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Items: 1 to 50 of 123

1.

Genome-wide association study of statin-induced myopathy in patients recruited using the UK clinical practice research datalink.

Carr DF, Francis B, Jorgensen AL, Zhang E, Chinoy H, Heckbert SR, Bis JC, Brody JA, Floyd J, Psaty BM, Molokhia M, Lapeyre-Mestre M, Conforti A, Alfirevic A, van Staa T, Pirmohamed M.

Clin Pharmacol Ther. 2019 Jun 20. doi: 10.1002/cpt.1557. [Epub ahead of print]

PMID:
31220337
2.

Shared genetic risk factors across carbamazepine-induced hypersensitivity reactions.

Nicoletti P, Barrett S, McEvoy L, Daly AK, Aithal G, Lucena MI, Andrade RJ, Wadelius M, Hallberg P, Stephens C, Bjornsson ES, Friedmann P, Kainu K, Laitinen T, Marson A, Molokhia M, Phillips E, Pichler W, Romano A, Shear N, Sills G, Tanno LK, Sawle A, Floratos A, Shen Y, Nelson MR, Watkins PB, Daly MJ, Morris AP, Alfirevic A, Pirmohamed M.

Clin Pharmacol Ther. 2019 May 7. doi: 10.1002/cpt.1493. [Epub ahead of print]

PMID:
31066027
3.

Polypharmacy is associated with treatment response and serious adverse events: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis.

Bechman K, Clarke BD, Rutherford AI, Yates M, Nikiphorou E, Molokhia M, Norton S, Cope AP, Hyrich KL, Galloway JB.

Rheumatology (Oxford). 2019 Apr 14. pii: kez037. doi: 10.1093/rheumatology/kez037. [Epub ahead of print]

PMID:
30982886
4.

The relationship between polypharmacy and trajectories of cognitive decline in people with dementia: A large representative cohort study.

Soysal P, Perera G, Isik AT, Onder G, Petrovic M, Cherubini A, Maggi S, Shetty H, Molokhia M, Smith L, Stubbs B, Stewart R, Veronese N, Mueller C.

Exp Gerontol. 2019 Jun;120:62-67. doi: 10.1016/j.exger.2019.02.019. Epub 2019 Mar 1.

PMID:
30831202
5.

Antibiotic management of urinary tract infection in elderly patients in primary care and its association with bloodstream infections and all cause mortality: population based cohort study.

Gharbi M, Drysdale JH, Lishman H, Goudie R, Molokhia M, Johnson AP, Holmes AH, Aylin P.

BMJ. 2019 Feb 27;364:l525. doi: 10.1136/bmj.l525.

6.

A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury.

Cirulli ET, Nicoletti P, Abramson K, Andrade RJ, Bjornsson ES, Chalasani N, Fontana RJ, Hallberg P, Li YJ, Lucena MI, Long N, Molokhia M, Nelson MR, Odin JA, Pirmohamed M, Rafnar T, Serrano J, Stefánsson K, Stolz A, Daly AK, Aithal GP, Watkins PB; Drug-Induced Liver Injury Network (DILIN) investigators; International DILI consortium (iDILIC).

Gastroenterology. 2019 May;156(6):1707-1716.e2. doi: 10.1053/j.gastro.2019.01.034. Epub 2019 Jan 18.

PMID:
30664875
7.

Drug-Induced Liver Injury due to Flucloxacillin: Relevance of Multiple Human Leukocyte Antigen Alleles.

Nicoletti P, Aithal GP, Chamberlain TC, Coulthard S, Alshabeeb M, Grove JI, Andrade RJ, Bjornsson E, Dillon JF, Hallberg P, Lucena MI, Maitland-van der Zee AH, Martin JH, Molokhia M, Pirmohamed M, Wadelius M, Shen Y, Nelson MR, Daly AK; International Drug-Induced Liver Injury Consortium (iDILIC).

Clin Pharmacol Ther. 2019 Jan 19. doi: 10.1002/cpt.1375. [Epub ahead of print]

PMID:
30661239
8.

