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Hyperglycemia and metformin use are associated with B-vitamin deficiency and cognitive dysfunction in older adults.

Porter KM, Ward M, Hughes CF, O'Kane M, Hoey L, McCann A, Molloy AM, Cunningham C, Casey M, Tracey F, Strain S, McCarroll K, Laird E, Gallagher AM, McNulty H.

J Clin Endocrinol Metab. 2019 Mar 28. pii: jc.2018-01791. doi: 10.1210/jc.2018-01791. [Epub ahead of print]


B-vitamins in Relation to Depression in Older Adults Over 60 Years of Age: The Trinity Ulster Department of Agriculture (TUDA) Cohort Study.

Moore K, Hughes CF, Hoey L, Ward M, Cunningham C, Molloy AM, Strain JJ, McCarroll K, Casey MC, Tracey F, Laird E, O'Kane M, McNulty H.

J Am Med Dir Assoc. 2019 May;20(5):551-557.e1. doi: 10.1016/j.jamda.2018.11.031. Epub 2019 Jan 25.


The relationship between maternal plasma homocysteine in early pregnancy and birth weight.

Cawley S, O'Malley EG, Kennedy RAK, Reynolds CME, Molloy AM, Turner MJ.

J Matern Fetal Neonatal Med. 2019 Jan 29:1-5. doi: 10.1080/14767058.2019.1567705. [Epub ahead of print]


The 677C→T variant of MTHFR is the major genetic modifier of biomarkers of folate status in a young, healthy Irish population.

Shane B, Pangilinan F, Mills JL, Fan R, Gong T, Cropp CD, Kim Y, Ueland PM, Bailey-Wilson JE, Wilson AF, Brody LC, Molloy AM.

Am J Clin Nutr. 2018 Dec 1;108(6):1334-1341. doi: 10.1093/ajcn/nqy209.


Folate and vitamin B12 levels in early pregnancy and maternal obesity.

O'Malley EG, Reynolds CME, Cawley S, Woodside JV, Molloy AM, Turner MJ.

Eur J Obstet Gynecol Reprod Biol. 2018 Dec;231:80-84. doi: 10.1016/j.ejogrb.2018.10.001. Epub 2018 Oct 4.


Mice lacking the transcobalamin-vitamin B12 receptor, CD320, suffer from anemia and reproductive deficits when fed vitamin B12-deficient diet.

Bernard DJ, Pangilinan FJ, Cheng J, Molloy AM, Brody LC.

Hum Mol Genet. 2018 Oct 15;27(20):3627-3640. doi: 10.1093/hmg/ddy267.


The relationship between adiposity and cognitive function in a large community-dwelling population: data from the Trinity Ulster Department of Agriculture (TUDA) ageing cohort study.

Ntlholang O, McCarroll K, Laird E, Molloy AM, Ward M, McNulty H, Hoey L, Hughes CF, Strain JJ, Casey M, Cunningham C.

Br J Nutr. 2018 Sep;120(5):517-527. doi: 10.1017/S0007114518001848. Epub 2018 Jul 30.


The impact of common genetic variants in the mitochondrial glycine cleavage system on relevant metabolites.

O'Reilly J, Pangilinan F, Hokamp K, Ueland PM, Brosnan JT, Brosnan ME, Brody LC, Molloy AM.

Mol Genet Metab Rep. 2018 Jun 11;16:20-22. doi: 10.1016/j.ymgmr.2018.05.006. eCollection 2018 Sep.


Voluntary fortification is ineffective to maintain the vitamin B12 and folate status of older Irish adults: evidence from the Irish Longitudinal Study on Ageing (TILDA).

Laird EJ, O'Halloran AM, Carey D, O'Connor D, Kenny RA, Molloy AM.

Br J Nutr. 2018 Jul;120(1):111-120. doi: 10.1017/S0007114518001356.


Fortifying food with folic acid to prevent neural tube defects: are we now where we ought to be?

Molloy AM, Mills JL.

Am J Clin Nutr. 2018 Jun 1;107(6):857-858. doi: 10.1093/ajcn/nqy110. No abstract available.


Author Correction: The Irish DNA Atlas: Revealing Fine-Scale Population Structure and History within Ireland.

Gilbert E, O'Reilly S, Merrigan M, McGettigan D, Molloy AM, Brody LC, Bodmer W, Hutnik K, Ennis S, Lawson DJ, Wilson JF, Cavalleri GL.

