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Items: 40

1.

Ancestry-specific association mapping in admixed populations.

Skotte L, Jørsboe E, Korneliussen TS, Moltke I, Albrechtsen A.

Genet Epidemiol. 2019 Mar 18. doi: 10.1002/gepi.22200. [Epub ahead of print]

PMID:
30883944
2.

Author Correction: Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits.

Gilly A, Suveges D, Kuchenbaecker K, Pollard M, Southam L, Hatzikotoulas K, Farmaki AE, Bjornland T, Waples R, Appel EVR, Casalone E, Melloni G, Kilian B, Rayner NW, Ntalla I, Kundu K, Walter K, Danesh J, Butterworth A, Barroso I, Tsafantakis E, Dedoussis G, Moltke I, Zeggini E.

Nat Commun. 2018 Dec 19;9(1):5460. doi: 10.1038/s41467-018-07730-9.

3.

Allele frequency-free inference of close familial relationships from genotypes or low-depth sequencing data.

Waples RK, Albrechtsen A, Moltke I.

Mol Ecol. 2019 Jan;28(1):35-48. doi: 10.1111/mec.14954.

PMID:
30462358
4.

Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits.

Gilly A, Suveges D, Kuchenbaecker K, Pollard M, Southam L, Hatzikotoulas K, Farmaki AE, Bjornland T, Waples R, Appel EVR, Casalone E, Melloni G, Kilian B, Rayner NW, Ntalla I, Kundu K, Walter K, Danesh J, Butterworth A, Barroso I, Tsafantakis E, Dedoussis G, Moltke I, Zeggini E.

Nat Commun. 2018 Nov 7;9(1):4674. doi: 10.1038/s41467-018-07070-8. Erratum in: Nat Commun. 2018 Dec 19;9(1):5460.

5.

Identification of novel high-impact recessively inherited type 2 diabetes risk variants in the Greenlandic population.

Grarup N, Moltke I, Andersen MK, Bjerregaard P, Larsen CVL, Dahl-Petersen IK, Jørsboe E, Tiwari HK, Hopkins SE, Wiener HW, Boyer BB, Linneberg A, Pedersen O, Jørgensen ME, Albrechtsen A, Hansen T.

Diabetologia. 2018 Sep;61(9):2005-2015. doi: 10.1007/s00125-018-4659-2. Epub 2018 Jun 20.

6.

Physiological and Genetic Adaptations to Diving in Sea Nomads.

Ilardo MA, Moltke I, Korneliussen TS, Cheng J, Stern AJ, Racimo F, de Barros Damgaard P, Sikora M, Seguin-Orlando A, Rasmussen S, van den Munckhof ICL, Ter Horst R, Joosten LAB, Netea MG, Salingkat S, Nielsen R, Willerslev E.

Cell. 2018 Apr 19;173(3):569-580.e15. doi: 10.1016/j.cell.2018.03.054.

PMID:
29677510
7.

Genetic architecture of obesity and related metabolic traits-recent insights from isolated populations.

Andersen MK, Grarup N, Moltke I, Albrechtsen A, Hansen T.

Curr Opin Genet Dev. 2018 Jun;50:74-78. doi: 10.1016/j.gde.2018.02.010. Epub 2018 Mar 3. Review.

PMID:
29510341
8.

Genetic determinants of glycated hemoglobin levels in the Greenlandic Inuit population.

Appel EVR, Moltke I, Jørgensen ME, Bjerregaard P, Linneberg A, Pedersen O, Albrechtsen A, Hansen T, Grarup N.

Eur J Hum Genet. 2018 Jun;26(6):868-875. doi: 10.1038/s41431-018-0109-3. Epub 2018 Feb 26.

PMID:
29483669
9.

Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes.

Grarup N, Moltke I, Andersen MK, Dalby M, Vitting-Seerup K, Kern T, Mahendran Y, Jørsboe E, Larsen CVL, Dahl-Petersen IK, Gilly A, Suveges D, Dedoussis G, Zeggini E, Pedersen O, Andersson R, Bjerregaard P, Jørgensen ME, Albrechtsen A, Hansen T.

