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The molecular mechanisms underlying reduced E-cadherin expression in invasive ductal carcinoma of the breast: high throughput analysis of large cohorts.

Alsaleem M, Toss MS, Joseph C, Aleskandarany M, Kurozumi S, Alshankyty I, Ogden A, Rida PCG, Ellis IO, Aneja R, Green AR, Mongan NP, Rakha EA.

Mod Pathol. 2019 Feb 13. doi: 10.1038/s41379-019-0209-9. [Epub ahead of print]


Overexpression of the cancer stem cell marker CD133 confers a poor prognosis in invasive breast cancer.

Joseph C, Arshad M, Kurozomi S, Althobiti M, Miligy IM, Al-Izzi S, Toss MS, Goh FQ, Johnston SJ, Martin SG, Ellis IO, Mongan NP, Green AR, Rakha EA.

Breast Cancer Res Treat. 2019 Apr;174(2):387-399. doi: 10.1007/s10549-018-05085-9. Epub 2018 Dec 15.


Predicting puberty in partial androgen insensitivity syndrome: Use of clinical and functional androgen receptor indices.

Lek N, Tadokoro-Cuccaro R, Whitchurch JB, Mazumder B, Miles H, Prentice P, Bunch T, Zielińska K, Metzler V, Mongan NP, Heery DM, Hughes IA.

EBioMedicine. 2018 Oct;36:401-409. doi: 10.1016/j.ebiom.2018.09.047. Epub 2018 Oct 11.


CARM1 (PRMT4) Acts as a Transcriptional Coactivator during Retinoic Acid-Induced Embryonic Stem Cell Differentiation.

Quintero CM, Laursen KB, Mongan NP, Luo M, Gudas LJ.

J Mol Biol. 2018 Oct 19;430(21):4168-4182. doi: 10.1016/j.jmb.2018.08.014. Epub 2018 Aug 25.


The role of PIP5K1α/pAKT and targeted inhibition of growth of subtypes of breast cancer using PIP5K1α inhibitor.

Sarwar M, Syed Khaja AS, Aleskandarany M, Karlsson R, Althobiti M, Ødum N, Mongan NP, Dizeyi N, Johnson H, Green AR, Ellis IO, Rakha EA, Persson JL.

Oncogene. 2019 Jan;38(3):375-389. doi: 10.1038/s41388-018-0438-2. Epub 2018 Aug 13.


Clinicopathological and prognostic significance of Ras association and pleckstrin homology domains 1 (RAPH1) in breast cancer.

Kurozumi S, Joseph C, Sonbul S, Aleskandarany MA, Pigera M, Alsaleem M, Alsaeed S, Kariri Y, Nolan CC, Diez-Rodriguez M, Johnston S, Mongan NP, Fujii T, Shirabe K, Martin SG, Ellis IO, Green AR, Rakha EA.

Breast Cancer Res Treat. 2018 Nov;172(1):61-68. doi: 10.1007/s10549-018-4891-y. Epub 2018 Jul 28.


The dog as an animal model for bladder and urethral urothelial carcinoma: Comparative epidemiology and histology.

de Brot S, Robinson BD, Scase T, Grau-Roma L, Wilkinson E, Boorjian SA, Gardner D, Mongan NP.

Oncol Lett. 2018 Aug;16(2):1641-1649. doi: 10.3892/ol.2018.8837. Epub 2018 May 30.


Impact of breast cancer grade discordance on prediction of outcome.

Rakha EA, Aleskandarany MA, Toss MS, Mongan NP, ElSayed ME, Green AR, Ellis IO, Dalton LW.

Histopathology. 2018 Dec;73(6):904-915. doi: 10.1111/his.13709. Epub 2018 Sep 19.


Corrigendum: Expression of NAD(P)H quinone dehydrogenase 1 (NQO1) is increased in the endometrium of women with endometrial cancer and women with polycystic ovary syndrome.

Atiomo W, Shafiee MN, Chapman C, Metzler VM, Abouzeid J, Latif A, Chadwick A, Kitson S, Sivalingam VN, Stratford IJ, Rutland CS, Persson JL, Ødum N, Fuentes-Utrilla P, Jeyapalan JN, Heery DM, Crosbie EJ, Mongan NP.

