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Items: 46


Kynurenine 3-monooxygenase is a critical regulator of renal ischemia-reperfusion injury.

Zheng X, Zhang A, Binnie M, McGuire K, Webster SP, Hughes J, Howie SEM, Mole DJ.

Exp Mol Med. 2019 Feb 13;51(2):15. doi: 10.1038/s12276-019-0210-x.


Survival and new-onset morbidity after critical care admission for acute pancreatitis in Scotland: a national electronic healthcare record linkage cohort study.

Ventre C, Nowell S, Graham C, Kidd D, Skouras C, Mole DJ.

BMJ Open. 2018 Dec 14;8(12):e023853. doi: 10.1136/bmjopen-2018-023853.


Study protocol: HepaT1ca - an observational clinical cohort study to quantify liver health in surgical candidates for liver malignancies.

Mole DJ, Fallowfield JA, Kendall TJ, Welsh F, Semple SI, Bachtiar V, Kelly M, Wigmore SJ, James Garden O, Wilman HR, Banerjee R, Rees M, Brady M.

BMC Cancer. 2018 Sep 12;18(1):890. doi: 10.1186/s12885-018-4737-3.


Diclofenac Identified as a Kynurenine 3-Monooxygenase Binder and Inhibitor by Molecular Similarity Techniques.

Shave S, McGuire K, Pham NT, Mole DJ, Webster SP, Auer M.

ACS Omega. 2018 Mar 31;3(3):2564-2568. doi: 10.1021/acsomega.7b02091. Epub 2018 Mar 2.


Evaluation of plasma microRNA-122, high-mobility group box 1 and keratin-18 concentrations to stratify acute gallstone disease: a pilot observational cohort study in an emergency general surgery unit.

Th'ng F, Vliegenthart B, Lea JD, Antoine DJ, Dear JW, Mole DJ; Edinburgh Emergency Surgery Study Group, Royal Infirmary of Edinburgh, NHS Lothian.

BMJ Open. 2018 Apr 27;8(4):e020061. doi: 10.1136/bmjopen-2017-020061.


Detecting drug-target binding in cells using fluorescence-activated cell sorting coupled with mass spectrometry analysis.

Wilson K, Webster SP, Iredale JP, Zheng X, Homer NZ, Pham NT, Auer M, Mole DJ.

Methods Appl Fluoresc. 2017 Dec 15;6(1):015002. doi: 10.1088/2050-6120/aa8c60.


Emergency general surgery 'Hot Clinics' reduce admission rates and duration of inpatient stay.

Th'ng F, Skouras C, Paterson-Brown A, Ravindran R, Lamb P, de Beaux A, Paterson-Brown S, Mole DJ.

Frontline Gastroenterol. 2017 Jan;8(1):53-61. doi: 10.1136/flgastro-2015-100634. Epub 2015 Dec 14.


Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase.

Hutchinson JP, Rowland P, Taylor MRD, Christodoulou EM, Haslam C, Hobbs CI, Holmes DS, Homes P, Liddle J, Mole DJ, Uings I, Walker AL, Webster SP, Mowat CG, Chung CW.

Nat Commun. 2017 Jun 12;8:15827. doi: 10.1038/ncomms15827.


Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.

Walker AL, Ancellin N, Beaufils B, Bergeal M, Binnie M, Bouillot A, Clapham D, Denis A, Haslam CP, Holmes DS, Hutchinson JP, Liddle J, McBride A, Mirguet O, Mowat CG, Rowland P, Tiberghien N, Trottet L, Uings I, Webster SP, Zheng X, Mole DJ.

J Med Chem. 2017 Apr 27;60(8):3383-3404. doi: 10.1021/acs.jmedchem.7b00055. Epub 2017 Apr 11.


The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis.

