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Author Correction: 'Stealth' corporate innovation: an emerging threat for therapeutic drug development.

Mastellos DC, Blom AM, Connolly ES, Daha MR, Geisbrecht BV, Ghebrehiwet B, Gros P, Hajishengallis G, Holers VM, Huber-Lang M, Kinoshita T, Mollnes TE, Montgomery RA, Morgan BP, Nilsson B, Pio R, Ricklin D, Risitano AM, Taylor RP, Mantovani A, Ioannidis JPA, Lambris JD.

Nat Immunol. 2019 Oct 11. doi: 10.1038/s41590-019-0531-x. [Epub ahead of print]


Perioperative infusion of glucagon like peptide-1 prevents insulin resistance after surgical trauma in female pigs.

Hagve M, Gjessing PF, Hole MJ, Jansen KM, Fuskevåg OM, Mollnes TE, Larsen TS, Irtun Ø.

Endocrinology. 2019 Oct 7. pii: en.2019-00374. doi: 10.1210/en.2019-00374. [Epub ahead of print]


'Stealth' corporate innovation: an emerging threat for therapeutic drug development.

Mastellos DC, Blom AM, Connolly ES, Daha MR, Geisbrecht BV, Ghebrehiwet B, Gros P, Hajishengallis G, Holers VM, Huber-Lang M, Kinoshita T, Mollnes TE, Montgomery RA, Morgan BP, Nilsson B, Pio R, Ricklin D, Risitano AM, Taylor RP, Mantovani A, Ioannidis JPA, Lambris JD.

Nat Immunol. 2019 Sep 27. doi: 10.1038/s41590-019-0503-1. [Epub ahead of print] No abstract available. Erratum in: Nat Immunol. 2019 Oct 11;:.


Corrigendum to "Changes in cytokines during treatment of elderly, hospitalized psychiatric patients-A naturalistic study" [Psychoneuroendocrinology, 108C (2019), 135-139].

Bugge E, Wynn R, Mollnes TE, Reitan SK, Lapid MI, Gronli OK.

Psychoneuroendocrinology. 2019 Sep 17:104427. doi: 10.1016/j.psyneuen.2019.104427. [Epub ahead of print] No abstract available.


Increased Complement Factor B and Bb Levels Are Associated with Mortality in Patients with Severe Aortic Stenosis.

Shahini N, Ueland T, Auensen A, Michelsen AE, Ludviksen JK, Hussain AI, Pettersen KI, Aakhus S, Espeland T, Lunde IG, Kirschfink M, Nilsson PH, Mollnes TE, Gullestad L, Aukrust P, Yndestad A, Louwe MC.

J Immunol. 2019 Oct 1;203(7):1973-1980. doi: 10.4049/jimmunol.1801244. Epub 2019 Sep 6.


Editorial: The Role of Complement in Health and Disease.

Cedzyński M, Thielens NM, Mollnes TE, Vorup-Jensen T.

Front Immunol. 2019 Aug 7;10:1869. doi: 10.3389/fimmu.2019.01869. eCollection 2019. No abstract available.


Complement Component C5 and TLR Molecule CD14 Mediate Heme-Induced Thromboinflammation in Human Blood.

Thomas AM, Gerogianni A, McAdam MB, Fløisand Y, Lau C, Espevik T, Nilsson PH, Mollnes TE, Barratt-Due A.

J Immunol. 2019 Sep 15;203(6):1571-1578. doi: 10.4049/jimmunol.1900047. Epub 2019 Aug 14.


Key role of the number of complement receptor 1 on erythrocytes for binding of Escherichia coli to erythrocytes and for leukocyte phagocytosis and oxidative burst in human whole blood.

Brekke OL, Christiansen D, Kisserli A, Fure H, Dahl JA, Donvito B, Reveil B, Ludviksen JK, Tabary T, Mollnes TE, Cohen JHM.

Mol Immunol. 2019 Oct;114:139-148. doi: 10.1016/j.molimm.2019.07.014. Epub 2019 Jul 25.


Pseudo-anaphylaxis to Polyethylene Glycol (PEG)-Coated Liposomes: Roles of Anti-PEG IgM and Complement Activation in a Porcine Model of Human Infusion Reactions.

Kozma GT, Mészáros T, Vashegyi I, Fülöp T, Örfi E, Dézsi L, Rosivall L, Bavli Y, Urbanics R, Mollnes TE, Barenholz Y, Szebeni J.

ACS Nano. 2019 Aug 27;13(8):9315-9324. doi: 10.1021/acsnano.9b03942. Epub 2019 Aug 6.


