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Items: 36


The Canonical Inflammasome: A Macromolecular Complex Driving Inflammation.

Monie TP.

Subcell Biochem. 2017;83:43-73. doi: 10.1007/978-3-319-46503-6_2.


Dynamic phosphorylation of RelA on Ser42 and Ser45 in response to TNFα stimulation regulates DNA binding and transcription.

Lanucara F, Lam C, Mann J, Monie TP, Colombo SA, Holman SW, Boyd J, Dange MC, Mann DA, White MR, Eyers CE.

Open Biol. 2016 Jul;6(7). pii: 160055. doi: 10.1098/rsob.160055.


Intestinal APCs of the endogenous nanomineral pathway fail to express PD-L1 in Crohn's disease.

Robertson J, Haas CT, Pele LC, Monie TP, Charalambos C, Parkes M, Hewitt RE, Powell JJ.

Sci Rep. 2016 May 26;6:26747. doi: 10.1038/srep26747.


Allergens and Activation of the Toll-Like Receptor Response.

Monie TP, Bryant CE.

Methods Mol Biol. 2016;1390:341-50. doi: 10.1007/978-1-4939-3335-8_21.


Bioinformatic Analysis of Toll-Like Receptor Sequences and Structures.

Monie TP, Gay NJ, Gangloff M.

Methods Mol Biol. 2016;1390:29-39. doi: 10.1007/978-1-4939-3335-8_2.


Dysfunctional Crohn's Disease-Associated NOD2 Polymorphisms Cannot be Reliably Predicted on the Basis of RIPK2 Binding or Membrane Association.

Parkhouse R, Monie TP.

Front Immunol. 2015 Oct 8;6:521. doi: 10.3389/fimmu.2015.00521. eCollection 2015.


Caspase-8 functions as a key mediator of inflammation and pro-IL-1β processing via both canonical and non-canonical pathways.

Monie TP, Bryant CE.

Immunol Rev. 2015 May;265(1):181-93. doi: 10.1111/imr.12284. Review.


International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease.

Bryant CE, Orr S, Ferguson B, Symmons MF, Boyle JP, Monie TP.

Pharmacol Rev. 2015;67(2):462-504. doi: 10.1124/pr.114.009928. Review.


Insights into the molecular basis of the NOD2 signalling pathway.

Boyle JP, Parkhouse R, Monie TP.

Open Biol. 2014 Dec;4(12). pii: 140178. doi: 10.1098/rsob.140178. Review.


Polymorphisms at amino acid residues 141 and 154 influence conformational variation in ovine PrP.

Yang S, Thackray AM, Hopkins L, Monie TP, Burke DF, Bujdoso R.

Biomed Res Int. 2014;2014:372491. doi: 10.1155/2014/372491. Epub 2014 Jul 14.


Blau syndrome polymorphisms in NOD2 identify nucleotide hydrolysis and helical domain 1 as signalling regulators.

Parkhouse R, Boyle JP, Monie TP.

FEBS Lett. 2014 Sep 17;588(18):3382-9. doi: 10.1016/j.febslet.2014.07.029. Epub 2014 Aug 2.


Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain.

Parkhouse R, Boyle JP, Mayle S, Sawmynaden K, Rittinger K, Monie TP.

FEBS Lett. 2014 Aug 25;588(17):2830-6. doi: 10.1016/j.febslet.2014.06.035. Epub 2014 Jun 21.


Engagement of nucleotide-binding oligomerization domain-containing protein 1 (NOD1) by receptor-interacting protein 2 (RIP2) is insufficient for signal transduction.

Mayle S, Boyle JP, Sekine E, Zurek B, Kufer TA, Monie TP.

J Biol Chem. 2014 Aug 15;289(33):22900-14. doi: 10.1074/jbc.M114.557900. Epub 2014 Jun 23.


Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex.

Man SM, Hopkins LJ, Nugent E, Cox S, Glück IM, Tourlomousis P, Wright JA, Cicuta P, Monie TP, Bryant CE.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7403-8. doi: 10.1073/pnas.1402911111. Epub 2014 May 6.


Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1β production.

Man SM, Tourlomousis P, Hopkins L, Monie TP, Fitzgerald KA, Bryant CE.

J Immunol. 2013 Nov 15;191(10):5239-46. doi: 10.4049/jimmunol.1301581. Epub 2013 Oct 11.


Comparative Genomic and Sequence Analysis Provides Insight into the Molecular Functionality of NOD1 and NOD2.

Boyle JP, Mayle S, Parkhouse R, Monie TP.

Front Immunol. 2013 Oct 7;4:317. doi: 10.3389/fimmu.2013.00317. eCollection 2013.


