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Items: 1 to 50 of 96

1.

The Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis.

Lozza L, Moura-Alves P, Domaszewska T, Lage Crespo C, Streata I, Kreuchwig A, Puyskens A, Bechtle M, Klemm M, Zedler U, Silviu Ungureanu B, Guhlich-Bornhof U, Koehler AB, Stäber M, Mollenkopf HJ, Hurwitz R, Furkert J, Krause G, Weiner J 3rd, Jacinto A, Mihai I, Leite-de-Moraes M, Siebenhaar F, Maurer M, Kaufmann SHE.

Sci Rep. 2019 Jul 26;9(1):10878. doi: 10.1038/s41598-019-47350-x.

2.

R-spondin-3 induces secretory, antimicrobial Lgr5+ cells in the stomach.

Sigal M, Reinés MDM, Müllerke S, Fischer C, Kapalczynska M, Berger H, Bakker ERM, Mollenkopf HJ, Rothenberg ME, Wiedenmann B, Sauer S, Meyer TF.

Nat Cell Biol. 2019 Jul;21(7):812-823. doi: 10.1038/s41556-019-0339-9. Epub 2019 Jun 24.

PMID:
31235935
3.

Mycofactocin Is Associated with Ethanol Metabolism in Mycobacteria.

Krishnamoorthy G, Kaiser P, Lozza L, Hahnke K, Mollenkopf HJ, Kaufmann SHE.

MBio. 2019 May 21;10(3). pii: e00190-19. doi: 10.1128/mBio.00190-19.

4.

Chronic Chlamydia infection in human organoids increases stemness and promotes age-dependent CpG methylation.

Kessler M, Hoffmann K, Fritsche K, Brinkmann V, Mollenkopf HJ, Thieck O, Teixeira da Costa AR, Braicu EI, Sehouli J, Mangler M, Berger H, Meyer TF.

Nat Commun. 2019 Mar 18;10(1):1194. doi: 10.1038/s41467-019-09144-7.

5.

cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity.

Liu H, Moura-Alves P, Pei G, Mollenkopf HJ, Hurwitz R, Wu X, Wang F, Liu S, Ma M, Fei Y, Zhu C, Koehler AB, Oberbeck-Mueller D, Hahnke K, Klemm M, Guhlich-Bornhof U, Ge B, Tuukkanen A, Kolbe M, Dorhoi A, Kaufmann SH.

EMBO Rep. 2019 Apr;20(4). pii: e46293. doi: 10.15252/embr.201846293. Epub 2019 Mar 14.

PMID:
30872316
6.

Long-Term Culture of Distal Airway Epithelial Cells Allows Differentiation Towards Alveolar Epithelial Cells Suited for Influenza Virus Studies.

Imai-Matsushima A, Martin-Sancho L, Karlas A, Imai S, Zoranovic T, Hocke AC, Mollenkopf HJ, Berger H, Meyer TF.

EBioMedicine. 2018 Jul;33:230-241. doi: 10.1016/j.ebiom.2018.05.032. Epub 2018 Jun 22.

7.

Inhibitors of Apoptosis Protein Antagonists (Smac Mimetic Compounds) Control Polarization of Macrophages during Microbial Challenge and Sterile Inflammatory Responses.

Nadella V, Mohanty A, Sharma L, Yellaboina S, Mollenkopf HJ, Mazumdar VB, Palaparthi R, Mylavarapu MB, Maurya R, Kurukuti S, Rudel T, Prakash H.

Front Immunol. 2018 Jan 9;8:1792. doi: 10.3389/fimmu.2017.01792. eCollection 2017.

8.

Helicobacter pylori Depletes Cholesterol in Gastric Glands to Prevent Interferon Gamma Signaling and Escape the Inflammatory Response.

Morey P, Pfannkuch L, Pang E, Boccellato F, Sigal M, Imai-Matsushima A, Dyer V, Koch M, Mollenkopf HJ, Schlaermann P, Meyer TF.

