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Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation.

Weber RA, Yen FS, Nicholson SPV, Alwaseem H, Bayraktar EC, Alam M, Timson RC, La K, Abu-Remaileh M, Molina H, Birsoy K.

Mol Cell. 2020 Feb 6;77(3):645-655.e7. doi: 10.1016/j.molcel.2020.01.003. Epub 2020 Jan 23.


The G3BP1-Family-USP10 Deubiquitinase Complex Rescues Ubiquitinated 40S Subunits of Ribosomes Stalled in Translation from Lysosomal Degradation.

Meyer C, Garzia A, Morozov P, Molina H, Tuschl T.

Mol Cell. 2020 Jan 20. pii: S1097-2765(19)30954-2. doi: 10.1016/j.molcel.2019.12.024. [Epub ahead of print]


Structure of an endosomal signaling GPCR-G protein-β-arrestin megacomplex.

Nguyen AH, Thomsen ARB, Cahill TJ 3rd, Huang R, Huang LY, Marcink T, Clarke OB, Heissel S, Masoudi A, Ben-Hail D, Samaan F, Dandey VP, Tan YZ, Hong C, Mahoney JP, Triest S, Little J 4th, Chen X, Sunahara R, Steyaert J, Molina H, Yu Z, des Georges A, Lefkowitz RJ.

Nat Struct Mol Biol. 2019 Dec;26(12):1123-1131. doi: 10.1038/s41594-019-0330-y. Epub 2019 Nov 18.


Non-reversible tissue fixation retains extracellular vesicles for in situ imaging.

Gupta MP, Tandalam S, Ostrager S, Lever AS, Fung AR, Hurley DD, Alegre GB, Espinal JE, Remmel HL, Mukherjee S, Levine BM, Robins RP, Molina H, Dill BD, Kenific CM, Tuschl T, Lyden D, D'Amico DJ, Pena JTG.

Nat Methods. 2019 Dec;16(12):1269-1273. doi: 10.1038/s41592-019-0623-4. Epub 2019 Nov 11.


Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis.

Rodrigues G, Hoshino A, Kenific CM, Matei IR, Steiner L, Freitas D, Kim HS, Oxley PR, Scandariato I, Casanova-Salas I, Dai J, Badwe CR, Gril B, Tešić Mark M, Dill BD, Molina H, Zhang H, Benito-Martin A, Bojmar L, Ararso Y, Offer K, LaPlant Q, Buehring W, Wang H, Jiang X, Lu TM, Liu Y, Sabari JK, Shin SJ, Narula N, Ginter PS, Rajasekhar VK, Healey JH, Meylan E, Costa-Silva B, Wang SE, Rafii S, Altorki NK, Rudin CM, Jones DR, Steeg PS, Peinado H, Ghajar CM, Bromberg J, de Sousa M, Pisapia D, Lyden D.

Nat Cell Biol. 2019 Nov;21(11):1403-1412. doi: 10.1038/s41556-019-0404-4. Epub 2019 Nov 4.


Basic suture techniques for medicine students: comparative results according to training by surgeons versus peers.

González R, Molina H, García-Huidobro M, Stevens P, Jadue A, Riquelme A, Torres J, Barra S, Alarcón F, Fasce E.

Cir Cir. 2019;87(6):624-629. doi: 10.24875/CIRU.18000771.


A deep intronic splice mutation of STAT3 underlies hyper IgE syndrome by negative dominance.

Khourieh J, Rao G, Habib T, Avery DT, Lefèvre-Utile A, Chandesris MO, Belkadi A, Chrabieh M, Alwaseem H, Grandin V, Sarrot-Reynauld F, Sénéchal A, Lortholary O, Kong XF, Boisson-Dupuis S, Picard C, Puel A, Béziat V, Zhang Q, Abel L, Molina H, Marr N, Tangye SG, Casanova JL, Boisson B.

Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16463-16472. doi: 10.1073/pnas.1901409116. Epub 2019 Jul 25.


PI31 Is an Adaptor Protein for Proteasome Transport in Axons and Required for Synaptic Development.

Liu K, Jones S, Minis A, Rodriguez J, Molina H, Steller H.

Dev Cell. 2019 Aug 19;50(4):509-524.e10. doi: 10.1016/j.devcel.2019.06.009. Epub 2019 Jul 18.


Nuclear TARBP2 Drives Oncogenic Dysregulation of RNA Splicing and Decay.

