Send to

Choose Destination
BMJ Case Rep. 2019 Jul 27;12(7). pii: e230427. doi: 10.1136/bcr-2019-230427.

Severe proximal myopathy secondary to Hashimoto's thyroiditis.

Author information

Endocrinology and Diabetes, Hull Royal Infirmary, Hull, UK.
Michael White Center of Diabetes & Endocrinology, Hull Royal Infirmary, Hull, UK.
Hull York Medical School, University of Hull, Hull, UK.


Muscular symptoms in hypothyroidism are common, including myalgia, fatigue and cramps; however, a significantly raised creatine kinase and muscle weakness are rare. Differential diagnosis of patients presenting with muscle weakness and a raised creatine kinase is wide, and hypothyroidism is rarely considered. We report this case of a 30-year-old female presenting with proximal muscle weakness as her primary symptom, hypothyroid symptoms of 3-month duration and a significantly raised creatine kinase. After ruling out other causes of a raised creatine kinase, thyroxine replacement was commenced, which led to complete resolution of her proximal weakness, myalgia and normalisation of creatine kinase level. This case illustrates severe proximal myopathy can be secondary to hypothyroidism, symptoms can resolve with thyroxine replacement and emphasises the importance of measuring thyroid function in patients with proximal weakness/myalgia and a significantly raised creatine kinase.


muscle disease; thyroid disease


Conflict of interest statement

Competing interests: None declared.

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center