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Host inflammasome defense mechanisms and bacterial pathogen evasion strategies.

Brewer SM, Brubaker SW, Monack DM.

Curr Opin Immunol. 2019 Oct;60:63-70. doi: 10.1016/j.coi.2019.05.001. Epub 2019 Jun 4. Review.


Escalating Threat Levels of Bacterial Infection Can Be Discriminated by Distinct MAPK and NF-κB Signaling Dynamics in Single Host Cells.

Lane K, Andres-Terre M, Kudo T, Monack DM, Covert MW.

Cell Syst. 2019 Mar 27;8(3):183-196.e4. doi: 10.1016/j.cels.2019.02.008. Epub 2019 Mar 20.


Controlling Epithelial Polarity: A Human Enteroid Model for Host-Pathogen Interactions.

Co JY, Margalef-Català M, Li X, Mah AT, Kuo CJ, Monack DM, Amieva MR.

Cell Rep. 2019 Feb 26;26(9):2509-2520.e4. doi: 10.1016/j.celrep.2019.01.108.


Western diet regulates immune status and the response to LPS-driven sepsis independent of diet-associated microbiome.

Napier BA, Andres-Terre M, Massis LM, Hryckowian AJ, Higginbottom SK, Cumnock K, Casey KM, Haileselassie B, Lugo KA, Schneider DS, Sonnenburg JL, Monack DM.

Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3688-3694. doi: 10.1073/pnas.1814273116. Epub 2019 Feb 11.


Adding function to the genome of African Salmonella Typhimurium ST313 strain D23580.

Canals R, Hammarlöf DL, Kröger C, Owen SV, Fong WY, Lacharme-Lora L, Zhu X, Wenner N, Carden SE, Honeycutt J, Monack DM, Kingsley RA, Brownridge P, Chaudhuri RR, Rowe WPM, Predeus AV, Hokamp K, Gordon MA, Hinton JCD.

PLoS Biol. 2019 Jan 15;17(1):e3000059. doi: 10.1371/journal.pbio.3000059. eCollection 2019 Jan.


The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages.

Chu LH, Indramohan M, Ratsimandresy RA, Gangopadhyay A, Morris EP, Monack DM, Dorfleutner A, Stehlik C.

Nat Commun. 2018 Mar 8;9(1):996. doi: 10.1038/s41467-018-03409-3.


LysMD3 is a type II membrane protein without an in vivo role in the response to a range of pathogens.

Yokoyama CC, Baldridge MT, Leung DW, Zhao G, Desai C, Liu TC, Diaz-Ochoa VE, Huynh JP, Kimmey JM, Sennott EL, Hole CR, Idol RA, Park S, Storek KM, Wang C, Hwang S, Viehmann Milam A, Chen E, Kerrinnes T, Starnbach MN, Handley SA, Mysorekar IU, Allen PM, Monack DM, Dinauer MC, Doering TL, Tsolis RM, Dworkin JE, Stallings CL, Amarasinghe GK, Micchelli CA, Virgin HW.

J Biol Chem. 2018 Apr 20;293(16):6022-6038. doi: 10.1074/jbc.RA117.001246. Epub 2018 Mar 1.


Creating a RAW264.7 CRISPR-Cas9 Genome Wide Library.

Napier BA, Monack DM.

Bio Protoc. 2017 May 20;7(10). pii: e2320. doi: 10.21769/BioProtoc.2320.


T6SS: The bacterial "fight club" in the host gut.

Sana TG, Lugo KA, Monack DM.

PLoS Pathog. 2017 Jun 8;13(6):e1006325. doi: 10.1371/journal.ppat.1006325. eCollection 2017 Jun. Review. No abstract available.


Cell-Intrinsic Defense at the Epithelial Border Wall: Salmonella Pays the Price.

Brubaker SW, Monack DM.

Immunity. 2017 Apr 18;46(4):522-524. doi: 10.1016/j.immuni.2017.03.021.


Editorial: The sum of all defenses: tolerance + resistance.

Napier BA, Monack DM.

Pathog Dis. 2017 Mar 1;75(2). doi: 10.1093/femspd/ftx015. No abstract available.


Complement pathway amplifies caspase-11-dependent cell death and endotoxin-induced sepsis severity.

Napier BA, Brubaker SW, Sweeney TE, Monette P, Rothmeier GH, Gertsvolf NA, Puschnik A, Carette JE, Khatri P, Monack DM.

J Exp Med. 2016 Oct 17;213(11):2365-2382. Epub 2016 Oct 3.


Editorial: Bacterial Exotoxins: How Bacteria Fight the Immune System.

Sastalla I, Monack DM, Kubatzky KF.

Front Immunol. 2016 Aug 2;7:300. doi: 10.3389/fimmu.2016.00300. eCollection 2016. No abstract available.


Salmonella Typhimurium utilizes a T6SS-mediated antibacterial weapon to establish in the host gut.

Sana TG, Flaugnatti N, Lugo KA, Lam LH, Jacobson A, Baylot V, Durand E, Journet L, Cascales E, Monack DM.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):E5044-51. doi: 10.1073/pnas.1608858113. Epub 2016 Aug 8.