Fish L, Navickas A, Culbertson B, Xu Y, Nguyen HCB, Zhang S, Hochman M, Okimoto R, Dill BD, Molina H, Najafabadi HS, Alarcón C, Ruggero D, Goodarzi H.

Mol Cell. 2019 Sep 5;75(5):967-981.e9. doi: 10.1016/j.molcel.2019.06.001. Epub 2019 Jul 9.


Neuronally Enriched RUFY3 Is Required for Caspase-Mediated Axon Degeneration.

Hertz NT, Adams EL, Weber RA, Shen RJ, O'Rourke MK, Simon DJ, Zebroski H, Olsen O, Morgan CW, Mileur TR, Hitchcock AM, Sinnott Armstrong NA, Wainberg M, Bassik MC, Molina H, Wells JA, Tessier-Lavigne M.

Neuron. 2019 Aug 7;103(3):412-422.e4. doi: 10.1016/j.neuron.2019.05.030. Epub 2019 Jun 17.


Conformational switches control early maturation of the eukaryotic small ribosomal subunit.

Hunziker M, Barandun J, Buzovetsky O, Steckler C, Molina H, Klinge S.

Elife. 2019 Jun 17;8. pii: e45185. doi: 10.7554/eLife.45185.


Characterization of Novel Splice Variants of Zinc Finger Antiviral Protein (ZAP).

Li MMH, Aguilar EG, Michailidis E, Pabon J, Park P, Wu X, de Jong YP, Schneider WM, Molina H, Rice CM, MacDonald MR.

J Virol. 2019 Aug 28;93(18). pii: e00715-19. doi: 10.1128/JVI.00715-19. Print 2019 Sep 15.


Structural plasticity of actin-spectrin membrane skeleton and functional role of actin and spectrin in axon degeneration.

Wang G, Simon DJ, Wu Z, Belsky DM, Heller E, O'Rourke MK, Hertz NT, Molina H, Zhong G, Tessier-Lavigne M, Zhuang X.

Elife. 2019 May 1;8. pii: e38730. doi: 10.7554/eLife.38730.


Acute Colchicine-induced Neuromyopathy in a Patient Treated with Atorvastatin and Clarithromycin.

Olmos-Martínez JM, Molina H, Salas C, Olmos JM, Hernández JL.

Eur J Case Rep Intern Med. 2019 Mar 18;6(3):001066. doi: 10.12890/2019_001066. eCollection 2019.


Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3.

Farrelly LA, Thompson RE, Zhao S, Lepack AE, Lyu Y, Bhanu NV, Zhang B, Loh YE, Ramakrishnan A, Vadodaria KC, Heard KJ, Erikson G, Nakadai T, Bastle RM, Lukasak BJ, Zebroski H 3rd, Alenina N, Bader M, Berton O, Roeder RG, Molina H, Gage FH, Shen L, Garcia BA, Li H, Muir TW, Maze I.

Nature. 2019 Mar;567(7749):535-539. doi: 10.1038/s41586-019-1024-7. Epub 2019 Mar 13.


CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4.

Zhu XG, Nicholson Puthenveedu S, Shen Y, La K, Ozlu C, Wang T, Klompstra D, Gultekin Y, Chi J, Fidelin J, Peng T, Molina H, Hang HC, Min W, Birsoy K.

Mol Cell. 2019 Apr 4;74(1):45-58.e7. doi: 10.1016/j.molcel.2019.01.037. Epub 2019 Mar 4.


Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity.

Dallner OS, Marinis JM, Lu YH, Birsoy K, Werner E, Fayzikhodjaeva G, Dill BD, Molina H, Moscati A, Kutalik Z, Marques-Vidal P, Kilpeläinen TO, Grarup N, Linneberg A, Zhang Y, Vaughan R, Loos RJF, Lazar MA, Friedman JM.

Nat Med. 2019 Mar;25(3):507-516. doi: 10.1038/s41591-019-0370-1. Epub 2019 Mar 6.


Cost-Effectiveness of a Guided Peripherally Inserted Central Catheter Placement System: A Single-Center Cohort Study.

Keller EJ, Aragona E, Molina H, Lee J, Salem R, Resnick SA, Chrisman H, Collins JD.

J Vasc Interv Radiol. 2019 May;30(5):709-714. doi: 10.1016/j.jvir.2018.07.032. Epub 2019 Feb 15.


Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors.

