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Promises and Pitfalls of In Vivo Evolution to Improve Phage Therapy.

Bull JJ, Levin BR, Molineux IJ.

Viruses. 2019 Nov 21;11(12). pii: E1083. doi: 10.3390/v11121083.


Structural dynamics of bacteriophage P22 infection initiation revealed by cryo-electron tomography.

Wang C, Tu J, Liu J, Molineux IJ.

Nat Microbiol. 2019 Jun;4(6):1049-1056. doi: 10.1038/s41564-019-0403-z. Epub 2019 Mar 18.


Directed in Vitro Evolution of Therapeutic Bacteriophages: The Appelmans Protocol.

Burrowes BH, Molineux IJ, Fralick JA.

Viruses. 2019 Mar 11;11(3). pii: E241. doi: 10.3390/v11030241.


Antibiotic Therapy Using Phage Depolymerases: Robustness Across a Range of Conditions.

Lin H, Paff ML, Molineux IJ, Bull JJ.

Viruses. 2018 Nov 12;10(11). pii: E622. doi: 10.3390/v10110622.


Experimental evolution of UV resistance in a phage.

Tom EF, Molineux IJ, Paff ML, Bull JJ.

PeerJ. 2018 Jul 9;6:e5190. doi: 10.7717/peerj.5190. eCollection 2018.


Viral attenuation by engineered protein fragmentation.

Garry DJ, Ellington AD, Molineux IJ, Bull JJ.

Virus Evol. 2018 Jun 19;4(1):vey017. doi: 10.1093/ve/vey017. eCollection 2018 Jan.


Therapeutic Application of Phage Capsule Depolymerases against K1, K5, and K30 Capsulated E. coli in Mice.

Lin H, Paff ML, Molineux IJ, Bull JJ.

Front Microbiol. 2017 Nov 16;8:2257. doi: 10.3389/fmicb.2017.02257. eCollection 2017.


Detection of Bacillus anthracis spores from environmental water using bioluminescent reporter phage.

Nguyen C, Makkar R, Sharp NJ, Page MA, Molineux IJ, Schofield DA.

J Appl Microbiol. 2017 Nov;123(5):1184-1193. doi: 10.1111/jam.13569. Epub 2017 Sep 21.


A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease.

Szymanski MR, Yu W, Gmyrek AM, White MA, Molineux IJ, Lee JC, Yin YW.

Nat Commun. 2017 May 3;8:14959. doi: 10.1038/ncomms14959.


Dual host specificity of phage SP6 is facilitated by tailspike rotation.

Tu J, Park T, Morado DR, Hughes KT, Molineux IJ, Liu J.

Virology. 2017 Jul;507:206-215. doi: 10.1016/j.virol.2017.04.017. Epub 2017 Apr 26.


Design and engineering of a transmissible antiviral defense.

Paff ML, Nuismer SL, Ellington AD, Molineux IJ, May RH, Bull JJ.

J Biol Eng. 2016 Oct 12;10:12. eCollection 2016.


Evolved Populations of Shigella flexneri Phage Sf6 Acquire Large Deletions, Altered Genomic Architecture, and Faster Life Cycles.

Dover JA, Burmeister AR, Molineux IJ, Parent KN.

Genome Biol Evol. 2016 Sep 19;8(9):2827-40. doi: 10.1093/gbe/evw177.


Ultrastructural analysis of bacteriophage Φ29 during infection of Bacillus subtilis.

Farley MM, Tu J, Kearns DB, Molineux IJ, Liu J.

J Struct Biol. 2017 Feb;197(2):163-171. doi: 10.1016/j.jsb.2016.07.019. Epub 2016 Jul 29.


Virus wars: using one virus to block the spread of another.

Paff ML, Nuismer SL, Ellington A, Molineux IJ, Bull JJ.

PeerJ. 2016 Jun 29;4:e2166. doi: 10.7717/peerj.2166. eCollection 2016.


Rapid Detection of Viable Bacillus anthracis Spores in Environmental Samples by Using Engineered Reporter Phages.

Sharp NJ, Molineux IJ, Page MA, Schofield DA.

Appl Environ Microbiol. 2016 Apr 4;82(8):2380-2387. doi: 10.1128/AEM.03772-15. Print 2016 Apr.


Structural remodeling of bacteriophage T4 and host membranes during infection initiation.

Hu B, Margolin W, Molineux IJ, Liu J.

Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4919-28. doi: 10.1073/pnas.1501064112. Epub 2015 Aug 17.


Rapid Detection of Bacillus anthracis in Complex Food Matrices Using Phage-Mediated Bioluminescence.

Sharp NJ, Vandamm JP, Molineux IJ, Schofield DA.

J Food Prot. 2015 May;78(5):963-8. doi: 10.4315/0362-028X.JFP-14-534.