Long-term trends in antithrombotic drug prescriptions among adults aged 80 years and over from primary care: a temporal trends analysis using electronic health records.

Dregan A, Ravindrarajah R, Charlton J, Ashworth M, Molokhia M.

Ann Epidemiol. 2018 Jul;28(7):440-446. doi: 10.1016/j.annepidem.2018.03.006. Epub 2018 Mar 19.

PMID:
29609872
9.

Polypharmacy in people with dementia: Associations with adverse health outcomes.

Mueller C, Molokhia M, Perera G, Veronese N, Stubbs B, Shetty H, Codling D, Huntley J, Stewart R.

Exp Gerontol. 2018 Jun;106:240-245. doi: 10.1016/j.exger.2018.02.011. Epub 2018 Feb 13.

PMID:
29452289
10.

Can information on functional and cognitive status improve short-term mortality risk prediction among community-dwelling older people? A cohort study using a UK primary care database.

Sultana J, Fontana A, Giorgianni F, Basile G, Patorno E, Pilotto A, Molokhia M, Stewart R, Sturkenboom M, Trifirò G.

Clin Epidemiol. 2017 Dec 19;10:31-39. doi: 10.2147/CLEP.S145530. eCollection 2018.

11.

Association between prior antibiotic therapy and subsequent risk of community-acquired infections: a systematic review.

Malik U, Armstrong D, Ashworth M, Dregan A, L'Esperance V, McDonnell L, Molokhia M, White P.

J Antimicrob Chemother. 2018 Feb 1;73(2):287-296. doi: 10.1093/jac/dkx374.

PMID:
29149266
12.

Polypharmacy and Unplanned Hospitalizations in Patients with Rheumatoid Arthritis.

Filkova M, Carvalho J, Norton S, Scott D, Mant T, Molokhia M, Cope A, Galloway J.

J Rheumatol. 2017 Dec;44(12):1786-1793. doi: 10.3899/jrheum.160818. Epub 2017 Oct 1.

PMID:
28966210
13.

Sulfasalazine-Induced Agranulocytosis Is Associated With the Human Leukocyte Antigen Locus.

Wadelius M, Eriksson N, Kreutz R, Bondon-Guitton E, Ibañez L, Carvajal A, Lucena MI, Sancho Ponce E, Molokhia M, Martin J, Axelsson T, Kohnke H, Yue QY, Magnusson PKE, Bengtsson M, Hallberg P; EuDAC.

Clin Pharmacol Ther. 2018 May;103(5):843-853. doi: 10.1002/cpt.805. Epub 2017 Sep 28.

14.

Cardiovascular and type 2 diabetes morbidity and all-cause mortality among diverse chronic inflammatory disorders.

Dregan A, Chowienczyk P, Molokhia M.

Heart. 2017 Dec;103(23):1867-1873. doi: 10.1136/heartjnl-2017-311214. Epub 2017 Jun 10.

15.

Current and future perspectives on the management of polypharmacy.

Molokhia M, Majeed A.

BMC Fam Pract. 2017 Jun 6;18(1):70. doi: 10.1186/s12875-017-0642-0.

16.

Use of azithromycin and risk of ventricular arrhythmia.

Trifirò G, de Ridder M, Sultana J, Oteri A, Rijnbeek P, Pecchioli S, Mazzaglia G, Bezemer I, Garbe E, Schink T, Poluzzi E, Frøslev T, Molokhia M, Diemberger I, Sturkenboom MCJM.

CMAJ. 2017 Apr 18;189(15):E560-E568. doi: 10.1503/cmaj.160355.

17.

Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study.

Nicoletti P, Aithal GP, Bjornsson ES, Andrade RJ, Sawle A, Arrese M, Barnhart HX, Bondon-Guitton E, Hayashi PH, Bessone F, Carvajal A, Cascorbi I, Cirulli ET, Chalasani N, Conforti A, Coulthard SA, Daly MJ, Day CP, Dillon JF, Fontana RJ, Grove JI, Hallberg P, Hernández N, Ibáñez L, Kullak-Ublick GA, Laitinen T, Larrey D, Lucena MI, Maitland-van der Zee AH, Martin JH, Molokhia M, Pirmohamed M, Powell EE, Qin S, Serrano J, Stephens C, Stolz A, Wadelius M, Watkins PB, Floratos A, Shen Y, Nelson MR, Urban TJ, Daly AK; International Drug-Induced Liver Injury Consortium, Drug-Induced Liver Injury Network Investigators, and International Serious Adverse Events Consortium.

