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Items: 1 to 50 of 237

1.

Aptamer Efficacies for In Vitro and In Vivo Modulation of αC-Conotoxin PrXA Pharmacology.

Taiwe GS, Montnach J, Nicolas S, De Waard S, Fiore E, Peyrin E, El-Aziz TMA, Amar M, Molgó J, Ronjat M, Servent D, Ravelet C, De Waard M.

Molecules. 2019 Jan 9;24(2). pii: E229. doi: 10.3390/molecules24020229.

2.

23rd and 24th Meetings of the French society of toxinology (SFET): Special issue on "Toxins: Immunity, inflammation and pain".

Benoit E, Barbier J, Molgó J.

Toxicon. 2018 Jul;149:1-5. doi: 10.1016/j.toxicon.2018.04.020. Epub 2018 Apr 25. No abstract available.

PMID:
30008289
3.

Inositol trisphosphate receptor-mediated Ca2+ signalling stimulates mitochondrial function and gene expression in core myopathy patients.

Suman M, Sharpe JA, Bentham RB, Kotiadis VN, Menegollo M, Pignataro V, Molgó J, Muntoni F, Duchen MR, Pegoraro E, Szabadkai G.

Hum Mol Genet. 2018 Jul 1;27(13):2367-2382. doi: 10.1093/hmg/ddy149.

4.

Prorocentrolide-A from Cultured Prorocentrum lima Dinoflagellates Collected in Japan Blocks Sub-Types of Nicotinic Acetylcholine Receptors.

Amar M, Aráoz R, Iorga BI, Yasumoto T, Servent D, Molgó J.

Toxins (Basel). 2018 Feb 28;10(3). pii: E97. doi: 10.3390/toxins10030097.

5.

Direct evidence for high affinity blockade of NaV1.6 channel subtype by huwentoxin-IV spider peptide, using multiscale functional approaches.

Gonçalves TC, Boukaiba R, Molgó J, Amar M, Partiseti M, Servent D, Benoit E.

Neuropharmacology. 2018 May 1;133:404-414. doi: 10.1016/j.neuropharm.2018.02.016. Epub 2018 Feb 21.

PMID:
29474819
6.

A precise measurement of the magnetic field in the corona of the black hole binary V404 Cygni.

Dallilar Y, Eikenberry SS, Garner A, Stelter RD, Gottlieb A, Gandhi P, Casella P, Dhillon VS, Marsh TR, Littlefair SP, Hardy L, Fender R, Mooley K, Walton DJ, Fuerst F, Bachetti M, Castro-Tirado AJ, Charcos M, Edwards ML, Lasso-Cabrera NM, Marin-Franch A, Raines SN, Ackley K, Bennett JG, Cenarro AJ, Chinn B, Donoso HV, Frommeyer R, Hanna K, Herlevich MD, Julian J, Miller P, Mullin S, Murphey CH, Packham C, Varosi F, Vega C, Warner C, Ramaprakash AN, Burse M, Punnadi S, Chordia P, Gerarts A, de Paz Martín H, Calero MM, Scarpa R, Acosta SF, Hernández Sánchez WM, Siegel B, Pérez FF, Viera Martín HD, Rodríguez Losada JA, Nuñez A, Tejero Á, Martín González CE, Rodríguez CC, Molgó J, Rodriguez JE, Cáceres JIF, Rodríguez García LA, Lopez MH, Dominguez R, Gaggstatter T, Lavers AC, Geier S, Pessev P, Sarajedini A.

Science. 2017 Dec 8;358(6368):1299-1302. doi: 10.1126/science.aan0249. Erratum in: Science. 2018 Apr 20;360(6386):.

7.

Efficient functional neutralization of lethal peptide toxins in vivo by oligonucleotides.

El-Aziz TMA, Ravelet C, Molgo J, Fiore E, Pale S, Amar M, Al-Khoury S, Dejeu J, Fadl M, Ronjat M, Taiwe GS, Servent D, Peyrin E, De Waard M.

Sci Rep. 2017 Aug 3;7(1):7202. doi: 10.1038/s41598-017-07554-5.

8.

Ostreolysin A/Pleurotolysin B and Equinatoxins: Structure, Function and Pathophysiological Effects of These Pore-Forming Proteins.

Frangež R, Šuput D, Molgó J, Benoit E.

Toxins (Basel). 2017 Apr 5;9(4). pii: E128. doi: 10.3390/toxins9040128. Review.

9.

Cyclic imine toxins from dinoflagellates: a growing family of potent antagonists of the nicotinic acetylcholine receptors.