Clin Endocrinol (Oxf). 2017 Dec;87(6):886. doi: 10.1111/cen.13515. No abstract available.


Peri-conception and first trimester diet modifies reproductive development in bulls.

Copping KJ, Ruiz-Diaz MD, Rutland CS, Mongan NP, Callaghan MJ, McMillen IC, Rodgers RJ, Perry VEA.

Reprod Fertil Dev. 2017 Nov 16. doi: 10.1071/RD17102. [Epub ahead of print]


Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics.

Simpson S, Dunning MD, de Brot S, Grau-Roma L, Mongan NP, Rutland CS.

Acta Vet Scand. 2017 Oct 24;59(1):71. doi: 10.1186/s13028-017-0341-9. Review.


Cytochalasin B-induced membrane vesicles convey angiogenic activity of parental cells.

Gomzikova MO, Zhuravleva MN, Miftakhova RR, Arkhipova SS, Evtugin VG, Khaiboullina SF, Kiyasov AP, Persson JL, Mongan NP, Pestell RG, Rizvanov AA.

Oncotarget. 2017 Jul 31;8(41):70496-70507. doi: 10.18632/oncotarget.19723. eCollection 2017 Sep 19.


Expression of NAD(P)H quinone dehydrogenase 1 (NQO1) is increased in the endometrium of women with endometrial cancer and women with polycystic ovary syndrome.

Atiomo W, Shafiee MN, Chapman C, Metzler VM, Abouzeid J, Latif A, Chadwick A, Kitson S, Sivalingam VN, Stratford IJ, Rutland CS, Persson JL, Ødum N, Fuentes-Utrilla P, Jeyapalan JN, Heery DM, Crosbie EJ, Mongan NP.

Clin Endocrinol (Oxf). 2017 Nov;87(5):557-565. doi: 10.1111/cen.13436. Epub 2017 Aug 18. Erratum in: Clin Endocrinol (Oxf). 2017 Dec;87(6):886.


Identification of factors required for m6 A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI.

Růžička K, Zhang M, Campilho A, Bodi Z, Kashif M, Saleh M, Eeckhout D, El-Showk S, Li H, Zhong S, De Jaeger G, Mongan NP, Hejátko J, Helariutta Y, Fray RG.

New Phytol. 2017 Jul;215(1):157-172. doi: 10.1111/nph.14586. Epub 2017 May 15.


Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor-γ (PPARγ) are disrupted by retinal disease-associated mutations.

Fulton J, Mazumder B, Whitchurch JB, Monteiro CJ, Collins HM, Chan CM, Clemente MP, Hernandez-Quiles M, Stewart EA, Amoaku WM, Moran PM, Mongan NP, Persson JL, Ali S, Heery DM.

Cell Death Dis. 2017 Mar 16;8(3):e2677. doi: 10.1038/cddis.2017.98.


Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development.

Metzler VM, de Brot S, Robinson RS, Jeyapalan JN, Rakha E, Walton T, Gardner DS, Lund EF, Whitchurch J, Haigh D, Lochray JM, Robinson BD, Allegrucci C, Fray RG, Persson JL, Ødum N, Miftakhova RR, Rizvanov AA, Hughes IA, Tadokoro-Cuccaro R, Heery DM, Rutland CS, Mongan NP.

Placenta. 2017 Aug;56:79-85. doi: 10.1016/j.placenta.2017.02.018. Epub 2017 Feb 20. Review.


HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells.

Shah M, Cardenas R, Wang B, Persson J, Mongan NP, Grabowska A, Allegrucci C.

Mol Cancer. 2017 Feb 16;16(1):38. doi: 10.1186/s12943-017-0605-z.


Multiple Genetic Associations with Irish Wolfhound Dilated Cardiomyopathy.

Simpson S, Dunning MD, Brownlie S, Patel J, Godden M, Cobb M, Mongan NP, Rutland CS.

Biomed Res Int. 2016;2016:6374082. doi: 10.1155/2016/6374082. Epub 2016 Dec 13.


Correction: TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants.

Sulak M, Fong L, Mika K, Chigurupati S, Yon L, Mongan NP, Emes RD, Lynch VJ.

