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Items: 1 to 50 of 117

1.

A Gut Commensal-Produced Metabolite Mediates Colonization Resistance to Salmonella Infection.

Jacobson A, Lam L, Rajendram M, Tamburini F, Honeycutt J, Pham T, Van Treuren W, Pruss K, Stabler SR, Lugo K, Bouley DM, Vilches-Moure JG, Smith M, Sonnenburg JL, Bhatt AS, Huang KC, Monack D.

Cell Host Microbe. 2018 Aug 8;24(2):296-307.e7. doi: 10.1016/j.chom.2018.07.002. Epub 2018 Jul 26.

PMID:
30057174
2.

The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages.

Chu LH, Indramohan M, Ratsimandresy RA, Gangopadhyay A, Morris EP, Monack DM, Dorfleutner A, Stehlik C.

Nat Commun. 2018 Mar 8;9(1):996. doi: 10.1038/s41467-018-03409-3.

3.

LysMD3 is a type II membrane protein without an in vivo role in the response to a range of pathogens.

Yokoyama CC, Baldridge MT, Leung DW, Zhao G, Desai C, Liu TC, Diaz-Ochoa VE, Huynh JP, Kimmey JM, Sennott EL, Hole CR, Idol RA, Park S, Storek KM, Wang C, Hwang S, Viehmann Milam A, Chen E, Kerrinnes T, Starnbach MN, Handley SA, Mysorekar IU, Allen PM, Monack DM, Dinauer MC, Doering TL, Tsolis RM, Dworkin JE, Stallings CL, Amarasinghe GK, Micchelli CA, Virgin HW.

J Biol Chem. 2018 Apr 20;293(16):6022-6038. doi: 10.1074/jbc.RA117.001246. Epub 2018 Mar 1.

PMID:
29496999
4.

Creating a RAW264.7 CRISPR-Cas9 Genome Wide Library.

Napier BA, Monack DM.

Bio Protoc. 2017 May 20;7(10). pii: e2320. doi: 10.21769/BioProtoc.2320.

5.

T6SS: The bacterial "fight club" in the host gut.

Sana TG, Lugo KA, Monack DM.

PLoS Pathog. 2017 Jun 8;13(6):e1006325. doi: 10.1371/journal.ppat.1006325. eCollection 2017 Jun. Review. No abstract available.

6.

Cell-Intrinsic Defense at the Epithelial Border Wall: Salmonella Pays the Price.

Brubaker SW, Monack DM.

Immunity. 2017 Apr 18;46(4):522-524. doi: 10.1016/j.immuni.2017.03.021.

7.

Pseudogenization of the Secreted Effector Gene sseI Confers Rapid Systemic Dissemination of S. Typhimurium ST313 within Migratory Dendritic Cells.

Carden SE, Walker GT, Honeycutt J, Lugo K, Pham T, Jacobson A, Bouley D, Idoyaga J, Tsolis RM, Monack D.

Cell Host Microbe. 2017 Feb 8;21(2):182-194. doi: 10.1016/j.chom.2017.01.009.

8.

Editorial: The sum of all defenses: tolerance + resistance.

Napier BA, Monack DM.

Pathog Dis. 2017 Mar 1;75(2). doi: 10.1093/femspd/ftx015. No abstract available.

9.

Complement pathway amplifies caspase-11-dependent cell death and endotoxin-induced sepsis severity.

Napier BA, Brubaker SW, Sweeney TE, Monette P, Rothmeier GH, Gertsvolf NA, Puschnik A, Carette JE, Khatri P, Monack DM.

J Exp Med. 2016 Oct 17;213(11):2365-2382. Epub 2016 Oct 3.

10.

Editorial: Bacterial Exotoxins: How Bacteria Fight the Immune System.

Sastalla I, Monack DM, Kubatzky KF.

Front Immunol. 2016 Aug 2;7:300. doi: 10.3389/fimmu.2016.00300. eCollection 2016. No abstract available.

11.

Salmonella Typhimurium utilizes a T6SS-mediated antibacterial weapon to establish in the host gut.