Molgó J, Marchot P, Aráoz R, Benoit E, Iorga BI, Zakarian A, Taylor P, Bourne Y, Servent D.

J Neurochem. 2017 Aug;142 Suppl 2:41-51. doi: 10.1111/jnc.13995. Epub 2017 Mar 21. Review.

10.

The Dinoflagellate Toxin 20-Methyl Spirolide-G Potently Blocks Skeletal Muscle and Neuronal Nicotinic Acetylcholine Receptors.

Couesnon A, Aráoz R, Iorga BI, Benoit E, Reynaud M, Servent D, Molgó J.

Toxins (Basel). 2016 Aug 24;8(9). pii: E249. doi: 10.3390/toxins8090249.

11.

Selective Vulnerability of Cancer Cells by Inhibition of Ca(2+) Transfer from Endoplasmic Reticulum to Mitochondria.

Cárdenas C, Müller M, McNeal A, Lovy A, Jaňa F, Bustos G, Urra F, Smith N, Molgó J, Diehl JA, Ridky TW, Foskett JK.

Cell Rep. 2016 Apr 5;15(1):219-220. doi: 10.1016/j.celrep.2016.03.045. No abstract available.

12.

Special Issue on "Toxins: New targets and new functions".

Benoit E, Barbier J, Popoff MR, Faure G, Molgó J, Servent D.

Toxicon. 2016 Jun 15;116:1-3. doi: 10.1016/j.toxicon.2016.03.012. Epub 2016 Mar 17. No abstract available.

PMID:
26996493
13.

Neuromuscular junction immaturity and muscle atrophy are hallmarks of the ColQ-deficient mouse, a model of congenital myasthenic syndrome with acetylcholinesterase deficiency.

Sigoillot SM, Bourgeois F, Karmouch J, Molgó J, Dobbertin A, Chevalier C, Houlgatte R, Léger J, Legay C.

FASEB J. 2016 Jun;30(6):2382-99. doi: 10.1096/fj.201500162. Epub 2016 Mar 18.

PMID:
26993635
14.

Selective Vulnerability of Cancer Cells by Inhibition of Ca(2+) Transfer from Endoplasmic Reticulum to Mitochondria.

Cárdenas C, Müller M, McNeal A, Lovy A, Jaňa F, Bustos G, Urra F, Smith N, Molgó J, Diehl JA, Ridky TW, Foskett JK.

Cell Rep. 2016 Mar 15;14(10):2313-24. doi: 10.1016/j.celrep.2016.02.030. Epub 2016 Mar 3. Erratum in: Cell Rep. 2016 Apr 5;15(1):219-20.

15.

Epithelial-mesenchymal transition, IP3 receptors and ER-PM junctions: translocation of Ca2+ signalling complexes and regulation of migration.

Okeke E, Parker T, Dingsdale H, Concannon M, Awais M, Voronina S, Molgó J, Begg M, Metcalf D, Knight AE, Sutton R, Haynes L, Tepikin AV.

Biochem J. 2016 Mar 15;473(6):757-67. doi: 10.1042/BJ20150364. Epub 2016 Jan 12.

16.

Sympathetic innervation controls homeostasis of neuromuscular junctions in health and disease.

Khan MM, Lustrino D, Silveira WA, Wild F, Straka T, Issop Y, O'Connor E, Cox D, Reischl M, Marquardt T, Labeit D, Labeit S, Benoit E, Molgó J, Lochmüller H, Witzemann V, Kettelhut IC, Navegantes LC, Pozzan T, Rudolf R.

Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):746-50. doi: 10.1073/pnas.1524272113. Epub 2016 Jan 5. Erratum in: Proc Natl Acad Sci U S A. 2017 Jun 19;:.

17.

HERPUD1 protects against oxidative stress-induced apoptosis through downregulation of the inositol 1,4,5-trisphosphate receptor.

Paredes F, Parra V, Torrealba N, Navarro-Marquez M, Gatica D, Bravo-Sagua R, Troncoso R, Pennanen C, Quiroga C, Chiong M, Caesar C, Taylor WR, Molgó J, San Martin A, Jaimovich E, Lavandero S.

Free Radic Biol Med. 2016 Jan;90:206-18. doi: 10.1016/j.freeradbiomed.2015.11.024. Epub 2015 Nov 23.

18.

Translocation and dissemination to target neurons of botulinum neurotoxin type B in the mouse intestinal wall.

Connan C, Varela-Chavez C, Mazuet C, Molgó J, Haustant GM, Disson O, Lecuit M, Vandewalle A, Popoff MR.

Cell Microbiol. 2016 Feb;18(2):282-301. doi: 10.1111/cmi.12502. Epub 2015 Sep 18.