Introduction to “Viruses of Microbes III” special section of Virology.

Leiman PG, Molineux IJ.

Virology. 2015 Mar;477:99. doi: 10.1016/j.virol.2015.01.001. Epub 2015 Feb 7. No abstract available.


Synergy as a rationale for phage therapy using phage cocktails.

Schmerer M, Molineux IJ, Bull JJ.

PeerJ. 2014 Sep 25;2:e590. doi: 10.7717/peerj.590. eCollection 2014.


Isolation and development of bioluminescent reporter phages for bacterial dysentery.

Schofield DA, Wray DJ, Molineux IJ.

Eur J Clin Microbiol Infect Dis. 2015 Feb;34(2):395-403. doi: 10.1007/s10096-014-2246-0. Epub 2014 Sep 25.


Challenges in predicting the evolutionary maintenance of a phage transgene.

Schmerer M, Molineux IJ, Ally D, Tyerman J, Cecchini N, Bull JJ.

J Biol Eng. 2014 Aug 1;8:21. doi: 10.1186/1754-1611-8-21. eCollection 2014.


Rapid detection and simultaneous antibiotic susceptibility analysis of Yersinia pestis directly from clinical specimens by use of reporter phage.

Vandamm JP, Rajanna C, Sharp NJ, Molineux IJ, Schofield DA.

J Clin Microbiol. 2014 Aug;52(8):2998-3003. doi: 10.1128/JCM.00316-14. Epub 2014 Jun 11.


Icosahedral bacteriophage ΦX174 forms a tail for DNA transport during infection.

Sun L, Young LN, Zhang X, Boudko SP, Fokine A, Zbornik E, Roznowski AP, Molineux IJ, Rossmann MG, Fane BA.

Nature. 2014 Jan 16;505(7483):432-5. doi: 10.1038/nature12816. Epub 2013 Dec 15.


Bacillus anthracis diagnostic detection and rapid antibiotic susceptibility determination using 'bioluminescent' reporter phage.

Schofield DA, Sharp NJ, Vandamm J, Molineux IJ, Spreng KA, Rajanna C, Westwater C, Stewart GC.

J Microbiol Methods. 2013 Nov;95(2):156-61. doi: 10.1016/j.mimet.2013.08.013. Epub 2013 Aug 28.


Exonuclease of human DNA polymerase gamma disengages its strand displacement function.

He Q, Shumate CK, White MA, Molineux IJ, Yin YW.

Mitochondrion. 2013 Nov;13(6):592-601. doi: 10.1016/j.mito.2013.08.003. Epub 2013 Aug 30.


Empirical complexities in the genetic foundations of lethal mutagenesis.

Bull JJ, Joyce P, Gladstone E, Molineux IJ.

Genetics. 2013 Oct;195(2):541-52. doi: 10.1534/genetics.113.154195. Epub 2013 Aug 9.


Evolutionarily stable attenuation by genome rearrangement in a virus.

Cecchini N, Schmerer M, Molineux IJ, Springman R, Bull JJ.

G3 (Bethesda). 2013 Aug 7;3(8):1389-97. doi: 10.1534/g3.113.006403.


Evolutionary stability of a refactored phage genome.

Springman R, Molineux IJ, Duong C, Bull RJ, Bull JJ.

ACS Synth Biol. 2012 Sep 21;1(9):425-30.


Role of osmotic and hydrostatic pressures in bacteriophage genome ejection.

Lemay SG, Panja D, Molineux IJ.

Phys Rev E Stat Nonlin Soft Matter Phys. 2013 Feb;87(2):022714. Epub 2013 Feb 20.


Popping the cork: mechanisms of phage genome ejection.

Molineux IJ, Panja D.

Nat Rev Microbiol. 2013 Mar;11(3):194-204. doi: 10.1038/nrmicro2988. Epub 2013 Feb 4. Review.


The bacteriophage t7 virion undergoes extensive structural remodeling during infection.

Hu B, Margolin W, Molineux IJ, Liu J.

Science. 2013 Feb 1;339(6119):576-9. doi: 10.1126/science.1231887. Epub 2013 Jan 10.


Introduction to special issue on viruses and microbes.

Toussaint A, Prangishvili D, Molineux IJ.

Virology. 2012 Dec 20;434(2):137. doi: 10.1016/j.virol.2012.11.006. No abstract available.


"Light-tagged" bacteriophage as a diagnostic tool for the detection of phytopathogens.

Schofield D, Bull CT, Rubio I, Wechter WP, Westwater C, Molineux IJ.

Bioengineered. 2013 Jan-Feb;4(1):50-4. doi: 10.4161/bioe.22159. Epub 2012 Sep 18.


Evolutionary principles and synthetic biology: avoiding a molecular tragedy of the commons with an engineered phage.