Microbiology: The dark side of antibiotics.

Sana TG, Monack DM.

Nature. 2016 Jun 30;534(7609):624-5. Epub 2016 Jun 15. No abstract available.


IMMUNOLOGY. A lipid arsenal to control inflammation.

Napier BA, Monack DM.

Science. 2016 Jun 3;352(6290):1173-4. doi: 10.1126/science.aag0366. Epub 2016 Jun 2. No abstract available.


Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death.

Sanman LE, Qian Y, Eisele NA, Ng TM, van der Linden WA, Monack DM, Weerapana E, Bogyo M.

Elife. 2016 Mar 24;5:e13663. doi: 10.7554/eLife.13663.


Variation in Taxonomic Composition of the Fecal Microbiota in an Inbred Mouse Strain across Individuals and Time.

Hoy YE, Bik EM, Lawley TD, Holmes SP, Monack DM, Theriot JA, Relman DA.

PLoS One. 2015 Nov 13;10(11):e0142825. doi: 10.1371/journal.pone.0142825. eCollection 2015.


Cutting Edge: Inflammasome Activation in Primary Human Macrophages Is Dependent on Flagellin.

Kortmann J, Brubaker SW, Monack DM.

J Immunol. 2015 Aug 1;195(3):815-9. doi: 10.4049/jimmunol.1403100. Epub 2015 Jun 24.


IMMUNOLOGY. Microbial metabolite triggers antimicrobial defense.

Brubaker SW, Monack DM.

Science. 2015 Jun 12;348(6240):1207-8. doi: 10.1126/science.aac5835. No abstract available.


Bacterial recognition pathways that lead to inflammasome activation.

Storek KM, Monack DM.

Immunol Rev. 2015 May;265(1):112-29. doi: 10.1111/imr.12289. Review.


cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infection.

Storek KM, Gertsvolf NA, Ohlson MB, Monack DM.

J Immunol. 2015 Apr 1;194(7):3236-45. doi: 10.4049/jimmunol.1402764. Epub 2015 Feb 20.


Intraspecies competition for niches in the distal gut dictate transmission during persistent Salmonella infection.

Lam LH, Monack DM.

PLoS Pathog. 2014 Dec 4;10(12):e1004527. doi: 10.1371/journal.ppat.1004527. eCollection 2014 Dec.


Role of disease-associated tolerance in infectious superspreaders.

Gopinath S, Lichtman JS, Bouley DM, Elias JE, Monack DM.

Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15780-5. doi: 10.1073/pnas.1409968111. Epub 2014 Oct 20.


Structure and function of REP34 implicates carboxypeptidase activity in Francisella tularensis host cell invasion.

Feld GK, El-Etr S, Corzett MH, Hunter MS, Belhocine K, Monack DM, Frank M, Segelke BW, Rasley A.

J Biol Chem. 2014 Oct 31;289(44):30668-79. doi: 10.1074/jbc.M114.599381. Epub 2014 Sep 17.


A microfluidic-based genetic screen to identify microbial virulence factors that inhibit dendritic cell migration.

McLaughlin LM, Xu H, Carden SE, Fisher S, Reyes M, Heilshorn SC, Monack DM.

Integr Biol (Camb). 2014 Apr;6(4):438-49. doi: 10.1039/c3ib40177d. Epub 2014 Mar 6.


The battle in the gut.

Monack DM.

Immunity. 2014 Feb 20;40(2):173-5. doi: 10.1016/j.immuni.2014.01.007.


Toll-like receptor and inflammasome signals converge to amplify the innate bactericidal capacity of T helper 1 cells.

O'Donnell H, Pham OH, Li LX, Atif SM, Lee SJ, Ravesloot MM, Stolfi JL, Nuccio SP, Broz P, Monack DM, Baumler AJ, McSorley SJ.

Immunity. 2014 Feb 20;40(2):213-24. doi: 10.1016/j.immuni.2013.12.013. Epub 2014 Feb 6.


Helicobacter and salmonella persistent infection strategies.

Monack DM.

Cold Spring Harb Perspect Med. 2013 Dec 1;3(12):a010348. doi: 10.1101/cshperspect.a010348. Review.


Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens.

Ng KM, Ferreyra JA, Higginbottom SK, Lynch JB, Kashyap PC, Gopinath S, Naidu N, Choudhury B, Weimer BC, Monack DM, Sonnenburg JL.

Nature. 2013 Oct 3;502(7469):96-9. doi: 10.1038/nature12503. Epub 2013 Sep 1.


Salmonella require the fatty acid regulator PPARδ for the establishment of a metabolic environment essential for long-term persistence.

Eisele NA, Ruby T, Jacobson A, Manzanillo PS, Cox JS, Lam L, Mukundan L, Chawla A, Monack DM.

Cell Host Microbe. 2013 Aug 14;14(2):171-182. doi: 10.1016/j.chom.2013.07.010.


PPARγ-mediated increase in glucose availability sustains chronic Brucella abortus infection in alternatively activated macrophages.