Gastroenterology. 2017 Apr;152(5):1078-1089. doi: 10.1053/j.gastro.2016.12.016. Epub 2016 Dec 30.

18.

The Effect of Safety Warnings on Antipsychotic Drug Prescribing in Elderly Persons with Dementia in the United Kingdom and Italy: A Population-Based Study.

Sultana J, Fontana A, Giorgianni F, Pasqua A, Cricelli C, Spina E, Gambassi G, Ivanovic J, Ferrajolo C, Molokhia M, Ballard C, Sharp S, Sturkenboom M, Trifirò G.

CNS Drugs. 2016 Nov;30(11):1097-1109.

PMID:
27423216
19.

Genetic variants associated with antithyroid drug-induced agranulocytosis: a genome-wide association study in a European population.

Hallberg P, Eriksson N, Ibañez L, Bondon-Guitton E, Kreutz R, Carvajal A, Lucena MI, Ponce ES, Molokhia M, Martin J, Axelsson T, Yue QY, Magnusson PK, Wadelius M; EuDAC collaborators.

Lancet Diabetes Endocrinol. 2016 Jun;4(6):507-16. doi: 10.1016/S2213-8587(16)00113-3. Epub 2016 May 3.

PMID:
27157822
20.

Prescribing pattern of antipsychotic drugs during the years 1996-2010: a population-based database study in Europe with a focus on torsadogenic drugs.

Oteri A, Mazzaglia G, Pecchioli S, Molokhia M, Ulrichsen SP, Pedersen L, Poluzzi E, De Ponti F, Garbe E, Schink T, Herings R, Bezemer ID, Sturkenboom MC, Trifirò G.

Br J Clin Pharmacol. 2016 Aug;82(2):487-97. doi: 10.1111/bcp.12955. Epub 2016 May 18. Erratum in: Br J Clin Pharmacol. 2017 Jun;83(6):1360.

21.

Carpal Tunnel Syndrome Associated with Oral Bisphosphonates. A Population-Based Cohort Study.

Carvajal A, Martín Arias LH, Sáinz M, Escudero A, Fierro I, Sauzet O, Cornelius VR, Molokhia M.

PLoS One. 2016 Jan 14;11(1):e0146772. doi: 10.1371/journal.pone.0146772. eCollection 2016.

22.

Bisphosphonates and evidence for association with esophageal and gastric cancer: a systematic review and meta-analysis.

Wright E, Schofield PT, Molokhia M.

BMJ Open. 2015 Dec 7;5(12):e007133. doi: 10.1136/bmjopen-2014-007133. Review.

23.

Identifying people with diabetes at high risk of blindness and amputation.

Majeed A, Molokhia M.

BMJ. 2015 Nov 11;351:h5643. doi: 10.1136/bmj.h5643. No abstract available.

24.

Association of systemic lupus erythematosus with decreased immunosuppressive potential of the IgG glycome.

Vučković F, Krištić J, Gudelj I, Teruel M, Keser T, Pezer M, Pučić-Baković M, Štambuk J, Trbojević-Akmačić I, Barrios C, Pavić T, Menni C, Wang Y, Zhou Y, Cui L, Song H, Zeng Q, Guo X, Pons-Estel BA, McKeigue P, Leslie Patrick A, Gornik O, Spector TD, Harjaček M, Alarcon-Riquelme M, Molokhia M, Wang W, Lauc G.

Arthritis Rheumatol. 2015 Nov;67(11):2978-89. doi: 10.1002/art.39273.

25.

Trends in paediatric macrolide use in five European countries-a population-based study.

