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Items: 1 to 50 of 397

1.

Fondation Leducq Transatlantic Network of Excellence Targeting Mitochondria to Treat Heart Disease.

Murphy E, Bernardi P, Cohen M, Di Lisa F, Forte M, Molkentin JD, Ovize M.

Circ Res. 2019 Apr 26;124(9):1294-1296. doi: 10.1161/CIRCRESAHA.119.314893. No abstract available.

PMID:
31021720
2.

Disruption of valosin-containing protein activity causes cardiomyopathy and reveals pleiotropic functions in cardiac homeostasis.

Brody MJ, Vanhoutte D, Bakshi CV, Liu R, Correll RN, Sargent MA, Molkentin JD.

J Biol Chem. 2019 May 31;294(22):8918-8929. doi: 10.1074/jbc.RA119.007585. Epub 2019 Apr 21.

PMID:
31006653
3.

ERK1/2 signaling induces skeletal muscle slow fiber-type switching and reduces muscular dystrophy disease severity.

Boyer JG, Prasad V, Song T, Lee D, Fu X, Grimes KM, Sargent MA, Sadayappan S, Molkentin JD.

JCI Insight. 2019 Apr 9;5. pii: 127356. doi: 10.1172/jci.insight.127356.

4.

Overlapping and differential functions of ATF6α versus ATF6β in the mouse heart.

Correll RN, Grimes KM, Prasad V, Lynch JM, Khalil H, Molkentin JD.

Sci Rep. 2019 Feb 14;9(1):2059. doi: 10.1038/s41598-019-39515-5.

5.

Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability.

Schips TG, Vanhoutte D, Vo A, Correll RN, Brody MJ, Khalil H, Karch J, Tjondrokoesoemo A, Sargent MA, Maillet M, Ross RS, Molkentin JD.

Nat Commun. 2019 Jan 8;10(1):76. doi: 10.1038/s41467-018-08026-8.

6.

Cardiac-specific deficiency of the mitochondrial calcium uniporter augments fatty acid oxidation and functional reserve.

Altamimi TR, Karwi QG, Uddin GM, Fukushima A, Kwong JQ, Molkentin JD, Lopaschuk GD.

J Mol Cell Cardiol. 2019 Feb;127:223-231. doi: 10.1016/j.yjmcc.2018.12.019. Epub 2019 Jan 4.

PMID:
30615880
7.

Myofibroblast-Specific TGFβ Receptor II Signaling in the Fibrotic Response to Cardiac Myosin Binding Protein C-Induced Cardiomyopathy.

Meng Q, Bhandary B, Bhuiyan MS, James J, Osinska H, Valiente-Alandi I, Shay-Winkler K, Gulick J, Molkentin JD, Blaxall BC, Robbins J.

Circ Res. 2018 Dec 7;123(12):1285-1297. doi: 10.1161/CIRCRESAHA.118.313089.

PMID:
30566042
8.

Evidence for Minimal Cardiogenic Potential of Stem Cell Antigen 1-Positive Cells in the Adult Mouse Heart.

Neidig LE, Weinberger F, Palpant NJ, Mignone J, Martinson AM, Sorensen DW, Bender I, Nemoto N, Reinecke H, Pabon L, Molkentin JD, Murry CE, van Berlo JH.

Circulation. 2018 Dec 18;138(25):2960-2962. doi: 10.1161/CIRCULATIONAHA.118.035273. No abstract available.

9.

The mitochondrial calcium uniporter underlies metabolic fuel preference in skeletal muscle.

Kwong JQ, Huo J, Bround MJ, Boyer JG, Schwanekamp JA, Ghazal N, Maxwell JT, Jang YC, Khuchua Z, Shi K, Bers DM, Davis J, Molkentin JD.

JCI Insight. 2018 Nov 15;3(22). pii: 121689. doi: 10.1172/jci.insight.121689.

10.

Cardiac Fibrosis in Proteotoxic Cardiac Disease is Dependent Upon Myofibroblast TGF -β Signaling.

Bhandary B, Meng Q, James J, Osinska H, Gulick J, Valiente-Alandi I, Sargent MA, Bhuiyan MS, Blaxall BC, Molkentin JD, Robbins J.