Sci Rep. 2018 May 3;8(1):7208. doi: 10.1038/s41598-018-24846-6.


Lifestyle, metabolite, and genetic determinants of formate concentrations in a cross-sectional study in young, healthy adults.

Brosnan JT, Mills JL, Ueland PM, Shane B, Fan R, Chiu CY, Pangilinan F, Brody LC, Brosnan ME, Pongnopparat T, Molloy AM.

Am J Clin Nutr. 2018 Mar 1;107(3):345-354. doi: 10.1093/ajcn/nqx065.


Do the benefits of folic acid fortification outweigh the risk of masking vitamin B12 deficiency?

Mills JL, Molloy AM, Reynolds EH.

BMJ. 2018 Mar 1;360:k724. doi: 10.1136/bmj.k724. No abstract available. Erratum in: BMJ. 2018 Mar 21;360:k1334.


Effect of Area-Level Socioeconomic Deprivation on Risk of Cognitive Dysfunction in Older Adults.

McCann A, McNulty H, Rigby J, Hughes CF, Hoey L, Molloy AM, Cunningham CJ, Casey MC, Tracey F, O'Kane MJ, McCarroll K, Ward M, Moore K, Strain JJ, Moore A.

J Am Geriatr Soc. 2018 Jul;66(7):1269-1275. doi: 10.1111/jgs.15258. Epub 2018 Feb 12.


Should vitamin B12 status be considered in assessing risk of neural tube defects?

Molloy AM.

Ann N Y Acad Sci. 2018 Feb;1414(1):109-125. doi: 10.1111/nyas.13574. Epub 2018 Jan 29.


The Irish DNA Atlas: Revealing Fine-Scale Population Structure and History within Ireland.

Gilbert E, O'Reilly S, Merrigan M, McGettigan D, Molloy AM, Brody LC, Bodmer W, Hutnik K, Ennis S, Lawson DJ, Wilson JF, Cavalleri GL.

Sci Rep. 2017 Dec 8;7(1):17199. doi: 10.1038/s41598-017-17124-4. Erratum in: Sci Rep. 2018 May 3;8(1):7208.


Dairy Intakes in Older Irish Adults and Effects on Vitamin Micronutrient Status: Data from the TUDA Study.

Laird E, Casey MC, Ward M, Hoey L, Hughes CF, McCarroll K, Cunningham C, Strain JJ, McNulty H, Molloy AM.

J Nutr Health Aging. 2017;21(9):954-961. doi: 10.1007/s12603-016-0845-4.


Optimization of folic acid supplementation in the prevention of neural tube defects.

Cawley S, McCartney D, Woodside JV, Sweeney MR, McDonnell R, Molloy AM, Turner MJ.

J Public Health (Oxf). 2018 Dec 1;40(4):827-834. doi: 10.1093/pubmed/fdx137.


The FUT2 secretor variant p.Trp154Ter influences serum vitamin B12 concentration via holo-haptocorrin, but not holo-transcobalamin, and is associated with haptocorrin glycosylation.

Velkova A, Diaz JEL, Pangilinan F, Molloy AM, Mills JL, Shane B, Sanchez E, Cunningham C, McNulty H, Cropp CD, Bailey-Wilson JE, Wilson AF, Brody LC.

Hum Mol Genet. 2017 Dec 15;26(24):4975-4988. doi: 10.1093/hmg/ddx369.


The Prevalence of Vitamin D Deficiency and the Determinants of 25(OH)D Concentration in Older Irish Adults: Data From The Irish Longitudinal Study on Ageing (TILDA).

Laird E, O'Halloran AM, Carey D, Healy M, O'Connor D, Moore P, Shannon T, Molloy AM, Kenny RA.

J Gerontol A Biol Sci Med Sci. 2018 Mar 14;73(4):519-525. doi: 10.1093/gerona/glx168.


Correction: Vitamin B12 deficiency.

Green R, Allen LH, Bjørke-Monsen AL, Brito A, Guéant JL, Miller JW, Molloy AM, Nexo E, Stabler S, Toh BH, Ueland PM, Yajnik C.

Nat Rev Dis Primers. 2017 Jul 20;3:17054. doi: 10.1038/nrdp.2017.54.


Vitamin B12 deficiency.

Green R, Allen LH, Bjørke-Monsen AL, Brito A, Guéant JL, Miller JW, Molloy AM, Nexo E, Stabler S, Toh BH, Ueland PM, Yajnik C.

