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High resolution combined molecular and structural optical imaging of colorectal cancer in a xenograft mouse model.

Feroldi F, Verlaan M, Knaus H, Davidoiu V, Vugts DJ, van Dongen GAMS, Molthoff CFM, de Boer JF.

Biomed Opt Express. 2018 Nov 13;9(12):6186-6204. doi: 10.1364/BOE.9.006186. eCollection 2018 Dec 1.


Splicing modulation as novel therapeutic strategy against diffuse malignant peritoneal mesothelioma.

Sciarrillo R, Wojtuszkiewicz A, El Hassouni B, Funel N, Gandellini P, Lagerweij T, Buonamici S, Blijlevens M, Zeeuw van der Laan EA, Zaffaroni N, Deraco M, Kusamura S, Würdinger T, Peters GJ, Molthoff CFM, Jansen G, Kaspers GJL, Cloos J, Giovannetti E.

EBioMedicine. 2019 Jan;39:215-225. doi: 10.1016/j.ebiom.2018.12.025. Epub 2018 Dec 20.


F8-IL10: A New Potential Antirheumatic Drug Evaluated by a PET-Guided Translational Approach.

Bruijnen STG, Chandrupatla DMSH, Giovanonni L, Neri D, Vugts DJ, Huisman MC, Hoekstra OS, Musters RJP, Lammertsma AA, van Dongen GAMS, Jansen G, Molthoff CFM, van der Laken CJ.

Mol Pharm. 2019 Jan 7;16(1):273-281. doi: 10.1021/acs.molpharmaceut.8b00982. Epub 2018 Dec 24.


Synthesis and preliminary preclinical evaluation of fluorine-18 labelled isatin-4-(4-methoxyphenyl)-3-thiosemicarbazone ([18F]4FIMPTC) as a novel PET tracer of P-glycoprotein expression.

Verbeek J, Eriksson J, Syvänen S, Huisman M, Schuit RC, Molthoff CFM, Voskuyl RA, de Lange EC, Lammertsma AA, Windhorst AD.

EJNMMI Radiopharm Chem. 2018 Sep 21;3:11. doi: 10.1186/s41181-018-0046-z. eCollection 2018 Dec.


The folate receptor β as a macrophage-mediated imaging and therapeutic target in rheumatoid arthritis.

Chandrupatla DMSH, Molthoff CFM, Lammertsma AA, van der Laken CJ, Jansen G.

Drug Deliv Transl Res. 2019 Feb;9(1):366-378. doi: 10.1007/s13346-018-0589-2. Review.


Prophylactic and therapeutic activity of alkaline phosphatase in arthritic rats: single-agent effects of alkaline phosphatase and synergistic effects in combination with methotrexate.

Chandrupatla DMSH, Molthoff CFM, Ritsema WIGR, Vos R, Elshof E, Matsuyama T, Low PS, Musters RJP, Hammond A, Windhorst AD, Lammertsma AA, van der Laken CJ, Brands R, Jansen G.

Transl Res. 2018 Sep;199:24-38. doi: 10.1016/j.trsl.2018.04.001. Epub 2018 May 17.


Imaging and Methotrexate Response Monitoring of Systemic Inflammation in Arthritic Rats Employing the Macrophage PET Tracer [18F]Fluoro-PEG-Folate.

Chandrupatla DMSH, Jansen G, Mantel E, Low PS, Matsuyama T, Musters RP, Windhorst AD, Lammertsma AA, Molthoff CFM, van der Laken CJ.

Contrast Media Mol Imaging. 2018 Feb 21;2018:8092781. doi: 10.1155/2018/8092781. eCollection 2018.


A bispecific nanobody approach to leverage the potent and widely applicable tumor cytolytic capacity of Vγ9Vδ2-T cells.

de Bruin RCG, Veluchamy JP, Lougheed SM, Schneiders FL, Lopez-Lastra S, Lameris R, Stam AG, Sebestyen Z, Kuball J, Molthoff CFM, Hooijberg E, Roovers RC, Santo JPD, van Bergen En Henegouwen PMP, Verheul HMW, de Gruijl TD, van der Vliet HJ.

Oncoimmunology. 2017 Oct 20;7(1):e1375641. doi: 10.1080/2162402X.2017.1375641. eCollection 2017.