Elife. 2016 Dec 20;5. pii: e24307. doi: 10.7554/eLife.24307. No abstract available.


m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination.

Haussmann IU, Bodi Z, Sanchez-Moran E, Mongan NP, Archer N, Fray RG, Soller M.

Nature. 2016 Dec 8;540(7632):301-304. doi: 10.1038/nature20577. Epub 2016 Nov 30.


Malignant inflammation in cutaneous T-cell lymphoma-a hostile takeover.

Krejsgaard T, Lindahl LM, Mongan NP, Wasik MA, Litvinov IV, Iversen L, Langhoff E, Woetmann A, Odum N.

Semin Immunopathol. 2017 Apr;39(3):269-282. doi: 10.1007/s00281-016-0594-9. Epub 2016 Oct 7. Review.


TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants.

Sulak M, Fong L, Mika K, Chigurupati S, Yon L, Mongan NP, Emes RD, Lynch VJ.

Elife. 2016 Sep 19;5. pii: e11994. doi: 10.7554/eLife.11994. Erratum in: Elife. 2016 Dec 20;5:.


Targeted suppression of AR-V7 using PIP5K1α inhibitor overcomes enzalutamide resistance in prostate cancer cells.

Sarwar M, Semenas J, Miftakhova R, Simoulis A, Robinson B, Gjörloff Wingren A, Mongan NP, Heery DM, Johnsson H, Abrahamsson PA, Dizeyi N, Luo J, Persson JL.

Oncotarget. 2016 Sep 27;7(39):63065-63081. doi: 10.18632/oncotarget.11757.


Association of Aromatase With Bladder Cancer Stage and Long-Term Survival: New Insights Into the Hormonal Paradigm in Bladder Cancer.

Nguyen DP, O'Malley P, Al Hussein Al Awamlh B, Furrer MA, Mongan NP, Robinson BD, Wang GJ, Scherr DS.

Clin Genitourin Cancer. 2017 Apr;15(2):256-262.e1. doi: 10.1016/j.clgc.2016.05.017. Epub 2016 May 27.


Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow.

Miftakhova R, Hedblom A, Semenas J, Robinson B, Simoulis A, Malm J, Rizvanov A, Heery DM, Mongan NP, Maitland NJ, Allegrucci C, Persson JL.

Cancer Res. 2016 Apr 15;76(8):2453-64. doi: 10.1158/0008-5472.CAN-15-2340. Epub 2016 Feb 26.


The Expression of IL-21 Is Promoted by MEKK4 in Malignant T Cells and Associated with Increased Progression Risk in Cutaneous T-Cell Lymphoma.

Fredholm S, Litvinov IV, Mongan NP, Schiele S, Willerslev-Olsen A, Petersen DL, Krejsgaard T, Sibbesen N, Nastasi C, Bonefeld CM, Persson JL, Straten PT, Andersen MH, Koralov SB, Wasik MM, Geisler C, Sasseville D, Woetmann A, Ødum N.

J Invest Dermatol. 2016 Apr;136(4):866-869. doi: 10.1016/j.jid.2015.12.033. Epub 2016 Jan 21. No abstract available.


Role of NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex 4-Like 2 in Clear Cell Renal Cell Carcinoma.

Minton DR, Fu L, Mongan NP, Shevchuk MM, Nanus DM, Gudas LJ.

Clin Cancer Res. 2016 Jun 1;22(11):2791-801. doi: 10.1158/1078-0432.CCR-15-1511. Epub 2016 Jan 18.


Staphylococcal enterotoxin A (SEA) stimulates STAT3 activation and IL-17 expression in cutaneous T-cell lymphoma.

Willerslev-Olsen A, Krejsgaard T, Lindahl LM, Litvinov IV, Fredholm S, Petersen DL, Nastasi C, Gniadecki R, Mongan NP, Sasseville D, Wasik MA, Bonefeld CM, Geisler C, Woetmann A, Iversen L, Kilian M, Koralov SB, Odum N.

Blood. 2016 Mar 10;127(10):1287-96. doi: 10.1182/blood-2015-08-662353. Epub 2016 Jan 5.


MiR137 is an androgen regulated repressor of an extended network of transcriptional coregulators.

