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Items: 26

1.

Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis.

Mosaei H, Molodtsov V, Kepplinger B, Harbottle J, Moon CW, Jeeves RE, Ceccaroni L, Shin Y, Morton-Laing S, Marrs ECL, Wills C, Clegg W, Yuzenkova Y, Perry JD, Bacon J, Errington J, Allenby NEE, Hall MJ, Murakami KS, Zenkin N.

Mol Cell. 2018 Oct 18;72(2):263-274.e5. doi: 10.1016/j.molcel.2018.08.028. Epub 2018 Sep 20.

2.

Structure-function comparisons of (p)ppApp vs (p)ppGpp for Escherichia coli RNA polymerase binding sites and for rrnB P1 promoter regulatory responses in vitro.

Bruhn-Olszewska B, Molodtsov V, Sobala M, Dylewski M, Murakami KS, Cashel M, Potrykus K.

Biochim Biophys Acta Gene Regul Mech. 2018 Aug;1861(8):731-742. doi: 10.1016/j.bbagrm.2018.07.005. Epub 2018 Jul 18.

3.

Minimalism and functionality: Structural lessons from the heterodimeric N4 bacteriophage RNA polymerase II.

Molodtsov V, Murakami KS.

J Biol Chem. 2018 Aug 31;293(35):13616-13625. doi: 10.1074/jbc.RA118.003447. Epub 2018 Jul 10.

4.

Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA.

Molodtsov V, Sineva E, Zhang L, Huang X, Cashel M, Ades SE, Murakami KS.

Mol Cell. 2018 Mar 1;69(5):828-839.e5. doi: 10.1016/j.molcel.2018.01.035. Epub 2018 Feb 22.

5.

X-ray crystal structure of a reiterative transcription complex reveals an atypical RNA extension pathway.

Murakami KS, Shin Y, Turnbough CL Jr, Molodtsov V.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8211-8216. doi: 10.1073/pnas.1702741114. Epub 2017 Jun 26.

6.

Gene expression profiling of tumor-initiating stem cells from mouse Krebs-2 carcinoma using a novel marker of poorly differentiated cells.

Potter EA, Dolgova EV, Proskurina AS, Efremov YR, Minkevich AM, Rozanov AS, Peltek SE, Nikolin VP, Popova NA, Seledtsov IA, Molodtsov VV, Zavyalov EL, Taranov OS, Baiborodin SI, Ostanin AA, Chernykh ER, Kolchanov NA, Bogachev SS.

Oncotarget. 2017 Feb 7;8(6):9425-9441. doi: 10.18632/oncotarget.14116.

7.

Novel Chemical Scaffolds for Inhibition of Rifamycin-Resistant RNA Polymerase Discovered from High-Throughput Screening.

Scharf NT, Molodtsov V, Kontos A, Murakami KS, Garcia GA.

SLAS Discov. 2017 Mar;22(3):287-297. doi: 10.1177/2472555216679994. Epub 2016 Dec 27.

8.

Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis.

Molodtsov V, Scharf NT, Stefan MA, Garcia GA, Murakami KS.

Mol Microbiol. 2017 Mar;103(6):1034-1045. doi: 10.1111/mmi.13606. Epub 2017 Jan 10.

9.

X-ray crystal structures of Escherichia coli RNA polymerase with switch region binding inhibitors enable rational design of squaramides with an improved fraction unbound to human plasma protein.

Molodtsov V, Fleming PR, Eyermann CJ, Ferguson AD, Foulk MA, McKinney DC, Masse CE, Buurman ET, Murakami KS.

J Med Chem. 2015 Apr 9;58(7):3156-71. doi: 10.1021/acs.jmedchem.5b00050. Epub 2015 Mar 23.

10.

Alignathon: a competitive assessment of whole-genome alignment methods.

Earl D, Nguyen N, Hickey G, Harris RS, Fitzgerald S, Beal K, Seledtsov I, Molodtsov V, Raney BJ, Clawson H, Kim J, Kemena C, Chang JM, Erb I, Poliakov A, Hou M, Herrero J, Kent WJ, Solovyev V, Darling AE, Ma J, Notredame C, Brudno M, Dubchak I, Haussler D, Paten B.

Genome Res. 2014 Dec;24(12):2077-89. doi: 10.1101/gr.174920.114. Epub 2014 Oct 1.

11.

The presence of an RNA:DNA hybrid that is prone to slippage promotes termination by T7 RNA polymerase.

Molodtsov V, Anikin M, McAllister WT.

J Mol Biol. 2014 Sep 9;426(18):3095-3107. doi: 10.1016/j.jmb.2014.06.012. Epub 2014 Jun 27.

