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Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4.

Wang Z, Wu VH, Allevato MM, Gilardi M, He Y, Luis Callejas-Valera J, Vitale-Cross L, Martin D, Amornphimoltham P, Mcdermott J, Yung BS, Goto Y, Molinolo AA, Sharabi AB, Cohen EEW, Chen Q, Lyons JG, Alexandrov LB, Gutkind JS.

Nat Commun. 2019 Dec 5;10(1):5546. doi: 10.1038/s41467-019-13471-0.


4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer.

Wang Z, Feng X, Molinolo AA, Martin D, Vitale-Cross L, Nohata N, Ando M, Wahba A, Amornphimoltham P, Wu X, Gilardi M, Allevato M, Wu V, Steffen DJ, Tofilon P, Sonenberg N, Califano J, Chen Q, Lippman SM, Gutkind JS.

Cancer Res. 2019 Apr 1;79(7):1438-1450. doi: 10.1158/0008-5472.CAN-18-1220. Epub 2019 Mar 20.


Activation of RANK/RANKL/OPG Pathway Is Involved in the Pathophysiology of Fibrous Dysplasia and Associated With Disease Burden.

de Castro LF, Burke AB, Wang HD, Tsai J, Florenzano P, Pan KS, Bhattacharyya N, Boyce AM, Gafni RI, Molinolo AA, Robey PG, Collins MT.

J Bone Miner Res. 2019 Feb;34(2):290-294. doi: 10.1002/jbmr.3602. Epub 2018 Nov 29.


Inhibition of mTOR Signaling and Clinical Activity of Rapamycin in Head and Neck Cancer in a Window of Opportunity Trial.

Day TA, Shirai K, O'Brien PE, Matheus MG, Godwin K, Sood AJ, Kompelli A, Vick JA, Martin D, Vitale-Cross L, Callejas-Varela JL, Wang Z, Wu X, Harismendy O, Molinolo AA, Lippman SM, Van Waes C, Szabo E, Gutkind JS.

Clin Cancer Res. 2019 Feb 15;25(4):1156-1164. doi: 10.1158/1078-0432.CCR-18-2024. Epub 2018 Nov 12.


Breast Cancer Mortality in Older and Younger Patients in California.

Tao L, Schwab RB, San Miguel Y, Gomez SL, Canchola AJ, Gago-Dominguez M, Komenaka IK, Murphy JD, Molinolo AA, Martinez ME.

Cancer Epidemiol Biomarkers Prev. 2019 Feb;28(2):303-310. doi: 10.1158/1055-9965.EPI-18-0353. Epub 2018 Oct 17.


Transcriptional signature primes human oral mucosa for rapid wound healing.

Iglesias-Bartolome R, Uchiyama A, Molinolo AA, Abusleme L, Brooks SR, Callejas-Valera JL, Edwards D, Doci C, Asselin-Labat ML, Onaitis MW, Moutsopoulos NM, Gutkind JS, Morasso MI.

Sci Transl Med. 2018 Jul 25;10(451). pii: eaap8798. doi: 10.1126/scitranslmed.aap8798.


Biological and clinical impact of imbalanced progesterone receptor isoform ratios in breast cancer.

Lamb CA, Fabris VT, Jacobsen B, Molinolo AA, Lanari C.

Endocr Relat Cancer. 2018 Jul 10. pii: ERC-18-0179. doi: 10.1530/ERC-18-0179. [Epub ahead of print]


Assembly and activation of the Hippo signalome by FAT1 tumor suppressor.

Martin D, Degese MS, Vitale-Cross L, Iglesias-Bartolome R, Valera JLC, Wang Z, Feng X, Yeerna H, Vadmal V, Moroishi T, Thorne RF, Zaida M, Siegele B, Cheong SC, Molinolo AA, Samuels Y, Tamayo P, Guan KL, Lippman SM, Lyons JG, Gutkind JS.

Nat Commun. 2018 Jul 9;9(1):2372. doi: 10.1038/s41467-018-04590-1.


Tumor-induced osteomalacia in association with PTEN-negative Cowden syndrome.