Gastroenterology. 2018 Apr;154(5):1391-1404.e9. doi: 10.1053/j.gastro.2017.12.008. Epub 2017 Dec 19.

9.

Mycobacterium tuberculosis infection modulates adipose tissue biology.

Beigier-Bompadre M, Montagna GN, Kühl AA, Lozza L, Weiner J 3rd, Kupz A, Vogelzang A, Mollenkopf HJ, Löwe D, Bandermann S, Dorhoi A, Brinkmann V, Matuschewski K, Kaufmann SHE.

PLoS Pathog. 2017 Oct 17;13(10):e1006676. doi: 10.1371/journal.ppat.1006676. eCollection 2017 Oct.

10.

Integration of Metabolomics and Transcriptomics Reveals a Complex Diet of Mycobacterium tuberculosis during Early Macrophage Infection.

Zimmermann M, Kogadeeva M, Gengenbacher M, McEwen G, Mollenkopf HJ, Zamboni N, Kaufmann SHE, Sauer U.

mSystems. 2017 Aug 22;2(4). pii: e00057-17. doi: 10.1128/mSystems.00057-17. eCollection 2017 Jul-Aug.

11.

Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis.

Sigal M, Logan CY, Kapalczynska M, Mollenkopf HJ, Berger H, Wiedenmann B, Nusse R, Amieva MR, Meyer TF.

Nature. 2017 Aug 24;548(7668):451-455. doi: 10.1038/nature23642. Epub 2017 Aug 16.

PMID:
28813421
12.

Propionibacterium acnes inhibits FOXM1 and induces cell cycle alterations in human primary prostate cells.

Sayanjali B, Christensen GJM, Al-Zeer MA, Mollenkopf HJ, Meyer TF, Brüggemann H.

Int J Med Microbiol. 2016 Nov;306(7):517-528. doi: 10.1016/j.ijmm.2016.06.006. Epub 2016 Jun 28.

13.

Developmental transcriptome of resting cell formation in Mycobacterium smegmatis.

Wu ML, Gengenbacher M, Chung JC, Chen SL, Mollenkopf HJ, Kaufmann SH, Dick T.

BMC Genomics. 2016 Oct 26;17(1):837.

14.

Deletion of nuoG from the Vaccine Candidate Mycobacterium bovis BCG ΔureC::hly Improves Protection against Tuberculosis.

Gengenbacher M, Nieuwenhuizen N, Vogelzang A, Liu H, Kaiser P, Schuerer S, Lazar D, Wagner I, Mollenkopf HJ, Kaufmann SH.

MBio. 2016 May 24;7(3). pii: e00679-16. doi: 10.1128/mBio.00679-16.

15.

IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid.

Naujoks J, Tabeling C, Dill BD, Hoffmann C, Brown AS, Kunze M, Kempa S, Peter A, Mollenkopf HJ, Dorhoi A, Kershaw O, Gruber AD, Sander LE, Witzenrath M, Herold S, Nerlich A, Hocke AC, van Driel I, Suttorp N, Bedoui S, Hilbi H, Trost M, Opitz B.

PLoS Pathog. 2016 Feb 1;12(2):e1005408. doi: 10.1371/journal.ppat.1005408. eCollection 2016 Feb.

16.

The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids.

Kessler M, Hoffmann K, Brinkmann V, Thieck O, Jackisch S, Toelle B, Berger H, Mollenkopf HJ, Mangler M, Sehouli J, Fotopoulou C, Meyer TF.

Nat Commun. 2015 Dec 8;6:8989. doi: 10.1038/ncomms9989.

17.

Epigenetics and Proteomics Join Transcriptomics in the Quest for Tuberculosis Biomarkers.

Esterhuyse MM, Weiner J 3rd, Caron E, Loxton AG, Iannaccone M, Wagman C, Saikali P, Stanley K, Wolski WE, Mollenkopf HJ, Schick M, Aebersold R, Linhart H, Walzl G, Kaufmann SH.