J Am Heart Assoc. 2018 Oct 16;7(20):e010013. doi: 10.1161/JAHA.118.010013.

11.

Undeniable Evidence That the Adult Mammalian Heart Lacks an Endogenous Regenerative Stem Cell.

Maliken BD, Molkentin JD.

Circulation. 2018 Aug 21;138(8):806-808. doi: 10.1161/CIRCULATIONAHA.118.035186. No abstract available.

PMID:
30359129
12.

Nuclear calcineurin is a sensor for detecting Ca2+ release from the nuclear envelope via IP3R.

Olivares-Florez S, Czolbe M, Riediger F, Seidlmayer L, Williams T, Nordbeck P, Strasen J, Glocker C, Jänsch M, Eder-Negrin P, Arias-Loza P, Mühlfelder M, Plačkić J, Heinze KG, Molkentin JD, Engelhardt S, Kockskämper J, Ritter O.

J Mol Med (Berl). 2018 Nov;96(11):1239-1249. doi: 10.1007/s00109-018-1701-2. Epub 2018 Oct 6.

PMID:
30293136
13.

Author Correction: Yolk sac macrophage progenitors traffic to the embryo during defined stages of development.

Stremmel C, Schuchert R, Wagner F, Thaler R, Weinberger T, Pick R, Mass E, Ishikawa-Ankerhold HC, Margraf A, Hutter S, Vagnozzi R, Klapproth S, Frampton J, Yona S, Scheiermann C, Molkentin JD, Jeschke U, Moser M, Sperandio M, Massberg S, Geissmann F, Schulz C.

Nat Commun. 2018 Sep 7;9(1):3699. doi: 10.1038/s41467-018-06065-9.

14.

Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction.

Sharp TE 3rd, Kubo H, Berretta RM, Starosta T, Wallner M, Schena GJ, Hobby AR, Yu D, Trappanese DM, George JC, Molkentin JD, Houser SR.

JACC Basic Transl Sci. 2017 Dec 25;2(6):669-683. doi: 10.1016/j.jacbts.2017.06.007. eCollection 2017 Dec.

15.

Genetic Lineage Tracing of Sca-1+ Cells Reveals Endothelial but Not Myogenic Contribution to the Murine Heart.

Vagnozzi RJ, Sargent MA, Lin SJ, Palpant NJ, Murry CE, Molkentin JD.

Circulation. 2018 Dec 18;138(25):2931-2939. doi: 10.1161/CIRCULATIONAHA.118.035210. Erratum in: Circulation. 2018 Oct 9;138(15):e424.

PMID:
29991486
16.

New Myocyte Formation in the Adult Heart: Endogenous Sources and Therapeutic Implications.

Vagnozzi RJ, Molkentin JD, Houser SR.

Circ Res. 2018 Jul 6;123(2):159-176. doi: 10.1161/CIRCRESAHA.118.311208.

17.

Developmental vascular regression is regulated by a Wnt/β-catenin, MYC and CDKN1A pathway that controls cell proliferation and cell death.

Nayak G, Odaka Y, Prasad V, Solano AF, Yeo EJ, Vemaraju S, Molkentin JD, Trumpp A, Williams B, Rao S, Lang RA.

Development. 2018 Jun 14;145(12). pii: dev154898. doi: 10.1242/dev.154898.

18.

Defective Flux of Thrombospondin-4 through the Secretory Pathway Impairs Cardiomyocyte Membrane Stability and Causes Cardiomyopathy.

Brody MJ, Vanhoutte D, Schips TG, Boyer JG, Bakshi CV, Sargent MA, York AJ, Molkentin JD.

Mol Cell Biol. 2018 Jun 28;38(14). pii: e00114-18. doi: 10.1128/MCB.00114-18. Print 2018 Jul 15.

19.

Gata4-Dependent Differentiation of c-Kit+-Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart.

Maliken BD, Kanisicak O, Karch J, Khalil H, Fu X, Boyer JG, Prasad V, Zheng Y, Molkentin JD.

Circulation. 2018 Sep 4;138(10):1012-1024. doi: 10.1161/CIRCULATIONAHA.118.033703.

20.

Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart.

Fu X, Khalil H, Kanisicak O, Boyer JG, Vagnozzi RJ, Maliken BD, Sargent MA, Prasad V, Valiente-Alandi I, Blaxall BC, Molkentin JD.