Berglund JA, Gafni RI, Wodajo F, Cowen EW, El-Maouche D, Chang R, Chen CC, Guthrie LC, Molinolo AA, Collins MT.

Osteoporos Int. 2018 Apr;29(4):993-997. doi: 10.1007/s00198-017-4372-x. Epub 2018 Jan 29.


Expression of an active Gαs mutant in skeletal stem cells is sufficient and necessary for fibrous dysplasia initiation and maintenance.

Zhao X, Deng P, Iglesias-Bartolome R, Amornphimoltham P, Steffen DJ, Jin Y, Molinolo AA, de Castro LF, Ovejero D, Yuan Q, Chen Q, Han X, Bai D, Taylor SS, Yang Y, Collins MT, Gutkind JS.

Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E428-E437. doi: 10.1073/pnas.1713710115. Epub 2017 Dec 27.


Early detection of squamous cell carcinoma in carcinogen induced oral cancer rodent model by ratiometric activatable cell penetrating peptides.

Hingorani DV, Lemieux AJ, Acevedo JR, Glasgow HL, Kedarisetty S, Whitney MA, Molinolo AA, Tsien RY, Nguyen QT.

Oral Oncol. 2017 Aug;71:156-162. doi: 10.1016/j.oraloncology.2017.06.009. Epub 2017 Jun 27.


Epidermal loss of Gαq confers a migratory and differentiation defect in keratinocytes.

Doçi CL, Mikelis CM, Callejas-Valera JL, Hansen KK, Molinolo AA, Inoue A, Offermanns S, Gutkind JS.

PLoS One. 2017 Mar 16;12(3):e0173692. doi: 10.1371/journal.pone.0173692. eCollection 2017.


mTOR inhibition prevents rapid-onset of carcinogen-induced malignancies in a novel inducible HPV-16 E6/E7 mouse model.

Callejas-Valera JL, Iglesias-Bartolome R, Amornphimoltham P, Palacios-Garcia J, Martin D, Califano JA, Molinolo AA, Gutkind JS.

Carcinogenesis. 2016 Oct;37(10):1014-25. doi: 10.1093/carcin/bgw086. Epub 2016 Aug 18.


A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers.

Yamaguchi K, Iglesias-Bartolomé R, Wang Z, Callejas-Valera JL, Amornphimoltham P, Molinolo AA, Cohen EE, Califano JA, Lippman SM, Luo J, Gutkind JS.

Oncotarget. 2016 Mar 8;7(10):10696-709. doi: 10.18632/oncotarget.7372.


Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα13/RhoA axis in B cells.

O'Hayre M, Inoue A, Kufareva I, Wang Z, Mikelis CM, Drummond RA, Avino S, Finkel K, Kalim KW, DiPasquale G, Guo F, Aoki J, Zheng Y, Lionakis MS, Molinolo AA, Gutkind JS.

Oncogene. 2016 Jul 21;35(29):3771-80. doi: 10.1038/onc.2015.442. Epub 2015 Nov 30.


A Simple Device to Rapidly Prepare Whole Mounts of the Mouse Intestine.

Yoneda M, Molinolo AA, Ward JM, Kimura S, Goodlad RA.

J Vis Exp. 2015 Oct 27;(105):e53042. doi: 10.3791/53042.


Nuclear staining of fgfr-2/stat-5 and runx-2 in mucinous breast cancer.

May M, Mosto J, Vazquez PM, Gonzalez P, Rojas P, Gass H, Lanari C, Molinolo AA.

Exp Mol Pathol. 2016 Feb;100(1):39-44. doi: 10.1016/j.yexmp.2015.11.003. Epub 2015 Nov 6.


Toxicological Studies of 212Pb Intravenously or Intraperitoneally Injected into Mice for a Phase 1 Trial.

Milenic DE, Molinolo AA, Solivella MS, Banaga E, Torgue J, Besnainou S, Brechbiel MW, Baidoo KE.

Pharmaceuticals (Basel). 2015 Jul 24;8(3):416-34. doi: 10.3390/ph8030416.


Inactivation of a Gα(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis.

Iglesias-Bartolome R, Torres D, Marone R, Feng X, Martin D, Simaan M, Chen M, Weinstein LS, Taylor SS, Molinolo AA, Gutkind JS.