Sana TG, Flaugnatti N, Lugo KA, Lam LH, Jacobson A, Baylot V, Durand E, Journet L, Cascales E, Monack DM.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):E5044-51. doi: 10.1073/pnas.1608858113. Epub 2016 Aug 8.

12.

Microbiology: The dark side of antibiotics.

Sana TG, Monack DM.

Nature. 2016 Jun 30;534(7609):624-5. Epub 2016 Jun 15. No abstract available.

PMID:
27309812
13.

IMMUNOLOGY. A lipid arsenal to control inflammation.

Napier BA, Monack DM.

Science. 2016 Jun 3;352(6290):1173-4. doi: 10.1126/science.aag0366. Epub 2016 Jun 2. No abstract available.

PMID:
27257241
14.

Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death.

Sanman LE, Qian Y, Eisele NA, Ng TM, van der Linden WA, Monack DM, Weerapana E, Bogyo M.

Elife. 2016 Mar 24;5:e13663. doi: 10.7554/eLife.13663.

15.

Coordinate actions of innate immune responses oppose those of the adaptive immune system during Salmonella infection of mice.

Hotson AN, Gopinath S, Nicolau M, Khasanova A, Finck R, Monack D, Nolan GP.

Sci Signal. 2016 Jan 12;9(410):ra4. doi: 10.1126/scisignal.aaa9303.

PMID:
26758212
16.

Variation in Taxonomic Composition of the Fecal Microbiota in an Inbred Mouse Strain across Individuals and Time.

Hoy YE, Bik EM, Lawley TD, Holmes SP, Monack DM, Theriot JA, Relman DA.

PLoS One. 2015 Nov 13;10(11):e0142825. doi: 10.1371/journal.pone.0142825. eCollection 2015.

17.

Cutting Edge: Inflammasome Activation in Primary Human Macrophages Is Dependent on Flagellin.

Kortmann J, Brubaker SW, Monack DM.

J Immunol. 2015 Aug 1;195(3):815-9. doi: 10.4049/jimmunol.1403100. Epub 2015 Jun 24.

18.

IMMUNOLOGY. Microbial metabolite triggers antimicrobial defense.

Brubaker SW, Monack DM.

Science. 2015 Jun 12;348(6240):1207-8. doi: 10.1126/science.aac5835. No abstract available.

PMID:
26068833
19.

Bacterial recognition pathways that lead to inflammasome activation.

Storek KM, Monack DM.

Immunol Rev. 2015 May;265(1):112-29. doi: 10.1111/imr.12289. Review.

20.

Non-typhoidal Salmonella Typhimurium ST313 isolates that cause bacteremia in humans stimulate less inflammasome activation than ST19 isolates associated with gastroenteritis.

Carden S, Okoro C, Dougan G, Monack D.

Pathog Dis. 2015 Jun;73(4). pii: ftu023. doi: 10.1093/femspd/ftu023. Epub 2014 Dec 24.

21.

cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infection.

Storek KM, Gertsvolf NA, Ohlson MB, Monack DM.

J Immunol. 2015 Apr 1;194(7):3236-45. doi: 10.4049/jimmunol.1402764. Epub 2015 Feb 20.

22.

Intraspecies competition for niches in the distal gut dictate transmission during persistent Salmonella infection.

Lam LH, Monack DM.

PLoS Pathog. 2014 Dec 4;10(12):e1004527. doi: 10.1371/journal.ppat.1004527. eCollection 2014 Dec.

23.

Role of disease-associated tolerance in infectious superspreaders.

Gopinath S, Lichtman JS, Bouley DM, Elias JE, Monack DM.

Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15780-5. doi: 10.1073/pnas.1409968111. Epub 2014 Oct 20.

24.

Structure and function of REP34 implicates carboxypeptidase activity in Francisella tularensis host cell invasion.

Feld GK, El-Etr S, Corzett MH, Hunter MS, Belhocine K, Monack DM, Frank M, Segelke BW, Rasley A.