Nilsson EM, Laursen KB, Whitchurch J, McWilliam A, Ødum N, Persson JL, Heery DM, Gudas LJ, Mongan NP.

Oncotarget. 2015 Nov 3;6(34):35710-25. doi: 10.18632/oncotarget.5958.


Androgen insensitivity syndrome.

Mongan NP, Tadokoro-Cuccaro R, Bunch T, Hughes IA.

Best Pract Res Clin Endocrinol Metab. 2015 Aug;29(4):569-80. doi: 10.1016/j.beem.2015.04.005. Epub 2015 Apr 26. Review.


Genetics of Human and Canine Dilated Cardiomyopathy.

Simpson S, Edwards J, Ferguson-Mignan TF, Cobb M, Mongan NP, Rutland CS.

Int J Genomics. 2015;2015:204823. doi: 10.1155/2015/204823. Epub 2015 Jul 22. Review.


Jak3, STAT3, and STAT5 inhibit expression of miR-22, a novel tumor suppressor microRNA, in cutaneous T-Cell lymphoma.

Sibbesen NA, Kopp KL, Litvinov IV, Jønson L, Willerslev-Olsen A, Fredholm S, Petersen DL, Nastasi C, Krejsgaard T, Lindahl LM, Gniadecki R, Mongan NP, Sasseville D, Wasik MA, Iversen L, Bonefeld CM, Geisler C, Woetmann A, Odum N.

Oncotarget. 2015 Aug 21;6(24):20555-69.


Induction of autophagy is a key component of all-trans-retinoic acid-induced differentiation in leukemia cells and a potential target for pharmacologic modulation.

Orfali N, O'Donovan TR, Nyhan MJ, Britschgi A, Tschan MP, Cahill MR, Mongan NP, Gudas LJ, McKenna SL.

Exp Hematol. 2015 Sep;43(9):781-93.e2. doi: 10.1016/j.exphem.2015.04.012. Epub 2015 May 16.


Regulation of vascular endothelial growth factor in prostate cancer.

de Brot S, Ntekim A, Cardenas R, James V, Allegrucci C, Heery DM, Bates DO, Ødum N, Persson JL, Mongan NP.

Endocr Relat Cancer. 2015 Jun;22(3):R107-23. doi: 10.1530/ERC-15-0123. Epub 2015 Apr 13. Review.


A predictive model for canine dilated cardiomyopathy-a meta-analysis of Doberman Pinscher data.

Simpson S, Edwards J, Emes RD, Cobb MA, Mongan NP, Rutland CS.

PeerJ. 2015 Mar 26;3:e842. doi: 10.7717/peerj.842. eCollection 2015.


Promoter-dependent activity on androgen receptor N-terminal domain mutations in androgen insensitivity syndrome.

Tadokoro-Cuccaro R, Davies J, Mongan NP, Bunch T, Brown RS, Audi L, Watt K, McEwan IJ, Hughes IA.

Sex Dev. 2014;8(6):339-49. doi: 10.1159/000369266. Epub 2014 Dec 6.


The role of HIF1α in renal cell carcinoma tumorigenesis.

Gudas LJ, Fu L, Minton DR, Mongan NP, Nanus DM.

J Mol Med (Berl). 2014 Aug;92(8):825-36. doi: 10.1007/s00109-014-1180-z. Epub 2014 Jun 12. Review.


Retinoid receptor signaling and autophagy in acute promyelocytic leukemia.

Orfali N, McKenna SL, Cahill MR, Gudas LJ, Mongan NP.

Exp Cell Res. 2014 May 15;324(1):1-12. doi: 10.1016/j.yexcr.2014.03.018. Epub 2014 Mar 30. Review.


Molecular characterization of adipose tissue in the African elephant (Loxodonta africana).

Nilsson EM, Fainberg HP, Choong SS, Giles TC, Sells J, May S, Stansfield FJ, Allen WR, Emes RD, Mostyn A, Mongan NP, Yon L.

PLoS One. 2014 Mar 14;9(3):e91717. doi: 10.1371/journal.pone.0091717. eCollection 2014.


Expression of cyclin d1 and its association with disease characteristics in bladder cancer.

