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Methylome and transcriptome maps of human visceral and subcutaneous adipocytes reveal key epigenetic differences at developmental genes.

Bradford ST, Nair SS, Statham AL, van Dijk SJ, Peters TJ, Anwar F, French HJ, von Martels JZH, Sutcliffe B, Maddugoda MP, Peranec M, Varinli H, Arnoldy R, Buckley M, Ross JP, Zotenko E, Song JZ, Stirzaker C, Bauer DC, Qu W, Swarbrick MM, Lutgers HL, Lord RV, Samaras K, Molloy PL, Clark SJ.

Sci Rep. 2019 Jul 2;9(1):9511. doi: 10.1038/s41598-019-45777-w.


Mother-child transmission of epigenetic information by tunable polymorphic imprinting.

Carpenter BL, Zhou W, Madaj Z, DeWitt AK, Ross JP, Grønbæk K, Liang G, Clark SJ, Molloy PL, Jones PA.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E11970-E11977. doi: 10.1073/pnas.1815005115. Epub 2018 Dec 3.


Helper-Dependent Chain Reaction (HDCR) for Selective Amplification of Methylated DNA Sequences.

Mitchell SM, Rand KN, Xu ZZ, Ho T, Brown GS, Ross JP, Molloy PL.

Methods Mol Biol. 2018;1708:587-601. doi: 10.1007/978-1-4939-7481-8_30.


DNA methylation in blood from neonatal screening cards and the association with BMI and insulin sensitivity in early childhood.

van Dijk SJ, Peters TJ, Buckley M, Zhou J, Jones PA, Gibson RA, Makrides M, Muhlhausler BS, Molloy PL.

Int J Obes (Lond). 2018 Jan;42(1):28-35. doi: 10.1038/ijo.2017.228. Epub 2017 Sep 25.


Smoke-Induced Changes to the Epigenome Provide Fertile Ground for Oncogenic Mutation.

Clark SJ, Molloy PL.

Cancer Cell. 2017 Sep 11;32(3):278-280. doi: 10.1016/j.ccell.2017.08.016.


Evaluation of Methylation Biomarkers for Detection of Circulating Tumor DNA and Application to Colorectal Cancer.

Mitchell SM, Ho T, Brown GS, Baker RT, Thomas ML, McEvoy A, Xu ZZ, Ross JP, Lockett TJ, Young GP, LaPointe LC, Pedersen SK, Molloy PL.

Genes (Basel). 2016 Dec 15;7(12). pii: E125.


Effect of prenatal DHA supplementation on the infant epigenome: results from a randomized controlled trial.

van Dijk SJ, Zhou J, Peters TJ, Buckley M, Sutcliffe B, Oytam Y, Gibson RA, McPhee A, Yelland LN, Makrides M, Molloy PL, Muhlhausler BS.

Clin Epigenetics. 2016 Nov 4;8:114. eCollection 2016.


BRAF V600E Mutant Colorectal Cancer Subtypes Based on Gene Expression.

Barras D, Missiaglia E, Wirapati P, Sieber OM, Jorissen RN, Love C, Molloy PL, Jones IT, McLaughlin S, Gibbs P, Guinney J, Simon IM, Roth AD, Bosman FT, Tejpar S, Delorenzi M.

Clin Cancer Res. 2017 Jan 1;23(1):104-115. doi: 10.1158/1078-0432.CCR-16-0140. Epub 2016 Jun 27.


Relative telomere lengths in tumor and normal mucosa are related to disease progression and chromosome instability profiles in colorectal cancer.

Suraweera N, Mouradov D, Li S, Jorissen RN, Hampson D, Ghosh A, Sengupta N, Thaha M, Ahmed S, Kirwan M, Aleva F, Propper D, Feakins RM, Vulliamy T, Elwood NJ, Tian P, Ward RL, Hawkins NJ, Xu ZZ, Molloy PL, Jones IT, Croxford M, Gibbs P, Silver A, Sieber OM.

Oncotarget. 2016 Jun 14;7(24):36474-36488. doi: 10.18632/oncotarget.9015.


COBRA-Seq: Sensitive and Quantitative Methylome Profiling.

Varinli H, Statham AL, Clark SJ, Molloy PL, Ross JP.

Genes (Basel). 2015 Oct 23;6(4):1140-63. doi: 10.3390/genes6041140.