Gladstone EG, Molineux IJ, Bull JJ.

J Biol Eng. 2012 Sep 4;6(1):13. doi: 10.1186/1754-1611-6-13.


Evolutionary recovery of a recombinant viral genome.

Springman R, Kapadia-Desai DS, Molineux IJ, Bull JJ.

G3 (Bethesda). 2012 Jul;2(7):825-30. doi: 10.1534/g3.112.002758. Epub 2012 Jul 1.


Bacteriophage protein-protein interactions.

Häuser R, Blasche S, Dokland T, Haggård-Ljungquist E, von Brunn A, Salas M, Casjens S, Molineux I, Uetz P.

Adv Virus Res. 2012;83:219-98. doi: 10.1016/B978-0-12-394438-2.00006-2. Review.


Rapid identification and antibiotic susceptibility testing of Yersinia pestis using bioluminescent reporter phage.

Schofield DA, Molineux IJ, Westwater C.

J Microbiol Methods. 2012 Aug;90(2):80-2. doi: 10.1016/j.mimet.2012.04.019. Epub 2012 May 2.


Slow fitness recovery in a codon-modified viral genome.

Bull JJ, Molineux IJ, Wilke CO.

Mol Biol Evol. 2012 Oct;29(10):2997-3004. Epub 2012 Apr 24.


Development of an engineered bioluminescent reporter phage for detection of bacterial blight of crucifers.

Schofield DA, Bull CT, Rubio I, Wechter WP, Westwater C, Molineux IJ.

Appl Environ Microbiol. 2012 May;78(10):3592-8. doi: 10.1128/AEM.00252-12. Epub 2012 Mar 16.


Short noncontractile tail machines: adsorption and DNA delivery by podoviruses.

Casjens SR, Molineux IJ.

Adv Exp Med Biol. 2012;726:143-79. doi: 10.1007/978-1-4614-0980-9_7. Review.


Multiple genetic pathways to similar fitness limits during viral adaptation to a new host.

Nguyen AH, Molineux IJ, Springman R, Bull JJ.

Evolution. 2012 Feb;66(2):363-74. doi: 10.1111/j.1558-5646.2011.01433.x. Epub 2011 Sep 20.


In vivo growth rates are poorly correlated with phage therapy success in a mouse infection model.

Bull JJ, Otto G, Molineux IJ.

Antimicrob Agents Chemother. 2012 Feb;56(2):949-54. doi: 10.1128/AAC.05842-11. Epub 2011 Nov 21.


'Bioluminescent' reporter phage for the detection of Category A bacterial pathogens.

Schofield DA, Molineux IJ, Westwater C.

J Vis Exp. 2011 Jul 8;(53):e2740. doi: 10.3791/2740.


Atomic structure of bacteriophage Sf6 tail needle knob.

Bhardwaj A, Molineux IJ, Casjens SR, Cingolani G.

J Biol Chem. 2011 Sep 2;286(35):30867-77. doi: 10.1074/jbc.M111.260877. Epub 2011 Jun 25.


Dynamics of bacteriophage genome ejection in vitro and in vivo.

Panja D, Molineux IJ.

Phys Biol. 2010 Dec 9;7(4):045006. doi: 10.1088/1478-3975/7/4/045006.


The role of the T7 Gp2 inhibitor of host RNA polymerase in phage development.

Savalia D, Robins W, Nechaev S, Molineux I, Severinov K.

J Mol Biol. 2010 Sep 10;402(1):118-26. doi: 10.1016/j.jmb.2010.07.012. Epub 2010 Jul 19.


A single mutation in human mitochondrial DNA polymerase Pol gammaA affects both polymerization and proofreading activities of only the holoenzyme.

Lee YS, Johnson KA, Molineux IJ, Yin YW.

J Biol Chem. 2010 Sep 3;285(36):28105-16. doi: 10.1074/jbc.M110.122283. Epub 2010 May 31.


Gp15 and gp16 cooperate in translocating bacteriophage T7 DNA into the infected cell.

Chang CY, Kemp P, Molineux IJ.

Virology. 2010 Mar 15;398(2):176-86. doi: 10.1016/j.virol.2009.12.002. Epub 2009 Dec 29.


A tale of tails: Sialidase is key to success in a model of phage therapy against K1-capsulated Escherichia coli.

Bull JJ, Vimr ER, Molineux IJ.

Virology. 2010 Mar 1;398(1):79-86. doi: 10.1016/j.virol.2009.11.040. Epub 2009 Dec 16.


Evolution at a high imposed mutation rate: adaptation obscures the load in phage T7.

Springman R, Keller T, Molineux IJ, Bull JJ.

Genetics. 2010 Jan;184(1):221-32. doi: 10.1534/genetics.109.108803. Epub 2009 Oct 26.

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