Liddle J, Beaufils B, Binnie M, Bouillot A, Denis AA, Hann MM, Haslam CP, Holmes DS, Hutchinson JP, Kranz M, McBride A, Mirguet O, Mole DJ, Mowat CG, Pal S, Rowland P, Trottet L, Uings IJ, Walker AL, Webster SP.

Bioorg Med Chem Lett. 2017 May 1;27(9):2023-2028. doi: 10.1016/j.bmcl.2017.02.078. Epub 2017 Mar 9.


Acute physiological effects of glucocorticoids on fuel metabolism in humans are permissive but not direct.

Stimson RH, Anderson AJ, Ramage LE, Macfarlane DP, de Beaux AC, Mole DJ, Andrew R, Walker BR.

Diabetes Obes Metab. 2017 Jun;19(6):883-891. doi: 10.1111/dom.12899. Epub 2017 Mar 28.


Increased levels of 3-hydroxykynurenine parallel disease severity in human acute pancreatitis.

Skouras C, Zheng X, Binnie M, Homer NZ, Murray TB, Robertson D, Briody L, Paterson F, Spence H, Derr L, Hayes AJ, Tsoumanis A, Lyster D, Parks RW, Garden OJ, Iredale JP, Uings IJ, Liddle J, Wright WL, Dukes G, Webster SP, Mole DJ.

Sci Rep. 2016 Sep 27;6:33951. doi: 10.1038/srep33951.


ABCC1 confers tissue-specific sensitivity to cortisol versus corticosterone: A rationale for safer glucocorticoid replacement therapy.

Nixon M, Mackenzie SD, Taylor AI, Homer NZ, Livingstone DE, Mouras R, Morgan RA, Mole DJ, Stimson RH, Reynolds RM, Elfick AP, Andrew R, Walker BR.

Sci Transl Med. 2016 Aug 17;8(352):352ra109. doi: 10.1126/scitranslmed.aaf9074.


Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase Inhibition During Sepsis Dampens the Early Systemic Inflammatory Response.

Hayes AJ, Mole DJ.

Crit Care Med. 2016 Aug;44(8):1628-9. doi: 10.1097/CCM.0000000000001752. No abstract available.


Identifying risk factors for progression to critical care admission and death among individuals with acute pancreatitis: a record linkage analysis of Scottish healthcare databases.

Mole DJ, Gungabissoon U, Johnston P, Cochrane L, Hopkins L, Wyper GM, Skouras C, Dibben C, Sullivan F, Morris A, Ward HJ, Lawton AM, Donnan PT.

BMJ Open. 2016 Jun 15;6(6):e011474. doi: 10.1136/bmjopen-2016-011474.


Overexpression of human kynurenine-3-monooxygenase protects against 3-hydroxykynurenine-mediated apoptosis through bidirectional nonlinear feedback.

Wilson K, Auer M, Binnie M, Zheng X, Pham NT, Iredale JP, Webster SP, Mole DJ.

Cell Death Dis. 2016 Apr 14;7:e2197. doi: 10.1038/cddis.2016.87.


Prostaglandin E₂ constrains systemic inflammation through an innate lymphoid cell-IL-22 axis.

Duffin R, O'Connor RA, Crittenden S, Forster T, Yu C, Zheng X, Smyth D, Robb CT, Rossi F, Skouras C, Tang S, Richards J, Pellicoro A, Weller RB, Breyer RM, Mole DJ, Iredale JP, Anderton SM, Narumiya S, Maizels RM, Ghazal P, Howie SE, Rossi AG, Yao C.

Science. 2016 Mar 18;351(6279):1333-8. doi: 10.1126/science.aad9903.


Lung ultrasonography as a direct measure of evolving respiratory dysfunction and disease severity in patients with acute pancreatitis.

Skouras C, Davis ZA, Sharkey J, Parks RW, Garden OJ, Murchison JT, Mole DJ.

HPB (Oxford). 2016 Feb;18(2):159-169. doi: 10.1016/j.hpb.2015.10.002. Epub 2015 Nov 18.


Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis.