Nat Genet. 2018 Feb;50(2):172-174. doi: 10.1038/s41588-017-0022-7. Epub 2018 Jan 8.

10.

Archaic Adaptive Introgression in TBX15/WARS2.

Racimo F, Gokhman D, Fumagalli M, Ko A, Hansen T, Moltke I, Albrechtsen A, Carmel L, Huerta-Sánchez E, Nielsen R.

Mol Biol Evol. 2017 Mar 1;34(3):509-524. doi: 10.1093/molbev/msw283.

11.

The Effect of an Extreme and Prolonged Population Bottleneck on Patterns of Deleterious Variation: Insights from the Greenlandic Inuit.

Pedersen CT, Lohmueller KE, Grarup N, Bjerregaard P, Hansen T, Siegismund HR, Moltke I, Albrechtsen A.

Genetics. 2017 Feb;205(2):787-801. doi: 10.1534/genetics.116.193821. Epub 2016 Nov 30.

12.

A genomic history of Aboriginal Australia.

Malaspinas AS, Westaway MC, Muller C, Sousa VC, Lao O, Alves I, Bergström A, Athanasiadis G, Cheng JY, Crawford JE, Heupink TH, Macholdt E, Peischl S, Rasmussen S, Schiffels S, Subramanian S, Wright JL, Albrechtsen A, Barbieri C, Dupanloup I, Eriksson A, Margaryan A, Moltke I, Pugach I, Korneliussen TS, Levkivskyi IP, Moreno-Mayar JV, Ni S, Racimo F, Sikora M, Xue Y, Aghakhanian FA, Brucato N, Brunak S, Campos PF, Clark W, Ellingvåg S, Fourmile G, Gerbault P, Injie D, Koki G, Leavesley M, Logan B, Lynch A, Matisoo-Smith EA, McAllister PJ, Mentzer AJ, Metspalu M, Migliano AB, Murgha L, Phipps ME, Pomat W, Reynolds D, Ricaut FX, Siba P, Thomas MG, Wales T, Wall CM, Oppenheimer SJ, Tyler-Smith C, Durbin R, Dortch J, Manica A, Schierup MH, Foley RA, Lahr MM, Bowern C, Wall JD, Mailund T, Stoneking M, Nielsen R, Sandhu MS, Excoffier L, Lambert DM, Willerslev E.

Nature. 2016 Oct 13;538(7624):207-214. doi: 10.1038/nature18299. Epub 2016 Sep 21.

PMID:
27654914
13.

Identification of Novel Genetic Determinants of Erythrocyte Membrane Fatty Acid Composition among Greenlanders.

Andersen MK, Jørsboe E, Sandholt CH, Grarup N, Jørgensen ME, Færgeman NJ, Bjerregaard P, Pedersen O, Moltke I, Hansen T, Albrechtsen A.

PLoS Genet. 2016 Jun 24;12(6):e1006119. doi: 10.1371/journal.pgen.1006119. eCollection 2016 Jun.

14.

Genetics of Type 2 Diabetes: the Power of Isolated Populations.

Andersen MK, Pedersen CE, Moltke I, Hansen T, Albrechtsen A, Grarup N.

Curr Diab Rep. 2016 Jul;16(7):65. doi: 10.1007/s11892-016-0757-z. Review.

PMID:
27189761
15.

Diabetes in Population Isolates: Lessons from Greenland.

Grarup N, Moltke I, Albrechtsen A, Hansen T.

Rev Diabet Stud. 2015 Fall-Winter;12(3-4):320-9. doi: 10.1900/RDS.2015.12.320. Epub 2016 Feb 10. Review.

16.

New evidence for hybrid zones of forest and savanna elephants in Central and West Africa.

Mondol S, Moltke I, Hart J, Keigwin M, Brown L, Stephens M, Wasser SK.

Mol Ecol. 2015 Dec;24(24):6134-47. doi: 10.1111/mec.13472. Epub 2015 Dec 12.

PMID:
26577954
17.

Greenlandic Inuit show genetic signatures of diet and climate adaptation.