19.

MCUR1 is an essential component of mitochondrial Ca(2+) uptake that regulates cellular metabolism.

Mallilankaraman K, Cárdenas C, Doonan PJ, Chandramoorthy HC, Irrinki KM, Golenár T, Csordás G, Madireddi P, Yang J, Müller M, Miller R, Kolesar JE, Molgó J, Kaufman B, Hajnóczky G, Foskett JK, Madesh M.

Nat Cell Biol. 2015 Jul;17(7):953. doi: 10.1038/ncb3202. No abstract available.

PMID:
26123113
20.

The Neurotoxic Effect of 13,19-Didesmethyl and 13-Desmethyl Spirolide C Phycotoxins Is Mainly Mediated by Nicotinic Rather Than Muscarinic Acetylcholine Receptors.

Aráoz R, Ouanounou G, Iorga BI, Goudet A, Alili D, Amar M, Benoit E, Molgó J, Servent D.

Toxicol Sci. 2015 Sep;147(1):156-67. doi: 10.1093/toxsci/kfv119. Epub 2015 Jun 10.

PMID:
26063663
21.

Marine Macrocyclic Imines, Pinnatoxins A and G: Structural Determinants and Functional Properties to Distinguish Neuronal α7 from Muscle α1(2)βγδ nAChRs.

Bourne Y, Sulzenbacher G, Radić Z, Aráoz R, Reynaud M, Benoit E, Zakarian A, Servent D, Molgó J, Taylor P, Marchot P.

Structure. 2015 Jun 2;23(6):1106-15. doi: 10.1016/j.str.2015.04.009. Epub 2015 May 21.

22.

MuSK frizzled-like domain is critical for mammalian neuromuscular junction formation and maintenance.

Messéant J, Dobbertin A, Girard E, Delers P, Manuel M, Mangione F, Schmitt A, Le Denmat D, Molgó J, Zytnicki D, Schaeffer L, Legay C, Strochlic L.

J Neurosci. 2015 Mar 25;35(12):4926-41. doi: 10.1523/JNEUROSCI.3381-14.2015.

23.

Endoplasmic reticulum Ca(2+) content decrease by PKA-dependent hyperphosphorylation of type 1 IP3 receptor contributes to prostate cancer cell resistance to androgen deprivation.

Boutin B, Tajeddine N, Monaco G, Molgo J, Vertommen D, Rider M, Parys JB, Bultynck G, Gailly P.

Cell Calcium. 2015 Apr;57(4):312-20. doi: 10.1016/j.ceca.2015.02.004. Epub 2015 Feb 18.

PMID:
25740420
24.

Ryanodine and inositol triphosphate receptors modulate facilitation and tetanic depression at the frog neuromuscular junction.

Silveira PE, Lima RF, Guimarães JD, Molgó J, Naves LA, Kushmerick C.

Muscle Nerve. 2015 Oct;52(4):623-30. doi: 10.1002/mus.24571. Epub 2015 Jul 2.

PMID:
25600698
25.

Special Issue on "freshwater and marine toxins".

Benoit E, Mattei C, Barbier J, Marchot P, Molgó J, Servent D.

Toxicon. 2014 Dec;91:1-4. doi: 10.1016/j.toxicon.2014.11.217. Epub 2014 Nov 20. No abstract available.

PMID:
25456567
26.

Isolation, purification and functional characterization of alpha-BnIA from Conus bandanus venom.

Nguyen B, Le Caer JP, Aráoz R, Thai R, Lamthanh H, Benoit E, Molgó J.

Toxicon. 2014 Dec;91:155-63. doi: 10.1016/j.toxicon.2014.10.006. Epub 2014 Oct 15.

PMID:
25449095
27.

Synthesis and biology of cyclic imine toxins, an emerging class of potent, globally distributed marine toxins.

Stivala CE, Benoit E, Aráoz R, Servent D, Novikov A, Molgó J, Zakarian A.

Nat Prod Rep. 2015 Mar;32(3):411-35. doi: 10.1039/c4np00089g. Review.

28.

Colorimetric microtiter plate receptor-binding assay for the detection of freshwater and marine neurotoxins targeting the nicotinic acetylcholine receptors.

Rubio F, Kamp L, Carpino J, Faltin E, Loftin K, Molgó J, Aráoz R.

Toxicon. 2014 Dec;91:45-56. doi: 10.1016/j.toxicon.2014.08.073. Epub 2014 Sep 27.

PMID:
25260255
29.

Involvement of both sodium influx and potassium efflux in ciguatoxin-induced nodal swelling of frog myelinated axons.