LipiD-QuanT: a novel method to quantify lipid accumulation in live cells.

Varinli H, Osmond-McLeod MJ, Molloy PL, Vallotton P.

J Lipid Res. 2015 Nov;56(11):2206-16. doi: 10.1194/jlr.D059758. Epub 2015 Sep 1.


Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer.

Jorissen RN, Christie M, Mouradov D, Sakthianandeswaren A, Li S, Love C, Xu ZZ, Molloy PL, Jones IT, McLaughlin S, Ward RL, Hawkins NJ, Ruszkiewicz AR, Moore J, Burgess AW, Busam D, Zhao Q, Strausberg RL, Lipton L, Desai J, Gibbs P, Sieber OM.

Br J Cancer. 2015 Sep 15;113(6):979-88. doi: 10.1038/bjc.2015.296. Epub 2015 Aug 25.


De novo identification of differentially methylated regions in the human genome.

Peters TJ, Buckley MJ, Statham AL, Pidsley R, Samaras K, V Lord R, Clark SJ, Molloy PL.

Epigenetics Chromatin. 2015 Jan 27;8:6. doi: 10.1186/1756-8935-8-6. eCollection 2015.


A two-gene blood test for methylated DNA sensitive for colorectal cancer.

Pedersen SK, Baker RT, McEvoy A, Murray DH, Thomas M, Molloy PL, Mitchell S, Lockett T, Young GP, LaPointe LC.

PLoS One. 2015 Apr 30;10(4):e0125041. doi: 10.1371/journal.pone.0125041. eCollection 2015.


Resistant starch alters colonic contractility and expression of related genes in rats fed a Western diet.

Patten GS, Kerr CA, Dunne RA, Shaw JM, Bird AR, Regina A, Morell MK, Lockett TJ, Molloy PL, Abeywardena MY, Topping DL, Conlon MA.

Dig Dis Sci. 2015 Jun;60(6):1624-32. doi: 10.1007/s10620-015-3537-8. Epub 2015 Jan 24.


Recent developments on the role of epigenetics in obesity and metabolic disease.

van Dijk SJ, Tellam RL, Morrison JL, Muhlhausler BS, Molloy PL.

Clin Epigenetics. 2015 Jul 11;7:66. doi: 10.1186/s13148-015-0101-5. eCollection 2015. Review.


Methylated Glutathione S-transferase 1 (mGSTP1) is a potential plasma free DNA epigenetic marker of prognosis and response to chemotherapy in castrate-resistant prostate cancer.

Mahon KL, Qu W, Devaney J, Paul C, Castillo L, Wykes RJ, Chatfield MD, Boyer MJ, Stockler MR, Marx G, Gurney H, Mallesara G, Molloy PL, Horvath LG, Clark SJ; PRIMe consortium.

Br J Cancer. 2014 Oct 28;111(9):1802-9. doi: 10.1038/bjc.2014.463. Epub 2014 Aug 21.


CAHM, a long non-coding RNA gene hypermethylated in colorectal neoplasia.

Pedersen SK, Mitchell SM, Graham LD, McEvoy A, Thomas ML, Baker RT, Ross JP, Xu ZZ, Ho T, LaPointe LC, Young GP, Molloy PL.

Epigenetics. 2014 Aug;9(8):1071-82. doi: 10.4161/epi.29046. Epub 2014 May 6.


Epigenetics and human obesity.

van Dijk SJ, Molloy PL, Varinli H, Morrison JL, Muhlhausler BS; Members of EpiSCOPE.

Int J Obes (Lond). 2015 Jan;39(1):85-97. doi: 10.1038/ijo.2014.34. Epub 2014 Feb 25. Review.


A panel of genes methylated with high frequency in colorectal cancer.

Mitchell SM, Ross JP, Drew HR, Ho T, Brown GS, Saunders NF, Duesing KR, Buckley MJ, Dunne R, Beetson I, Rand KN, McEvoy A, Thomas ML, Baker RT, Wattchow DA, Young GP, Lockett TJ, Pedersen SK, Lapointe LC, Molloy PL.

BMC Cancer. 2014 Jan 31;14:54. doi: 10.1186/1471-2407-14-54.


CRNDE, a long non-coding RNA responsive to insulin/IGF signaling, regulates genes involved in central metabolism.

Ellis BC, Graham LD, Molloy PL.