J Biol Chem. 2014 Oct 31;289(44):30668-79. doi: 10.1074/jbc.M114.599381. Epub 2014 Sep 17.

25.

A microfluidic-based genetic screen to identify microbial virulence factors that inhibit dendritic cell migration.

McLaughlin LM, Xu H, Carden SE, Fisher S, Reyes M, Heilshorn SC, Monack DM.

Integr Biol (Camb). 2014 Apr;6(4):438-49. doi: 10.1039/c3ib40177d. Epub 2014 Mar 6.

26.

The battle in the gut.

Monack DM.

Immunity. 2014 Feb 20;40(2):173-5. doi: 10.1016/j.immuni.2014.01.007.

27.

Toll-like receptor and inflammasome signals converge to amplify the innate bactericidal capacity of T helper 1 cells.

O'Donnell H, Pham OH, Li LX, Atif SM, Lee SJ, Ravesloot MM, Stolfi JL, Nuccio SP, Broz P, Monack DM, Baumler AJ, McSorley SJ.

Immunity. 2014 Feb 20;40(2):213-24. doi: 10.1016/j.immuni.2013.12.013. Epub 2014 Feb 6.

28.

Helicobacter and salmonella persistent infection strategies.

Monack DM.

Cold Spring Harb Perspect Med. 2013 Dec 1;3(12):a010348. doi: 10.1101/cshperspect.a010348. Review.

29.

Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens.

Ng KM, Ferreyra JA, Higginbottom SK, Lynch JB, Kashyap PC, Gopinath S, Naidu N, Choudhury B, Weimer BC, Monack DM, Sonnenburg JL.

Nature. 2013 Oct 3;502(7469):96-9. doi: 10.1038/nature12503. Epub 2013 Sep 1.

30.

Salmonella require the fatty acid regulator PPARδ for the establishment of a metabolic environment essential for long-term persistence.

Eisele NA, Ruby T, Jacobson A, Manzanillo PS, Cox JS, Lam L, Mukundan L, Chawla A, Monack DM.

Cell Host Microbe. 2013 Aug 14;14(2):171-182. doi: 10.1016/j.chom.2013.07.010.

31.

PPARγ-mediated increase in glucose availability sustains chronic Brucella abortus infection in alternatively activated macrophages.

Xavier MN, Winter MG, Spees AM, den Hartigh AB, Nguyen K, Roux CM, Silva TM, Atluri VL, Kerrinnes T, Keestra AM, Monack DM, Luciw PA, Eigenheer RA, Bäumler AJ, Santos RL, Tsolis RM.

Cell Host Microbe. 2013 Aug 14;14(2):159-70. doi: 10.1016/j.chom.2013.07.009.

32.

Revisiting caspase-11 function in host defense.

Ng TM, Monack DM.

Cell Host Microbe. 2013 Jul 17;14(1):9-14. doi: 10.1016/j.chom.2013.06.009. Review.

33.

Measuring inflammasome activation in response to bacterial infection.

Broz P, Monack DM.

Methods Mol Biol. 2013;1040:65-84. doi: 10.1007/978-1-62703-523-1_6.

PMID:
23852597
34.

Newly described pattern recognition receptors team up against intracellular pathogens.

Broz P, Monack DM.

Nat Rev Immunol. 2013 Aug;13(8):551-65. doi: 10.1038/nri3479. Epub 2013 Jul 12. Review.

PMID:
23846113
35.

The systemic immune state of super-shedder mice is characterized by a unique neutrophil-dependent blunting of TH1 responses.

Gopinath S, Hotson A, Johns J, Nolan G, Monack D.

PLoS Pathog. 2013;9(6):e1003408. doi: 10.1371/journal.ppat.1003408. Epub 2013 Jun 6.

36.

A coupled protein and probe engineering approach for selective inhibition and activity-based probe labeling of the caspases.

Xiao J, Broz P, Puri AW, Deu E, Morell M, Monack DM, Bogyo M.

J Am Chem Soc. 2013 Jun 19;135(24):9130-8. doi: 10.1021/ja403521u. Epub 2013 Jun 6.