Nat Cell Biol. 2015 Jun;17(6):793-803. doi: 10.1038/ncb3164. Epub 2015 May 11.


Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma.

Doçi CL, Mikelis CM, Lionakis MS, Molinolo AA, Gutkind JS.

Cancer Res. 2015 Jul 15;75(14):2937-48. doi: 10.1158/0008-5472.CAN-14-3121. Epub 2015 May 7.


Targeting matriptase in breast cancer abrogates tumour progression via impairment of stromal-epithelial growth factor signalling.

Zoratti GL, Tanabe LM, Varela FA, Murray AS, Bergum C, Colombo É, Lang JE, Molinolo AA, Leduc R, Marsault E, Boerner J, List K.

Nat Commun. 2015 Apr 15;6:6776. doi: 10.1038/ncomms7776.


Prevention of tumor growth driven by PIK3CA and HPV oncogenes by targeting mTOR signaling with metformin in oral squamous carcinomas expressing OCT3.

Madera D, Vitale-Cross L, Martin D, Schneider A, Molinolo AA, Gangane N, Carey TE, McHugh JB, Komarck CM, Walline HM, William WN Jr, Seethala RR, Ferris RL, Gutkind JS.

Cancer Prev Res (Phila). 2015 Mar;8(3):197-207. doi: 10.1158/1940-6207.CAPR-14-0348. Epub 2015 Feb 13.


SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis.

Dillenburg-Pilla P, Patel V, Mikelis CM, Zárate-Bladés CR, Doçi CL, Amornphimoltham P, Wang Z, Martin D, Leelahavanichkul K, Dorsam RT, Masedunskas A, Weigert R, Molinolo AA, Gutkind JS.

FASEB J. 2015 Mar;29(3):1056-68. doi: 10.1096/fj.14-260083. Epub 2014 Dec 2.


A systems genetics approach identifies CXCL14, ITGAX, and LPCAT2 as novel aggressive prostate cancer susceptibility genes.

Williams KA, Lee M, Hu Y, Andreas J, Patel SJ, Zhang S, Chines P, Elkahloun A, Chandrasekharappa S, Gutkind JS, Molinolo AA, Crawford NP.

PLoS Genet. 2014 Nov 20;10(11):e1004809. doi: 10.1371/journal.pgen.1004809. eCollection 2014 Nov. Erratum in: PLoS Genet. 2015 May;11(5):e1005127.


Heterotrimeric G-protein alpha-12 (Gα12) subunit promotes oral cancer metastasis.

Gan CP, Patel V, Mikelis CM, Zain RB, Molinolo AA, Abraham MT, Teo SH, Abdul Rahman ZA, Gutkind JS, Cheong SC.

Oncotarget. 2014 Oct 30;5(20):9626-40.


The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies.

Martin D, Abba MC, Molinolo AA, Vitale-Cross L, Wang Z, Zaida M, Delic NC, Samuels Y, Lyons JG, Gutkind JS.

Oncotarget. 2014 Oct 15;5(19):8906-23.


mTOR co-targeting in cetuximab resistance in head and neck cancers harboring PIK3CA and RAS mutations.

Wang Z, Martin D, Molinolo AA, Patel V, Iglesias-Bartolome R, Degese MS, Vitale-Cross L, Chen Q, Gutkind JS.

J Natl Cancer Inst. 2014 Aug 5;106(9). pii: dju215. doi: 10.1093/jnci/dju215. Print 2014 Sep.


Immune consequences of decreasing tumor vasculature with antiangiogenic tyrosine kinase inhibitors in combination with therapeutic vaccines.

Farsaci B, Donahue RN, Coplin MA, Grenga I, Lepone LM, Molinolo AA, Hodge JW.

Cancer Immunol Res. 2014 Nov;2(11):1090-102. doi: 10.1158/2326-6066.CIR-14-0076. Epub 2014 Aug 4.


Cholecystokinin receptor antagonist halts progression of pancreatic cancer precursor lesions and fibrosis in mice.

Smith JP, Cooper TK, McGovern CO, Gilius EL, Zhong Q, Liao J, Molinolo AA, Gutkind JS, Matters GL.