MBio. 2015 Sep 15;6(5):e01187-15. doi: 10.1128/mBio.01187-15.

18.

Macrophages recognize the Helicobacter pylori type IV secretion system in the absence of toll-like receptor signalling.

Koch M, Mollenkopf HJ, Meyer TF.

Cell Microbiol. 2016 Jan;18(1):137-47. doi: 10.1111/cmi.12492. Epub 2015 Sep 3.

PMID:
26243717
19.

Global expression profiling reveals shared and distinct transcript signatures in arrested act2(-) and CDPK4(-) Plasmodium berghei gametocytes.

Andreadaki M, Mollenkopf HJ, Nika F, Brady D, Tewari R, Matuschewski K, Siden-Kiamos I.

Mol Biochem Parasitol. 2015 Jun;201(2):100-7. doi: 10.1016/j.molbiopara.2015.07.001. Epub 2015 Jul 26.

PMID:
26222913
20.

Differential transcriptomic and metabolic profiles of M. africanum- and M. tuberculosis-infected patients after, but not before, drug treatment.

Tientcheu LD, Maertzdorf J, Weiner J, Adetifa IM, Mollenkopf HJ, Sutherland JS, Donkor S, Kampmann B, Kaufmann SH, Dockrell HM, Ota MO.

Genes Immun. 2015 Jul-Aug;16(5):347-55. doi: 10.1038/gene.2015.21. Epub 2015 Jun 4.

21.

Indirect Toll-like receptor 5-mediated activation of conventional dendritic cells promotes the mucosal adjuvant activity of flagellin in the respiratory tract.

Fougeron D, Van Maele L, Songhet P, Cayet D, Hot D, Van Rooijen N, Mollenkopf HJ, Hardt WD, Benecke AG, Sirard JC.

Vaccine. 2015 Jun 26;33(29):3331-41. doi: 10.1016/j.vaccine.2015.05.022. Epub 2015 May 21.

PMID:
26003491
22.

Correction: pathological impact of hepatitis B virus surface proteins on the liver is associated with the host genetic background.

Churin Y, Roderfeld M, Stiefel J, Würger T, Schröder D, Matono T, Mollenkopf HJ, Montalbano R, Pompaiah M, Reifenberg K, Zahner D, Ocker M, Gerlich W, Glebe D, Roeb E.

PLoS One. 2015 May 1;10(5):e0127375. doi: 10.1371/journal.pone.0127375. eCollection 2015. No abstract available.

23.

Comprehensive insights into transcriptional adaptation of intracellular mycobacteria by microbe-enriched dual RNA sequencing.

Rienksma RA, Suarez-Diez M, Mollenkopf HJ, Dolganov GM, Dorhoi A, Schoolnik GK, Martins Dos Santos VA, Kaufmann SH, Schaap PJ, Gengenbacher M.

BMC Genomics. 2015 Feb 5;16:34. doi: 10.1186/s12864-014-1197-2.

24.

A novel human gastric primary cell culture system for modelling Helicobacter pylori infection in vitro.

Schlaermann P, Toelle B, Berger H, Schmidt SC, Glanemann M, Ordemann J, Bartfeld S, Mollenkopf HJ, Meyer TF.

Gut. 2016 Feb;65(2):202-13. doi: 10.1136/gutjnl-2014-307949. Epub 2014 Dec 24.

25.

The Recombinant BCG ΔureC::hly Vaccine Targets the AIM2 Inflammasome to Induce Autophagy and Inflammation.

Saiga H, Nieuwenhuizen N, Gengenbacher M, Koehler AB, Schuerer S, Moura-Alves P, Wagner I, Mollenkopf HJ, Dorhoi A, Kaufmann SH.

J Infect Dis. 2015 Jun 1;211(11):1831-41. doi: 10.1093/infdis/jiu675. Epub 2014 Dec 11.

PMID:
25505299
26.