The N-terminal region of the human autophagy protein ATG16L1 contains a domain that folds into a helical structure consistent with formation of a coiled-coil.

Parkhouse R, Ebong IO, Robinson CV, Monie TP.

PLoS One. 2013 Sep 24;8(9):e76237. doi: 10.1371/journal.pone.0076237. eCollection 2013.


Cell swelling and the NLRP3 inflammasome.

Boyle JP, Bryant CE, Monie TP.

Immunity. 2013 Mar 21;38(3):399. doi: 10.1016/j.immuni.2013.02.006. No abstract available.


NLR activation takes a direct route.

Monie TP.

Trends Biochem Sci. 2013 Mar;38(3):131-9. doi: 10.1016/j.tibs.2013.01.001. Epub 2013 Feb 8. Review.


The immunoglobulin domain of the sodium channel β3 subunit contains a surface-localized disulfide bond that is required for homophilic binding.

Yereddi NR, Cusdin FS, Namadurai S, Packman LC, Monie TP, Slavny P, Clare JJ, Powell AJ, Jackson AP.

FASEB J. 2013 Feb;27(2):568-80. doi: 10.1096/fj.12-209445. Epub 2012 Nov 1.


Mice, men and the relatives: cross-species studies underpin innate immunity.

Bryant CE, Monie TP.

Open Biol. 2012 Apr;2(4):120015. doi: 10.1098/rsob.120015. Review.


Pathogen sensing by nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is mediated by direct binding to muramyl dipeptide and ATP.

Mo J, Boyle JP, Howard CB, Monie TP, Davis BK, Duncan JA.

J Biol Chem. 2012 Jun 29;287(27):23057-67. doi: 10.1074/jbc.M112.344283. Epub 2012 May 1.


Computational analysis predicts the Kaposi's sarcoma-associated herpesvirus tegument protein ORF63 to be alpha helical.

Boyle JP, Monie TP.

Proteins. 2012 Aug;80(8):2063-70. doi: 10.1002/prot.24097. Epub 2012 May 17.


Innate immune sensors and gastrointestinal bacterial infections.

Hold GL, Mukhopadhya I, Monie TP.

Clin Dev Immunol. 2011;2011:579650. doi: 10.1155/2011/579650. Epub 2011 May 19. Review.


Activating immunity: lessons from the TLRs and NLRs.

Monie TP, Bryant CE, Gay NJ.

Trends Biochem Sci. 2009 Nov;34(11):553-61. doi: 10.1016/j.tibs.2009.06.011. Epub 2009 Oct 7. Review.


Bioinformatic analysis of Toll-like receptor sequences and structures.

Monie TP, Gay NJ, Gangloff M.

Methods Mol Biol. 2009;517:69-79. doi: 10.1007/978-1-59745-541-1_5.


Structure and regulation of cytoplasmic adapter proteins involved in innate immune signaling.

Monie TP, Moncrieffe MC, Gay NJ.

Immunol Rev. 2009 Jan;227(1):161-75. doi: 10.1111/j.1600-065X.2008.00735.x. Review.


A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins.

Núñez Miguel R, Wong J, Westoll JF, Brooks HJ, O'Neill LA, Gay NJ, Bryant CE, Monie TP.

PLoS One. 2007 Aug 29;2(8):e788.


Structural insights into the transcriptional and translational roles of Ebp1.

Monie TP, Perrin AJ, Birtley JR, Sweeney TR, Karakasiliotis I, Chaudhry Y, Roberts LO, Matthews S, Goodfellow IG, Curry S.

EMBO J. 2007 Sep 5;26(17):3936-44. Epub 2007 Aug 9.


A peptide motif in Raver1 mediates splicing repression by interaction with the PTB RRM2 domain.

Rideau AP, Gooding C, Simpson PJ, Monie TP, Lorenz M, Hüttelmaier S, Singer RH, Matthews S, Curry S, Smith CW.

Nat Struct Mol Biol. 2006 Sep;13(9):839-48. Epub 2006 Aug 27.


Conformation of polypyrimidine tract binding protein in solution.

Petoukhov MV, Monie TP, Allain FH, Matthews S, Curry S, Svergun DI.

Structure. 2006 Jun;14(6):1021-7.


The polypyrimidine tract binding protein is a monomer.

Monie TP, Hernandez H, Robinson CV, Simpson P, Matthews S, Curry S.

RNA. 2005 Dec;11(12):1803-8.


Structure and RNA interactions of the N-terminal RRM domains of PTB.

Simpson PJ, Monie TP, Szendröi A, Davydova N, Tyzack JK, Conte MR, Read CM, Cary PD, Svergun DI, Konarev PV, Curry S, Matthews S.

Structure. 2004 Sep;12(9):1631-43.


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