Cytolytic virus activation therapy and treatment monitoring for Epstein-Barr virus associated nasopharyngeal carcinoma in a mouse tumor model.

Novalić Z, Verkuijlen SAWM, Verlaan M, Eersels JLH, de Greeuw I, Molthoff CFM, Middeldorp JM, Greijer AE.

J Med Virol. 2017 Dec;89(12):2207-2216. doi: 10.1002/jmv.24870. Epub 2017 Aug 29.


Pretargeted PET Imaging of trans-Cyclooctene-Modified Porous Silicon Nanoparticles.

Keinänen O, Mäkilä EM, Lindgren R, Virtanen H, Liljenbäck H, Oikonen V, Sarparanta M, Molthoff C, Windhorst AD, Roivainen A, Salonen JJ, Airaksinen AJ.

ACS Omega. 2017 Jan 31;2(1):62-69. doi: 10.1021/acsomega.6b00269. Epub 2017 Jan 6.


In-vivo monitoring of anti-folate therapy in arthritic rats using [18F]fluoro-PEG-folate and positron emission tomography.

Chandrupatla DMSH, Jansen G, Vos R, Verlaan M, Chen Q, Low PS, Windhorst AD, Lammertsma AA, van der Laken CJ, Molthoff CFM.

Arthritis Res Ther. 2017 May 31;19(1):114. doi: 10.1186/s13075-017-1325-x.


A Multimodal Imaging Approach for Longitudinal Evaluation of Bladder Tumor Development in an Orthotopic Murine Model.

Scheepbouwer C, Meyer S, Burggraaf MJ, Jose J, Molthoff CF.

PLoS One. 2016 Aug 17;11(8):e0161284. doi: 10.1371/journal.pone.0161284. eCollection 2016.


Bevacizumab Targeting Diffuse Intrinsic Pontine Glioma: Results of 89Zr-Bevacizumab PET Imaging in Brain Tumor Models.

Jansen MH, Lagerweij T, Sewing AC, Vugts DJ, van Vuurden DG, Molthoff CF, Caretti V, Veringa SJ, Petersen N, Carcaboso AM, Noske DP, Vandertop WP, Wesseling P, van Dongen GA, Kaspers GJ, Hulleman E.

Mol Cancer Ther. 2016 Sep;15(9):2166-74. doi: 10.1158/1535-7163.MCT-15-0558. Epub 2016 Jun 20.


A New Highly Reactive and Low Lipophilicity Fluorine-18 Labeled Tetrazine Derivative for Pretargeted PET Imaging.

Keinänen O, Li XG, Chenna NK, Lumen D, Ott J, Molthoff CF, Sarparanta M, Helariutta K, Vuorinen T, Windhorst AD, Airaksinen AJ.

ACS Med Chem Lett. 2015 Dec 10;7(1):62-6. doi: 10.1021/acsmedchemlett.5b00330. eCollection 2016 Jan 14.


Sustained macrophage infiltration upon multiple intra-articular injections: an improved rat model of rheumatoid arthritis for PET guided therapy evaluation.

Chandrupatla DM, Weijers K, Gent YY, de Greeuw I, Lammertsma AA, Jansen G, van der Laken CJ, Molthoff CF.

Biomed Res Int. 2015;2015:509295. doi: 10.1155/2015/509295. Epub 2015 Jan 28.


89Zr-immuno-PET for imaging of long circulating drugs and disease targets: why, how and when to be applied?

Van Dongen GA, Huisman MC, Boellaard R, Harry Hendrikse N, Windhorst AD, Visser GW, Molthoff CF, Vugts DJ.

Q J Nucl Med Mol Imaging. 2015 Mar;59(1):18-38. Epub 2014 Dec 17. Review.


Convection enhanced delivery of carmustine to the murine brainstem: a feasibility study.

Sewing AC, Caretti V, Lagerweij T, Schellen P, Jansen MH, van Vuurden DG, Idema S, Molthoff CF, Vandertop WP, Kaspers GJ, Noske DP, Hulleman E.

J Neurosci Methods. 2014 Dec 30;238:88-94. doi: 10.1016/j.jneumeth.2014.09.020. Epub 2014 Sep 27.


Promising potential of new generation translocator protein tracers providing enhanced contrast of arthritis imaging by positron emission tomography in a rat model of arthritis.