Mole DJ, Webster SP, Uings I, Zheng X, Binnie M, Wilson K, Hutchinson JP, Mirguet O, Walker A, Beaufils B, Ancellin N, Trottet L, Bénéton V, Mowat CG, Wilkinson M, Rowland P, Haslam C, McBride A, Homer NZ, Baily JE, Sharp MG, Garden OJ, Hughes J, Howie SE, Holmes DS, Liddle J, Iredale JP.

Nat Med. 2016 Feb;22(2):202-9. doi: 10.1038/nm.4020. Epub 2016 Jan 11.


Lung ultrasonography as a direct measure of evolving respiratory dysfunction and disease severity in patients with acute pancreatitis.

Skouras C, Davis ZA, Sharkey J, Parks RW, Garden JO, Murchison JT, Mole DJ.

HPB (Oxford). 2015 Oct 16. doi: 10.1111/hpb.12515. [Epub ahead of print]


A magnetic bead-based ligand binding assay to facilitate human kynurenine 3-monooxygenase drug discovery.

Wilson K, Mole DJ, Homer NZ, Iredale JP, Auer M, Webster SP.

J Biomol Screen. 2015 Feb;20(2):292-8. doi: 10.1177/1087057114554171. Epub 2014 Oct 8.


The intestinal mucus layer is a critical component of the gut barrier that is damaged during acute pancreatitis.

Fishman JE, Levy G, Alli V, Zheng X, Mole DJ, Deitch EA.

Shock. 2014 Sep;42(3):264-70. doi: 10.1097/SHK.0000000000000209.


Early organ dysfunction affects long-term survival in acute pancreatitis patients.

Skouras C, Hayes AJ, Williams L, Garden OJ, Parks RW, Mole DJ.

HPB (Oxford). 2014 Sep;16(9):789-96. doi: 10.1111/hpb.12259. Epub 2014 Apr 9.


Lead discovery for human kynurenine 3-monooxygenase by high-throughput RapidFire mass spectrometry.

Lowe DM, Gee M, Haslam C, Leavens B, Christodoulou E, Hissey P, Hardwicke P, Argyrou A, Webster SP, Mole DJ, Wilson K, Binnie M, Yard BA, Dean T, Liddle J, Uings I, Hutchinson JP.

J Biomol Screen. 2014 Apr;19(4):508-15. doi: 10.1177/1087057113518069. Epub 2013 Dec 31.


Bacterial expression of human kynurenine 3-monooxygenase: solubility, activity, purification.

Wilson K, Mole DJ, Binnie M, Homer NZ, Zheng X, Yard BA, Iredale JP, Auer M, Webster SP.

Protein Expr Purif. 2014 Mar;95:96-103. doi: 10.1016/j.pep.2013.11.015. Epub 2013 Dec 4.


Relaxin modulates human and rat hepatic myofibroblast function and ameliorates portal hypertension in vivo.

Fallowfield JA, Hayden AL, Snowdon VK, Aucott RL, Stutchfield BM, Mole DJ, Pellicoro A, Gordon-Walker TT, Henke A, Schrader J, Trivedi PJ, Princivalle M, Forbes SJ, Collins JE, Iredale JP.

Hepatology. 2014 Apr;59(4):1492-504. doi: 10.1002/hep.26627. Epub 2014 Mar 3.


Expression of osteopontin coregulators in primary colorectal cancer and associated liver metastases.

Mole DJ, O'Neill C, Hamilton P, Olabi B, Robinson V, Williams L, Diamond T, El-Tanani M, Campbell FC.

Br J Cancer. 2011 Mar 15;104(6):1007-12. doi: 10.1038/bjc.2011.33. Epub 2011 Feb 22.


Detailed fluid resuscitation profiles in patients with severe acute pancreatitis.

Mole DJ, Hall A, McKeown D, Garden OJ, Parks RW.