Xavier MN, Winter MG, Spees AM, den Hartigh AB, Nguyen K, Roux CM, Silva TM, Atluri VL, Kerrinnes T, Keestra AM, Monack DM, Luciw PA, Eigenheer RA, Bäumler AJ, Santos RL, Tsolis RM.

Cell Host Microbe. 2013 Aug 14;14(2):159-70. doi: 10.1016/j.chom.2013.07.009.


Revisiting caspase-11 function in host defense.

Ng TM, Monack DM.

Cell Host Microbe. 2013 Jul 17;14(1):9-14. doi: 10.1016/j.chom.2013.06.009. Review.


Measuring inflammasome activation in response to bacterial infection.

Broz P, Monack DM.

Methods Mol Biol. 2013;1040:65-84. doi: 10.1007/978-1-62703-523-1_6.


Newly described pattern recognition receptors team up against intracellular pathogens.

Broz P, Monack DM.

Nat Rev Immunol. 2013 Aug;13(8):551-65. doi: 10.1038/nri3479. Epub 2013 Jul 12. Review.


A coupled protein and probe engineering approach for selective inhibition and activity-based probe labeling of the caspases.

Xiao J, Broz P, Puri AW, Deu E, Morell M, Monack DM, Bogyo M.

J Am Chem Soc. 2013 Jun 19;135(24):9130-8. doi: 10.1021/ja403521u. Epub 2013 Jun 6.


The complex interactions of bacterial pathogens and host defenses.

Monack DM, Hultgren SJ.

Curr Opin Microbiol. 2013 Feb;16(1):1-3. doi: 10.1016/j.mib.2013.03.001. Epub 2013 Mar 19. No abstract available.


Noncanonical inflammasomes: caspase-11 activation and effector mechanisms.

Broz P, Monack DM.

PLoS Pathog. 2013 Feb;9(2):e1003144. doi: 10.1371/journal.ppat.1003144. Epub 2013 Feb 28. No abstract available.


The NeST long ncRNA controls microbial susceptibility and epigenetic activation of the interferon-γ locus.

Gomez JA, Wapinski OL, Yang YW, Bureau JF, Gopinath S, Monack DM, Chang HY, Brahic M, Kirkegaard K.

Cell. 2013 Feb 14;152(4):743-54. doi: 10.1016/j.cell.2013.01.015.


Policing the cytosol--bacterial-sensing inflammasome receptors and pathways.

Ng TM, Kortmann J, Monack DM.

Curr Opin Immunol. 2013 Feb;25(1):34-9. doi: 10.1016/j.coi.2012.11.009. Epub 2012 Dec 20. Review.


Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1.

Broz P, Ruby T, Belhocine K, Bouley DM, Kayagaki N, Dixit VM, Monack DM.

Nature. 2012 Oct 11;490(7419):288-91. doi: 10.1038/nature11419. Epub 2012 Aug 15.


Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection.

Puri AW, Broz P, Shen A, Monack DM, Bogyo M.

Nat Chem Biol. 2012 Sep;8(9):745-7. doi: 10.1038/nchembio.1023. Epub 2012 Jul 15.


Innate immune response to Salmonella typhimurium, a model enteric pathogen.

Broz P, Ohlson MB, Monack DM.

Gut Microbes. 2012 Mar-Apr;3(2):62-70. doi: 10.4161/gmic.19141. Epub 2012 Mar 1. Review.


Salmonella persistence and transmission strategies.

Monack DM.

Curr Opin Microbiol. 2012 Feb;15(1):100-7. doi: 10.1016/j.mib.2011.10.013. Epub 2011 Dec 1. Review.


Immunology: recognition of a unique partner.

Monack DM.

Nature. 2011 Sep 28;477(7366):543-4. doi: 10.1038/477543a. No abstract available.


Dermacentor andersoni transmission of Francisella tularensis subsp. novicida reflects bacterial colonization, dissemination, and replication coordinated with tick feeding.

Reif KE, Palmer GH, Ueti MW, Scoles GA, Margolis JJ, Monack DM, Noh SM.

Infect Immun. 2011 Dec;79(12):4941-6. doi: 10.1128/IAI.05676-11. Epub 2011 Sep 19.


Francisella infection triggers activation of the AIM2 inflammasome in murine dendritic cells.

Belhocine K, Monack DM.

Cell Microbiol. 2012 Jan;14(1):71-80. doi: 10.1111/j.1462-5822.2011.01700.x. Epub 2011 Oct 17.


Molecular mechanisms of inflammasome activation during microbial infections.

Broz P, Monack DM.

Immunol Rev. 2011 Sep;243(1):174-90. doi: 10.1111/j.1600-065X.2011.01041.x. Review.


The two-component sensor kinase KdpD is required for Salmonella typhimurium colonization of Caenorhabditis elegans and survival in macrophages.

Alegado RA, Chin CY, Monack DM, Tan MW.

Cell Microbiol. 2011 Oct;13(10):1618-37. doi: 10.1111/j.1462-5822.2011.01645.x. Epub 2011 Aug 24.


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