Gent YY, Weijers K, Molthoff CF, Windhorst AD, Huisman MC, Kassiou M, Jansen G, Lammertsma AA, van der Laken CJ.

Arthritis Res Ther. 2014 Mar 14;16(2):R70. doi: 10.1186/ar4509.


Evaluation of the novel folate receptor ligand [18F]fluoro-PEG-folate for macrophage targeting in a rat model of arthritis.

Gent YY, Weijers K, Molthoff CF, Windhorst AD, Huisman MC, Smith DE, Kularatne SA, Jansen G, Low PS, Lammertsma AA, van der Laken CJ.

Arthritis Res Ther. 2013 Mar 1;15(2):R37. doi: 10.1186/ar4191.


VECTor: a preclinical imaging system for simultaneous submillimeter SPECT and PET.

Goorden MC, van der Have F, Kreuger R, Ramakers RM, Vastenhouw B, Burbach JP, Booij J, Molthoff CF, Beekman FJ.

J Nucl Med. 2013 Feb;54(2):306-12. doi: 10.2967/jnumed.112.109538. Epub 2012 Oct 17.


Synthesis, biodistribution and PET studies in rats of (18)F-Labeled bridgehead fluoromethyl analogues of WAY-100635.

Al Hussainy R, Verbeek J, van der Born D, Molthoff C, Booij J, Herscheid JK.

Nucl Med Biol. 2012 Oct;39(7):1068-76. doi: 10.1016/j.nucmedbio.2012.04.002. Epub 2012 May 17.


[11C]Flumazenil brain uptake is influenced by the blood-brain barrier efflux transporter P-glycoprotein.

Froklage FE, Syvänen S, Hendrikse NH, Huisman MC, Molthoff CF, Tagawa Y, Reijneveld JC, Heimans JJ, Lammertsma AA, Eriksson J, de Lange EC, Voskuyl RA.

EJNMMI Res. 2012 Mar 28;2:12. doi: 10.1186/2191-219X-2-12.


Validity of simplified 3'-deoxy-3'-[18F]fluorothymidine uptake measures for monitoring response to chemotherapy in locally advanced breast cancer.

Lubberink M, Direcks W, Emmering J, van Tinteren H, Hoekstra OS, van der Hoeven JJ, Molthoff CF, Lammertsma AA.

Mol Imaging Biol. 2012 Dec;14(6):777-82. doi: 10.1007/s11307-012-0547-1.


Increased cerebral (R)-[(11)C]PK11195 uptake and glutamate release in a rat model of traumatic brain injury: a longitudinal pilot study.

Folkersma H, Foster Dingley JC, van Berckel BN, Rozemuller A, Boellaard R, Huisman MC, Lammertsma AA, Vandertop WP, Molthoff CF.

J Neuroinflammation. 2011 Jun 14;8:67. doi: 10.1186/1742-2094-8-67.


Simultaneous in vivo measurements of receptor density and affinity using [11C]flumazenil and positron emission tomography: comparison of full saturation and steady state methods.

Syvänen S, de Lange EC, Tagawa Y, Schenke M, Molthoff CF, Windhorst AD, Lammertsma AA, Voskuyl RA.

Neuroimage. 2011 Aug 1;57(3):928-37. doi: 10.1016/j.neuroimage.2011.05.022. Epub 2011 May 14.


(R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus.

Syvänen S, Luurtsema G, Molthoff CF, Windhorst AD, Huisman MC, Lammertsma AA, Voskuyl RA, de Lange EC.

BMC Med Imaging. 2011 Jan 3;11:1. doi: 10.1186/1471-2342-11-1.


Monitoring of tumor growth and post-irradiation recurrence in a diffuse intrinsic pontine glioma mouse model.

Caretti V, Zondervan I, Meijer DH, Idema S, Vos W, Hamans B, Bugiani M, Hulleman E, Wesseling P, Vandertop WP, Noske DP, Kaspers G, Molthoff CF, Wurdinger T.

Brain Pathol. 2011 Jul;21(4):441-51. doi: 10.1111/j.1750-3639.2010.00468.x. Epub 2010 Dec 29.


Diabetic cardiomyopathy in Zucker diabetic fatty rats: the forgotten right ventricle.

van den Brom CE, Bosmans JW, Vlasblom R, Handoko LM, Huisman MC, Lubberink M, Molthoff CF, Lammertsma AA, Ouwens MD, Diamant M, Boer C.

