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Bioanalytical evaluation of dried plasma spots for monitoring of abiraterone and ∆(4)-abiraterone from cancer patients.

Bhatnagar A, McKay MJ, Thaysen-Andersen M, Arasaratnam M, Crumbaker M, Gurney H, Molloy MP.

J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Sep 15;1126-1127:121741. doi: 10.1016/j.jchromb.2019.121741. Epub 2019 Jul 31.


Protein Paucimannosylation Is an Enriched N-Glycosylation Signature of Human Cancers.

Chatterjee S, Lee LY, Kawahara R, Abrahams JL, Adamczyk B, Anugraham M, Ashwood C, Sumer-Bayraktar Z, Briggs MT, Chik JHL, Everest-Dass A, Förster S, Hinneburg H, Leite KRM, Loke I, Möginger U, Moh ESX, Nakano M, Recuero S, Sethi MK, Srougi M, Stavenhagen K, Venkatakrishnan V, Wongtrakul-Kish K, Diestel S, Hoffmann P, Karlsson NG, Kolarich D, Molloy MP, Muders MH, Oehler MK, Packer NH, Palmisano G, Thaysen-Andersen M.

Proteomics. 2019 Aug 16:e1900010. doi: 10.1002/pmic.201900010. [Epub ahead of print]


Proteomic screen with the proto-oncogene beta-catenin identifies interaction with Golgi coatomer complex I.

Semaan C, Henderson BR, Molloy MP.

Biochem Biophys Rep. 2019 Jul 10;19:100662. doi: 10.1016/j.bbrep.2019.100662. eCollection 2019 Sep.


Inter- and intra-patient variability in pharmacokinetics of abiraterone acetate in metastatic prostate cancer.

Arasaratnam M, Crumbaker M, Bhatnagar A, McKay MJ, Molloy MP, Gurney H.

Cancer Chemother Pharmacol. 2019 Jul;84(1):139-146. doi: 10.1007/s00280-019-03862-x. Epub 2019 May 13.


Proteome profiling of Pseudomonas aeruginosa PAO1 identifies novel responders to copper stress.

Wright BW, Kamath KS, Krisp C, Molloy MP.

BMC Microbiol. 2019 Apr 1;19(1):69. doi: 10.1186/s12866-019-1441-7.


Using proteomics to identify ubiquitin ligase-substrate pairs: how novel methods may unveil therapeutic targets for neurodegenerative diseases.

Rayner SL, Morsch M, Molloy MP, Shi B, Chung R, Lee A.

Cell Mol Life Sci. 2019 Jul;76(13):2499-2510. doi: 10.1007/s00018-019-03082-9. Epub 2019 Mar 27. Review.


Precision medicine beyond medical oncology: using molecular analysis to guide treatments of colorectal neoplasia.

Molloy MP, Engel A.

Expert Rev Gastroenterol Hepatol. 2018 Dec;12(12):1179-1181. doi: 10.1080/17474124.2018.1535897. Epub 2018 Oct 17. No abstract available.


Targeted Mass Spectrometry of S100 Proteins.

Martínez-Aguilar J, Molloy MP.

Methods Mol Biol. 2019;1929:663-678. doi: 10.1007/978-1-4939-9030-6_41.


Proteomics identification of radiation-induced changes of membrane proteins in the rat model of arteriovenous malformation in pursuit of targets for brain AVM molecular therapy.

Simonian M, Shirasaki D, Lee VS, Bervini D, Grace M, Loo RRO, Loo JA, Molloy MP, Stoodley MA.

Clin Proteomics. 2018 Dec 26;15:43. doi: 10.1186/s12014-018-9217-x. eCollection 2018.


Examining Cellular Responses to Kinase Drug Inhibition Through Phosphoproteome Mapping of Substrates.

Bucio-Noble D, Semaan C, Molloy MP.

Methods Mol Biol. 2019;1888:141-152. doi: 10.1007/978-1-4939-8891-4_8.


Pharmacological Inhibition of Casein Kinase 2 Enhances the Effectiveness of PI3K Inhibition in Colon Cancer Cells.

Semaan C, Neilson KA, Brown B, Molloy MP.

Anticancer Res. 2018 Nov;38(11):6195-6200. doi: 10.21873/anticanres.12973.


