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Identification of LPS-Activated Endothelial Subpopulations With Distinct Inflammatory Phenotypes and Regulatory Signaling Mechanisms.

Dayang EZ, Plantinga J, Ter Ellen B, van Meurs M, Molema G, Moser J.

Front Immunol. 2019 May 24;10:1169. doi: 10.3389/fimmu.2019.01169. eCollection 2019.


Kidney histopathology in lethal human sepsis.

Aslan A, van den Heuvel MC, Stegeman CA, Popa ER, Leliveld AM, Molema G, Zijlstra JG, Moser J, van Meurs M.

Crit Care. 2018 Dec 27;22(1):359. doi: 10.1186/s13054-018-2287-3.


Partial Deletion of Tie2 Affects Microvascular Endothelial Responses to Critical Illness in A Vascular Bed and Organ-Specific Way.

Jongman RM, Zwiers PJ, van de Sluis B, van der Laan M, Moser J, Zijlstra JG, Dekker D, Huijkman N, Moorlag HE, Popa ER, Molema G, van Meurs M.

Shock. 2019 Jun;51(6):757-769. doi: 10.1097/SHK.0000000000001226.


Serum concentrations of endothelial cell adhesion molecules and their shedding enzymes and early onset sepsis in newborns in Suriname.

Zonneveld R, Jongman RM, Juliana A, Molema G, van Meurs M, Plötz FB.

BMJ Paediatr Open. 2018 Oct 9;2(1):e000312. doi: 10.1136/bmjpo-2018-000312. eCollection 2018.


Renal Klotho is Reduced in Septic Patients and Pretreatment With Recombinant Klotho Attenuates Organ Injury in Lipopolysaccharide-Challenged Mice.

Jou-Valencia D, Molema G, Popa E, Aslan A, van Dijk F, Mencke R, Hillebrands JL, Heeringa P, Hoenderop JG, Zijlstra JG, van Meurs M, Moser J.

Crit Care Med. 2018 Dec;46(12):e1196-e1203. doi: 10.1097/CCM.0000000000003427.


Endothelium-targeted delivery of dexamethasone by anti-VCAM-1 SAINT-O-Somes in mouse endotoxemia.

Li R, Kowalski PS, Morselt HWM, Schepel I, Jongman RM, Aslan A, Ruiters MHJ, Zijlstra JG, Molema G, van Meurs M, Kamps JAAM.

PLoS One. 2018 May 15;13(5):e0196976. doi: 10.1371/journal.pone.0196976. eCollection 2018.


Early Heterogenic Response of Renal Microvasculature to Hemorrhagic Shock/Resuscitation and the Influence of NF-κB Pathway Blockade.

Yan R, van Meurs M, Popa ER, Li R, Zwiers PJ, Zijlstra JG, Moser J, Molema G.

Shock. 2019 Feb;51(2):200-212. doi: 10.1097/SHK.0000000000001126.


Endothelial Interferon Regulatory Factor 1 Regulates Lipopolysaccharide-Induced VCAM-1 Expression Independent of NFκB.

Yan R, van Meurs M, Popa ER, Jongman RM, Zwiers PJ, Niemarkt AE, Kuiper T, Kamps JA, Heeringa P, Zijlstra JG, Molema G, Moser J.

J Innate Immun. 2017;9(6):546-560. doi: 10.1159/000477211. Epub 2017 Jun 29.


Low Serum Angiopoietin-1, High Serum Angiopoietin-2, and High Ang-2/Ang-1 Protein Ratio are Associated with Early Onset Sepsis in Surinamese Newborns.

Zonneveld R, Jongman R, Juliana A, Zijlmans W, Plötz F, Molema G, van Meurs M.

Shock. 2017 Dec;48(6):638-643. doi: 10.1097/SHK.0000000000000903.


Hyperglycaemic memory affects the neurovascular unit of the retina in a diabetic mouse model.

Friedrichs P, Schlotterer A, Sticht C, Kolibabka M, Wohlfart P, Dietrich A, Linn T, Molema G, Hammes HP.

Diabetologia. 2017 Jul;60(7):1354-1358. doi: 10.1007/s00125-017-4254-y. Epub 2017 Mar 20.