J Clin Invest. 2018 May 1;128(5):2127-2143. doi: 10.1172/JCI98215. Epub 2018 Apr 16.

21.

Inhibiting Fibronectin Attenuates Fibrosis and Improves Cardiac Function in a Model of Heart Failure.

Valiente-Alandi I, Potter SJ, Salvador AM, Schafer AE, Schips T, Carrillo-Salinas F, Gibson AM, Nieman ML, Perkins C, Sargent MA, Huo J, Lorenz JN, DeFalco T, Molkentin JD, Alcaide P, Blaxall BC.

Circulation. 2018 Sep 18;138(12):1236-1252. doi: 10.1161/CIRCULATIONAHA.118.034609.

PMID:
29653926
22.

van Berlo et al. reply.

van Berlo JH, Kanisicak O, Maillet M, Vagnozzi RJ, Karch J, Lin SJ, Middleton RC, Marbán E, Molkentin JD.

Nature. 2018 Mar 21;555(7697):E18. doi: 10.1038/nature25772. No abstract available.

PMID:
29565361
23.

Genetic Reduction in Left Ventricular Protein Kinase C-α and Adverse Ventricular Remodeling in Human Subjects.

Hu R, Morley MP, Brandimarto J, Tucker NR, Parsons VA, Zhao SD, Meder B, Katus HA, Rühle F, Stoll M, Villard E, Cambien F, Lin H, Smith NL, Felix JF, Vasan RS, van der Harst P, Newton-Cheh C, Li J, Kim CE, Hakonarson H, Hannenhalli S, Ashley EA, Moravec CS, Tang WHW, Maillet M, Molkentin JD, Ellinor PT, Margulies KB, Cappola TP.

Circ Genom Precis Med. 2018 Mar;11(3):e001901. doi: 10.1161/CIRCGEN.117.001901.

24.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review.

25.

Yolk sac macrophage progenitors traffic to the embryo during defined stages of development.

Stremmel C, Schuchert R, Wagner F, Thaler R, Weinberger T, Pick R, Mass E, Ishikawa-Ankerhold HC, Margraf A, Hutter S, Vagnozzi R, Klapproth S, Frampton J, Yona S, Scheiermann C, Molkentin JD, Jeschke U, Moser M, Sperandio M, Massberg S, Geissmann F, Schulz C.

Nat Commun. 2018 Jan 8;9(1):75. doi: 10.1038/s41467-017-02492-2. Erratum in: Nat Commun. 2018 Sep 7;9(1):3699.

26.

Increasing T-type calcium channel activity by β-adrenergic stimulation contributes to β-adrenergic regulation of heart rates.

Li Y, Zhang X, Zhang C, Zhang X, Li Y, Qi Z, Szeto C, Tang M, Peng Y, Molkentin JD, Houser SR, Xie M, Chen X.

J Physiol. 2018 Apr 1;596(7):1137-1151. doi: 10.1113/JP274756. Epub 2018 Jan 24.

27.

BEX1 is an RNA-dependent mediator of cardiomyopathy.

Accornero F, Schips TG, Petrosino JM, Gu SQ, Kanisicak O, van Berlo JH, Molkentin JD.

Nat Commun. 2017 Nov 30;8(1):1875. doi: 10.1038/s41467-017-02005-1.

28.

Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak.

Karch J, Schips TG, Maliken BD, Brody MJ, Sargent MA, Kanisicak O, Molkentin JD.

Elife. 2017 Nov 17;6. pii: e30543. doi: 10.7554/eLife.30543.

29.

Identity Crisis for Regenerative Cardiac cKit+ Cells.

Kanisicak O, Vagnozzi RJ, Molkentin JD.

Circ Res. 2017 Oct 27;121(10):1130-1132. doi: 10.1161/CIRCRESAHA.117.311921. Review. No abstract available.

30.

Spatial Gene Profiling in the Ischemic Heart: Fibroblasts Put on Their SOX.

Khalil H, Maillet M, Molkentin JD.

Circulation. 2017 Oct 10;136(15):1410-1411. doi: 10.1161/CIRCULATIONAHA.117.030625. No abstract available.

31.