Li H, Saucedo-Cuevas L, Yuan L, Ross D, Johansen A, Sands D, Stanley V, Guemez-Gamboa A, Gregor A, Evans T, Chen S, Tan L, Molina H, Sheets N, Shiryaev SA, Terskikh AV, Gladfelter AS, Shresta S, Xu Z, Gleeson JG.

Neuron. 2019 Mar 20;101(6):1089-1098.e4. doi: 10.1016/j.neuron.2019.01.010. Epub 2019 Jan 31.


Functional Peptide Nanofibers with Unique Tumor Targeting and Enzyme-Induced Local Retention Properties.

Bellat V, Ting R, Southard TL, Vahdat L, Molina H, Fernandez J, Aras O, Stokol T, Law B.

Adv Funct Mater. 2018 Oct 31;28(44). pii: 1803969. doi: 10.1002/adfm.201803969. Epub 2018 Sep 14.


Bioorthogonal Profiling of a Cancer Cell Proteome Identifies a Large Set of 3-Bromopyruvate Targets beyond Glycolysis.

Darabedian N, Chen TC, Molina H, Pratt MR, Schönthal AH.

ACS Chem Biol. 2018 Nov 16;13(11):3054-3058. doi: 10.1021/acschembio.8b00743. Epub 2018 Nov 7.


Author Correction: Retinal progenitor cells release extracellular vesicles containing developmental transcription factors, microRNA and membrane proteins.

Zhou J, Benito-Martin A, Mighty J, Chang L, Ghoroghi S, Wu H, Wong M, Guariglia S, Baranov P, Young M, Gharbaran R, Emerson M, Mark MT, Molina H, Canto-Soler MV, Selgas HP, Redenti S.

Sci Rep. 2018 Oct 22;8(1):15801. doi: 10.1038/s41598-018-32118-6.


Publisher Correction: Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours.

Garcia-Bermudez J, Baudrier L, La K, Zhu XG, Fidelin J, Sviderskiy VO, Papagiannakopoulos T, Molina H, Snuderl M, Lewis CA, Possemato RL, Birsoy K.

Nat Cell Biol. 2018 Oct;20(10):1228. doi: 10.1038/s41556-018-0184-2.


Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours.

Garcia-Bermudez J, Baudrier L, La K, Zhu XG, Fidelin J, Sviderskiy VO, Papagiannakopoulos T, Molina H, Snuderl M, Lewis CA, Possemato RL, Birsoy K.

Nat Cell Biol. 2018 Jul;20(7):775-781. doi: 10.1038/s41556-018-0118-z. Epub 2018 Jun 25. Erratum in: Nat Cell Biol. 2018 Oct;20(10):1228.


Cdc42 Regulates Neuronal Polarity during Cerebellar Axon Formation and Glial-Guided Migration.

Govek EE, Wu Z, Acehan D, Molina H, Rivera K, Zhu X, Fang Y, Tessier-Lavigne M, Hatten ME.

iScience. 2018 Mar 23;1:35-48. doi: 10.1016/j.isci.2018.01.004.


Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites.

Thinon E, Fernandez JP, Molina H, Hang HC.

J Proteome Res. 2018 May 4;17(5):1907-1922. doi: 10.1021/acs.jproteome.8b00002. Epub 2018 Apr 6.


Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation.

Zhang H, Freitas D, Kim HS, Fabijanic K, Li Z, Chen H, Mark MT, Molina H, Martin AB, Bojmar L, Fang J, Rampersaud S, Hoshino A, Matei I, Kenific CM, Nakajima M, Mutvei AP, Sansone P, Buehring W, Wang H, Jimenez JP, Cohen-Gould L, Paknejad N, Brendel M, Manova-Todorova K, Magalhães A, Ferreira JA, Osório H, Silva AM, Massey A, Cubillos-Ruiz JR, Galletti G, Giannakakou P, Cuervo AM, Blenis J, Schwartz R, Brady MS, Peinado H, Bromberg J, Matsui H, Reis CA, Lyden D.

Nat Cell Biol. 2018 Mar;20(3):332-343. doi: 10.1038/s41556-018-0040-4. Epub 2018 Feb 19.


Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens.

Hover BM, Kim SH, Katz M, Charlop-Powers Z, Owen JG, Ternei MA, Maniko J, Estrela AB, Molina H, Park S, Perlin DS, Brady SF.

Nat Microbiol. 2018 Apr;3(4):415-422. doi: 10.1038/s41564-018-0110-1. Epub 2018 Feb 12.