Organ-Specific Differences in Endothelial Permeability-Regulating Molecular Responses in Mouse and Human Sepsis.

Aslan A, van Meurs M, Moser J, Popa ER, Jongman RM, Zwiers PJ, Molema G, Zijlstra JG.

Shock. 2017 Jul;48(1):69-77. doi: 10.1097/SHK.0000000000000841.


Measurement of functional and morphodynamic neutrophil phenotypes in systemic inflammation and sepsis.

Zonneveld R, Molema G, Plötz FB.

Crit Care. 2016 Aug 24;20:235. doi: 10.1186/s13054-016-1391-5. No abstract available.


Intracellular RIG-I Signaling Regulates TLR4-Independent Endothelial Inflammatory Responses to Endotoxin.

Moser J, Heeringa P, Jongman RM, Zwiers PJ, Niemarkt AE, Yan R, de Graaf IA, Li R, Ravasz Regan E, Kümpers P, Aird WC, van Nieuw Amerongen GP, Zijlstra JG, Molema G, van Meurs M.

J Immunol. 2016 Jun 1;196(11):4681-91. doi: 10.4049/jimmunol.1501819. Epub 2016 Apr 29.


A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity.

Yuan L, Chan GC, Beeler D, Janes L, Spokes KC, Dharaneeswaran H, Mojiri A, Adams WJ, Sciuto T, Garcia-Cardeña G, Molema G, Kang PM, Jahroudi N, Marsden PA, Dvorak A, Regan ER, Aird WC.

Nat Commun. 2016 Jan 8;7:10160. doi: 10.1038/ncomms10160.


Targeting Rapamycin to Podocytes Using a Vascular Cell Adhesion Molecule-1 (VCAM-1)-Harnessed SAINT-Based Lipid Carrier System.

Visweswaran GR, Gholizadeh S, Ruiters MH, Molema G, Kok RJ, Kamps JA.

PLoS One. 2015 Sep 25;10(9):e0138870. doi: 10.1371/journal.pone.0138870. eCollection 2015.


Angiopoietin/Tie2 Dysbalance Is Associated with Acute Kidney Injury after Cardiac Surgery Assisted by Cardiopulmonary Bypass.

Jongman RM, van Klarenbosch J, Molema G, Zijlstra JG, de Vries AJ, van Meurs M.

PLoS One. 2015 Aug 26;10(8):e0136205. doi: 10.1371/journal.pone.0136205. eCollection 2015.


Analyzing Neutrophil Morphology, Mechanics, and Motility in Sepsis: Options and Challenges for Novel Bedside Technologies.

Zonneveld R, Molema G, Plötz FB.

Crit Care Med. 2016 Jan;44(1):218-28. doi: 10.1097/CCM.0000000000001266. Review.


Histone Deacetylase Inhibition and IκB Kinase/Nuclear Factor-κB Blockade Ameliorate Microvascular Proinflammatory Responses Associated With Hemorrhagic Shock/Resuscitation in Mice.

Li R, Aslan A, Yan R, Jongman RM, Moser J, Zwiers PJ, Moorlag HE, Zijlstra JG, Molema G, van Meurs M.

Crit Care Med. 2015 Dec;43(12):e567-80. doi: 10.1097/CCM.0000000000001203.


SAINT-liposome-polycation particles, a new carrier for improved delivery of siRNAs to inflamed endothelial cells.

Kowalski PS, Kuninty PR, Bijlsma KT, Stuart MC, Leus NG, Ruiters MH, Molema G, Kamps JA.

Eur J Pharm Biopharm. 2015 Jan;89:40-7. doi: 10.1016/j.ejpb.2014.11.015. Epub 2014 Nov 25.


Abrupt reflow enhances cytokine-induced proinflammatory activation of endothelial cells during simulated shock and resuscitation.

Li R, Zijlstra JG, Kamps JA, van Meurs M, Molema G.

Shock. 2014 Oct;42(4):356-64. doi: 10.1097/SHK.0000000000000223.


A critical role for Egr-1 during vascular remodelling in pulmonary arterial hypertension.