Tumor necrosis factor inhibitors are associated with reduced complement activation in spondylarthropathies: An observational study.

Hokstad I, Deyab G, Wang Fagerland M, Lyberg T, Hjeltnes G, Førre Ø, Agewall S, Mollnes TE, Hollan I.

PLoS One. 2019 Jul 23;14(7):e0220079. doi: 10.1371/journal.pone.0220079. eCollection 2019.


Effects of gamma radiation sterilization on the structural and biological properties of decellularized corneal xenografts.

Islam MM, Sharifi R, Mamodaly S, Islam R, Nahra D, Abusamra DB, Hui PC, Adibnia Y, Goulamaly M, Paschalis EI, Cruzat A, Kong J, Nilsson PH, Argüeso P, Mollnes TE, Chodosh J, Dohlman CH, Gonzalez-Andrades M.

Acta Biomater. 2019 Sep 15;96:330-344. doi: 10.1016/j.actbio.2019.07.002. Epub 2019 Jul 5.


Changes in cytokines during treatment of elderly, hospitalized psychiatric patients - a naturalistic study.

Bugge E, Wynn R, Mollnes TE, Reitan SK, Lapid MI, Grønli OK.

Psychoneuroendocrinology. 2019 Oct;108:135-139. doi: 10.1016/j.psyneuen.2019.06.014. Epub 2019 Jun 26. Erratum in: Psychoneuroendocrinology. 2019 Sep 17;:104427.


Cholesterol Crystals Induce Coagulation Activation through Complement-Dependent Expression of Monocytic Tissue Factor.

Gravastrand CS, Steinkjer B, Halvorsen B, Landsem A, Skjelland M, Jacobsen EA, Woodruff TM, Lambris JD, Mollnes TE, Brekke OL, Espevik T, Rokstad AMA.

J Immunol. 2019 Aug 15;203(4):853-863. doi: 10.4049/jimmunol.1900503. Epub 2019 Jul 3.


Impaired HDL Function Amplifies Systemic Inflammation in Common Variable Immunodeficiency.

Macpherson ME, Halvorsen B, Yndestad A, Ueland T, Mollnes TE, Berge RK, Rashidi A, Otterdal K, Gregersen I, Kong XY, Holven KB, Aukrust P, Fevang B, Jørgensen SF.

Sci Rep. 2019 Jul 1;9(1):9427. doi: 10.1038/s41598-019-45861-1.


Elevated Complement C3 and C4 Levels are Associated with Postnatal Pregnancy-Related Venous Thrombosis.

Dahm AEA, Jacobsen EM, Wik HS, Jacobsen AF, Mollnes TE, Kanse SM, Sandset PM.

Thromb Haemost. 2019 Sep;119(9):1481-1488. doi: 10.1055/s-0039-1692426. Epub 2019 Jun 29.


Sepsis causes right ventricular myocardial inflammation independent of pulmonary hypertension in a porcine sepsis model.

Pischke SE, Hestenes S, Johansen HT, Fure H, Bugge JF, Espinoza A, Skulstad H, Edvardsen T, Fosse E, Mollnes TE, Halvorsen PS, Nielsen EW.

PLoS One. 2019 Jun 27;14(6):e0218624. doi: 10.1371/journal.pone.0218624. eCollection 2019.


Plasma levels of mannose-binding lectin and future risk of venous thromboembolism.

Liang RA, Høiland II, Ueland T, Aukrust P, Snir O, Hindberg K, Braekkan SK, Garred P, Mollnes TE, Hansen JB.

J Thromb Haemost. 2019 Oct;17(10):1661-1669. doi: 10.1111/jth.14539. Epub 2019 Jul 1.


Biphasic Release of the Alarmin High Mobility Group Box 1 Protein Early After Trauma Predicts Poor Clinical Outcome.

Ottestad W, Rognes IN, Pischke SE, Mollnes TE, Andersson U, Eken T.

Crit Care Med. 2019 Aug;47(8):e614-e622. doi: 10.1097/CCM.0000000000003800.


Phagocytosis of live and dead Escherichia coli and Staphylococcus aureus in human whole blood is markedly reduced by combined inhibition of C5aR1 and CD14.

Skjeflo EW, Christiansen D, Landsem A, Stenvik J, Woodruff TM, Espevik T, Nielsen EW, Mollnes TE.

Mol Immunol. 2019 Aug;112:131-139. doi: 10.1016/j.molimm.2019.03.014. Epub 2019 May 15.