Nat Rev Dis Primers. 2017 Jun 29;3:17040. doi: 10.1038/nrdp.2017.40. Review. Erratum in: Nat Rev Dis Primers. 2017 Jul 20;3:17054.


Genetic Risk Factors for Folate-Responsive Neural Tube Defects.

Molloy AM, Pangilinan F, Brody LC.

Annu Rev Nutr. 2017 Aug 21;37:269-291. doi: 10.1146/annurev-nutr-071714-034235. Epub 2017 Jun 19. Review.


Greater yogurt consumption is associated with increased bone mineral density and physical function in older adults.

Laird E, Molloy AM, McNulty H, Ward M, McCarroll K, Hoey L, Hughes CF, Cunningham C, Strain JJ, Casey MC.

Osteoporos Int. 2017 Aug;28(8):2409-2419. doi: 10.1007/s00198-017-4049-5. Epub 2017 May 1.


Ambient UVB Dose and Sun Enjoyment Are Important Predictors of Vitamin D Status in an Older Population.

O'Sullivan F, Laird E, Kelly D, van Geffen J, van Weele M, McNulty H, Hoey L, Healy M, McCarroll K, Cunningham C, Casey M, Ward M, Strain JJ, Molloy AM, Zgaga L.

J Nutr. 2017 May;147(5):858-868. doi: 10.3945/jn.116.244079. Epub 2017 Mar 22.


B-Vitamin Intake and Biomarker Status in Relation to Cognitive Decline in Healthy Older Adults in a 4-Year Follow-Up Study.

Hughes CF, Ward M, Tracey F, Hoey L, Molloy AM, Pentieva K, McNulty H.

Nutrients. 2017 Jan 10;9(1). pii: E53. doi: 10.3390/nu9010053.


The Frontal Assessment Battery: Normative Performance in a Large Sample of Older Community-Dwelling Hospital Outpatient or General Practitioner Attenders.

Coen RF, McCarroll K, Casey M, McNulty H, Laird E, Molloy AM, Ward M, Strain JJ, Hoey L, Hughes C, Cunningham CJ.

J Geriatr Psychiatry Neurol. 2016 Nov;29(6):338-343. doi: 10.1177/0891988716666381. Epub 2016 Sep 21.


Serum Immune System Biomarkers Neopterin and Interleukin-10 Are Strongly Related to Tryptophan Metabolism in Healthy Young Adults.

Deac OM, Mills JL, Gardiner CM, Shane B, Quinn L, Midttun Ø, McCann A, Meyer K, Ueland PM, Fan R, Lu Z, Brody LC, Molloy AM.

J Nutr. 2016 Sep;146(9):1801-6. doi: 10.3945/jn.116.230698. Epub 2016 Aug 3.


Genome-wide studies of von Willebrand factor propeptide identify loci contributing to variation in propeptide levels and von Willebrand factor clearance.

Ozel AB, McGee B, Siemieniak D, Jacobi PM, Haberichter SL, Brody LC, Mills JL, Molloy AM, Ginsburg D, Li JZ, Desch KC.

J Thromb Haemost. 2016 Sep;14(9):1888-98. doi: 10.1111/jth.13401. Epub 2016 Aug 19.


A Common Polymorphism in HIBCH Influences Methylmalonic Acid Concentrations in Blood Independently of Cobalamin.

Molloy AM, Pangilinan F, Mills JL, Shane B, O'Neill MB, McGaughey DM, Velkova A, Abaan HO, Ueland PM, McNulty H, Ward M, Strain JJ, Cunningham C, Casey M, Cropp CD, Kim Y, Bailey-Wilson JE, Wilson AF, Brody LC.

Am J Hum Genet. 2016 May 5;98(5):869-882. doi: 10.1016/j.ajhg.2016.03.005. Epub 2016 Apr 28.


Folic Acid Supplementation in Postpolypectomy Patients in a Randomized Controlled Trial Increases Tissue Folate Concentrations and Reduces Aberrant DNA Biomarkers in Colonic Tissues Adjacent to the Former Polyp Site.

O'Reilly SL, McGlynn AP, McNulty H, Reynolds J, Wasson GR, Molloy AM, Strain JJ, Weir DG, Ward M, McKerr G, Scott JM, Downes CS.

J Nutr. 2016 May;146(5):933-9. doi: 10.3945/jn.115.222547. Epub 2016 Apr 13.