Mattei C, Molgó J, Benoit E.

Neuropharmacology. 2014 Oct;85:417-26. doi: 10.1016/j.neuropharm.2014.06.001. Epub 2014 Jun 17.

PMID:
24950451
30.

Characterization of a novel Conus bandanus conopeptide belonging to the M-superfamily containing bromotryptophan.

Nguyen B, Caer JP, Mourier G, Thai R, Lamthanh H, Servent D, Benoit E, Molgó J.

Mar Drugs. 2014 Jun 5;12(6):3449-65. doi: 10.3390/md12063449.

31.

Bcl-2 binds to and inhibits ryanodine receptors.

Vervliet T, Decrock E, Molgó J, Sorrentino V, Missiaen L, Leybaert L, De Smedt H, Kasri NN, Parys JB, Bultynck G.

J Cell Sci. 2014 Jun 15;127(Pt 12):2782-92. doi: 10.1242/jcs.150011. Epub 2014 Apr 24.

32.

Detection of anatoxin-a and three analogs in Anabaena spp. cultures: new fluorescence polarization assay and toxin profile by LC-MS/MS.

Sanchez JA, Otero P, Alfonso A, Ramos V, Vasconcelos V, Aráoz R, Molgó J, Vieytes MR, Botana LM.

Toxins (Basel). 2014 Jan 24;6(2):402-15. doi: 10.3390/toxins6020402.

33.

Toxic c17-sphinganine analogue mycotoxin, contaminating tunisian mussels, causes flaccid paralysis in rodents.

Marrouchi R, Benoit E, Le Caer JP, Belayouni N, Belghith H, Molgó J, Kharrat R.

Mar Drugs. 2013 Nov 28;11(12):4724-40. doi: 10.3390/md11124724.

34.

A roadmap for hazard monitoring and risk assessment of marine biotoxins on the basis of chemical and biological test systems.

Daneshian M, Botana LM, Dechraoui Bottein MY, Buckland G, Campàs M, Dennison N, Dickey RW, Diogène J, Fessard V, Hartung T, Humpage A, Leist M, Molgó J, Quilliam MA, Rovida C, Suarez-Isla BA, Tubaro A, Wagner K, Zoller O, Dietrich D.

ALTEX. 2013;30(4):487-545. doi: 10.14573/altex.2013.4.487. Review.

35.

Analysis of the action of gymnodimine-A and 13-desmethyl spirolide C on the mouse neuromuscular system in vivo.

Marrouchi R, Rome G, Kharrat R, Molgó J, Benoit E.

Toxicon. 2013 Dec 1;75:27-34. doi: 10.1016/j.toxicon.2013.08.050. Epub 2013 Aug 15.

PMID:
23954513
36.

Special issue on «Toxins: from threats to benefits».

Martin-Eauclaire MF, Benoit E, Marchot P, Barbier J, Molgó J, Servent D.

Toxicon. 2013 Dec 1;75:1-2. doi: 10.1016/j.toxicon.2013.08.001. Epub 2013 Aug 6. No abstract available.

PMID:
23927926
37.

Physical and virtual screening methods for marine toxins and drug discovery targeting nicotinic acetylcholine receptors.

Molgó J, Aráoz R, Benoit E, Iorga BI.

Expert Opin Drug Discov. 2013 Oct;8(10):1203-23. doi: 10.1517/17460441.2013.822365. Epub 2013 Aug 6. Review.

PMID:
23919818
38.

High-throughput receptor-based assay for the detection of spirolides by chemiluminescence.

Rodríguez LP, Vilariño N, Molgó J, Aráoz R, Botana LM.

Toxicon. 2013 Dec 1;75:35-43. doi: 10.1016/j.toxicon.2013.06.015. Epub 2013 Jul 1.

PMID:
23827412
39.

High accuracy mass spectrometry comparison of Conus bandanus and Conus marmoreus venoms from the South Central Coast of Vietnam.

Nguyen B, Molgó J, Lamthanh H, Benoit E, Khuc TA, Ngo DN, Nguyen NT, Millares P, Le Caer JP.

Toxicon. 2013 Dec 1;75:148-59. doi: 10.1016/j.toxicon.2013.06.005. Epub 2013 Jun 21.

PMID:
23792454
40.

Pinnatoxin G is responsible for atypical toxicity in mussels (Mytilus galloprovincialis) and clams (Venerupis decussata) from Ingril, a French Mediterranean lagoon.

Hess P, Abadie E, Hervé F, Berteaux T, Séchet V, Aráoz R, Molgó J, Zakarian A, Sibat M, Rundberget T, Miles CO, Amzil Z.