Holstiege J, Enders D, Schink T, Innocenti F, Oteri A, Bezemer I, Kaguelidou F, Molokhia M, Poluzzi E, Puccini A, Ulrichsen SP, Sturkenboom MC, Trifirò G, Garbe E.

Eur J Clin Pharmacol. 2015 Aug;71(8):991-9. doi: 10.1007/s00228-015-1870-7. Epub 2015 May 22.

PMID:
25998220
26.

Efficacy and Harms of Direct Oral Anticoagulants in the Elderly for Stroke Prevention in Atrial Fibrillation and Secondary Prevention of Venous Thromboembolism: Systematic Review and Meta-Analysis.

Sharma M, Cornelius VR, Patel JP, Davies JG, Molokhia M.

Circulation. 2015 Jul 21;132(3):194-204. doi: 10.1161/CIRCULATIONAHA.114.013267. Epub 2015 May 20. Review.

27.

Systemic antibiotic prescribing to paediatric outpatients in 5 European countries: a population-based cohort study.

Holstiege J, Schink T, Molokhia M, Mazzaglia G, Innocenti F, Oteri A, Bezemer I, Poluzzi E, Puccini A, Ulrichsen SP, Sturkenboom MC, Trifirò G, Garbe E.

BMC Pediatr. 2014 Jul 5;14:174. doi: 10.1186/1471-2431-14-174.

28.

Urgent need to establish the true incidence of the side effects of statins.

Majeed A, Molokhia M.

BMJ. 2014 Jun 11;348:g3650. doi: 10.1136/bmj.g3650. No abstract available.

PMID:
24920685
29.

Validation study in four health-care databases: upper gastrointestinal bleeding misclassification affects precision but not magnitude of drug-related upper gastrointestinal bleeding risk.

Valkhoff VE, Coloma PM, Masclee GM, Gini R, Innocenti F, Lapi F, Molokhia M, Mosseveld M, Nielsson MS, Schuemie M, Thiessard F, van der Lei J, Sturkenboom MC, Trifirò G; EU-ADR Consortium.

J Clin Epidemiol. 2014 Aug;67(8):921-31. doi: 10.1016/j.jclinepi.2014.02.020. Epub 2014 May 1.

PMID:
24794575
30.

Obesity paradox in people newly diagnosed with type 2 diabetes with and without prior cardiovascular disease.

Thomas G, Khunti K, Curcin V, Molokhia M, Millett C, Majeed A, Paul S.

Diabetes Obes Metab. 2014 Apr;16(4):317-25. doi: 10.1111/dom.12217. Epub 2013 Oct 29.

PMID:
24118783
31.

Drug-induced acute myocardial infarction: identifying 'prime suspects' from electronic healthcare records-based surveillance system.

Coloma PM, Schuemie MJ, Trifirò G, Furlong L, van Mulligen E, Bauer-Mehren A, Avillach P, Kors J, Sanz F, Mestres J, Oliveira JL, Boyer S, Helgee EA, Molokhia M, Matthews J, Prieto-Merino D, Gini R, Herings R, Mazzaglia G, Picelli G, Scotti L, Pedersen L, van der Lei J, Sturkenboom M; EU-ADR consortium.

PLoS One. 2013 Aug 28;8(8):e72148. doi: 10.1371/journal.pone.0072148. eCollection 2013. Erratum in: PLoS One. 2013;8(9). doi:10.1371/annotation/8824e161-bf8f-4f78-81e0-a62a1540276d.

32.

Identification of acute myocardial infarction from electronic healthcare records using different disease coding systems: a validation study in three European countries.

Coloma PM, Valkhoff VE, Mazzaglia G, Nielsson MS, Pedersen L, Molokhia M, Mosseveld M, Morabito P, Schuemie MJ, van der Lei J, Sturkenboom M, Trifirò G; EU-ADR Consortium.

BMJ Open. 2013 Jun 20;3(6). pii: e002862. doi: 10.1136/bmjopen-2013-002862.

33.

Cyclo-oxygenase-2 inhibitors or nonselective NSAIDs plus gastroprotective agents: what to prescribe in daily clinical practice?