Expression of ALS/FTD-linked mutant CCNF in zebrafish leads to increased cell death in the spinal cord and an aberrant motor phenotype.

Hogan AL, Don EK, Rayner SL, Lee A, Laird AS, Watchon M, Winnick C, Tarr IS, Morsch M, Fifita JA, Gwee SSL, Formella I, Hortle E, Yuan KC, Molloy MP, Williams KL, Nicholson GA, Chung RS, Blair IP, Cole NJ.

Hum Mol Genet. 2019 Feb 15;28(4):698. doi: 10.1093/hmg/ddy362. No abstract available.


Proteomic phenotyping of metastatic melanoma reveals putative signatures of MEK inhibitor response and prognosis.

Krisp C, Parker R, Pascovici D, Hayward NK, Wilmott JS, Thompson JF, Mann GJ, Long GV, Scolyer RA, Molloy MP.

Br J Cancer. 2018 Sep;119(6):713-723. doi: 10.1038/s41416-018-0227-2. Epub 2018 Aug 17.


Fiber Supplements Derived From Sugarcane Stem, Wheat Dextrin and Psyllium Husk Have Different In Vitro Effects on the Human Gut Microbiota.

Gamage HKAH, Tetu SG, Chong RWW, Bucio-Noble D, Rosewarne CP, Kautto L, Ball MS, Molloy MP, Packer NH, Paulsen IT.

Front Microbiol. 2018 Jul 20;9:1618. doi: 10.3389/fmicb.2018.01618. eCollection 2018.


iSwathX: an interactive web-based application for extension of DIA peptide reference libraries.

Noor Z, Wu JX, Pascovici D, Mohamedali A, Molloy MP, Baker MS, Ranganathan S.

Bioinformatics. 2019 Feb 1;35(3):538-539. doi: 10.1093/bioinformatics/bty660.


Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints.

Bezawork-Geleta A, Wen H, Dong L, Yan B, Vider J, Boukalova S, Krobova L, Vanova K, Zobalova R, Sobol M, Hozak P, Novais SM, Caisova V, Abaffy P, Naraine R, Pang Y, Zaw T, Zhang P, Sindelka R, Kubista M, Zuryn S, Molloy MP, Berridge MV, Pacak K, Rohlena J, Park S, Neuzil J.

Nat Commun. 2018 Jun 7;9(1):2221. doi: 10.1038/s41467-018-04603-z.


Quantitation of the anticancer drug abiraterone and its metabolite Δ(4)-abiraterone in human plasma using high-resolution mass spectrometry.

Bhatnagar A, McKay MJ, Crumbaker M, Ahire K, Karuso P, Gurney H, Molloy MP.

J Pharm Biomed Anal. 2018 May 30;154:66-74. doi: 10.1016/j.jpba.2018.03.012. Epub 2018 Mar 6.


Multi-laboratory analysis of the variability of shipped samples for proteomics following non-cooled international transport.

Steffen P, Krisp C, Yi W, Yang P, Molloy MP, Schlüter H.

Anal Biochem. 2018 May 1;548:60-65. doi: 10.1016/j.ab.2018.02.026. Epub 2018 Feb 25.


Polyphenol extracts from dried sugarcane inhibit inflammatory mediators in an in vitro colon cancer model.

Bucio-Noble D, Kautto L, Krisp C, Ball MS, Molloy MP.

J Proteomics. 2018 Apr 15;177:1-10. doi: 10.1016/j.jprot.2018.02.009. Epub 2018 Feb 10.


Development of a data independent acquisition mass spectrometry workflow to enable glycopeptide analysis without predefined glycan compositional knowledge.

Lin CH, Krisp C, Packer NH, Molloy MP.

J Proteomics. 2018 Feb 10;172:68-75. doi: 10.1016/j.jprot.2017.10.011. Epub 2017 Oct 22.


Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex.

Lee A, Rayner SL, De Luca A, Gwee SSL, Morsch M, Sundaramoorthy V, Shahheydari H, Ragagnin A, Shi B, Yang S, Williams KL, Don EK, Walker AK, Zhang KY, Yerbury JJ, Cole NJ, Atkin JD, Blair IP, Molloy MP, Chung RS.