Toxicon. 2013 Dec 1;75:16-26. doi: 10.1016/j.toxicon.2013.05.001. Epub 2013 May 30.

41.

IP3R2 levels dictate the apoptotic sensitivity of diffuse large B-cell lymphoma cells to an IP3R-derived peptide targeting the BH4 domain of Bcl-2.

Akl H, Monaco G, La Rovere R, Welkenhuyzen K, Kiviluoto S, Vervliet T, Molgó J, Distelhorst CW, Missiaen L, Mikoshiba K, Parys JB, De Smedt H, Bultynck G.

Cell Death Dis. 2013 May 16;4:e632. doi: 10.1038/cddis.2013.140.

42.

Identification and functional characterization of a novel α-conotoxin (EIIA) from Conus ermineus.

Quinton L, Servent D, Girard E, Molgó J, Le Caer JP, Malosse C, Haidar el A, Lecoq A, Gilles N, Chamot-Rooke J.

Anal Bioanal Chem. 2013 Jun;405(15):5341-51. doi: 10.1007/s00216-013-6926-x. Epub 2013 Apr 14.

PMID:
23584713
43.

CLIPR-59: a protein essential for neuromuscular junction stability during mouse late embryonic development.

Couesnon A, Offner N, Bernard V, Chaverot N, Backer S, Dimitrov A, Perez F, Molgó J, Bloch-Gallego E.

Development. 2013 Apr;140(7):1583-93. doi: 10.1242/dev.087106. Erratum in: Development. 2013 Jun;140(11):2444.

44.

Botulinum neurotoxin type A is internalized and translocated from small synaptic vesicles at the neuromuscular junction.

Colasante C, Rossetto O, Morbiato L, Pirazzini M, Molgó J, Montecucco C.

Mol Neurobiol. 2013 Aug;48(1):120-7. doi: 10.1007/s12035-013-8423-9. Epub 2013 Mar 8.

PMID:
23471747
45.

Development of a solid-phase receptor-based assay for the detection of cyclic imines using a microsphere-flow cytometry system.

Rodríguez LP, Vilariño N, Molgó J, Aráoz R, Louzao MC, Taylor P, Talley T, Botana LM.

Anal Chem. 2013 Feb 19;85(4):2340-7. doi: 10.1021/ac3033432. Epub 2013 Feb 7.

46.

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism.

Mallilankaraman K, Cárdenas C, Doonan PJ, Chandramoorthy HC, Irrinki KM, Golenár T, Csordás G, Madireddi P, Yang J, Müller M, Miller R, Kolesar JE, Molgó J, Kaufman B, Hajnóczky G, Foskett JK, Madesh M.

Nat Cell Biol. 2012 Dec;14(12):1336-43. doi: 10.1038/ncb2622. Epub 2012 Nov 25. Erratum in: Nat Cell Biol. 2015 Jul;17(7):953. Nat Cell Biol. 2013 Jan;15(1):123.

47.

Toxicity of the synthetic polymeric 3-alkylpyridinium salt (APS3) is due to specific block of nicotinic acetylcholine receptors.

Grandič M, Aráoz R, Molgó J, Turk T, Sepčić K, Benoit E, Frangež R.

Toxicology. 2013 Jan 7;303:25-33. doi: 10.1016/j.tox.2012.10.013. Epub 2012 Nov 9.

PMID:
23146756
48.

Coupling the Torpedo microplate-receptor binding assay with mass spectrometry to detect cyclic imine neurotoxins.

Aráoz R, Ramos S, Pelissier F, Guérineau V, Benoit E, Vilariño N, Botana LM, Zakarian A, Molgó J.

Anal Chem. 2012 Dec 4;84(23):10445-53. doi: 10.1021/ac3027564. Epub 2012 Nov 21.

49.

Stability of cyclic imine toxins: interconversion of pinnatoxin amino ketone and pinnatoxin A in aqueous media.

Jackson JJ, Stivala CE, Iorga BI, Molgó J, Zakarian A.

J Org Chem. 2012 Nov 16;77(22):10435-40. doi: 10.1021/jo301632d. Epub 2012 Nov 6.

50.

MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival.

Mallilankaraman K, Doonan P, Cárdenas C, Chandramoorthy HC, Müller M, Miller R, Hoffman NE, Gandhirajan RK, Molgó J, Birnbaum MJ, Rothberg BS, Mak DO, Foskett JK, Madesh M.

Cell. 2012 Oct 26;151(3):630-44. doi: 10.1016/j.cell.2012.10.011.

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