Lung-residing myeloid-derived suppressors display dual functionality in murine pulmonary tuberculosis.

Knaul JK, Jörg S, Oberbeck-Mueller D, Heinemann E, Scheuermann L, Brinkmann V, Mollenkopf HJ, Yeremeev V, Kaufmann SH, Dorhoi A.

Am J Respir Crit Care Med. 2014 Nov 1;190(9):1053-66. doi: 10.1164/rccm.201405-0828OC.

PMID:
25275852
27.

AhR sensing of bacterial pigments regulates antibacterial defence.

Moura-Alves P, Faé K, Houthuys E, Dorhoi A, Kreuchwig A, Furkert J, Barison N, Diehl A, Munder A, Constant P, Skrahina T, Guhlich-Bornhof U, Klemm M, Koehler AB, Bandermann S, Goosmann C, Mollenkopf HJ, Hurwitz R, Brinkmann V, Fillatreau S, Daffe M, Tümmler B, Kolbe M, Oschkinat H, Krause G, Kaufmann SH.

Nature. 2014 Aug 28;512(7515):387-92. doi: 10.1038/nature13684. Epub 2014 Aug 13.

PMID:
25119038
28.

Platelets direct monocyte differentiation into epithelioid-like multinucleated giant foam cells with suppressive capacity upon mycobacterial stimulation.

Feng Y, Dorhoi A, Mollenkopf HJ, Yin H, Dong Z, Mao L, Zhou J, Bi A, Weber S, Maertzdorf J, Chen G, Chen Y, Kaufmann SH.

J Infect Dis. 2014 Dec 1;210(11):1700-10. doi: 10.1093/infdis/jiu355. Epub 2014 Jul 1.

29.

TRANSVAC workshop on standardisation and harmonisation of analytical platforms for HIV, TB and malaria vaccines: 'how can big data help?'.

Dutruel C, Thole J, Geels M, Mollenkopf HJ, Ottenhoff T, Guzman CA, Fletcher HA, Leroy O, Kaufmann SH.

Vaccine. 2014 Jul 31;32(35):4365-8. doi: 10.1016/j.vaccine.2014.06.014. Epub 2014 Jun 17.

30.

Type I IFN signaling triggers immunopathology in tuberculosis-susceptible mice by modulating lung phagocyte dynamics.

Dorhoi A, Yeremeev V, Nouailles G, Weiner J 3rd, Jörg S, Heinemann E, Oberbeck-Müller D, Knaul JK, Vogelzang A, Reece ST, Hahnke K, Mollenkopf HJ, Brinkmann V, Kaufmann SH.

Eur J Immunol. 2014 Aug;44(8):2380-93. doi: 10.1002/eji.201344219. Epub 2014 Jun 24.

31.

Pathological impact of hepatitis B virus surface proteins on the liver is associated with the host genetic background.

Churin Y, Roderfeld M, Stiefel J, Würger T, Schröder D, Matono T, Mollenkopf HJ, Montalbano R, Pompaiah M, Reifenberg K, Zahner D, Ocker M, Gerlich W, Glebe D, Roeb E.

PLoS One. 2014 Mar 4;9(3):e90608. doi: 10.1371/journal.pone.0090608. eCollection 2014. Erratum in: PLoS One. 2015;10(5):e0127375.

32.

CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis.

Nouailles G, Dorhoi A, Koch M, Zerrahn J, Weiner J 3rd, Faé KC, Arrey F, Kuhlmann S, Bandermann S, Loewe D, Mollenkopf HJ, Vogelzang A, Meyer-Schwesinger C, Mittrücker HW, McEwen G, Kaufmann SH.

J Clin Invest. 2014 Mar;124(3):1268-82. doi: 10.1172/JCI72030. Epub 2014 Feb 10.

33.

Eimeria falciformis infection of the mouse caecum identifies opposing roles of IFNγ-regulated host pathways for the parasite development.

Schmid M, Heitlinger E, Spork S, Mollenkopf HJ, Lucius R, Gupta N.