Fumagalli M, Moltke I, Grarup N, Racimo F, Bjerregaard P, Jørgensen ME, Korneliussen TS, Gerbault P, Skotte L, Linneberg A, Christensen C, Brandslund I, Jørgensen T, Huerta-Sánchez E, Schmidt EB, Pedersen O, Hansen T, Albrechtsen A, Nielsen R.

Science. 2015 Sep 18;349(6254):1343-7. doi: 10.1126/science.aab2319.

18.

NgsRelate: a software tool for estimating pairwise relatedness from next-generation sequencing data.

Korneliussen TS, Moltke I.

Bioinformatics. 2015 Dec 15;31(24):4009-11. doi: 10.1093/bioinformatics/btv509. Epub 2015 Aug 30.

19.

POPULATION GENETICS. Genomic evidence for the Pleistocene and recent population history of Native Americans.

Raghavan M, Steinrücken M, Harris K, Schiffels S, Rasmussen S, DeGiorgio M, Albrechtsen A, Valdiosera C, Ávila-Arcos MC, Malaspinas AS, Eriksson A, Moltke I, Metspalu M, Homburger JR, Wall J, Cornejo OE, Moreno-Mayar JV, Korneliussen TS, Pierre T, Rasmussen M, Campos PF, de Barros Damgaard P, Allentoft ME, Lindo J, Metspalu E, Rodríguez-Varela R, Mansilla J, Henrickson C, Seguin-Orlando A, Malmström H, Stafford T Jr, Shringarpure SS, Moreno-Estrada A, Karmin M, Tambets K, Bergström A, Xue Y, Warmuth V, Friend AD, Singarayer J, Valdes P, Balloux F, Leboreiro I, Vera JL, Rangel-Villalobos H, Pettener D, Luiselli D, Davis LG, Heyer E, Zollikofer CPE, Ponce de León MS, Smith CI, Grimes V, Pike KA, Deal M, Fuller BT, Arriaza B, Standen V, Luz MF, Ricaut F, Guidon N, Osipova L, Voevoda MI, Posukh OL, Balanovsky O, Lavryashina M, Bogunov Y, Khusnutdinova E, Gubina M, Balanovska E, Fedorova S, Litvinov S, Malyarchuk B, Derenko M, Mosher MJ, Archer D, Cybulski J, Petzelt B, Mitchell J, Worl R, Norman PJ, Parham P, Kemp BM, Kivisild T, Tyler-Smith C, Sandhu MS, Crawford M, Villems R, Smith DG, Waters MR, Goebel T, Johnson JR, Malhi RS, Jakobsson M, Meltzer DJ, Manica A, Durbin R, Bustamante CD, Song YS, Nielsen R, Willerslev E.

Science. 2015 Aug 21;349(6250):aab3884. doi: 10.1126/science.aab3884. Epub 2015 Jul 21.

20.

The ancestry and affiliations of Kennewick Man.

Rasmussen M, Sikora M, Albrechtsen A, Korneliussen TS, Moreno-Mayar JV, Poznik GD, Zollikofer CPE, de León MP, Allentoft ME, Moltke I, Jónsson H, Valdiosera C, Malhi RS, Orlando L, Bustamante CD, Stafford TW Jr, Meltzer DJ, Nielsen R, Willerslev E.

Nature. 2015 Jul 23;523(7561):455-458. doi: 10.1038/nature14625.

21.

Uncovering the genetic history of the present-day Greenlandic population.

Moltke I, Fumagalli M, Korneliussen TS, Crawford JE, Bjerregaard P, Jørgensen ME, Grarup N, Gulløv HC, Linneberg A, Pedersen O, Hansen T, Nielsen R, Albrechtsen A.

Am J Hum Genet. 2015 Jan 8;96(1):54-69. doi: 10.1016/j.ajhg.2014.11.012. Epub 2014 Dec 31.

22.

Two ancient human genomes reveal Polynesian ancestry among the indigenous Botocudos of Brazil.