Kopparapu PK, Boorjian SA, Robinson BD, Downes M, Gudas LJ, Mongan NP, Persson JL.

Anticancer Res. 2013 Dec;33(12):5235-42.


A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.

Chan CM, Fulton J, Montiel-Duarte C, Collins HM, Bharti N, Wadelin FR, Moran PM, Mongan NP, Heery DM.

Nucleic Acids Res. 2013 Nov;41(21):9663-79. doi: 10.1093/nar/gkt761. Epub 2013 Aug 23.


Mutations in ZMYND10, a gene essential for proper axonemal assembly of inner and outer dynein arms in humans and flies, cause primary ciliary dyskinesia.

Moore DJ, Onoufriadis A, Shoemark A, Simpson MA, zur Lage PI, de Castro SC, Bartoloni L, Gallone G, Petridi S, Woollard WJ, Antony D, Schmidts M, Didonna T, Makrythanasis P, Bevillard J, Mongan NP, Djakow J, Pals G, Lucas JS, Marthin JK, Nielsen KG, Santoni F, Guipponi M, Hogg C, Antonarakis SE, Emes RD, Chung EM, Greene ND, Blouin JL, Jarman AP, Mitchison HM.

Am J Hum Genet. 2013 Aug 8;93(2):346-56. doi: 10.1016/j.ajhg.2013.07.009. Epub 2013 Jul 25.


Expression of VEGF and its receptors VEGFR1/VEGFR2 is associated with invasiveness of bladder cancer.

Kopparapu PK, Boorjian SA, Robinson BD, Downes M, Gudas LJ, Mongan NP, Persson JL.

Anticancer Res. 2013 Jun;33(6):2381-90.


Polycomb recruitment attenuates retinoic acid-induced transcription of the bivalent NR2F1 gene.

Laursen KB, Mongan NP, Zhuang Y, Ng MM, Benoit YD, Gudas LJ.

Nucleic Acids Res. 2013 Jul;41(13):6430-43. doi: 10.1093/nar/gkt367. Epub 2013 May 10.


Estrogen receptor-β expression and pharmacological targeting in bladder cancer.

Kauffman EC, Robinson BD, Downes M, Marcinkiewicz K, Vourganti S, Scherr DS, Gudas LJ, Mongan NP.

Oncol Rep. 2013 Jul;30(1):131-8. doi: 10.3892/or.2013.2416. Epub 2013 Apr 23.


CDK1 interacts with RARγ and plays an important role in treatment response of acute myeloid leukemia.

Hedblom A, Laursen KB, Miftakhova R, Sarwar M, Anagnostaki L, Bredberg A, Mongan NP, Gudas LJ, Persson JL.

Cell Cycle. 2013 Apr 15;12(8):1251-66. doi: 10.4161/cc.24313. Epub 2013 Mar 21.


The lysine specific demethylase-1 (LSD1/KDM1A) regulates VEGF-A expression in prostate cancer.

Kashyap V, Ahmad S, Nilsson EM, Helczynski L, Kenna S, Persson JL, Gudas LJ, Mongan NP.

Mol Oncol. 2013 Jun;7(3):555-66. doi: 10.1016/j.molonc.2013.01.003. Epub 2013 Jan 19.


Reduced neonatal mortality in Meishan piglets: a role for hepatic fatty acids?

Fainberg HP, Bodley K, Bacardit J, Li D, Wessely F, Mongan NP, Symonds ME, Clarke L, Mostyn A.

PLoS One. 2012;7(11):e49101. doi: 10.1371/journal.pone.0049101. Epub 2012 Nov 14.


Overcoming drug resistance and treating advanced prostate cancer.

Semenas J, Allegrucci C, Boorjian SA, Mongan NP, Persson JL.

Curr Drug Targets. 2012 Sep 1;13(10):1308-23. Review.


The androgen receptor and stem cell pathways in prostate and bladder cancers (review).

Marcinkiewicz K, Scotland KB, Boorjian SA, Nilsson EM, Persson JL, Abrahamsson PA, Allegrucci C, Hughes IA, Gudas LJ, Mongan NP.

Int J Oncol. 2012 Jan;40(1):5-12. doi: 10.3892/ijo.2011.1212. Epub 2011 Sep 28. Review.

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