Cardiovasc Diabetol. 2010 Jun 15;9:25. doi: 10.1186/1475-2840-9-25.


Altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: studies using positron emission tomography.

van den Brom CE, Huisman MC, Vlasblom R, Boontje NM, Duijst S, Lubberink M, Molthoff CF, Lammertsma AA, van der Velden J, Boer C, Ouwens DM, Diamant M.

Cardiovasc Diabetol. 2009 Jul 22;8:39. doi: 10.1186/1475-2840-8-39.


Peripheral metabolism of [(18)F]FDDNP and cerebral uptake of its labelled metabolites.

Luurtsema G, Schuit RC, Takkenkamp K, Lubberink M, Hendrikse NH, Windhorst AD, Molthoff CF, Tolboom N, van Berckel BN, Lammertsma AA.

Nucl Med Biol. 2008 Nov;35(8):869-74. doi: 10.1016/j.nucmedbio.2008.09.002.


Clarifying the diagnosis of clinically suspected recurrence of cervical cancer: impact of 18F-FDG PET.

van der Veldt AA, Buist MR, van Baal MW, Comans EF, Hoekstra OS, Molthoff CF.

J Nucl Med. 2008 Dec;49(12):1936-43. doi: 10.2967/jnumed.108.055046. Epub 2008 Nov 7.


Noninvasive imaging of macrophages in rheumatoid synovitis using 11C-(R)-PK11195 and positron emission tomography.

van der Laken CJ, Elzinga EH, Kropholler MA, Molthoff CF, van der Heijden JW, Maruyama K, Boellaard R, Dijkmans BA, Lammertsma AA, Voskuyl AE.

Arthritis Rheum. 2008 Nov;58(11):3350-5. doi: 10.1002/art.23955.


Changes in GABAA receptor properties in amygdala kindled animals: in vivo studies using [11C]flumazenil and positron emission tomography.

Liefaard LC, Ploeger BA, Molthoff CF, de Jong HW, Dijkstra J, van der Weerd L, Lammertsma AA, Danhof M, Voskuyl RA.

Epilepsia. 2009 Jan;50(1):88-98. doi: 10.1111/j.1528-1167.2008.01763.x. Epub 2008 Aug 25.


[18F]FDG and [18F]FLT uptake in human breast cancer cells in relation to the effects of chemotherapy: an in vitro study.

Direcks WG, Berndsen SC, Proost N, Peters GJ, Balzarini J, Spreeuwenberg MD, Lammertsma AA, Molthoff CF.

Br J Cancer. 2008 Aug 5;99(3):481-7. doi: 10.1038/sj.bjc.6604523.


Gap filling strategies for 3-D-FBP reconstructions of High-Resolution Research Tomograph scans.

van Velden FH, Kloet RW, van Berckel BN, Molthoff CF, Lammertsma AA, Boellaard R.

IEEE Trans Med Imaging. 2008;27(7):934-42. doi: 10.1109/TMI.2008.922702.


A new rat model of human breast cancer for evaluating efficacy of new anti-cancer agents in vivo.

Direcks WG, van Gelder M, Lammertsma AA, Molthoff CF.

Cancer Biol Ther. 2008 Apr;7(4):532-7. Epub 2008 Jan 3.


Impact of attenuation correction strategies on the quantification of High Resolution Research Tomograph PET studies.

van Velden FH, Kloet RW, van Berckel BN, Molthoff CF, de Jong HW, Lammertsma AA, Boellaard R.

Phys Med Biol. 2008 Jan 7;53(1):99-118. doi: 10.1088/0031-9155/53/1/007. Epub 2007 Dec 13.


The correlation between clinical, nuclear and histologic findings in a patient with Von Recklinghausen's disease.

Brinkman JM, Bron JL, Wuisman PI, van Diest PJ, Comans EF, Molthoff CF.

World J Surg Oncol. 2007 Nov 12;5:130.


Hexokinase III, cyclin A and galectin-3 are overexpressed in malignant follicular thyroid nodules.

Hooft L, van der Veldt AA, Hoekstra OS, Boers M, Molthoff CF, van Diest PJ.

Clin Endocrinol (Oxf). 2008 Feb;68(2):252-7. Epub 2007 Sep 13.