Complement activation assessed by the plasma terminal complement complex and future risk of venous thromboembolism.

Høiland II, Liang RA, Braekkan SK, Pettersen K, Ludviksen JK, Latysheva N, Snir O, Ueland T, Hindberg K, Mollnes TE, Hansen JB.

J Thromb Haemost. 2019 Jun;17(6):934-943. doi: 10.1111/jth.14438. Epub 2019 May 13.


The synthetic antimicrobial peptide LTX21 induces inflammatory responses in a human whole blood model and a murine peritoneum model.

Granslo HN, Aarag Fredheim EG, Esaiassen E, Christophersen L, Jensen PØ, Mollnes TE, Moser C, Flaegstad T, Klingenberg C, Cavanagh JP.

APMIS. 2019 Jun;127(6):475-483. doi: 10.1111/apm.12946. Epub 2019 Apr 26.


Inflammatory biomarkers are associated with aetiology and predict outcomes in community-acquired pneumonia: results of a 5-year follow-up cohort study.

Siljan WW, Holter JC, Michelsen AE, Nymo SH, Lauritzen T, Oppen K, Husebye E, Ueland T, Mollnes TE, Aukrust P, Heggelund L.

ERJ Open Res. 2019 Mar 11;5(1). pii: 00014-2019. doi: 10.1183/23120541.00014-2019. eCollection 2019 Feb.


Clinical and Complement Long-Term Follow-Up of a Pediatric Patient with C3 Mutation-Related Atypical Hemolytic Uremic Syndrome.

Bjerre A, Bergseth G, Ludviksen JK, Stokke A, Bosnes V, Karpman D, Mollnes TE.

Case Rep Nephrol. 2018 Dec 18;2018:3810249. doi: 10.1155/2018/3810249. eCollection 2018.


Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency.

Jørgensen SF, Macpherson ME, Bjørnetrø T, Holm K, Kummen M, Rashidi A, Michelsen AE, Lekva T, Halvorsen B, Trøseid M, Mollnes TE, Berge RK, Yndestad A, Ueland T, Karlsen TH, Aukrust P, Hov JR, Fevang B.

Sci Rep. 2019 Jan 17;9(1):167. doi: 10.1038/s41598-018-35367-7.


The Role of Complement in Liver Injury, Regeneration, and Transplantation.

Thorgersen EB, Barratt-Due A, Haugaa H, Harboe M, Pischke SE, Nilsson PH, Mollnes TE.

Hepatology. 2019 Aug;70(2):725-736. doi: 10.1002/hep.30508. Epub 2019 Jul 15. Review.


Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population.

Gaya da Costa M, Poppelaars F, van Kooten C, Mollnes TE, Tedesco F, Würzner R, Trouw LA, Truedsson L, Daha MR, Roos A, Seelen MA.

Front Immunol. 2018 Nov 20;9:2664. doi: 10.3389/fimmu.2018.02664. eCollection 2018.


High neopterin and IP-10 levels in cerebrospinal fluid are associated with neurotoxic tryptophan metabolites in acute central nervous system infections.

Quist-Paulsen E, Aukrust P, Kran AB, Dunlop O, Ormaasen V, Stiksrud B, Midttun Ø, Ueland T, Ueland PM, Mollnes TE, Dyrhol-Riise AM.

J Neuroinflammation. 2018 Nov 23;15(1):327. doi: 10.1186/s12974-018-1366-3.


Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli-induced coagulation accompanied by Toll-like receptor 4.

Landsem A, Fure H, Krey Ludviksen J, Christiansen D, Lau C, Mathisen M, Bergseth G, Nymo S, Lappegård KT, Woodruff TM, Espevik T, Mollnes TE, Brekke OL.

Clin Exp Immunol. 2019 Apr;196(1):97-110. doi: 10.1111/cei.13240. Epub 2018 Dec 19.


C-C Motif Ligand 20 (CCL20) and C-C Motif Chemokine Receptor 6 (CCR6) in Human Peripheral Blood Mononuclear Cells: Dysregulated in Ulcerative Colitis and a Potential Role for CCL20 in IL-1β Release.

Skovdahl HK, Damås JK, Granlund AVB, Østvik AE, Doseth B, Bruland T, Mollnes TE, Sandvik AK.

Int J Mol Sci. 2018 Oct 20;19(10). pii: E3257. doi: 10.3390/ijms19103257.


The Palliative Radiotherapy and Inflammation Study (PRAIS) - protocol for a longitudinal observational multicenter study on patients with cancer induced bone pain.

