dec 6. Review.


Gpr126/Adgrg6 Has Schwann Cell Autonomous and Nonautonomous Functions in Peripheral Nerve Injury and Repair.

Mogha A, Harty BL, Carlin D, Joseph J, Sanchez NE, Suter U, Piao X, Cavalli V, Monk KR.

J Neurosci. 2016 Dec 7;36(49):12351-12367.


Adhesion GPCRs as Novel Actors in Neural and Glial Cell Functions: From Synaptogenesis to Myelination.

Sigoillot SM, Monk KR, Piao X, Selimi F, Harty BL.

Handb Exp Pharmacol. 2016;234:275-298. Review.


Adhesion GPCRs as a Putative Class of Metabotropic Mechanosensors.

Scholz N, Monk KR, Kittel RJ, Langenhan T.

Handb Exp Pharmacol. 2016;234:221-247. Review.


G Protein-Coupled Receptors in Myelinating Glia.

Mogha A, D'Rozario M, Monk KR.

Trends Pharmacol Sci. 2016 Nov;37(11):977-987. doi: 10.1016/ Epub 2016 Sep 23. Review. Erratum in: Trends Pharmacol Sci. 2017 Mar;38(3):316.


Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains.

Salzman GS, Ackerman SD, Ding C, Koide A, Leon K, Luo R, Stoveken HM, Fernandez CG, Tall GG, Piao X, Monk KR, Koide S, Araç D.

Neuron. 2016 Sep 21;91(6):1292-1304. doi: 10.1016/j.neuron.2016.08.022.


The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6.

Küffer A, Lakkaraju AK, Mogha A, Petersen SC, Airich K, Doucerain C, Marpakwar R, Bakirci P, Senatore A, Monnard A, Schiavi C, Nuvolone M, Grosshans B, Hornemann S, Bassilana F, Monk KR, Aguzzi A.

Nature. 2016 Aug 25;536(7617):464-8. Epub 2016 Aug 8.


Adhesion G protein-coupled receptors in nervous system development and disease.

Langenhan T, Piao X, Monk KR.

Nat Rev Neurosci. 2016 Sep;17(9):550-61. doi: 10.1038/nrn.2016.86. Epub 2016 Jul 28. Review.


The scales and tales of myelination: using zebrafish and mouse to study myelinating glia.

Ackerman SD, Monk KR.

Brain Res. 2016 Jun 15;1641(Pt A):79-91. doi: 10.1016/j.brainres.2015.10.011. Epub 2015 Oct 20. Review.


How to wake a giant.

Liebscher I, Monk KR, Schöneberg T.

Oncotarget. 2015 Sep 15;6(27):23038-9. No abstract available.


Tethered agonists: a new mechanism underlying adhesion G protein-coupled receptor activation.

Schöneberg T, Liebscher I, Luo R, Monk KR, Piao X.

J Recept Signal Transduct Res. 2015 Jun;35(3):220-3. doi: 10.3109/10799893.2015.1072978. Epub 2015 Sep 14.


Neurobiology: Myelin Goes Where the Action Is.

Petersen SC, Monk KR.

Curr Biol. 2015 Jun 29;25(13):R562-5. doi: 10.1016/j.cub.2015.04.054.


Model Organisms in G Protein-Coupled Receptor Research.

Langenhan T, Barr MM, Bruchas MR, Ewer J, Griffith LC, Maiellaro I, Taghert PH, White BH, Monk KR.

Mol Pharmacol. 2015 Sep;88(3):596-603. doi: 10.1124/mol.115.098764. Epub 2015 May 15. Review.


Adhesion G Protein-Coupled Receptors: From In Vitro Pharmacology to In Vivo Mechanisms.

Monk KR, Hamann J, Langenhan T, Nijmeijer S, Schöneberg T, Liebscher I.

Mol Pharmacol. 2015 Sep;88(3):617-23. doi: 10.1124/mol.115.098749. Epub 2015 May 8. Review.


Gpr126/Adgrg6 deletion in cartilage models idiopathic scoliosis and pectus excavatum in mice.

Karner CM, Long F, Solnica-Krezel L, Monk KR, Gray RS.

Hum Mol Genet. 2015 Aug 1;24(15):4365-73. doi: 10.1093/hmg/ddv170. Epub 2015 May 7.


New insights on Schwann cell development.

Monk KR, Feltri ML, Taveggia C.

Glia. 2015 Aug;63(8):1376-93. doi: 10.1002/glia.22852. Epub 2015 Apr 29. Review.


Defining the gene repertoire and spatiotemporal expression profiles of adhesion G protein-coupled receptors in zebrafish.

Harty BL, Krishnan A, Sanchez NE, Schiöth HB, Monk KR.

BMC Genomics. 2015 Feb 8;16:62. doi: 10.1186/s12864-015-1296-8.


International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.

Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB.

Pharmacol Rev. 2015;67(2):338-67. doi: 10.1124/pr.114.009647. Review.


The adhesion GPCR GPR126 has distinct, domain-dependent functions in Schwann cell development mediated by interaction with laminin-211.

Petersen SC, Luo R, Liebscher I, Giera S, Jeong SJ, Mogha A, Ghidinelli M, Feltri ML, Schöneberg T, Piao X, Monk KR.