Dickinson MG, Kowalski PS, Bartelds B, Borgdorff MA, van der Feen D, Sietsma H, Molema G, Kamps JA, Berger RM.

Cardiovasc Res. 2014 Sep 1;103(4):573-84. doi: 10.1093/cvr/cvu169. Epub 2014 Jul 14.


The renal angiopoietin/Tie2 system in lethal human sepsis.

Aslan A, Jongman RM, Moser J, Stegeman CA, van Goor H, Diepstra A, van den Heuvel MC, Heeringa P, Molema G, Zijlstra JG, van Meurs M.

Crit Care. 2014 Mar 31;18(2):423. doi: 10.1186/cc13806. No abstract available.


Synthesis and structure-activity relationships of 4-fluorophenyl-imidazole p38α MAPK, CK1δ and JAK2 kinase inhibitors.

Seerden JP, Leusink-Ionescu G, Woudenberg-Vrenken T, Dros B, Molema G, Kamps JA, Kellogg RM.

Bioorg Med Chem Lett. 2014 Aug 1;24(15):3412-8. doi: 10.1016/j.bmcl.2014.05.080. Epub 2014 Jun 2.


Streptococcus pneumoniae Interacts with pIgR expressed by the brain microvascular endothelium but does not co-localize with PAF receptor.

Iovino F, Molema G, Bijlsma JJ.

PLoS One. 2014 May 19;9(5):e97914. doi: 10.1371/journal.pone.0097914. eCollection 2014.


Correlation of microRNA-16, microRNA-21 and microRNA-101 expression with cyclooxygenase-2 expression and angiogenic factors in cirrhotic and noncirrhotic human hepatocellular carcinoma.

Zeng W, van den Berg A, Huitema S, Gouw AS, Molema G, de Jong KP.

PLoS One. 2014 Apr 23;9(4):e95826. doi: 10.1371/journal.pone.0095826. eCollection 2014.


VCAM-1 specific PEGylated SAINT-based lipoplexes deliver siRNA to activated endothelium in vivo but do not attenuate target gene expression.

Leus NG, Morselt HW, Zwiers PJ, Kowalski PS, Ruiters MH, Molema G, Kamps JA.

Int J Pharm. 2014 Jul 20;469(1):121-31. doi: 10.1016/j.ijpharm.2014.04.041. Epub 2014 Apr 18.


Off-pump CABG surgery reduces systemic inflammation compared with on-pump surgery but does not change systemic endothelial responses: a prospective randomized study.

Jongman RM, Zijlstra JG, Kok WF, van Harten AE, Mariani MA, Moser J, Struys MM, Absalom AR, Molema G, Scheeren TW, van Meurs M.

Shock. 2014 Aug;42(2):121-8. doi: 10.1097/SHK.0000000000000190.


Reply to letter: "Markers of angiogenesis in synchronous and in metachronous colorectal hepatic metastases".

van der Wal GE, Gouw AS, Kamps JA, Moorlag HE, Bulthuis ML, Molema G, de Jong KP.

Ann Surg. 2015 Jan;261(1):e20-1. doi: 10.1097/SLA.0000000000000563. No abstract available.


Syntheses and structure-activity relationships for some triazolyl p38α MAPK inhibitors.

Seerden JP, Leusink-Ionescu G, Leguijt R, Saccavini C, Gelens E, Dros B, Woudenberg-Vrenken T, Molema G, Kamps JA, Kellogg RM.

Bioorg Med Chem Lett. 2014 Mar 1;24(5):1352-7. doi: 10.1016/j.bmcl.2014.01.034. Epub 2014 Jan 28.


Anti-VCAM-1 SAINT-O-Somes enable endothelial-specific delivery of siRNA and downregulation of inflammatory genes in activated endothelium in vivo.

Kowalski PS, Zwiers PJ, Morselt HW, Kuldo JM, Leus NG, Ruiters MH, Molema G, Kamps JA.

J Control Release. 2014 Feb 28;176:64-75. doi: 10.1016/j.jconrel.2013.12.029. Epub 2014 Jan 3.


Effective siRNA delivery to inflamed primary vascular endothelial cells by anti-E-selectin and anti-VCAM-1 PEGylated SAINT-based lipoplexes.