18FDG uptake in oesophageal adenocarcinoma: linking biology and outcome.

Westerterp M, Sloof GW, Hoekstra OS, Ten Kate FJ, Meijer GA, Reitsma JB, Boellaard R, van Lanschot JJ, Molthoff CF.

J Cancer Res Clin Oncol. 2008 Feb;134(2):227-36. Epub 2007 Jul 25.


Monitoring response to radiotherapy in human squamous cell cancer bearing nude mice: comparison of 2'-deoxy-2'-[18F]fluoro-D-glucose (FDG) and 3'-[18F]fluoro-3'-deoxythymidine (FLT).

Molthoff CF, Klabbers BM, Berkhof J, Felten JT, van Gelder M, Windhorst AD, Slotman BJ, Lammertsma AA.

Mol Imaging Biol. 2007 Nov-Dec;9(6):340-7.


Angiogenesis-independent tumor growth mediated by stem-like cancer cells.

Sakariassen PØ, Prestegarden L, Wang J, Skaftnesmo KO, Mahesparan R, Molthoff C, Sminia P, Sundlisaeter E, Misra A, Tysnes BB, Chekenya M, Peters H, Lende G, Kalland KH, Øyan AM, Petersen K, Jonassen I, van der Kogel A, Feuerstein BG, Terzis AJ, Bjerkvig R, Enger PØ.

Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16466-71. Epub 2006 Oct 20.


Microvessel density and p53 in detecting cervical cancer by FDG PET in cases of suspected recurrence.

van der Veldt AA, Hooft L, van Diest PJ, Berkhof J, Buist MR, Comans EF, Hoekstra OS, Molthoff CF.

Eur J Nucl Med Mol Imaging. 2006 Dec;33(12):1408-16. Epub 2006 Jul 14.


Population pharmacokinetic analysis for simultaneous determination of B (max) and K (D) in vivo by positron emission tomography.

Liefaard LC, Ploeger BA, Molthoff CF, Boellaard R, Lammertsma AA, Danhof M, Voskuyl RA.

Mol Imaging Biol. 2005 Nov-Dec;7(6):411-21.


Evaluation of (R)-[11C]verapamil as PET tracer of P-glycoprotein function in the blood-brain barrier: kinetics and metabolism in the rat.

Luurtsema G, Molthoff CF, Schuit RC, Windhorst AD, Lammertsma AA, Franssen EJ.

Nucl Med Biol. 2005 Jan;32(1):87-93.


[18F]fluorodeoxyglucose uptake in recurrent thyroid cancer is related to hexokinase i expression in the primary tumor.

Hooft L, van der Veldt AA, van Diest PJ, Hoekstra OS, Berkhof J, Teule GJ, Molthoff CF.

J Clin Endocrinol Metab. 2005 Jan;90(1):328-34. Epub 2004 Oct 27.


Tracers to monitor the response to chemotherapy: in vitro screening of four radiopharmaceuticals.

de Geus-Oei LF, van Eerd-Vismale J, Molthoff C, Corstens F, Oyen W, Boerman O.

Cancer Biother Radiopharm. 2004 Aug;19(4):457-65.


Use of an in-field-of-view shield to improve count rate performance of the single crystal layer high-resolution research tomograph PET scanner for small animal brain scans.

Boellaard R, de Jong HW, Molthoff CF, Buijs F, Lenox M, Nutt R, Lammertsma AA.

Phys Med Biol. 2003 Dec 7;48(23):N335-42.


(R)- and (S)-[11C]verapamil as PET-tracers for measuring P-glycoprotein function: in vitro and in vivo evaluation.

Luurtsema G, Molthoff CF, Windhorst AD, Smit JW, Keizer H, Boellaard R, Lammertsma AA, Franssen EJ.

Nucl Med Biol. 2003 Oct;30(7):747-51.


Cellular and humoral responses after multiple injections of unconjugated chimeric monoclonal antibody MOv18 in ovarian cancer patients: a pilot study.

van Zanten-Przybysz I, Molthoff C, Gebbinck JK, von Mensdorff-Pouilly S, Verstraeten R, Kenemans P, Verheijen R.

J Cancer Res Clin Oncol. 2002 Sep;128(9):484-92. Epub 2002 Aug 23.


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