Habberstad R, Frøseth TCS, Aass N, Abramova T, Baas T, Mørkeset ST, Caraceni A, Laird B, Boland JW, Rossi R, Garcia-Alonso E, Stensheim H, Loge JH, Hjermstad MJ, Bjerkeset E, Bye A, Lund JÅ, Solheim TS, Vagnildhaug OM, Brunelli C, Damås JK, Mollnes TE, Kaasa S, Klepstad P.

BMC Palliat Care. 2018 Sep 28;17(1):110. doi: 10.1186/s12904-018-0362-9.


Cytokine profiles and diagnoses in elderly, hospitalized psychiatric patients.

Bugge E, Wynn R, Mollnes TE, Reitan SK, Grønli OK.

BMC Psychiatry. 2018 Sep 27;18(1):315. doi: 10.1186/s12888-018-1900-y.


IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction.

Orrem HL, Nilsson PH, Pischke SE, Kleveland O, Yndestad A, Ekholt K, Damås JK, Espevik T, Bendz B, Halvorsen B, Gregersen I, Wiseth R, Andersen GØ, Ueland T, Gullestad L, Aukrust P, Barratt-Due A, Mollnes TE.

Front Immunol. 2018 Sep 12;9:2035. doi: 10.3389/fimmu.2018.02035. eCollection 2018.


Cytokine profiling and post-transfusion haemoglobin increment in patients with haematological diseases.

Wendelbo Ø, Opheim EN, Hervig T, Felli Lunde TH, Bruserud Ø, Mollnes TE, Reikvam H.

Vox Sang. 2018 Oct;113(7):657-668. doi: 10.1111/vox.12703. Epub 2018 Aug 29.


Iron oxide nanoparticles enhance Toll-like receptor-induced cytokines in a particle size- and actin-dependent manner in human blood.

Wolf-Grosse S, Mollnes TE, Ali S, Stenvik J, Nilsen AM.

Nanomedicine (Lond). 2018 Aug 7. doi: 10.2217/nnm-2017-0362. [Epub ahead of print]


Associations between complement pathways activity, mannose-binding lectin, and odds of unprovoked venous thromboembolism.

Høiland II, Liang RA, Hindberg K, Latysheva N, Brekke OL, Mollnes TE, Hansen JB.

Thromb Res. 2018 Sep;169:50-56. doi: 10.1016/j.thromres.2018.06.019. Epub 2018 Jun 30.


Interleukin-6 receptor inhibition with tocilizumab induces a selective and substantial increase in plasma IP-10 and MIP-1β in non-ST-elevation myocardial infarction.

Kleveland O, Ueland T, Kunszt G, Bratlie M, Yndestad A, Broch K, Holte E, Ryan L, Amundsen BH, Bendz B, Aakhus S, Espevik T, Halvorsen B, Mollnes TE, Wiseth R, Gullestad L, Aukrust P, Damås JK.

Int J Cardiol. 2018 Nov 15;271:1-7. doi: 10.1016/j.ijcard.2018.04.136. Epub 2018 Jun 29.


Exploration of 27 plasma immune markers: a cross-sectional comparison of 64 old psychiatric inpatients having unipolar major depression and 18 non-depressed old persons.

Gaarden TL, Engedal K, Benth JŠ, Larsen M, Lorentzen B, Mollnes TE, Bjølseth TM, Castellheim A.

BMC Geriatr. 2018 Jun 25;18(1):149. doi: 10.1186/s12877-018-0836-x.


Soluble IL-1 receptor 2 is associated with left ventricular remodelling in patients with ST-elevation myocardial infarction.

Orrem HL, Shetelig C, Ueland T, Limalanathan S, Nilsson PH, Husebye T, Aukrust P, Seljeflot I, Hoffmann P, Eritsland J, Mollnes TE, Andersen GØ, Yndestad A.

Int J Cardiol. 2018 Oct 1;268:187-192. doi: 10.1016/j.ijcard.2018.05.032. Epub 2018 May 28.


Plasma n-6 Polyunsaturated Fatty Acid Levels and Survival in Renal Transplantation.

Skaare H, Svensson M, Jenssen T, Åsberg A, Schmidt EB, Chandra A, Ueland T, Mollnes TE, Hartmann A, Eide IA.

J Ren Nutr. 2018 Sep;28(5):333-339. doi: 10.1053/j.jrn.2018.02.008. Epub 2018 Apr 24.


Granulocyte and monocyte CD11b expression during plasma separation is dependent on complement factor 5 (C5) - an ex vivo study with blood from a C5-deficient individual.