Leus NG, Talman EG, Ramana P, Kowalski PS, Woudenberg-Vrenken TE, Ruiters MH, Molema G, Kamps JA.

Int J Pharm. 2014 Jan 1;459(1-2):40-50. doi: 10.1016/j.ijpharm.2013.11.008. Epub 2013 Nov 12.


Innovations in studying in vivo cell behavior and pharmacology in complex tissues--microvascular endothelial cells in the spotlight.

Langenkamp E, Kamps JA, Mrug M, Verpoorte E, Niyaz Y, Horvatovich P, Bischoff R, Struijker-Boudier H, Molema G.

Cell Tissue Res. 2013 Dec;354(3):647-69. doi: 10.1007/s00441-013-1714-7. Epub 2013 Sep 27. Review.


Renal heparan sulfate proteoglycans modulate fibroblast growth factor 2 signaling in experimental chronic transplant dysfunction.

Katta K, Boersema M, Adepu S, Rienstra H, Celie JWAM, Mencke R, Molema G, van Goor H, Berden JHM, Navis G, Hillebrands JL, van den Born J.

Am J Pathol. 2013 Nov;183(5):1571-1584. doi: 10.1016/j.ajpath.2013.07.030. Epub 2013 Sep 11.


Interactions between blood-borne Streptococcus pneumoniae and the blood-brain barrier preceding meningitis.

Iovino F, Orihuela CJ, Moorlag HE, Molema G, Bijlsma JJ.

PLoS One. 2013 Jul 16;8(7):e68408. doi: 10.1371/journal.pone.0068408. Print 2013.


Anti-VCAM-1 and anti-E-selectin SAINT-O-Somes for selective delivery of siRNA into inflammation-activated primary endothelial cells.

Kowalski PS, Lintermans LL, Morselt HW, Leus NG, Ruiters MH, Molema G, Kamps JA.

Mol Pharm. 2013 Aug 5;10(8):3033-44. doi: 10.1021/mp4001124. Epub 2013 Jul 12.


The flow dependency of Tie2 expression in endotoxemia.

Kurniati NF, Jongman RM, vom Hagen F, Spokes KC, Moser J, Regan ER, Krenning G, Moonen JR, Harmsen MC, Struys MM, Hammes HP, Zijlstra JG, Aird WC, Heeringa P, Molema G, van Meurs M.

Intensive Care Med. 2013 Jul;39(7):1262-71. doi: 10.1007/s00134-013-2899-7. Epub 2013 Apr 6.


Signalling or binding: the role of the platelet-activating factor receptor in invasive pneumococcal disease.

Iovino F, Brouwer MC, van de Beek D, Molema G, Bijlsma JJ.

Cell Microbiol. 2013 Jun;15(6):870-81. doi: 10.1111/cmi.12129. Epub 2013 Mar 20. Review.


Targeted adenovirus mediated inhibition of NF-κB-dependent inflammatory gene expression in endothelial cells in vitro and in vivo.

Kułdo JM, Ásgeirsdóttir SA, Zwiers PJ, Bellu AR, Rots MG, Schalk JA, Ogawara KI, Trautwein C, Banas B, Haisma HJ, Molema G, Kamps JA.

J Control Release. 2013 Feb 28;166(1):57-65. doi: 10.1016/j.jconrel.2012.12.016. Epub 2012 Dec 20.


Deeper penetration into tumor tissues and enhanced in vivo antitumor activity of liposomal paclitaxel by pretreatment with angiogenesis inhibitor SU5416.

Yoshizawa Y, Ogawara K, Fushimi A, Abe S, Ishikawa K, Araki T, Molema G, Kimura T, Higaki K.

Mol Pharm. 2012 Dec 3;9(12):3486-94. doi: 10.1021/mp300318q. Epub 2012 Nov 14.


Beneficial effects of an alternating high- fat dietary regimen on systemic insulin resistance, hepatic and renal inflammation and renal function.

Yakala GK, van der Heijden R, Molema G, Schipper M, Wielinga PY, Kleemann R, Kooistra T, Heeringa P.