Fibroblast-specific TGF-β-Smad2/3 signaling underlies cardiac fibrosis.

Khalil H, Kanisicak O, Prasad V, Correll RN, Fu X, Schips T, Vagnozzi RJ, Liu R, Huynh T, Lee SJ, Karch J, Molkentin JD.

J Clin Invest. 2017 Oct 2;127(10):3770-3783. doi: 10.1172/JCI94753. Epub 2017 Sep 11.

32.

Pharmacological and Activated Fibroblast Targeting of Gβγ-GRK2 After Myocardial Ischemia Attenuates Heart Failure Progression.

Travers JG, Kamal FA, Valiente-Alandi I, Nieman ML, Sargent MA, Lorenz JN, Molkentin JD, Blaxall BC.

J Am Coll Cardiol. 2017 Aug 22;70(8):958-971. doi: 10.1016/j.jacc.2017.06.049.

33.

TGFBI functions similar to periostin but is uniquely dispensable during cardiac injury.

Schwanekamp JA, Lorts A, Sargent MA, York AJ, Grimes KM, Fischesser DM, Gokey JJ, Whitsett JA, Conway SJ, Molkentin JD.

PLoS One. 2017 Jul 27;12(7):e0181945. doi: 10.1371/journal.pone.0181945. eCollection 2017.

34.

Mitsugumin 29 regulates t-tubule architecture in the failing heart.

Correll RN, Lynch JM, Schips TG, Prasad V, York AJ, Sargent MA, Brochet DXP, Ma J, Molkentin JD.

Sci Rep. 2017 Jul 13;7(1):5328. doi: 10.1038/s41598-017-05284-2.

35.

Cardiomyocyte Regeneration: A Consensus Statement.

Eschenhagen T, Bolli R, Braun T, Field LJ, Fleischmann BK, Frisén J, Giacca M, Hare JM, Houser S, Lee RT, Marbán E, Martin JF, Molkentin JD, Murry CE, Riley PR, Ruiz-Lozano P, Sadek HA, Sussman MA, Hill JA.

Circulation. 2017 Aug 15;136(7):680-686. doi: 10.1161/CIRCULATIONAHA.117.029343. Epub 2017 Jul 6. Review. No abstract available.

36.

An Unbiased High-Throughput Screen to Identify Novel Effectors That Impact on Cardiomyocyte Aggregate Levels.

McLendon PM, Davis G, Gulick J, Singh SR, Xu N, Salomonis N, Molkentin JD, Robbins J.

Circ Res. 2017 Sep 1;121(6):604-616. doi: 10.1161/CIRCRESAHA.117.310945. Epub 2017 Jun 27.

37.

Preexisting endothelial cells mediate cardiac neovascularization after injury.

He L, Huang X, Kanisicak O, Li Y, Wang Y, Li Y, Pu W, Liu Q, Zhang H, Tian X, Zhao H, Liu X, Zhang S, Nie Y, Hu S, Miao X, Wang QD, Wang F, Chen T, Xu Q, Lui KO, Molkentin JD, Zhou B.

J Clin Invest. 2017 Aug 1;127(8):2968-2981. doi: 10.1172/JCI93868. Epub 2017 Jun 26.

38.

The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability.

Luongo TS, Lambert JP, Gross P, Nwokedi M, Lombardi AA, Shanmughapriya S, Carpenter AC, Kolmetzky D, Gao E, van Berlo JH, Tsai EJ, Molkentin JD, Chen X, Madesh M, Houser SR, Elrod JW.

Nature. 2017 May 4;545(7652):93-97. doi: 10.1038/nature22082. Epub 2017 Apr 26.

39.

Redefining the identity of cardiac fibroblasts.

Tallquist MD, Molkentin JD.

Nat Rev Cardiol. 2017 Aug;14(8):484-491. doi: 10.1038/nrcardio.2017.57. Epub 2017 Apr 24. Review.

40.

Caveolae-localized L-type Ca2+ channels do not contribute to function or hypertrophic signalling in the mouse heart.

Correll RN, Makarewich CA, Zhang H, Zhang C, Sargent MA, York AJ, Berretta RM, Chen X, Houser SR, Molkentin JD.

Cardiovasc Res. 2017 Jun 1;113(7):749-759. doi: 10.1093/cvr/cvx046.