Hardersen R, Enebakk T, Christiansen D, Bergseth G, Brekke OL, Mollnes TE, Lappegård KT, Hovland A.

APMIS. 2018 Apr;126(4):342-352. doi: 10.1111/apm.12821.


Staphylococcus aureus Membrane-Derived Vesicles Promote Bacterial Virulence and Confer Protective Immunity in Murine Infection Models.

Askarian F, Lapek JD Jr, Dongre M, Tsai CM, Kumaraswamy M, Kousha A, Valderrama JA, Ludviksen JA, Cavanagh JP, Uchiyama S, Mollnes TE, Gonzalez DJ, Wai SN, Nizet V, Johannessen M.

Front Microbiol. 2018 Feb 20;9:262. doi: 10.3389/fmicb.2018.00262. eCollection 2018.


Combined Inhibition of C5 and CD14 Attenuates Systemic Inflammation in a Piglet Model of Meconium Aspiration Syndrome.

Thomas AM, Schjalm C, Nilsson PH, Lindenskov PHH, Rørtveit R, Solberg R, Saugstad OD, Berglund MM, Strömberg P, Lau C, Espevik T, Jansen JH, Castellheim A, Mollnes TE, Barratt-Due A.

Neonatology. 2018;113(4):322-330. doi: 10.1159/000486542. Epub 2018 Feb 27.


Staphylococcus aureus-induced complement activation promotes tissue factor-mediated coagulation.

Skjeflo EW, Christiansen D, Fure H, Ludviksen JK, Woodruff TM, Espevik T, Nielsen EW, Brekke OL, Mollnes TE.

J Thromb Haemost. 2018 May;16(5):905-918. doi: 10.1111/jth.13979. Epub 2018 Mar 23.


Acute heart failure following myocardial infarction: complement activation correlates with the severity of heart failure in patients developing cardiogenic shock.

Orrem HL, Nilsson PH, Pischke SE, Grindheim G, Garred P, Seljeflot I, Husebye T, Aukrust P, Yndestad A, Andersen GØ, Barratt-Due A, Mollnes TE.

ESC Heart Fail. 2018 Jun;5(3):292-301. doi: 10.1002/ehf2.12266. Epub 2018 Feb 9.


Low Levels of Immunoglobulins and Mannose-Binding Lectin Are Not Associated With Etiology, Severity, or Outcome in Community-Acquired Pneumonia.

Siljan WW, Holter JC, Nymo SH, Husebye E, Ueland T, Skattum L, Bosnes V, Garred P, Frøland SS, Mollnes TE, Aukrust P, Heggelund L.

Open Forum Infect Dis. 2018 Jan 5;5(2):ofy002. doi: 10.1093/ofid/ofy002. eCollection 2018 Feb.


Transitions Between Circulatory States After Out-of-Hospital Cardiac Arrest: Protocol for an Observational, Prospective Cohort Study.

Langeland H, Bergum D, Løberg M, Bjørnstad K, Damås JK, Mollnes TE, Skjærvold NK, Klepstad P.

JMIR Res Protoc. 2018 Jan 19;7(1):e17. doi: 10.2196/resprot.8558.


Reduced inflammatory response by transcatheter, as compared to surgical aortic valve replacement.

Fiane KKH, Dahle G, Bendz B, Halvorsen PS, Abdelnoor M, Mollnes TE, Fosse E.

Scand Cardiovasc J. 2018 Feb;52(1):43-50. doi: 10.1080/14017431.2017.1416157. Epub 2017 Dec 12.


Transforming growth factor beta (TGF-β) in adolescent chronic fatigue syndrome.

Wyller VB, Nguyen CB, Ludviksen JA, Mollnes TE.

J Transl Med. 2017 Dec 4;15(1):245. doi: 10.1186/s12967-017-1350-1.


Cytokine responses, microbial aetiology and short-term outcome in community-acquired pneumonia.

Siljan WW, Holter JC, Nymo SH, Husebye E, Ueland T, Aukrust P, Mollnes TE, Heggelund L.

Eur J Clin Invest. 2018 Jan;48(1). doi: 10.1111/eci.12865. Epub 2017 Dec 7.


Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation.

Bakke SS, Aune MH, Niyonzima N, Pilely K, Ryan L, Skjelland M, Garred P, Aukrust P, Halvorsen B, Latz E, Damås JK, Mollnes TE, Espevik T.

J Immunol. 2017 Oct 15;199(8):2910-2920. doi: 10.4049/jimmunol.1700302. Epub 2017 Aug 30.

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