12.

Structural basis of transcription initiation by bacterial RNA polymerase holoenzyme.

Basu RS, Warner BA, Molodtsov V, Pupov D, Esyunina D, Fernández-Tornero C, Kulbachinskiy A, Murakami KS.

J Biol Chem. 2014 Aug 29;289(35):24549-59. doi: 10.1074/jbc.M114.584037. Epub 2014 Jun 27.

13.

X-ray crystal structures of the Escherichia coli RNA polymerase in complex with benzoxazinorifamycins.

Molodtsov V, Nawarathne IN, Scharf NT, Kirchhoff PD, Showalter HD, Garcia GA, Murakami KS.

J Med Chem. 2013 Jun 13;56(11):4758-63. doi: 10.1021/jm4004889. Epub 2013 May 31.

14.

[Apoptosis regulation in hypothalamic neurosecretory cells of HER2/neu transgenic mice in ontogenesis].

Bazhanova ED, Molodtsov VN, Popovich IG, Anisimov VN.

Adv Gerontol. 2007;20(4):31-5. Russian.

PMID:
18383707
15.

Aging-related changes in the expression of apoptosis-associated molecules in neurosecretory cells of the mouse hypothalamus.

Bazhanova ED, Molodtsov VN, Pavlov KI.

Neurosci Behav Physiol. 2008 Jan;38(1):43-7.

PMID:
18097759
16.

[Age-dependent peculiarities of apoptotic marker proteins expression in the neuroendocrine system of Her2/neu transgenic mice].

Bazhanova ED, Molodtsov VN, Popovich IG, Anisimov VN.

Morfologiia. 2007;131(3):22-5. Russian.

PMID:
17722567
17.

[Changes in expression of apoptosis-associated molecules in hypothalamic neurosecretory cells of mice during aging].

Bazhanova ED, Molodtsov VN, Pavlov KI.

Morfologiia. 2006;130(6):35-9. Russian.

PMID:
17338214
18.

[Apoptosis and vasopressin, insulin and Bcl-2 expression in neurosecretory system of old mice].

Molodtsov VN, Senchenkov EV, Bazhanova ED.

Zh Evol Biokhim Fiziol. 2006 May-Jun;42(3):283-8. Russian. No abstract available.

PMID:
16808289
19.

[Analysis of heat shock proteins and thermotolerance in a thermoresistant strain of Drosophila melanogaster].

Molodtsov VB, Velikodvorskaia VV, Garbuz DG, Zatsepina OG, Evgen'ev MB.

Izv Akad Nauk Ser Biol. 2001 Sep-Oct;(5):522-32. Russian.

PMID:
15926315
20.

[Methodical means for investigating visual perception of fragmented images].

Chikhman VN, Pronin SV, Solnushkin SD, Shelepin IuE, Foreman N, Molodtsov VO, Przhybysh NE, Liakhov OI.

Ross Fiziol Zh Im I M Sechenova. 2003 Oct;89(10):1314-22. Review. Russian. No abstract available.

PMID:
14758656
21.

[Evolution of the response to heat shock in genus Drosophila].

Garbuz DG, Molodtsov VB, Velikodvorskaia VV, Evgen'ev MB, Zatsepina OG.

Genetika. 2002 Aug;38(8):1097-109. Russian.

PMID:
12244694
22.

[A case of extrapulmonary tuberculosis with laryngeal and intestinal involvement].

Molodtsov VG, Biriukova LA, Shipkov AV, Dobzhanskiĭ AV.

Vestn Otorinolaringol. 2001;(4):57. Russian. No abstract available.

PMID:
11530486
24.

A Drosophila melanogaster strain from sub-equatorial Africa has exceptional thermotolerance but decreased Hsp70 expression.

Zatsepina OG, Velikodvorskaia VV, Molodtsov VB, Garbuz D, Lerman DN, Bettencourt BR, Feder ME, Evgenev MB.

J Exp Biol. 2001 Jun;204(Pt 11):1869-81.

25.

Thermotolerant desert lizards characteristically differ in terms of heat-shock system regulation.

Zatsepina OG, Ulmasov KA, Beresten SF, Molodtsov VB, Rybtsov SA, Evgen'ev MB.

J Exp Biol. 2000 Mar;203(Pt 6):1017-25.

26.

[A computer-automated electrophysiological device for studying the motor function of the gastrointestinal tract in the anesthetized rat].

Panteleev SS, Chikhman VN, Molodtsov VO.

Fiziol Zh Im I M Sechenova. 1996 Apr;82(4):135-40. Russian. No abstract available.

PMID:
8963331

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