Malaspinas AS, Lao O, Schroeder H, Rasmussen M, Raghavan M, Moltke I, Campos PF, Sagredo FS, Rasmussen S, Gonçalves VF, Albrechtsen A, Allentoft ME, Johnson PL, Li M, Reis S, Bernardo DV, DeGiorgio M, Duggan AT, Bastos M, Wang Y, Stenderup J, Moreno-Mayar JV, Brunak S, Sicheritz-Ponten T, Hodges E, Hannon GJ, Orlando L, Price TD, Jensen JD, Nielsen R, Heinemeier J, Olsen J, Rodrigues-Carvalho C, Lahr MM, Neves WA, Kayser M, Higham T, Stoneking M, Pena SD, Willerslev E.

Curr Biol. 2014 Nov 3;24(21):R1035-7. doi: 10.1016/j.cub.2014.09.078. Epub 2014 Oct 23.

23.

Paleogenomics. Genomic structure in Europeans dating back at least 36,200 years.

Seguin-Orlando A, Korneliussen TS, Sikora M, Malaspinas AS, Manica A, Moltke I, Albrechtsen A, Ko A, Margaryan A, Moiseyev V, Goebel T, Westaway M, Lambert D, Khartanovich V, Wall JD, Nigst PR, Foley RA, Lahr MM, Nielsen R, Orlando L, Willerslev E.

Science. 2014 Nov 28;346(6213):1113-8. doi: 10.1126/science.aaa0114. Epub 2014 Nov 6.

24.

The genetic prehistory of the New World Arctic.

Raghavan M, DeGiorgio M, Albrechtsen A, Moltke I, Skoglund P, Korneliussen TS, Grønnow B, Appelt M, Gulløv HC, Friesen TM, Fitzhugh W, Malmström H, Rasmussen S, Olsen J, Melchior L, Fuller BT, Fahrni SM, Stafford T Jr, Grimes V, Renouf MA, Cybulski J, Lynnerup N, Lahr MM, Britton K, Knecht R, Arneborg J, Metspalu M, Cornejo OE, Malaspinas AS, Wang Y, Rasmussen M, Raghavan V, Hansen TV, Khusnutdinova E, Pierre T, Dneprovsky K, Andreasen C, Lange H, Hayes MG, Coltrain J, Spitsyn VA, Götherström A, Orlando L, Kivisild T, Villems R, Crawford MH, Nielsen FC, Dissing J, Heinemeier J, Meldgaard M, Bustamante C, O'Rourke DH, Jakobsson M, Gilbert MT, Nielsen R, Willerslev E.

Science. 2014 Aug 29;345(6200):1255832. doi: 10.1126/science.1255832.

25.

A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes.

Moltke I, Grarup N, Jørgensen ME, Bjerregaard P, Treebak JT, Fumagalli M, Korneliussen TS, Andersen MA, Nielsen TS, Krarup NT, Gjesing AP, Zierath JR, Linneberg A, Wu X, Sun G, Jin X, Al-Aama J, Wang J, Borch-Johnsen K, Pedersen O, Nielsen R, Albrechtsen A, Hansen T.

Nature. 2014 Aug 14;512(7513):190-3. doi: 10.1038/nature13425. Epub 2014 Jun 18.

PMID:
25043022
26.

The genome of a Late Pleistocene human from a Clovis burial site in western Montana.

Rasmussen M, Anzick SL, Waters MR, Skoglund P, DeGiorgio M, Stafford TW Jr, Rasmussen S, Moltke I, Albrechtsen A, Doyle SM, Poznik GD, Gudmundsdottir V, Yadav R, Malaspinas AS, White SS 5th, Allentoft ME, Cornejo OE, Tambets K, Eriksson A, Heintzman PD, Karmin M, Korneliussen TS, Meltzer DJ, Pierre TL, Stenderup J, Saag L, Warmuth VM, Lopes MC, Malhi RS, Brunak S, Sicheritz-Ponten T, Barnes I, Collins M, Orlando L, Balloux F, Manica A, Gupta R, Metspalu M, Bustamante CD, Jakobsson M, Nielsen R, Willerslev E.

Nature. 2014 Feb 13;506(7487):225-9. doi: 10.1038/nature13025.

27.

Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans.