Pancreas. 2014 Oct;43(7):1050-9. doi: 10.1097/MPA.0000000000000194.


Comparative toxicity and efficacy of engineered anthrax lethal toxin variants with broad anti-tumor activities.

Peters DE, Hoover B, Cloud LG, Liu S, Molinolo AA, Leppla SH, Bugge TH.

Toxicol Appl Pharmacol. 2014 Sep 1;279(2):220-9. doi: 10.1016/j.taap.2014.06.010. Epub 2014 Jun 24.


Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry.

Feng X, Degese MS, Iglesias-Bartolome R, Vaque JP, Molinolo AA, Rodrigues M, Zaidi MR, Ksander BR, Merlino G, Sodhi A, Chen Q, Gutkind JS.

Cancer Cell. 2014 Jun 16;25(6):831-45. doi: 10.1016/j.ccr.2014.04.016. Epub 2014 May 29.


TMPRSS13 deficiency impairs stratum corneum formation and epidermal barrier acquisition.

Madsen DH, Szabo R, Molinolo AA, Bugge TH.

Biochem J. 2014 Aug 1;461(3):487-95. doi: 10.1042/BJ20140337.


Effects of denosumab treatment and discontinuation on human growth plates.

Wang HD, Boyce AM, Tsai JY, Gafni RI, Farley FA, Kasa-Vubu JZ, Molinolo AA, Collins MT.

J Clin Endocrinol Metab. 2014 Mar;99(3):891-7. doi: 10.1210/jc.2013-3081. Epub 2014 Jan 1.


A role for p38 MAPK in head and neck cancer cell growth and tumor-induced angiogenesis and lymphangiogenesis.

Leelahavanichkul K, Amornphimoltham P, Molinolo AA, Basile JR, Koontongkaew S, Gutkind JS.

Mol Oncol. 2014 Feb;8(1):105-18. doi: 10.1016/j.molonc.2013.10.003. Epub 2013 Oct 12.


Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma.

Simpson RM, Bastian BC, Michael HT, Webster JD, Prasad ML, Conway CM, Prieto VM, Gary JM, Goldschmidt MH, Esplin DG, Smedley RC, Piris A, Meuten DJ, Kiupel M, Lee CC, Ward JM, Dwyer JE, Davis BJ, Anver MR, Molinolo AA, Hoover SB, Rodriguez-Canales J, Hewitt SM.

Pigment Cell Melanoma Res. 2014 Jan;27(1):37-47. doi: 10.1111/pcmr.12185. Epub 2013 Nov 21.


Improved clearance during treatment of HPV-positive head and neck cancer through mTOR inhibition.

Coppock JD, Wieking BG, Molinolo AA, Gutkind JS, Miskimins WK, Lee JH.

Neoplasia. 2013 Jun;15(6):620-30.


Germline genetic variation modulates tumor progression and metastasis in a mouse model of neuroendocrine prostate carcinoma.

Patel SJ, Molinolo AA, Gutkind S, Crawford NP.

PLoS One. 2013 Apr 19;8(4):e61848. doi: 10.1371/journal.pone.0061848. Print 2013.


DSG3 as a biomarker for the ultrasensitive detection of occult lymph node metastasis in oral cancer using nanostructured immunoarrays.

Patel V, Martin D, Malhotra R, Marsh CA, Doçi CL, Veenstra TD, Nathan CA, Sinha UK, Singh B, Molinolo AA, Rusling JF, Gutkind JS.

Oral Oncol. 2013 Feb;49(2):93-101. doi: 10.1016/j.oraloncology.2012.08.001. Epub 2012 Sep 23.


mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis.

Iglesias-Bartolome R, Patel V, Cotrim A, Leelahavanichkul K, Molinolo AA, Mitchell JB, Gutkind JS.

Cell Stem Cell. 2012 Sep 7;11(3):401-14. doi: 10.1016/j.stem.2012.06.007.


[The role of estrogen receptor alpha in breast cancer cell proliferation mediated by progestins].

Giulianelli S, Vaqué JP, Wargon V, Soldati R, Vanzulli SI, Martins R, Zeitlin E, Helguero L, Lamb C, Molinolo AA, Gutkind JS, Lanari C.