Mucosal Immunol. 2014 Jul;7(4):969-82. doi: 10.1038/mi.2013.115. Epub 2013 Dec 25.

PMID:
24368565
34.

MicroRNA-223 controls susceptibility to tuberculosis by regulating lung neutrophil recruitment.

Dorhoi A, Iannaccone M, Farinacci M, Faé KC, Schreiber J, Moura-Alves P, Nouailles G, Mollenkopf HJ, Oberbeck-Müller D, Jörg S, Heinemann E, Hahnke K, Löwe D, Del Nonno F, Goletti D, Capparelli R, Kaufmann SH.

J Clin Invest. 2013 Nov;123(11):4836-48.

35.

miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome.

Ratert N, Meyer HA, Jung M, Lioudmer P, Mollenkopf HJ, Wagner I, Miller K, Kilic E, Erbersdobler A, Weikert S, Jung K.

J Mol Diagn. 2013 Sep;15(5):695-705. doi: 10.1016/j.jmoldx.2013.05.008. Epub 2013 Aug 12.

PMID:
23945108
36.

The Mycobacterium tuberculosis regulatory network and hypoxia.

Galagan JE, Minch K, Peterson M, Lyubetskaya A, Azizi E, Sweet L, Gomes A, Rustad T, Dolganov G, Glotova I, Abeel T, Mahwinney C, Kennedy AD, Allard R, Brabant W, Krueger A, Jaini S, Honda B, Yu WH, Hickey MJ, Zucker J, Garay C, Weiner B, Sisk P, Stolte C, Winkler JK, Van de Peer Y, Iazzetti P, Camacho D, Dreyfuss J, Liu Y, Dorhoi A, Mollenkopf HJ, Drogaris P, Lamontagne J, Zhou Y, Piquenot J, Park ST, Raman S, Kaufmann SH, Mohney RP, Chelsky D, Moody DB, Sherman DR, Schoolnik GK.

Nature. 2013 Jul 11;499(7457):178-83. doi: 10.1038/nature12337. Epub 2013 Jul 3.

37.

A new algorithm for integrated analysis of miRNA-mRNA interactions based on individual classification reveals insights into bladder cancer.

Hecker N, Stephan C, Mollenkopf HJ, Jung K, Preissner R, Meyer HA.

PLoS One. 2013 May 24;8(5):e64543. doi: 10.1371/journal.pone.0064543. Print 2013.

38.

Direct proteomic quantification of the secretome of activated immune cells.

Meissner F, Scheltema RA, Mollenkopf HJ, Mann M.

Science. 2013 Apr 26;340(6131):475-8. doi: 10.1126/science.1232578.

39.

Identification of metastamirs as metastasis-associated microRNAs in clear cell renal cell carcinomas.

Wotschofsky Z, Liep J, Meyer HA, Jung M, Wagner I, Disch AC, Schaser KD, Melcher I, Kilic E, Busch J, Weikert S, Miller K, Erbersdobler A, Mollenkopf HJ, Jung K.

Int J Biol Sci. 2012;8(10):1363-74. doi: 10.7150/ijbs.5106. Epub 2012 Oct 28.

40.

Biphenotypic B-lymphoid/myeloid cells expressing low levels of Pax5: potential targets of BAL development.

Simmons S, Knoll M, Drewell C, Wolf I, Mollenkopf HJ, Bouquet C, Melchers F.

Blood. 2012 Nov 1;120(18):3688-98. doi: 10.1182/blood-2012-03-414821. Epub 2012 Aug 27.

PMID:
22927250
41.

Propionibacterium acnes host cell tropism contributes to vimentin-mediated invasion and induction of inflammation.

Mak TN, Fischer N, Laube B, Brinkmann V, Metruccio MM, Sfanos KS, Mollenkopf HJ, Meyer TF, Brüggemann H.