Raghavan M, Skoglund P, Graf KE, Metspalu M, Albrechtsen A, Moltke I, Rasmussen S, Stafford TW Jr, Orlando L, Metspalu E, Karmin M, Tambets K, Rootsi S, Mägi R, Campos PF, Balanovska E, Balanovsky O, Khusnutdinova E, Litvinov S, Osipova LP, Fedorova SA, Voevoda MI, DeGiorgio M, Sicheritz-Ponten T, Brunak S, Demeshchenko S, Kivisild T, Villems R, Nielsen R, Jakobsson M, Willerslev E.

Nature. 2014 Jan 2;505(7481):87-91. doi: 10.1038/nature12736. Epub 2013 Nov 20.

28.

RelateAdmix: a software tool for estimating relatedness between admixed individuals.

Moltke I, Albrechtsen A.

Bioinformatics. 2014 Apr 1;30(7):1027-8. doi: 10.1093/bioinformatics/btt652. Epub 2013 Nov 8.

PMID:
24215025
29.

Calculation of Tajima's D and other neutrality test statistics from low depth next-generation sequencing data.

Korneliussen TS, Moltke I, Albrechtsen A, Nielsen R.

BMC Bioinformatics. 2013 Oct 2;14:289. doi: 10.1186/1471-2105-14-289.

30.

Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse.

Orlando L, Ginolhac A, Zhang G, Froese D, Albrechtsen A, Stiller M, Schubert M, Cappellini E, Petersen B, Moltke I, Johnson PL, Fumagalli M, Vilstrup JT, Raghavan M, Korneliussen T, Malaspinas AS, Vogt J, Szklarczyk D, Kelstrup CD, Vinther J, Dolocan A, Stenderup J, Velazquez AM, Cahill J, Rasmussen M, Wang X, Min J, Zazula GD, Seguin-Orlando A, Mortensen C, Magnussen K, Thompson JF, Weinstock J, Gregersen K, Røed KH, Eisenmann V, Rubin CJ, Miller DC, Antczak DF, Bertelsen MF, Brunak S, Al-Rasheid KA, Ryder O, Andersson L, Mundy J, Krogh A, Gilbert MT, Kjær K, Sicheritz-Ponten T, Jensen LJ, Olsen JV, Hofreiter M, Nielsen R, Shapiro B, Wang J, Willerslev E.

Nature. 2013 Jul 4;499(7456):74-8. doi: 10.1038/nature12323. Epub 2013 Jun 26.

PMID:
23803765
31.

New families of human regulatory RNA structures identified by comparative analysis of vertebrate genomes.

Parker BJ, Moltke I, Roth A, Washietl S, Wen J, Kellis M, Breaker R, Pedersen JS.

Genome Res. 2011 Nov;21(11):1929-43. doi: 10.1101/gr.112516.110. Epub 2011 Oct 12.

32.

A high-resolution map of human evolutionary constraint using 29 mammals.

Lindblad-Toh K, Garber M, Zuk O, Lin MF, Parker BJ, Washietl S, Kheradpour P, Ernst J, Jordan G, Mauceli E, Ward LD, Lowe CB, Holloway AK, Clamp M, Gnerre S, Alföldi J, Beal K, Chang J, Clawson H, Cuff J, Di Palma F, Fitzgerald S, Flicek P, Guttman M, Hubisz MJ, Jaffe DB, Jungreis I, Kent WJ, Kostka D, Lara M, Martins AL, Massingham T, Moltke I, Raney BJ, Rasmussen MD, Robinson J, Stark A, Vilella AJ, Wen J, Xie X, Zody MC; Broad Institute Sequencing Platform and Whole Genome Assembly Team, Baldwin J, Bloom T, Chin CW, Heiman D, Nicol R, Nusbaum C, Young S, Wilkinson J, Worley KC, Kovar CL, Muzny DM, Gibbs RA; Baylor College of Medicine Human Genome Sequencing Center Sequencing Team, Cree A, Dihn HH, Fowler G, Jhangiani S, Joshi V, Lee S, Lewis LR, Nazareth LV, Okwuonu G, Santibanez J, Warren WC, Mardis ER, Weinstock GM, Wilson RK; Genome Institute at Washington University, Delehaunty K, Dooling D, Fronik C, Fulton L, Fulton B, Graves T, Minx P, Sodergren E, Birney E, Margulies EH, Herrero J, Green ED, Haussler D, Siepel A, Goldman N, Pollard KS, Pedersen JS, Lander ES, Kellis M.