Medicina (B Aires). 2012;72(4):315-20. Spanish.


Activation of the mTOR pathway in primary medullary thyroid carcinoma and lymph node metastases.

Tamburrino A, Molinolo AA, Salerno P, Chernock RD, Raffeld M, Xi L, Gutkind JS, Moley JF, Wells SA Jr, Santoro M.

Clin Cancer Res. 2012 Jul 1;18(13):3532-40. doi: 10.1158/1078-0432.CCR-11-2700.


Future directions and treatment strategies for head and neck squamous cell carcinomas.

Wise-Draper TM, Draper DJ, Gutkind JS, Molinolo AA, Wikenheiser-Brokamp KA, Wells SI.

Transl Res. 2012 Sep;160(3):167-77. doi: 10.1016/j.trsl.2012.02.002. Epub 2012 Feb 28.


Nuclear localization of heme oxygenase-1 is associated with tumor progression of head and neck squamous cell carcinomas.

Gandini NA, Fermento ME, Salomón DG, Blasco J, Patel V, Gutkind JS, Molinolo AA, Facchinetti MM, Curino AC.

Exp Mol Pathol. 2012 Oct;93(2):237-45. doi: 10.1016/j.yexmp.2012.05.001. Epub 2012 May 8.


Capillary morphogenesis protein-2 is required for mouse parturition by maintaining uterine collagen homeostasis.

Peters DE, Zhang Y, Molinolo AA, Miller-Randolph S, Szabo R, Bugge TH, Leppla SH, Liu S.

Biochem Biophys Res Commun. 2012 Jun 8;422(3):393-7. doi: 10.1016/j.bbrc.2012.04.160. Epub 2012 May 7.


Metformin prevents the development of oral squamous cell carcinomas from carcinogen-induced premalignant lesions.

Vitale-Cross L, Molinolo AA, Martin D, Younis RH, Maruyama T, Patel V, Chen W, Schneider A, Gutkind JS.

Cancer Prev Res (Phila). 2012 Apr;5(4):562-73. doi: 10.1158/1940-6207.CAPR-11-0502. Epub 2012 Mar 31.


Denosumab treatment for fibrous dysplasia.

Boyce AM, Chong WH, Yao J, Gafni RI, Kelly MH, Chamberlain CE, Bassim C, Cherman N, Ellsworth M, Kasa-Vubu JZ, Farley FA, Molinolo AA, Bhattacharyya N, Collins MT.

J Bone Miner Res. 2012 Jul;27(7):1462-70. doi: 10.1002/jbmr.1603.


mTOR as a molecular target in HPV-associated oral and cervical squamous carcinomas.

Molinolo AA, Marsh C, El Dinali M, Gangane N, Jennison K, Hewitt S, Patel V, Seiwert TY, Gutkind JS.

Clin Cancer Res. 2012 May 1;18(9):2558-68. doi: 10.1158/1078-0432.CCR-11-2824. Epub 2012 Mar 12.


Estrogen receptor alpha mediates progestin-induced mammary tumor growth by interacting with progesterone receptors at the cyclin D1/MYC promoters.

Giulianelli S, Vaqué JP, Soldati R, Wargon V, Vanzulli SI, Martins R, Zeitlin E, Molinolo AA, Helguero LA, Lamb CA, Gutkind JS, Lanari C.

Cancer Res. 2012 May 1;72(9):2416-27. doi: 10.1158/0008-5472.CAN-11-3290. Epub 2012 Mar 6.


Antiprogestins in breast cancer treatment: are we ready?

Lanari C, Wargon V, Rojas P, Molinolo AA.

Endocr Relat Cancer. 2012 May 3;19(3):R35-50. doi: 10.1530/ERC-11-0378. Print 2012 Jun. Review.


Suppression of Tumorigenicity-14, encoding matriptase, is a critical suppressor of colitis and colitis-associated colon carcinogenesis.

Kosa P, Szabo R, Molinolo AA, Bugge TH.

Oncogene. 2012 Aug 9;31(32):3679-95. doi: 10.1038/onc.2011.545. Epub 2011 Dec 5.

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