Biochim Biophys Acta. 2014 Feb;1843(2):372-86. doi: 10.1016/j.bbamcr.2013.10.016. Epub 2013 Nov 1.


CRNDE: A Long Non-Coding RNA Involved in CanceR, Neurobiology, and DEvelopment.

Ellis BC, Molloy PL, Graham LD.

Front Genet. 2012 Nov 29;3:270. doi: 10.3389/fgene.2012.00270. eCollection 2012.


Sensitive and selective amplification of methylated DNA sequences using helper-dependent chain reaction in combination with a methylation-dependent restriction enzymes.

Rand KN, Young GP, Ho T, Molloy PL.

Nucleic Acids Res. 2013 Jan 7;41(1):e15. doi: 10.1093/nar/gks831. Epub 2012 Sep 10.


Relative distribution of folate species is associated with global DNA methylation in human colorectal mucosa.

Liu J, Hesson LB, Meagher AP, Bourke MJ, Hawkins NJ, Rand KN, Molloy PL, Pimanda JE, Ward RL.

Cancer Prev Res (Phila). 2012 Jul;5(7):921-9. doi: 10.1158/1940-6207.CAPR-11-0577. Epub 2012 May 18.


Resistant starches protect against colonic DNA damage and alter microbiota and gene expression in rats fed a Western diet.

Conlon MA, Kerr CA, McSweeney CS, Dunne RA, Shaw JM, Kang S, Bird AR, Morell MK, Lockett TJ, Molloy PL, Regina A, Toden S, Clarke JM, Topping DL.

J Nutr. 2012 May;142(5):832-40. doi: 10.3945/jn.111.147660. Epub 2012 Mar 28.


Colorectal Neoplasia Differentially Expressed (CRNDE), a Novel Gene with Elevated Expression in Colorectal Adenomas and Adenocarcinomas.

Graham LD, Pedersen SK, Brown GS, Ho T, Kassir Z, Moynihan AT, Vizgoft EK, Dunne R, Pimlott L, Young GP, Lapointe LC, Molloy PL.

Genes Cancer. 2011 Aug;2(8):829-40. doi: 10.1177/1947601911431081.


Discovery and validation of molecular biomarkers for colorectal adenomas and cancer with application to blood testing.

LaPointe LC, Pedersen SK, Dunne R, Brown GS, Pimlott L, Gaur S, McEvoy A, Thomas M, Wattchow D, Molloy PL, Young GP.

PLoS One. 2012;7(1):e29059. doi: 10.1371/journal.pone.0029059. Epub 2012 Jan 19.


Evidence of linkage to chromosomes 10p15.3-p15.1, 14q24.3-q31.1 and 9q33.3-q34.3 in non-syndromic colorectal cancer families.

Saunders IW, Ross J, Macrae F, Young GP, Blanco I, Brohede J, Brown G, Brookes D, Lockett T, Molloy PL, Moreno V, Capella G, Hannan GN.

Eur J Hum Genet. 2012 Jan;20(1):91-6. doi: 10.1038/ejhg.2011.149. Epub 2011 Aug 10.


Sensitive measurement of unmethylated repeat DNA sequences by end-specific PCR.

Rand KN, Molloy PL.

Biotechniques. 2010 Oct;49(4):xiii-xvii. doi: 10.2144/000113494.


Thirteenth AACR Special Conference on Cancer Epigenetics.

Ross JP, Molloy PL.

Cancer Res. 2010 Oct 1;70(19):7372-8. doi: 10.1158/0008-5472.CAN-10-2102.


Recombinant mammalian DNA methyltransferase activity on model transcriptional gene silencing short RNA-DNA heteroduplex substrates.

Ross JP, Suetake I, Tajima S, Molloy PL.

Biochem J. 2010 Dec 1;432(2):323-32. doi: 10.1042/BJ20100579.


Hypomethylation of repeated DNA sequences in cancer.

Ross JP, Rand KN, Molloy PL.

Epigenomics. 2010 Apr;2(2):245-69. doi: 10.2217/epi.10.2. Review.


Map of differential transcript expression in the normal human large intestine.

LaPointe LC, Dunne R, Brown GS, Worthley DL, Molloy PL, Wattchow D, Young GP.

Physiol Genomics. 2008 Mar 14;33(1):50-64. Epub 2007 Dec 4.