Retinal progenitor cells release extracellular vesicles containing developmental transcription factors, microRNA and membrane proteins.

Zhou J, Benito-Martin A, Mighty J, Chang L, Ghoroghi S, Wu H, Wong M, Guariglia S, Baranov P, Young M, Gharbaran R, Emerson M, Mark MT, Molina H, Canto-Soler MV, Selgas HP, Redenti S.

Sci Rep. 2018 Feb 12;8(1):2823. doi: 10.1038/s41598-018-20421-1. Erratum in: Sci Rep. 2018 Oct 22;8(1):15801.


The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression.

Meyer C, Garzia A, Mazzola M, Gerstberger S, Molina H, Tuschl T.

Mol Cell. 2018 Feb 15;69(4):622-635.e6. doi: 10.1016/j.molcel.2018.01.011.


Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation.

Sabari BR, Tang Z, Huang H, Yong-Gonzalez V, Molina H, Kong HE, Dai L, Shimada M, Cross JR, Zhao Y, Roeder RG, Allis CD.

Mol Cell. 2018 Feb 1;69(3):533. doi: 10.1016/j.molcel.2018.01.013. No abstract available.


IKKβ is a β-catenin kinase that regulates mesenchymal stem cell differentiation.

Sui Y, Liu Z, Park SH, Thatcher SE, Zhu B, Fernandez JP, Molina H, Kern PA, Zhou C.

JCI Insight. 2018 Jan 25;3(2). pii: 96660. doi: 10.1172/jci.insight.96660. eCollection 2018 Jan 25.


Extracellular matrix proteins and carcinoembryonic antigen-related cell adhesion molecules characterize pancreatic duct fluid exosomes in patients with pancreatic cancer.

Zheng J, Hernandez JM, Doussot A, Bojmar L, Zambirinis CP, Costa-Silva B, van Beek EJAH, Mark MT, Molina H, Askan G, Basturk O, Gonen M, Kingham TP, Allen PJ, D'Angelica MI, DeMatteo RP, Lyden D, Jarnagin WR.

HPB (Oxford). 2018 Jul;20(7):597-604. doi: 10.1016/j.hpb.2017.12.010. Epub 2018 Jan 12.


αIIbβ3 binding to a fibrinogen fragment lacking the γ-chain dodecapeptide is activation dependent and EDTA inducible.

Zafar H, Shang Y, Li J, David GA 3rd, Fernandez JP, Molina H, Filizola M, Coller BS.

Blood Adv. 2017 Feb 22;1(7):417-428. doi: 10.1182/bloodadvances.2017004689. eCollection 2017 Feb 28.


A Peptide Signaling System that Rapidly Enforces Paternity in the Aedes aegypti Mosquito.

Duvall LB, Basrur NS, Molina H, McMeniman CJ, Vosshall LB.

Curr Biol. 2017 Dec 4;27(23):3734-3742.e5. doi: 10.1016/j.cub.2017.10.074. Epub 2017 Nov 22.


Draft Nuclear Genome Sequence of the Halophilic and Beta-Carotene-Accumulating Green Alga Dunaliella salina Strain CCAP19/18.

Polle JEW, Barry K, Cushman J, Schmutz J, Tran D, Hathwaik LT, Yim WC, Jenkins J, McKie-Krisberg Z, Prochnik S, Lindquist E, Dockter RB, Adam C, Molina H, Bunkenborg J, Jin E, Buchheim M, Magnuson J.

Genome Announc. 2017 Oct 26;5(43). pii: e01105-17. doi: 10.1128/genomeA.01105-17.


The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity.

Yi W, Gupta S, Ricker E, Manni M, Jessberger R, Chinenov Y, Molina H, Pernis AB.

Nat Commun. 2017 Aug 15;8(1):254. doi: 10.1038/s41467-017-00348-3.


The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.

Garzia A, Jafarnejad SM, Meyer C, Chapat C, Gogakos T, Morozov P, Amiri M, Shapiro M, Molina H, Tuschl T, Sonenberg N.

Nat Commun. 2017 Jul 7;8:16056. doi: 10.1038/ncomms16056.


Blocking FSH induces thermogenic adipose tissue and reduces body fat.