Open Biol. 2017 Oct;7(10). pii: 170058. doi: 10.1098/rsob.170058.


Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes.

Mirzaei M, Gupta VB, Chick JM, Greco TM, Wu Y, Chitranshi N, Wall RV, Hone E, Deng L, Dheer Y, Abbasi M, Rezaeian M, Braidy N, You Y, Salekdeh GH, Haynes PA, Molloy MP, Martins R, Cristea IM, Gygi SP, Graham SL, Gupta VK.

Sci Rep. 2017 Oct 4;7(1):12685. doi: 10.1038/s41598-017-12858-7.


Plasma biomarker proteins for detection of human growth hormone administration in athletes.

Tan SH, Lee A, Pascovici D, Care N, Birzniece V, Ho K, Molloy MP, Khan A.

Sci Rep. 2017 Aug 30;7(1):10039. doi: 10.1038/s41598-017-09968-7.


Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy.

Lee A, Rayner SL, Gwee SSL, De Luca A, Shahheydari H, Sundaramoorthy V, Ragagnin A, Morsch M, Radford R, Galper J, Freckleton S, Shi B, Walker AK, Don EK, Cole NJ, Yang S, Williams KL, Yerbury JJ, Blair IP, Atkin JD, Molloy MP, Chung RS.

Cell Mol Life Sci. 2018 Jan;75(2):335-354. doi: 10.1007/s00018-017-2632-8. Epub 2017 Aug 29.


Improving Protein Detection Confidence Using SWATH-Mass Spectrometry with Large Peptide Reference Libraries.

Wu JX, Pascovici D, Ignjatovic V, Song X, Krisp C, Molloy MP.

Proteomics. 2017 Oct;17(19). doi: 10.1002/pmic.201700174.


Pseudomonas aeruginosa Proteome under Hypoxic Stress Conditions Mimicking the Cystic Fibrosis Lung.

Kamath KS, Krisp C, Chick J, Pascovici D, Gygi SP, Molloy MP.

J Proteome Res. 2017 Oct 6;16(10):3917-3928. doi: 10.1021/acs.jproteome.7b00561. Epub 2017 Aug 31.


Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry.

Collins BC, Hunter CL, Liu Y, Schilling B, Rosenberger G, Bader SL, Chan DW, Gibson BW, Gingras AC, Held JM, Hirayama-Kurogi M, Hou G, Krisp C, Larsen B, Lin L, Liu S, Molloy MP, Moritz RL, Ohtsuki S, Schlapbach R, Selevsek N, Thomas SN, Tzeng SC, Zhang H, Aebersold R.

Nat Commun. 2017 Aug 21;8(1):291. doi: 10.1038/s41467-017-00249-5.


SWATH Mass Spectrometry for Proteomics of Non-Depleted Plasma.

Krisp C, Molloy MP.

Methods Mol Biol. 2017;1619:373-383. doi: 10.1007/978-1-4939-7057-5_25.


Identification of protein targets in cerebral endothelial cells for brain arteriovenous malformation (AVMs) molecular therapies.

Simonian M, Loo RRO, Rannulu N, Loo JA, Molloy MP, Stoodley MA.

Clin Proteomics. 2017 May 16;14:17. doi: 10.1186/s12014-017-9151-3. eCollection 2017.


Expression of ALS/FTD-linked mutant CCNF in zebrafish leads to increased cell death in the spinal cord and an aberrant motor phenotype.

Hogan AL, Don EK, Rayner SL, Lee A, Laird AS, Watchon M, Winnick C, Tarr IS, Morsch M, Fifita JA, Gwee SSL, Formella I, Hortle E, Yuan KC, Molloy MP, Williams KL, Nicholson GA, Chung RS, Blair IP, Cole NJ.

Hum Mol Genet. 2017 Jul 15;26(14):2616-2626. doi: 10.1093/hmg/ddx136. Erratum in: Hum Mol Genet. 2019 Feb 15;28(4):698.


Ionizing radiation reduces ADAM10 expression in brain microvascular endothelial cells undergoing stress-induced senescence.

McRobb LS, McKay MJ, Gamble JR, Grace M, Moutrie V, Santos ED, Lee VS, Zhao Z, Molloy MP, Stoodley MA.