HPB (Oxford). 2011 Jan;13(1):51-8. doi: 10.1111/j.1477-2574.2010.00241.x. Epub 2010 Nov 15.


Once bitten, twice shy: defective monocyte signaling in acute pancreatitis.

McGregor RJ, Mole DJ.

Crit Care Med. 2010 Aug;38(8):1751-2. doi: 10.1097/CCM.0b013e3181e8787c. No abstract available.


Management of liver trauma.

Badger SA, Barclay R, Campbell P, Mole DJ, Diamond T.

World J Surg. 2009 Dec;33(12):2522-37. doi: 10.1007/s00268-009-0215-z. Review.


Discrepancy between the extent of pancreatic necrosis and multiple organ failure score in severe acute pancreatitis.

Mole DJ, McClymont KL, Lau S, Mills R, Stamp-Vincent C, Garden OJ, Parks RW.

World J Surg. 2009 Nov;33(11):2427-32. doi: 10.1007/s00268-009-0161-9.


Incidence of individual organ dysfunction in fatal acute pancreatitis: analysis of 1024 death records.

Mole DJ, Olabi B, Robinson V, Garden OJ, Parks RW.

HPB (Oxford). 2009 Mar;11(2):166-70. doi: 10.1111/j.1477-2574.2009.00038.x.


Host matters most.

Mole DJ, Garden OJ.

Am J Surg. 2008 Sep;196(3):351-2. doi: 10.1016/j.amjsurg.2007.12.059. No abstract available.


Moving the goalposts? Fluid volume assessment in severe acute pancreatitis.

Mole DJ, McKeown D.

Crit Care Med. 2008 Aug;36(8):2464-6. doi: 10.1097/CCM.0b013e318181140f. No abstract available.


Tryptophan catabolites in mesenteric lymph may contribute to pancreatitis-associated organ failure.

Mole DJ, McFerran NV, Collett G, O'Neill C, Diamond T, Garden OJ, Kylanpaa L, Repo H, Deitch EA.

Br J Surg. 2008 Jul;95(7):855-67. doi: 10.1002/bjs.6112.


Treitz's hernia.

Zonca P, Maly T, Mole DJ, Stigler J.

Hernia. 2008 Oct;12(5):531-4. doi: 10.1007/s10029-008-0339-3. Epub 2008 Jan 30.


Electronic patient data confidentiality practices among surgical trainees: questionnaire study.

Mole DJ, Fox C, Napolitano G.

Ann R Coll Surg Engl. 2006 Oct;88(6):550-3.


Diffuse coronary artery disease and dystrophic calcification of the radial artery--is there an association?

Badmanaban B, Sachithanandan A, Mole DJ, Graham AN, Sarsam MA.

J Card Surg. 2006 Jan-Feb;21(1):98-100; discussion 101.


Mesenteric lymph duct ligation decreases red blood cell alterations caused by acute pancreatitis.

Berezina TL, Zaets SB, Mole DJ, Spolarics Z, Deitch EA, Machiedo GW.

Am J Surg. 2005 Nov;190(5):800-4.


The isolated perfused liver response to a 'second hit' of portal endotoxin during severe acute pancreatitis.

Mole DJ, Taylor MA, McFerran NV, Diamond T.

Pancreatology. 2005;5(4-5):475-85. Epub 2005 Jun 28.


Anatomical orientation and cross-checking-the key to safer laparoscopic cholecystectomy.

Diamond T, Mole DJ.

Br J Surg. 2005 Jun;92(6):663-4. No abstract available.


Delayed paraplegia after endovascular repair of abdominal aortic aneurysm.

Reid JA, Mole DJ, Johnston LC, Lee B.

J Vasc Surg. 2003 Jun;37(6):1322-3.


Spontaneous coronary artery dissection presenting as cardiac tamponade.

Badmanaban B, McCarty D, Mole DJ, McKeown PP, Sarsam MA.

Ann Thorac Surg. 2002 Apr;73(4):1324-6.


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