Nature. 2011 Oct 12;478(7370):476-82. doi: 10.1038/nature10530.

33.

True single-molecule DNA sequencing of a pleistocene horse bone.

Orlando L, Ginolhac A, Raghavan M, Vilstrup J, Rasmussen M, Magnussen K, Steinmann KE, Kapranov P, Thompson JF, Zazula G, Froese D, Moltke I, Shapiro B, Hofreiter M, Al-Rasheid KA, Gilbert MT, Willerslev E.

Genome Res. 2011 Oct;21(10):1705-19. doi: 10.1101/gr.122747.111. Epub 2011 Jul 29.

34.

A method for detecting IBD regions simultaneously in multiple individuals--with applications to disease genetics.

Moltke I, Albrechtsen A, Hansen TV, Nielsen FC, Nielsen R.

Genome Res. 2011 Jul;21(7):1168-80. doi: 10.1101/gr.115360.110. Epub 2011 Apr 14.

35.

A genome-wide scan in affected sibling pairs with idiopathic recurrent miscarriage suggests genetic linkage.

Kolte AM, Nielsen HS, Moltke I, Degn B, Pedersen B, Sunde L, Nielsen FC, Christiansen OB.

Mol Hum Reprod. 2011 Jun;17(6):379-85. doi: 10.1093/molehr/gar003. Epub 2011 Jan 20.

PMID:
21257601
36.

Natural selection and the distribution of identity-by-descent in the human genome.

Albrechtsen A, Moltke I, Nielsen R.

Genetics. 2010 Sep;186(1):295-308. doi: 10.1534/genetics.110.113977. Epub 2010 Jun 30.

37.

Ancient human genome sequence of an extinct Palaeo-Eskimo.

Rasmussen M, Li Y, Lindgreen S, Pedersen JS, Albrechtsen A, Moltke I, Metspalu M, Metspalu E, Kivisild T, Gupta R, Bertalan M, Nielsen K, Gilbert MT, Wang Y, Raghavan M, Campos PF, Kamp HM, Wilson AS, Gledhill A, Tridico S, Bunce M, Lorenzen ED, Binladen J, Guo X, Zhao J, Zhang X, Zhang H, Li Z, Chen M, Orlando L, Kristiansen K, Bak M, Tommerup N, Bendixen C, Pierre TL, Grønnow B, Meldgaard M, Andreasen C, Fedorova SA, Osipova LP, Higham TF, Ramsey CB, Hansen TV, Nielsen FC, Crawford MH, Brunak S, Sicheritz-Pontén T, Villems R, Nielsen R, Krogh A, Wang J, Willerslev E.

Nature. 2010 Feb 11;463(7282):757-62. doi: 10.1038/nature08835.

38.

A probabilistic model of RNA conformational space.

Frellsen J, Moltke I, Thiim M, Mardia KV, Ferkinghoff-Borg J, Hamelryck T.

PLoS Comput Biol. 2009 Jun;5(6):e1000406. doi: 10.1371/journal.pcbi.1000406. Epub 2009 Jun 19.

39.

Relatedness mapping and tracts of relatedness for genome-wide data in the presence of linkage disequilibrium.

Albrechtsen A, Sand Korneliussen T, Moltke I, van Overseem Hansen T, Nielsen FC, Nielsen R.

Genet Epidemiol. 2009 Apr;33(3):266-74. doi: 10.1002/gepi.20378.

PMID:
19025785
40.

Asap: a framework for over-representation statistics for transcription factor binding sites.

Marstrand TT, Frellsen J, Moltke I, Thiim M, Valen E, Retelska D, Krogh A.

PLoS One. 2008 Feb 20;3(2):e1623. doi: 10.1371/journal.pone.0001623.

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