Masclee GM, Valkhoff VE, van Soest EM, Schade R, Mazzaglia G, Molokhia M, Trifirò G, Goldstein JL, Hernández-Díaz S, Kuipers EJ, Sturkenboom MC.

Aliment Pharmacol Ther. 2013 Jul;38(2):178-89. doi: 10.1111/apt.12348. Epub 2013 May 28.

34.

Illustration of the weibull shape parameter signal detection tool using electronic healthcare record data.

Sauzet O, Carvajal A, Escudero A, Molokhia M, Cornelius VR.

Drug Saf. 2013 Oct;36(10):995-1006. doi: 10.1007/s40264-013-0061-7.

PMID:
23673816
35.

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.

Lauc G, Huffman JE, Pučić M, Zgaga L, Adamczyk B, Mužinić A, Novokmet M, Polašek O, Gornik O, Krištić J, Keser T, Vitart V, Scheijen B, Uh HW, Molokhia M, Patrick AL, McKeigue P, Kolčić I, Lukić IK, Swann O, van Leeuwen FN, Ruhaak LR, Houwing-Duistermaat JJ, Slagboom PE, Beekman M, de Craen AJ, Deelder AM, Zeng Q, Wang W, Hastie ND, Gyllensten U, Wilson JF, Wuhrer M, Wright AF, Rudd PM, Hayward C, Aulchenko Y, Campbell H, Rudan I.

PLoS Genet. 2013;9(1):e1003225. doi: 10.1371/journal.pgen.1003225. Epub 2013 Jan 31.

36.

A reference standard for evaluation of methods for drug safety signal detection using electronic healthcare record databases.

Coloma PM, Avillach P, Salvo F, Schuemie MJ, Ferrajolo C, Pariente A, Fourrier-Réglat A, Molokhia M, Patadia V, van der Lei J, Sturkenboom M, Trifirò G.

Drug Saf. 2013 Jan;36(1):13-23. doi: 10.1007/s40264-012-0002-x.

PMID:
23315292
37.

Academic output from EU-funded health research projects.

Molokhia M, De Ponti F, Behr ER, Trifirò G, Sturkenboom M; ARITMO consortium.

Lancet. 2012 Dec 1;380(9857):1903-4. doi: 10.1016/S0140-6736(12)62103-5. No abstract available.

PMID:
23200492
38.

Bisphosphonates and risk of upper gastrointestinal cancer--a case control study using the General Practice Research Database (GPRD).

Wright E, Schofield PT, Seed P, Molokhia M.

PLoS One. 2012;7(10):e47616. doi: 10.1371/journal.pone.0047616. Epub 2012 Oct 24.

39.

Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs.

Urban TJ, Shen Y, Stolz A, Chalasani N, Fontana RJ, Rochon J, Ge D, Shianna KV, Daly AK, Lucena MI, Nelson MR, Molokhia M, Aithal GP, Floratos A, Pe'er I, Serrano J, Bonkovsky H, Davern TJ, Lee WM, Navarro VJ, Talwalkar JA, Goldstein DB, Watkins PB; Drug-Induced Liver Injury Network; DILIGEN; EUDRAGENE; Spanish DILI Registry; International Serious Adverse Events Consortium.

Pharmacogenet Genomics. 2012 Nov;22(11):784-95. doi: 10.1097/FPC.0b013e3283589a76.

40.

Harmonization process for the identification of medical events in eight European healthcare databases: the experience from the EU-ADR project.

Avillach P, Coloma PM, Gini R, Schuemie M, Mougin F, Dufour JC, Mazzaglia G, Giaquinto C, Fornari C, Herings R, Molokhia M, Pedersen L, Fourrier-Réglat A, Fieschi M, Sturkenboom M, van der Lei J, Pariente A, Trifirò G; EU-ADR consortium.

J Am Med Inform Assoc. 2013 Jan 1;20(1):184-92. doi: 10.1136/amiajnl-2012-000933. Epub 2012 Sep 6.

41.

Association of systolic and diastolic blood pressure and all cause mortality in people with newly diagnosed type 2 diabetes: retrospective cohort study.

Vamos EP, Harris M, Millett C, Pape UJ, Khunti K, Curcin V, Molokhia M, Majeed A.