Association of a transcobalamin II genetic variant with falsely low results for the holotranscobalamin immunoassay.

Sobczyńska-Malefora A, Pangilinan F, Plant GT, Velkova A, Harrington DJ, Molloy AM, Brody LC.

Eur J Clin Invest. 2016 May;46(5):434-9. doi: 10.1111/eci.12617. Epub 2016 Apr 15.


r2VIM: A new variable selection method for random forests in genome-wide association studies.

Szymczak S, Holzinger E, Dasgupta A, Malley JD, Molloy AM, Mills JL, Brody LC, Stambolian D, Bailey-Wilson JE.

BioData Min. 2016 Feb 1;9:7. doi: 10.1186/s13040-016-0087-3. eCollection 2016.


Evidence from a Randomized Trial That Exposure to Supplemental Folic Acid at Recommended Levels during Pregnancy Does Not Lead to Increased Unmetabolized Folic Acid Concentrations in Maternal or Cord Blood.

Pentieva K, Selhub J, Paul L, Molloy AM, McNulty B, Ward M, Marshall B, Dornan J, Reilly R, Parle-McDermott A, Bradbury I, Ozaki M, Scott JM, McNulty H.

J Nutr. 2016 Mar;146(3):494-500. doi: 10.3945/jn.115.223644. Epub 2016 Jan 27.


Moderately elevated maternal homocysteine at preconception is inversely associated with cognitive performance in children 4  months and 6  years after birth.

Murphy MM, Fernandez-Ballart JD, Molloy AM, Canals J.

Matern Child Nutr. 2017 Apr;13(2). doi: 10.1111/mcn.12289. Epub 2016 Jan 27.


Evaluation of proton-coupled folate transporter (SLC46A1) polymorphisms as risk factors for neural tube defects and oral clefts.

VanderMeer JE, Carter TC, Pangilinan F, Mitchell A, Kurnat-Thoma E, Kirke PN, Troendle JF, Molloy AM, Munger RG, Feldkamp ML, Mansilla MA, Mills JL, Murray JC, Brody LC.

Am J Med Genet A. 2016 Apr;170A(4):1007-16. doi: 10.1002/ajmg.a.37539. Epub 2016 Jan 20.


Synthetic folic acid intakes and status in children living in Ireland exposed to voluntary fortification.

Vaish S, White M, Daly L, Molloy AM, Staines A, Sweeney MR.

Am J Clin Nutr. 2016 Feb;103(2):512-8. doi: 10.3945/ajcn.115.107615. Epub 2016 Jan 13.


Folate and long-chain polyunsaturated fatty acid supplementation during pregnancy has long-term effects on the attention system of 8.5-y-old offspring: a randomized controlled trial.

Catena A, Muñoz-Machicao JA, Torres-Espínola FJ, Martínez-Zaldívar C, Diaz-Piedra C, Gil A, Haile G, Györei E, Molloy AM, Decsi T, Koletzko B, Campoy C.

Am J Clin Nutr. 2016 Jan;103(1):115-27. doi: 10.3945/ajcn.115.109108. Epub 2015 Nov 11.


Common Polymorphisms That Affect Folate Transport or Metabolism Modify the Effect of the MTHFR 677C > T Polymorphism on Folate Status.

Bueno O, Molloy AM, Fernandez-Ballart JD, García-Minguillán CJ, Ceruelo S, Ríos L, Ueland PM, Meyer K, Murphy MM.

J Nutr. 2016 Jan;146(1):1-8. doi: 10.3945/jn.115.223685. Epub 2015 Nov 11.


Biomarkers of Nutrition for Development-Folate Review.

Bailey LB, Stover PJ, McNulty H, Fenech MF, Gregory JF 3rd, Mills JL, Pfeiffer CM, Fazili Z, Zhang M, Ueland PM, Molloy AM, Caudill MA, Shane B, Berry RJ, Bailey RL, Hausman DB, Raghavan R, Raiten DJ.

J Nutr. 2015 Jul;145(7):1636S-1680S. doi: 10.3945/jn.114.206599. Epub 2015 Jun 3. Review.


The Dihydrofolate Reductase 19 bp Polymorphism Is Not Associated with Biomarkers of Folate Status in Healthy Young Adults, Irrespective of Folic Acid Intake.

Ozaki M, Molloy AM, Mills JL, Fan R, Wang Y, Gibney ER, Shane B, Brody LC, Parle-McDermott A.