Neuron. 2015 Feb 18;85(4):755-69. doi: 10.1016/j.neuron.2014.12.057.


A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133.

Liebscher I, Schön J, Petersen SC, Fischer L, Auerbach N, Demberg LM, Mogha A, Cöster M, Simon KU, Rothemund S, Monk KR, Schöneberg T.

Cell Rep. 2015 Feb 17;10(6):1021. doi: 10.1016/j.celrep.2015.01.065. Epub 2015 Feb 17. No abstract available.


The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA.

Ackerman SD, Garcia C, Piao X, Gutmann DH, Monk KR.

Nat Commun. 2015 Jan 21;6:6122. doi: 10.1038/ncomms7122.


The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development.

Giera S, Deng Y, Luo R, Ackerman SD, Mogha A, Monk KR, Ying Y, Jeong SJ, Makinodan M, Bialas AR, Chang BS, Stevens B, Corfas G, Piao X.

Nat Commun. 2015 Jan 21;6:6121. doi: 10.1038/ncomms7121.


A tethered agonist within the ectodomain activates the adhesion G protein-coupled receptors GPR126 and GPR133.

Liebscher I, Schön J, Petersen SC, Fischer L, Auerbach N, Demberg LM, Mogha A, Cöster M, Simon KU, Rothemund S, Monk KR, Schöneberg T.

Cell Rep. 2014 Dec 24;9(6):2018-26. doi: 10.1016/j.celrep.2014.11.036. Epub 2014 Dec 18. Erratum in: Cell Rep. 2015 Feb 17;10(6):1021.


The multiple signaling modalities of adhesion G protein-coupled receptor GPR126 in development.

Patra C, Monk KR, Engel FB.

Receptors Clin Investig. 2014 Jul 1;1(3):79.


New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors.

Liebscher I, Ackley B, Araç D, Ariestanti DM, Aust G, Bae BI, Bista BR, Bridges JP, Duman JG, Engel FB, Giera S, Goffinet AM, Hall RA, Hamann J, Hartmann N, Lin HH, Liu M, Luo R, Mogha A, Monk KR, Peeters MC, Prömel S, Ressl S, Schiöth HB, Sigoillot SM, Song H, Talbot WS, Tall GG, White JP, Wolfrum U, Xu L, Piao X.

Ann N Y Acad Sci. 2014 Dec;1333:43-64. doi: 10.1111/nyas.12580. Epub 2014 Nov 25.


An anti-inflammatory NOD-like receptor is required for microglia development.

Shiau CE, Monk KR, Joo W, Talbot WS.

Cell Rep. 2013 Dec 12;5(5):1342-52. doi: 10.1016/j.celrep.2013.11.004. Epub 2013 Dec 5.


Gpr126 functions in Schwann cells to control differentiation and myelination via G-protein activation.

Mogha A, Benesh AE, Patra C, Engel FB, Schöneberg T, Liebscher I, Monk KR.

J Neurosci. 2013 Nov 13;33(46):17976-85. doi: 10.1523/JNEUROSCI.1809-13.2013.


Organ-specific function of adhesion G protein-coupled receptor GPR126 is domain-dependent.

Patra C, van Amerongen MJ, Ghosh S, Ricciardi F, Sajjad A, Novoyatleva T, Mogha A, Monk KR, Mühlfeld C, Engel FB.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16898-903. doi: 10.1073/pnas.1304837110. Epub 2013 Sep 30. Erratum in: Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1222.


Dissecting signaling and functions of adhesion G protein-coupled receptors.

Araç D, Aust G, Calebiro D, Engel FB, Formstone C, Goffinet A, Hamann J, Kittel RJ, Liebscher I, Lin HH, Monk KR, Petrenko A, Piao X, Prömel S, Schiöth HB, Schwartz TW, Stacey M, Ushkaryov YA, Wobus M, Wolfrum U, Xu L, Langenhan T.

Ann N Y Acad Sci. 2012 Dec;1276:1-25. doi: 10.1111/j.1749-6632.2012.06820.x. Epub 2012 Dec 7.


Mutation of sec63 in zebrafish causes defects in myelinated axons and liver pathology.

Monk KR, Voas MG, Franzini-Armstrong C, Hakkinen IS, Talbot WS.

Dis Model Mech. 2013 Jan;6(1):135-45. doi: 10.1242/dmm.009217. Epub 2012 Aug 3.


The NF2 tumor suppressor regulates microtubule-based vesicle trafficking via a novel Rac, MLK and p38(SAPK) pathway.

Hennigan RF, Moon CA, Parysek LM, Monk KR, Morfini G, Berth S, Brady S, Ratner N.

Oncogene. 2013 Feb 28;32(9):1135-43. doi: 10.1038/onc.2012.135. Epub 2012 Apr 23.


Gpr126 is essential for peripheral nerve development and myelination in mammals.

Monk KR, Oshima K, Jörs S, Heller S, Talbot WS.

Development. 2011 Jul;138(13):2673-80. doi: 10.1242/dev.062224. Epub 2011 May 25.


A G protein-coupled receptor is essential for Schwann cells to initiate myelination.

Monk KR, Naylor SG, Glenn TD, Mercurio S, Perlin JR, Dominguez C, Moens CB, Talbot WS.

Science. 2009 Sep 11;325(5946):1402-5. doi: 10.1126/science.1173474.

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