Bisulphite differential denaturation PCR for analysis of DNA methylation.

Rand KN, Mitchell SM, Clark SJ, Molloy PL.

Epigenetics. 2006 Apr-Jun;1(2):94-100. Epub 2006 Mar 7.


DNA methylation: bisulphite modification and analysis.

Clark SJ, Statham A, Stirzaker C, Molloy PL, Frommer M.

Nat Protoc. 2006;1(5):2353-64.


DNA hypomethylation and human diseases.

Wilson AS, Power BE, Molloy PL.

Biochim Biophys Acta. 2007 Jan;1775(1):138-62. Epub 2006 Sep 1. Review.


Headloop suppression PCR and its application to selective amplification of methylated DNA sequences.

Rand KN, Ho T, Qu W, Mitchell SM, White R, Clark SJ, Molloy PL.

Nucleic Acids Res. 2005 Aug 9;33(14):e127.


Preclinical evaluation of a prostate-targeted gene-directed enzyme prodrug therapy delivered by ovine atadenovirus.

Wang XY, Martiniello-Wilks R, Shaw JM, Ho T, Coulston N, Cooke-Yarborough C, Molloy PL, Cameron F, Moghaddam M, Lockett TJ, Webster LK, Smith IK, Both GW, Russell PJ.

Gene Ther. 2004 Nov;11(21):1559-67.


Cytotoxic properties of immunoconjugates containing melittin-like peptide 101 against prostate cancer: in vitro and in vivo studies.

Russell PJ, Hewish D, Carter T, Sterling-Levis K, Ow K, Hattarki M, Doughty L, Guthrie R, Shapira D, Molloy PL, Werkmeister JA, Kortt AA.

Cancer Immunol Immunother. 2004 May;53(5):411-21. Epub 2004 Jan 13.


Calcitonin-specific transcription and splicing targets gene-directed enzyme prodrug therapy to medullary thyroid carcinoma cells.

Messina M, Yu DM, Both GW, Molloy PL, Robinson BG.

J Clin Endocrinol Metab. 2003 Mar;88(3):1310-8.


Transcription-targeted gene therapy for androgen-independent prostate cancer.

Martiniello-Wilks R, Tsatralis T, Russell P, Brookes DE, Zandvliet D, Lockett LJ, Both GW, Molloy PL, Russell PJ.

Cancer Gene Ther. 2002 May;9(5):443-52.


Hypermethylation of the inhibin alpha-subunit gene in prostate carcinoma.

Schmitt JF, Millar DS, Pedersen JS, Clark SL, Venter DJ, Frydenberg M, Molloy PL, Risbridger GP.

Mol Endocrinol. 2002 Feb;16(2):213-20.


A tissue-specific enhancer of the prostate-specific membrane antigen gene, FOLH1.

Watt F, Martorana A, Brookes DE, Ho T, Kingsley E, O'Keefe DS, Russell PJ, Heston WD, Molloy PL.

Genomics. 2001 May 1;73(3):243-54.


Overview of evolving strategies incorporating prostate-specific membrane antigen as target for therapy.

Gong MC, Chang SS, Watt F, O'Keefe DS, Bacich DJ, Uchida A, Bander NH, Reuter VE, Gaudin PB, Molloy PL, Sadelian M, Heston WD.

Mol Urol. 2000 Fall;4(3):217-22;discussion 223. Review.


Prostate-specific suicide gene therapy using the prostate-specific membrane antigen promoter and enhancer.

O'Keefe DS, Uchida A, Bacich DJ, Watt FB, Martorana A, Molloy PL, Heston WD.

Prostate. 2000 Oct 1;45(2):149-57.


High level, tissue-specific expression of a modified calcitonin/calcitonin gene-related peptide promoter in a human medullary thyroid carcinoma cell line.

Messina M, Yu DM, Learoyd DL, Both GW, Molloy PL, Robinson BG.

Mol Cell Endocrinol. 2000 Jun;164(1-2):219-24.


A distinct sequence (ATAAA)n separates methylated and unmethylated domains at the 5'-end of the GSTP1 CpG island.

Millar DS, Paul CL, Molloy PL, Clark SJ.

J Biol Chem. 2000 Aug 11;275(32):24893-9.


Electrophoretic mobility shift assays.

Molloy PL.

Methods Mol Biol. 2000;130:235-46. Review. No abstract available.


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