PLoS One. 2012;7(9):e45866. doi: 10.1371/journal.pone.0045866. Epub 2012 Sep 25.


Pleiotropic effects of angiopoietin-2 deficiency do not protect mice against endotoxin-induced acute kidney injury.

Kurniati NF, van Meurs M, Vom Hagen F, Jongman RM, Moser J, Zwiers PJ, Struys MM, Westra J, Zijlstra JG, Hammes HP, Molema G, Heeringa P.

Nephrol Dial Transplant. 2013 Mar;28(3):567-75. doi: 10.1093/ndt/gfs336. Epub 2012 Aug 7.


Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFβ2 in vascular abnormalization.

Dieterich LC, Mellberg S, Langenkamp E, Zhang L, Zieba A, Salomäki H, Teichert M, Huang H, Edqvist PH, Kraus T, Augustin HG, Olofsson T, Larsson E, Söderberg O, Molema G, Pontén F, Georgii-Hemming P, Alafuzoff I, Dimberg A.

J Pathol. 2012 Nov;228(3):378-90. doi: 10.1002/path.4072. Epub 2012 Aug 31.


Age-dependent role of microvascular endothelial and polymorphonuclear cells in lipopolysaccharide-induced acute kidney injury.

Wulfert FM, van Meurs M, Kurniati NF, Jongman RM, Houwertjes MC, Heeringa P, Struys MM, Zijlstra JG, Molema G.

Anesthesiology. 2012 Jul;117(1):126-36. doi: 10.1097/ALN.0b013e31825b57c9.


Vascular heterogeneity in the kidney.

Molema G, Aird WC.

Semin Nephrol. 2012 Mar;32(2):145-55. doi: 10.1016/j.semnephrol.2012.02.001. Review.


Local medial microenvironment directs phenotypic modulation of smooth muscle cells after experimental renal transplantation.

Boersema M, Katta K, Rienstra H, Molema G, Nguyen TQ, Goldschmeding R, Navis G, van den Born J, Popa ER, Hillebrands JL.

Am J Transplant. 2012 Jun;12(6):1429-40. doi: 10.1111/j.1600-6143.2012.04001.x. Epub 2012 Mar 15.


MicroRNA-126 contributes to renal microvascular heterogeneity of VCAM-1 protein expression in acute inflammation.

Asgeirsdóttir SA, van Solingen C, Kurniati NF, Zwiers PJ, Heeringa P, van Meurs M, Satchell SC, Saleem MA, Mathieson PW, Banas B, Kamps JA, Rabelink TJ, van Zonneveld AJ, Molema G.

Am J Physiol Renal Physiol. 2012 Jun 15;302(12):F1630-9. doi: 10.1152/ajprenal.00400.2011. Epub 2012 Mar 14.


Adiponectin diminishes organ-specific microvascular endothelial cell activation associated with sepsis.

van Meurs M, Castro P, Shapiro NI, Lu S, Yano M, Maeda N, Funahashi T, Shimomura I, Zijlstra JG, Molema G, Parikh SM, Aird WC, Yano K.

Shock. 2012 Apr;37(4):392-8. doi: 10.1097/SHK.0b013e318248225e.


Tumor Vascular Morphology Undergoes Dramatic Changes during Outgrowth of B16 Melanoma While Proangiogenic Gene Expression Remains Unchanged.

Langenkamp E, Vom Hagen FM, Zwiers PJ, Moorlag HE, Schouten JP, Hammes HP, Gouw AS, Molema G.

ISRN Oncol. 2011;2011:409308. doi: 10.5402/2011/409308. Epub 2011 Dec 4.


Inhibition of VCAM-1 expression in endothelial cells by CORM-3: the role of the ubiquitin-proteasome system, p38, and mitochondrial respiration.

Bergstraesser C, Hoeger S, Song H, Ermantraut L, Hottenrot M, Czymai T, Schmidt M, Goebeler M, Ponelies N, Stich C, Loesel R, Molema G, Seelen M, van Son W, Yard BA, Rafat N.

Free Radic Biol Med. 2012 Feb 15;52(4):794-802. doi: 10.1016/j.freeradbiomed.2011.11.035. Epub 2011 Dec 21.


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