41.

Fibroblast-Specific Genetic Manipulation of p38 Mitogen-Activated Protein Kinase In Vivo Reveals Its Central Regulatory Role in Fibrosis.

Molkentin JD, Bugg D, Ghearing N, Dorn LE, Kim P, Sargent MA, Gunaje J, Otsu K, Davis J.

Circulation. 2017 Aug 8;136(6):549-561. doi: 10.1161/CIRCULATIONAHA.116.026238. Epub 2017 Mar 29.

42.

The Elusive Progenitor Cell in Cardiac Regeneration: Slip Slidin' Away.

Cai CL, Molkentin JD.

Circ Res. 2017 Jan 20;120(2):400-406. doi: 10.1161/CIRCRESAHA.116.309710. Review.

43.

Applying Modern Transcriptomics to Interrogate the Human Cardiac Fibroblast.

Kanisicak O, Molkentin JD.

JACC Basic Transl Sci. 2016 Dec 26;1(7):603-605. doi: 10.1016/j.jacbts.2016.10.002. eCollection 2016 Dec. No abstract available.

44.

RCANs regulate the convergent roles of NFATc1 in bone homeostasis.

Kim JH, Kim K, Kim I, Seong S, Jeong BC, Nam KI, Kim KK, Molkentin JD, Kim N.

Sci Rep. 2016 Dec 5;6:38526. doi: 10.1038/srep38526.

45.

Nemo-Like Kinase (NLK) Is a Pathological Signaling Effector in the Mouse Heart.

Liu R, Khalil H, Lin SJ, Sargent MA, York AJ, Molkentin JD.

PLoS One. 2016 Oct 20;11(10):e0164897. doi: 10.1371/journal.pone.0164897. eCollection 2016.

46.

Thrombospondin expression in myofibers stabilizes muscle membranes.

Vanhoutte D, Schips TG, Kwong JQ, Davis J, Tjondrokoesoemo A, Brody MJ, Sargent MA, Kanisicak O, Yi H, Gao QQ, Rabinowitz JE, Volk T, McNally EM, Molkentin JD.

Elife. 2016 Sep 26;5. pii: e17589. doi: 10.7554/eLife.17589.

47.

Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK-NRF2 pathway.

Cunha DA, Cito M, Carlsson PO, Vanderwinden JM, Molkentin JD, Bugliani M, Marchetti P, Eizirik DL, Cnop M.

Cell Death Differ. 2016 Dec;23(12):1995-2006. doi: 10.1038/cdd.2016.89. Epub 2016 Sep 2.

48.

Regulation of cardiac hypertrophy and remodeling through the dual-specificity MAPK phosphatases (DUSPs).

Liu R, Molkentin JD.

J Mol Cell Cardiol. 2016 Dec;101:44-49. doi: 10.1016/j.yjmcc.2016.08.018. Epub 2016 Aug 27. Review.

49.

Inositol 1,4,5-trisphosphate-mediated sarcoplasmic reticulum-mitochondrial crosstalk influences adenosine triphosphate production via mitochondrial Ca2+ uptake through the mitochondrial ryanodine receptor in cardiac myocytes.

Seidlmayer LK, Kuhn J, Berbner A, Arias-Loza PA, Williams T, Kaspar M, Czolbe M, Kwong JQ, Molkentin JD, Heinze KG, Dedkova EN, Ritter O.

Cardiovasc Res. 2016 Oct;112(1):491-501. doi: 10.1093/cvr/cvw185. Epub 2016 Aug 5.

PMID:
27496868
50.

Acute Catecholamine Exposure Causes Reversible Myocyte Injury Without Cardiac Regeneration.

Wallner M, Duran JM, Mohsin S, Troupes CD, Vanhoutte D, Borghetti G, Vagnozzi RJ, Gross P, Yu D, Trappanese DM, Kubo H, Toib A, Sharp TE 3rd, Harper SC, Volkert MA, Starosta T, Feldsott EA, Berretta RM, Wang T, Barbe MF, Molkentin JD, Houser SR.

Circ Res. 2016 Sep 16;119(7):865-79. doi: 10.1161/CIRCRESAHA.116.308687. Epub 2016 Jul 26.

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