BMJ. 2012 Aug 30;345:e5567. doi: 10.1136/bmj.e5567.

42.

Using electronic health care records for drug safety signal detection: a comparative evaluation of statistical methods.

Schuemie MJ, Coloma PM, Straatman H, Herings RM, Trifirò G, Matthews JN, Prieto-Merino D, Molokhia M, Pedersen L, Gini R, Innocenti F, Mazzaglia G, Picelli G, Scotti L, van der Lei J, Sturkenboom MC.

Med Care. 2012 Oct;50(10):890-7.

PMID:
22929992
43.

Prescription of nonselective NSAIDs, coxibs and gastroprotective agents in the era of rofecoxib withdrawal - a 617,400-patient study.

Valkhoff VE, van Soest EM, Masclee GM, de Bie S, Mazzaglia G, Molokhia M, Kuipers EJ, Sturkenboom MC.

Aliment Pharmacol Ther. 2012 Oct;36(8):790-9. doi: 10.1111/apt.12028. Epub 2012 Aug 28.

44.

The EU-ADR corpus: annotated drugs, diseases, targets, and their relationships.

van Mulligen EM, Fourrier-Reglat A, Gurwitz D, Molokhia M, Nieto A, Trifiro G, Kors JA, Furlong LI.

J Biomed Inform. 2012 Oct;45(5):879-84. doi: 10.1016/j.jbi.2012.04.004. Epub 2012 Apr 25.

45.

Adherence to gastroprotection during cyclooxygenase 2 inhibitor treatment and the risk of upper gastrointestinal tract events: a population-based study.

Valkhoff VE, van Soest EM, Mazzaglia G, Molokhia M, Schade R, Trifiro G, Goldstein JL, Hernandez-Diaz S, Kuipers EJ, Sturkenboom MC.

Arthritis Rheum. 2012 Aug;64(8):2792-802. doi: 10.1002/art.34433.

46.

667C>T and 1298A>C polymorphisms of MTHFR do not predict response to methotrexate in patients with gestational trophoblastic neoplasia.

Lasecka L, Dixon PH, Molokhia M, Sharma N, Schleh A, Wang CM, Steel JH, Seckl MJ, Savage PM, Fisher RA.

Gynecol Oncol. 2011 Dec;123(3):605-9. doi: 10.1016/j.ygyno.2011.08.012. Epub 2011 Sep 13.

PMID:
21920590
47.

Association of practice size and pay-for-performance incentives with the quality of diabetes management in primary care.

Vamos EP, Pape UJ, Bottle A, Hamilton FL, Curcin V, Ng A, Molokhia M, Car J, Majeed A, Millett C.

CMAJ. 2011 Sep 6;183(12):E809-16. doi: 10.1503/cmaj.101187. Epub 2011 Aug 2.

48.

Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in three regions of England: a repeated cross-sectional study in primary care.

Nacul LC, Lacerda EM, Pheby D, Campion P, Molokhia M, Fayyaz S, Leite JC, Poland F, Howe A, Drachler ML.

BMC Med. 2011 Jul 28;9:91. doi: 10.1186/1741-7015-9-91.

49.

Suboptimal gastroprotective coverage of NSAID use and the risk of upper gastrointestinal bleeding and ulcers: an observational study using three European databases.

van Soest EM, Valkhoff VE, Mazzaglia G, Schade R, Molokhia M, Goldstein JL, Hernández-Díaz S, Trifirò G, Dieleman JP, Kuipers EJ, Sturkenboom MC.

Gut. 2011 Dec;60(12):1650-9. doi: 10.1136/gut.2011.239848. Epub 2011 Jun 2.

PMID:
21636644
50.

The functional status and well being of people with myalgic encephalomyelitis/chronic fatigue syndrome and their carers.

Nacul LC, Lacerda EM, Campion P, Pheby D, Drachler Mde L, Leite JC, Poland F, Howe A, Fayyaz S, Molokhia M.

BMC Public Health. 2011 May 27;11:402. doi: 10.1186/1471-2458-11-402.

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