Aging (Albany NY). 2017 Apr;9(4):1248-1268. doi: 10.18632/aging.101225.


Quantitative Age-specific Variability of Plasma Proteins in Healthy Neonates, Children and Adults.

Bjelosevic S, Pascovici D, Ping H, Karlaftis V, Zaw T, Song X, Molloy MP, Monagle P, Ignjatovic V.

Mol Cell Proteomics. 2017 May;16(5):924-935. doi: 10.1074/mcp.M116.066720. Epub 2017 Mar 23.


Unravelling the role of protein kinase CK2 in metal toxicity using gene deletion mutants.

Johnson AJ, Zaman MS, Veljanoski F, Phrakaysone AA, Li S, O'Doherty PJ, Petersingham G, Perrone GG, Molloy MP, Wu MJ.

Metallomics. 2017 Mar 22;9(3):301-308. doi: 10.1039/c6mt00230g.


Radiosurgery Alters the Endothelial Surface Proteome: Externalized Intracellular Molecules as Potential Vascular Targets in Irradiated Brain Arteriovenous Malformations.

McRobb LS, Lee VS, Simonian M, Zhao Z, Thomas SG, Wiedmann M, Raj JV, Grace M, Moutrie V, McKay MJ, Molloy MP, Stoodley MA.

Radiat Res. 2017 Jan;187(1):66-78. doi: 10.1667/RR14518.1. Epub 2017 Jan 5.


TMT One-Stop Shop: From Reliable Sample Preparation to Computational Analysis Platform.

Mirzaei M, Pascovici D, Wu JX, Chick J, Wu Y, Cooke B, Haynes P, Molloy MP.

Methods Mol Biol. 2017;1549:45-66.


Characterisation of the immune compounds in koala milk using a combined transcriptomic and proteomic approach.

Morris KM, O'Meally D, Zaw T, Song X, Gillett A, Molloy MP, Polkinghorne A, Belov K.

Sci Rep. 2016 Oct 7;6:35011. doi: 10.1038/srep35011.


Exhaled breath condensate for lung cancer protein analysis: a review of methods and biomarkers.

Hayes SA, Haefliger S, Harris B, Pavlakis N, Clarke SJ, Molloy MP, Howell VM.

J Breath Res. 2016 Jul 5;10(3):034001. doi: 10.1088/1752-7155/10/3/034001. Review.


Pseudomonas aeruginosa Cell Membrane Protein Expression from Phenotypically Diverse Cystic Fibrosis Isolates Demonstrates Host-Specific Adaptations.

Kamath KS, Pascovici D, Penesyan A, Goel A, Venkatakrishnan V, Paulsen IT, Packer NH, Molloy MP.

J Proteome Res. 2016 Jul 1;15(7):2152-63. doi: 10.1021/acs.jproteome.6b00058. Epub 2016 Jun 9.


Analytical performance of nano-LC-SRM using nondepleted human plasma over an 18-month period.

Song X, Amirkhani A, Wu JX, Pascovici D, Zaw T, Xavier D, Clarke SJ, Molloy MP.

Proteomics. 2016 Aug;16(15-16):2118-27. doi: 10.1002/pmic.201500507. Epub 2016 Jul 25.


SWATH Mass Spectrometry Performance Using Extended Peptide MS/MS Assay Libraries.

Wu JX, Song X, Pascovici D, Zaw T, Care N, Krisp C, Molloy MP.

Mol Cell Proteomics. 2016 Jul;15(7):2501-14. doi: 10.1074/mcp.M115.055558. Epub 2016 May 9.


CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia.

Williams KL, Topp S, Yang S, Smith B, Fifita JA, Warraich ST, Zhang KY, Farrawell N, Vance C, Hu X, Chesi A, Leblond CS, Lee A, Rayner SL, Sundaramoorthy V, Dobson-Stone C, Molloy MP, van Blitterswijk M, Dickson DW, Petersen RC, Graff-Radford NR, Boeve BF, Murray ME, Pottier C, Don E, Winnick C, McCann EP, Hogan A, Daoud H, Levert A, Dion PA, Mitsui J, Ishiura H, Takahashi Y, Goto J, Kost J, Gellera C, Gkazi AS, Miller J, Stockton J, Brooks WS, Boundy K, Polak M, Muñoz-Blanco JL, Esteban-Pérez J, Rábano A, Hardiman O, Morrison KE, Ticozzi N, Silani V, de Belleroche J, Glass JD, Kwok JB, Guillemin GJ, Chung RS, Tsuji S, Brown RH Jr, García-Redondo A, Rademakers R, Landers JE, Gitler AD, Rouleau GA, Cole NJ, Yerbury JJ, Atkin JD, Shaw CE, Nicholson GA, Blair IP.