37.

The complex interactions of bacterial pathogens and host defenses.

Monack DM, Hultgren SJ.

Curr Opin Microbiol. 2013 Feb;16(1):1-3. doi: 10.1016/j.mib.2013.03.001. Epub 2013 Mar 19. No abstract available.

38.

Noncanonical inflammasomes: caspase-11 activation and effector mechanisms.

Broz P, Monack DM.

PLoS Pathog. 2013 Feb;9(2):e1003144. doi: 10.1371/journal.ppat.1003144. Epub 2013 Feb 28. No abstract available.

39.

The NeST long ncRNA controls microbial susceptibility and epigenetic activation of the interferon-γ locus.

Gomez JA, Wapinski OL, Yang YW, Bureau JF, Gopinath S, Monack DM, Chang HY, Brahic M, Kirkegaard K.

Cell. 2013 Feb 14;152(4):743-54. doi: 10.1016/j.cell.2013.01.015.

40.

Policing the cytosol--bacterial-sensing inflammasome receptors and pathways.

Ng TM, Kortmann J, Monack DM.

Curr Opin Immunol. 2013 Feb;25(1):34-9. doi: 10.1016/j.coi.2012.11.009. Epub 2012 Dec 20. Review.

41.

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1.

Broz P, Ruby T, Belhocine K, Bouley DM, Kayagaki N, Dixit VM, Monack DM.

Nature. 2012 Oct 11;490(7419):288-91. doi: 10.1038/nature11419. Epub 2012 Aug 15.

42.

Phosphorylation of NLRC4 is critical for inflammasome activation.

Qu Y, Misaghi S, Izrael-Tomasevic A, Newton K, Gilmour LL, Lamkanfi M, Louie S, Kayagaki N, Liu J, Kömüves L, Cupp JE, Arnott D, Monack D, Dixit VM.

Nature. 2012 Oct 25;490(7421):539-42. doi: 10.1038/nature11429. Epub 2012 Aug 12.

PMID:
22885697
43.

Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection.

Puri AW, Broz P, Shen A, Monack DM, Bogyo M.

Nat Chem Biol. 2012 Sep;8(9):745-7. doi: 10.1038/nchembio.1023. Epub 2012 Jul 15.

44.

Shedding light on Salmonella carriers.

Gopinath S, Carden S, Monack D.

Trends Microbiol. 2012 Jul;20(7):320-7. doi: 10.1016/j.tim.2012.04.004. Epub 2012 May 14. Review.

PMID:
22591832
45.

Salmonella's long-term relationship with its host.

Ruby T, McLaughlin L, Gopinath S, Monack D.

FEMS Microbiol Rev. 2012 May;36(3):600-15. doi: 10.1111/j.1574-6976.2012.00332.x. Epub 2012 Mar 9. Review.

46.

Innate immune response to Salmonella typhimurium, a model enteric pathogen.

Broz P, Ohlson MB, Monack DM.

Gut Microbes. 2012 Mar-Apr;3(2):62-70. doi: 10.4161/gmic.19141. Epub 2012 Mar 1. Review.

47.

Salmonella persistence and transmission strategies.

Monack DM.

Curr Opin Microbiol. 2012 Feb;15(1):100-7. doi: 10.1016/j.mib.2011.10.013. Epub 2011 Dec 1. Review.

PMID:
22137596
48.
49.

Immunology: recognition of a unique partner.

Monack DM.

Nature. 2011 Sep 28;477(7366):543-4. doi: 10.1038/477543a. No abstract available.

PMID:
21956324
50.

Dermacentor andersoni transmission of Francisella tularensis subsp. novicida reflects bacterial colonization, dissemination, and replication coordinated with tick feeding.

Reif KE, Palmer GH, Ueti MW, Scoles GA, Margolis JJ, Monack DM, Noh SM.

Infect Immun. 2011 Dec;79(12):4941-6. doi: 10.1128/IAI.05676-11. Epub 2011 Sep 19.

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