Cell Microbiol. 2012 Nov;14(11):1720-33. doi: 10.1111/j.1462-5822.2012.01833.x. Epub 2012 Jul 22.

PMID:
22759266
42.

Reference miRNAs for miRNAome analysis of urothelial carcinomas.

Ratert N, Meyer HA, Jung M, Mollenkopf HJ, Wagner I, Miller K, Kilic E, Erbersdobler A, Weikert S, Jung K.

PLoS One. 2012;7(6):e39309. doi: 10.1371/journal.pone.0039309. Epub 2012 Jun 20.

43.

Comprehensive analysis of CD4+ T cells in the decision between tolerance and immunity in vivo reveals a pivotal role for ICOS.

Lischke T, Hegemann A, Gurka S, Vu Van D, Burmeister Y, Lam KP, Kershaw O, Mollenkopf HJ, Mages HW, Hutloff A, Kroczek RA.

J Immunol. 2012 Jul 1;189(1):234-44. doi: 10.4049/jimmunol.1102034. Epub 2012 Jun 1.

44.

Common patterns and disease-related signatures in tuberculosis and sarcoidosis.

Maertzdorf J, Weiner J 3rd, Mollenkopf HJ; TBornotTB Network, Bauer T, Prasse A, Müller-Quernheim J, Kaufmann SH.

Proc Natl Acad Sci U S A. 2012 May 15;109(20):7853-8. doi: 10.1073/pnas.1121072109. Epub 2012 Apr 30.

45.

MiR-133b targets antiapoptotic genes and enhances death receptor-induced apoptosis.

Patron JP, Fendler A, Bild M, Jung U, Müller H, Arntzen MØ, Piso C, Stephan C, Thiede B, Mollenkopf HJ, Jung K, Kaufmann SH, Schreiber J.

PLoS One. 2012;7(4):e35345. doi: 10.1371/journal.pone.0035345. Epub 2012 Apr 20.

46.

Induction of microRNA-155 is TLR- and type IV secretion system-dependent in macrophages and inhibits DNA-damage induced apoptosis.

Koch M, Mollenkopf HJ, Klemm U, Meyer TF.

Proc Natl Acad Sci U S A. 2012 May 8;109(19):E1153-62. doi: 10.1073/pnas.1116125109. Epub 2012 Apr 16.

47.

Chlamydia trachomatis disturbs epithelial tissue homeostasis in fallopian tubes via paracrine Wnt signaling.

Kessler M, Zielecki J, Thieck O, Mollenkopf HJ, Fotopoulou C, Meyer TF.

Am J Pathol. 2012 Jan;180(1):186-98. doi: 10.1016/j.ajpath.2011.09.015. Epub 2011 Nov 7.

PMID:
22067911
48.

Functional correlations of pathogenesis-driven gene expression signatures in tuberculosis.

Maertzdorf J, Ota M, Repsilber D, Mollenkopf HJ, Weiner J, Hill PC, Kaufmann SH.

PLoS One. 2011;6(10):e26938. doi: 10.1371/journal.pone.0026938. Epub 2011 Oct 28.

49.

Reference genes for the relative quantification of microRNAs in renal cell carcinomas and their metastases.

Wotschofsky Z, Meyer HA, Jung M, Fendler A, Wagner I, Stephan C, Busch J, Erbersdobler A, Disch AC, Mollenkopf HJ, Jung K.

Anal Biochem. 2011 Oct 15;417(2):233-41. doi: 10.1016/j.ab.2011.06.009. Epub 2011 Jun 13.

PMID:
21741950
50.

Comparative genomics and transcriptomics of Propionibacterium acnes.

Brzuszkiewicz E, Weiner J, Wollherr A, Thürmer A, Hüpeden J, Lomholt HB, Kilian M, Gottschalk G, Daniel R, Mollenkopf HJ, Meyer TF, Brüggemann H.

PLoS One. 2011;6(6):e21581. doi: 10.1371/journal.pone.0021581. Epub 2011 Jun 27.

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