Liu P, Ji Y, Yuen T, Rendina-Ruedy E, DeMambro VE, Dhawan S, Abu-Amer W, Izadmehr S, Zhou B, Shin AC, Latif R, Thangeswaran P, Gupta A, Li J, Shnayder V, Robinson ST, Yu YE, Zhang X, Yang F, Lu P, Zhou Y, Zhu LL, Oberlin DJ, Davies TF, Reagan MR, Brown A, Kumar TR, Epstein S, Iqbal J, Avadhani NG, New MI, Molina H, van Klinken JB, Guo EX, Buettner C, Haider S, Bian Z, Sun L, Rosen CJ, Zaidi M.

Nature. 2017 Jun 1;546(7656):107-112. doi: 10.1038/nature22342. Epub 2017 May 24.


Fumarase Deficiency Causes Protein and Metabolite Succination and Intoxicates Mycobacterium tuberculosis.

Ruecker N, Jansen R, Trujillo C, Puckett S, Jayachandran P, Piroli GG, Frizzell N, Molina H, Rhee KY, Ehrt S.

Cell Chem Biol. 2017 Mar 16;24(3):306-315. doi: 10.1016/j.chembiol.2017.01.005. Epub 2017 Feb 16.


Chemical proteomics reveals ADP-ribosylation of small GTPases during oxidative stress.

Westcott NP, Fernandez JP, Molina H, Hang HC.

Nat Chem Biol. 2017 Mar;13(3):302-308. doi: 10.1038/nchembio.2280. Epub 2017 Jan 16.


Translation from unconventional 5' start sites drives tumour initiation.

Sendoel A, Dunn JG, Rodriguez EH, Naik S, Gomez NC, Hurwitz B, Levorse J, Dill BD, Schramek D, Molina H, Weissman JS, Fuchs E.

Nature. 2017 Jan 26;541(7638):494-499. doi: 10.1038/nature21036. Epub 2017 Jan 11.


TRIM25 Enhances the Antiviral Action of Zinc-Finger Antiviral Protein (ZAP).

Li MM, Lau Z, Cheung P, Aguilar EG, Schneider WM, Bozzacco L, Molina H, Buehler E, Takaoka A, Rice CM, Felsenfeld DP, MacDonald MR.

PLoS Pathog. 2017 Jan 6;13(1):e1006145. doi: 10.1371/journal.ppat.1006145. eCollection 2017 Jan.


High-Titer Rheumatoid Arthritis Antibodies Preferentially Bind Fibrinogen Citrullinated by Peptidylarginine Deiminase 4.

Blachère NE, Parveen S, Frank MO, Dill BD, Molina H, Orange DE.

Arthritis Rheumatol. 2017 May;69(5):986-995. doi: 10.1002/art.40035.


Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion.

Hong S, Zhou W, Fang B, Lu W, Loro E, Damle M, Ding G, Jager J, Zhang S, Zhang Y, Feng D, Chu Q, Dill BD, Molina H, Khurana TS, Rabinowitz JD, Lazar MA, Sun Z.

Nat Med. 2017 Feb;23(2):223-234. doi: 10.1038/nm.4245. Epub 2016 Dec 19.


BspK, a Serine Protease from the Predatory Bacterium Bdellovibrio bacteriovorus with Utility for Analysis of Therapeutic Antibodies.

Bratanis E, Molina H, Naegeli A, Collin M, Lood R.

Appl Environ Microbiol. 2017 Feb 1;83(4). pii: e03037-16. doi: 10.1128/AEM.03037-16. Print 2017 Feb 15.


PIC Activation through Functional Interplay between Mediator and TFIIH.

Malik S, Molina H, Xue Z.

J Mol Biol. 2017 Jan 6;429(1):48-63. doi: 10.1016/j.jmb.2016.11.026. Epub 2016 Dec 1.


Aberrant H3.3 dynamics in NAc promote vulnerability to depressive-like behavior.

Lepack AE, Bagot RC, Peña CJ, Loh YE, Farrelly LA, Lu Y, Powell SK, Lorsch ZS, Issler O, Cates HM, Tamminga CA, Molina H, Shen L, Nestler EJ, Allis CD, Maze I.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12562-12567. Epub 2016 Oct 18.


Chromatin Kinases Act on Transcription Factors and Histone Tails in Regulation of Inducible Transcription.

Josefowicz SZ, Shimada M, Armache A, Li CH, Miller RM, Lin S, Yang A, Dill BD, Molina H, Park HS, Garcia BA, Taunton J, Roeder RG, Allis CD.

Mol Cell. 2016 Oct 20;64(2):347-361. doi: 10.1016/j.molcel.2016.09.026.

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