Nat Commun. 2016 Apr 15;7:11253. doi: 10.1038/ncomms11253.


Proteomics of thyroid tumours provides new insights into their molecular composition and changes associated with malignancy.

Martínez-Aguilar J, Clifton-Bligh R, Molloy MP.

Sci Rep. 2016 Mar 30;6:23660. doi: 10.1038/srep23660.


Priming Adipose-Derived Mesenchymal Stem Cells with Hyaluronan Alters Growth Kinetics and Increases Attachment to Articular Cartilage.

Succar P, Medynskyj M, Breen EJ, Batterham T, Molloy MP, Herbert BR.

Stem Cells Int. 2016;2016:9364213. doi: 10.1155/2016/9364213. Epub 2016 Feb 15.


A proteomics-based approach identifies secreted protein acidic and rich in cysteine as a prognostic biomarker in malignant pleural mesothelioma.

Kao SC, Kirschner MB, Cooper WA, Tran T, Burgers S, Wright C, Korse T, van den Broek D, Edelman J, Vallely M, McCaughan B, Pavlakis N, Clarke S, Molloy MP, van Zandwijk N, Reid G.

Br J Cancer. 2016 Mar 1;114(5):524-31. doi: 10.1038/bjc.2015.470. Epub 2016 Feb 18.


Characterization of a beta-catenin nuclear localization defect in MCF-7 breast cancer cells.

Jamieson C, Mills KM, Lui C, Semaan C, Molloy MP, Sharma M, Forwood JK, Henderson BR.

Exp Cell Res. 2016 Feb 15;341(2):196-206. doi: 10.1016/j.yexcr.2016.01.020. Epub 2016 Feb 1.


Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired Glucose Metabolism.

Meex RC, Hoy AJ, Morris A, Brown RD, Lo JC, Burke M, Goode RJ, Kingwell BA, Kraakman MJ, Febbraio MA, Greve JW, Rensen SS, Molloy MP, Lancaster GI, Bruce CR, Watt MJ.

Cell Metab. 2015 Dec 1;22(6):1078-89. doi: 10.1016/j.cmet.2015.09.023. Epub 2015 Oct 22.


Correction to "Combining Protein Ratio p-Values as a Pragmatic Approach to the Analysis of Multirun iTRAQ Experiments".

Pascovici D, Song X, Solomon PS, Winterberg B, Mirzaei M, Goodchild A, Stanley WC, Liu J, Molloy MP.

J Proteome Res. 2015 Nov 6;14(11):4944. doi: 10.1021/acs.jproteome.5b00897. Epub 2015 Oct 8. No abstract available.


Genetically and Phenotypically Distinct Pseudomonas aeruginosa Cystic Fibrosis Isolates Share a Core Proteomic Signature.

Penesyan A, Kumar SS, Kamath K, Shathili AM, Venkatakrishnan V, Krisp C, Packer NH, Molloy MP, Paulsen IT.

PLoS One. 2015 Oct 2;10(10):e0138527. doi: 10.1371/journal.pone.0138527. eCollection 2015.


Phosphoproteomic Analysis of Cell-Based Resistance to BRAF Inhibitor Therapy in Melanoma.

Parker R, Vella LJ, Xavier D, Amirkhani A, Parker J, Cebon J, Molloy MP.

Front Oncol. 2015 May 15;5:95. doi: 10.3389/fonc.2015.00095. eCollection 2015.


A multiplexed, targeted mass spectrometry assay of the S100 protein family uncovers the isoform-specific expression in thyroid tumours.

Martínez-Aguilar J, Clifton-Bligh R, Molloy MP.

BMC Cancer. 2015 Mar 29;15:199. doi: 10.1186/s12885-015-1217-x.

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