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Items: 20


Identification of RNase-sensitive LINE-1 Ribonucleoprotein Interactions by Differential Affinity Immobilization.

Jiang H, Taylor MS, Molloy KR, Altukhov I, LaCava J.

Bio Protoc. 2019 Apr 5;9(7). pii: e3200. doi: 10.21769/BioProtoc.3200.


Monitoring the stabilities of a mixture of peptides by mass-spectrometry-based techniques.

Fuller DR, Conant CR, El-Baba TJ, Zhang Z, Molloy KR, Zhang CS, Hales DA, Clemmer DE.

Eur J Mass Spectrom (Chichester). 2019 Feb;25(1):73-81. doi: 10.1177/1469066718798718.


Mcm10 has potent strand-annealing activity and limits translocase-mediated fork regression.

Mayle R, Langston L, Molloy KR, Zhang D, Chait BT, O'Donnell ME.

Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):798-803. doi: 10.1073/pnas.1819107116. Epub 2018 Dec 31.


Modular assembly of the nucleolar pre-60S ribosomal subunit.

Sanghai ZA, Miller L, Molloy KR, Barandun J, Hunziker M, Chaker-Margot M, Wang J, Chait BT, Klinge S.

Nature. 2018 Apr 5;556(7699):126-129. doi: 10.1038/nature26156. Epub 2018 Mar 5.


Dissection of affinity captured LINE-1 macromolecular complexes.

Taylor MS, Altukhov I, Molloy KR, Mita P, Jiang H, Adney EM, Wudzinska A, Badri S, Ischenko D, Eng G, Burns KH, Fenyö D, Chait BT, Alexeev D, Rout MP, Boeke JD, LaCava J.

Elife. 2018 Jan 8;7. pii: e30094. doi: 10.7554/eLife.30094.


Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.

Winczura K, Schmid M, Iasillo C, Molloy KR, Harder LM, Andersen JS, LaCava J, Jensen TH.

Cell Rep. 2018 Jan 2;22(1):44-58. doi: 10.1016/j.celrep.2017.12.037.


A Chemical Proteomics Approach to Reveal Direct Protein-Protein Interactions in Living Cells.

Kleiner RE, Hang LE, Molloy KR, Chait BT, Kapoor TM.

Cell Chem Biol. 2018 Jan 18;25(1):110-120.e3. doi: 10.1016/j.chembiol.2017.10.001. Epub 2017 Nov 5.


The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity.

Santanach A, Blanco E, Jiang H, Molloy KR, Sansó M, LaCava J, Morey L, Di Croce L.

Nat Commun. 2017 Nov 1;8(1):1235. doi: 10.1038/s41467-017-01464-w.


The complete structure of the small-subunit processome.

Barandun J, Chaker-Margot M, Hunziker M, Molloy KR, Chait BT, Klinge S.

Nat Struct Mol Biol. 2017 Nov;24(11):944-953. doi: 10.1038/nsmb.3472. Epub 2017 Sep 25.


Purification and analysis of endogenous human RNA exosome complexes.

Domanski M, Upla P, Rice WJ, Molloy KR, Ketaren NE, Stokes DL, Jensen TH, Rout MP, LaCava J.

RNA. 2016 Sep;22(9):1467-75. doi: 10.1261/rna.057760.116. Epub 2016 Jul 11.


UtpA and UtpB chaperone nascent pre-ribosomal RNA and U3 snoRNA to initiate eukaryotic ribosome assembly.

Hunziker M, Barandun J, Petfalski E, Tan D, Delan-Forino C, Molloy KR, Kim KH, Dunn-Davies H, Shi Y, Chaker-Margot M, Chait BT, Walz T, Tollervey D, Klinge S.

Nat Commun. 2016 Jun 29;7:12090. doi: 10.1038/ncomms12090.


Chemical proteomics reveals a γH2AX-53BP1 interaction in the DNA damage response.

Kleiner RE, Verma P, Molloy KR, Chait BT, Kapoor TM.

Nat Chem Biol. 2015 Oct;11(10):807-14. doi: 10.1038/nchembio.1908. Epub 2015 Sep 7.


Rapid, optimized interactomic screening.

Hakhverdyan Z, Domanski M, Hough LE, Oroskar AA, Oroskar AR, Keegan S, Dilworth DJ, Molloy KR, Sherman V, Aitchison JD, Fenyö D, Chait BT, Jensen TH, Rout MP, LaCava J.

Nat Methods. 2015 Jun;12(6):553-60. doi: 10.1038/nmeth.3395. Epub 2015 May 4.


Affinity proteomics to study endogenous protein complexes: pointers, pitfalls, preferences and perspectives.

LaCava J, Molloy KR, Taylor MS, Domanski M, Chait BT, Rout MP.

Biotechniques. 2015 Mar 1;58(3):103-19. doi: 10.2144/000114262. eCollection 2015 Mar.


Affinity proteomics reveals human host factors implicated in discrete stages of LINE-1 retrotransposition.

Taylor MS, LaCava J, Mita P, Molloy KR, Huang CR, Li D, Adney EM, Jiang H, Burns KH, Chait BT, Rout MP, Boeke JD, Dai L.

Cell. 2013 Nov 21;155(5):1034-48. doi: 10.1016/j.cell.2013.10.021.


The nuclear basket proteins Mlp1p and Mlp2p are part of a dynamic interactome including Esc1p and the proteasome.

Niepel M, Molloy KR, Williams R, Farr JC, Meinema AC, Vecchietti N, Cristea IM, Chait BT, Rout MP, Strambio-De-Castillia C.

Mol Biol Cell. 2013 Dec;24(24):3920-38. doi: 10.1091/mbc.E13-07-0412. Epub 2013 Oct 23.


Examining post-translational modification-mediated protein-protein interactions using a chemical proteomics approach.

Li X, Foley EA, Kawashima SA, Molloy KR, Li Y, Chait BT, Kapoor TM.

Protein Sci. 2013 Mar;22(3):287-95. doi: 10.1002/pro.2210. Epub 2013 Jan 27.


Quantitative chemical proteomics approach to identify post-translational modification-mediated protein-protein interactions.

Li X, Foley EA, Molloy KR, Li Y, Chait BT, Kapoor TM.

J Am Chem Soc. 2012 Feb 1;134(4):1982-5. doi: 10.1021/ja210528v. Epub 2012 Jan 24.


Host factors associated with the Sindbis virus RNA-dependent RNA polymerase: role for G3BP1 and G3BP2 in virus replication.

Cristea IM, Rozjabek H, Molloy KR, Karki S, White LL, Rice CM, Rout MP, Chait BT, MacDonald MR.

J Virol. 2010 Jul;84(13):6720-32. doi: 10.1128/JVI.01983-09. Epub 2010 Apr 14.


Folding and organization of a contiguous chromosome region according to the gene distribution pattern in primary genomic sequence.

Shopland LS, Lynch CR, Peterson KA, Thornton K, Kepper N, Hase Jv, Stein S, Vincent S, Molloy KR, Kreth G, Cremer C, Bult CJ, O'Brien TP.

J Cell Biol. 2006 Jul 3;174(1):27-38.

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