J Nutr. 2015 Oct;145(10):2207-11. doi: 10.3945/jn.115.216101. Epub 2015 Aug 12.


Common Variants at Putative Regulatory Sites of the Tissue Nonspecific Alkaline Phosphatase Gene Influence Circulating Pyridoxal 5'-Phosphate Concentration in Healthy Adults.

Carter TC, Pangilinan F, Molloy AM, Fan R, Wang Y, Shane B, Gibney ER, Midttun Ø, Ueland PM, Cropp CD, Kim Y, Wilson AF, Bailey-Wilson JE, Brody LC, Mills JL.

J Nutr. 2015 Jul;145(7):1386-93. doi: 10.3945/jn.114.208769. Epub 2015 May 13.


Impact of voluntary fortification and supplement use on dietary intakes and biomarker status of folate and vitamin B-12 in Irish adults.

Hopkins SM, Gibney MJ, Nugent AP, McNulty H, Molloy AM, Scott JM, Flynn A, Strain JJ, Ward M, Walton J, McNulty BA.

Am J Clin Nutr. 2015 Jun;101(6):1163-72. doi: 10.3945/ajcn.115.107151. Epub 2015 Apr 15.


B-vitamin status in relation to bone mineral density in treated celiac disease patients.

Clarke M, Ward M, Dickey W, Hoey L, Molloy AM, Waldron L, Varghese A, McCann A, Blayney JK, McNulty H.

Scand J Gastroenterol. 2015 Aug;50(8):975-84. doi: 10.3109/00365521.2015.1015603. Epub 2015 Apr 10.


Tryptophan catabolism and vitamin B-6 status are affected by gender and lifestyle factors in healthy young adults.

Deac OM, Mills JL, Shane B, Midttun Ø, Ueland PM, Brosnan JT, Brosnan ME, Laird E, Gibney ER, Fan R, Wang Y, Brody LC, Molloy AM.

J Nutr. 2015 Apr;145(4):701-7. doi: 10.3945/jn.114.203091. Epub 2015 Feb 18.


Postprandial plasma betaine and other methyl donor-related responses after consumption of minimally processed wheat bran or wheat aleurone, or wheat aleurone incorporated into bread.

Keaveney EM, Price RK, Hamill LL, Wallace JM, McNulty H, Ward M, Strain JJ, Ueland PM, Molloy AM, Piironen V, von Reding W, Shewry PR, Ward JL, Welch RW.

Br J Nutr. 2015 Feb 14;113(3):445-53. doi: 10.1017/S0007114514003778. Epub 2015 Jan 13.


Riboflavin status modifies the effects of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) polymorphisms on homocysteine.

García-Minguillán CJ, Fernandez-Ballart JD, Ceruelo S, Ríos L, Bueno O, Berrocal-Zaragoza MI, Molloy AM, Ueland PM, Meyer K, Murphy MM.

Genes Nutr. 2014 Nov;9(6):435. doi: 10.1007/s12263-014-0435-1. Epub 2014 Oct 17.


Replication and exploratory analysis of 24 candidate risk polymorphisms for neural tube defects.

Pangilinan F, Molloy AM, Mills JL, Troendle JF, Parle-McDermott A, Kay DM, Browne ML, McGrath EC, Abaan HO, Sutton M, Kirke PN, Caggana M, Shane B, Scott JM, Brody LC.

BMC Med Genet. 2014 Oct 8;15:102. doi: 10.1186/s12881-014-0102-9.


Maternal choline concentrations during pregnancy and choline-related genetic variants as risk factors for neural tube defects.

Mills JL, Fan R, Brody LC, Liu A, Ueland PM, Wang Y, Kirke PN, Shane B, Molloy AM.

Am J Clin Nutr. 2014 Oct;100(4):1069-74. doi: 10.3945/ajcn.113.079319. Epub 2014 Aug 13.


Genetic variants in PLG, LPA, and SIGLEC 14 as well as smoking contribute to plasma plasminogen levels.

Ma Q, Ozel AB, Ramdas S, McGee B, Khoriaty R, Siemieniak D, Li HD, Guan Y, Brody LC, Mills JL, Molloy AM, Ginsburg D, Li JZ, Desch KC.

Blood. 2014 Nov 13;124(20):3155-64. doi: 10.1182/blood-2014-03-560086. Epub 2014 Sep 10.

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