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Items: 1 to 50 of 457

1.

Effect of Beta-Blockade on the Expression of Regulatory MicroRNA after Severe Trauma and Chronic Stress.

Apple CG, Miller ES, Loftus TJ, Kannan KB, Thompson CW, Lopez MC, Baker HV, Moldawer LL, Efron PA, Mohr AM.

J Am Coll Surg. 2019 Oct 28. pii: S1072-7515(19)32114-3. doi: 10.1016/j.jamcollsurg.2019.09.011. [Epub ahead of print]

PMID:
31672639
2.

Immune checkpoint inhibition in sepsis: a Phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab.

Hotchkiss RS, Colston E, Yende S, Crouser ED, Martin GS, Albertson T, Bartz RR, Brakenridge SC, Delano MJ, Park PK, Donnino MW, Tidswell M, Mayr FB, Angus DC, Coopersmith CM, Moldawer LL, Catlett IM, Girgis IG, Ye J, Grasela DM.

Intensive Care Med. 2019 Oct;45(10):1360-1371. doi: 10.1007/s00134-019-05704-z. Epub 2019 Oct 1.

PMID:
31576433
3.

Cell-free nuclear, but not mitochondrial, DNA concentrations correlate with the early host inflammatory response after severe trauma.

Stortz JA, Hawkins RB, Holden DC, Raymond SL, Wang Z, Brakenridge SC, Cuschieri J, Moore FA, Maier RV, Moldawer LL, Efron PA.

Sci Rep. 2019 Sep 20;9(1):13648. doi: 10.1038/s41598-019-50044-z.

4.

LIPid Intensive Drug therapy for Sepsis Pilot (LIPIDS-P): Phase I/II clinical trial protocol of lipid emulsion therapy for stabilising cholesterol levels in sepsis and septic shock.

Guirgis FW, Black LP, Rosenthal MD, Henson M, Ferreira J, Leeuwenburgh C, Kalynych C, Moldawer LL, Miller T, Jones L, Crandall M, Reddy ST, Wu SS, Moore FA.

BMJ Open. 2019 Sep 18;9(9):e029348. doi: 10.1136/bmjopen-2019-029348.

5.

The authors reply.

Hotchkiss RS, Yende S, Angus DC, Moldawer LL, Crouser E, Martin G, Coopersmith CM, Brakenridge S, Mayr FB, Park PK.

Crit Care Med. 2019 Sep;47(9):e788-e789. doi: 10.1097/CCM.0000000000003887. No abstract available.

PMID:
31415323
6.

Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model.

Stortz JA, Hollen MK, Nacionales DC, Horiguchi H, Ungaro R, Dirain ML, Wang Z, Wu Q, Wu KK, Kumar A, Foster TC, Stewart BD, Ross JA, Segal M, Bihorac A, Brakenridge S, Moore FA, Wohlgemuth SE, Leeuwenburgh C, Mohr AM, Moldawer LL, Efron PA.

Crit Care Med. 2019 Nov;47(11):e919-e929. doi: 10.1097/CCM.0000000000003926.

PMID:
31389840
7.

Current Epidemiology of Surgical Sepsis: Discordance Between Inpatient Mortality and 1-year Outcomes.

Brakenridge SC, Efron PA, Cox MC, Stortz JA, Hawkins RB, Ghita G, Gardner A, Mohr AM, Anton SD, Moldawer LL, Moore FA.

Ann Surg. 2019 Sep;270(3):502-510. doi: 10.1097/SLA.0000000000003458.

PMID:
31356275
8.

Age and Sex Influence the Hippocampal Response and Recovery Following Sepsis.

Barter J, Kumar A, Stortz JA, Hollen M, Nacionales D, Efron PA, Moldawer LL, Foster TC.

Mol Neurobiol. 2019 Dec;56(12):8557-8572. doi: 10.1007/s12035-019-01681-y. Epub 2019 Jul 5.

PMID:
31278440
9.

Prognostic value of NT-proBNP levels in the acute phase of sepsis on lower long-term physical function and muscle strength in sepsis survivors.

Custodero C, Wu Q, Ghita GL, Anton SD, Brakenridge SC, Brumback BA, Efron PA, Gardner AK, Leeuwenburgh C, Moldawer LL, Petersen JW, Moore FA, Mankowski RT.

Crit Care. 2019 Jun 24;23(1):230. doi: 10.1186/s13054-019-2505-7.

10.

Persistently Elevated Glucagon-Like Peptide-1 Levels among Critically Ill Surgical Patients after Sepsis and Development of Chronic Critical Illness and Dismal Long-Term Outcomes.

Brakenridge SC, Moore FA, Mercier NR, Cox M, Wu Q, Moldawer LL, Mohr AM, Efron PA, Smith RS.

J Am Coll Surg. 2019 Jul;229(1):58-67.e1. doi: 10.1016/j.jamcollsurg.2019.04.014. Epub 2019 Apr 13.

PMID:
30991107
11.

Immune Checkpoint Inhibition in Sepsis: A Phase 1b Randomized, Placebo-Controlled, Single Ascending Dose Study of Antiprogrammed Cell Death-Ligand 1 Antibody (BMS-936559).

Hotchkiss RS, Colston E, Yende S, Angus DC, Moldawer LL, Crouser ED, Martin GS, Coopersmith CM, Brakenridge S, Mayr FB, Park PK, Ye J, Catlett IM, Girgis IG, Grasela DM.

Crit Care Med. 2019 May;47(5):632-642. doi: 10.1097/CCM.0000000000003685.

PMID:
30747773
12.

Prospective Validation of a Transcriptomic Metric in Severe Trauma.

Raymond SL, Hawkins RB, Wang Z, Mira JC, Stortz JA, Han F, Lanz JD, Hennessy LV, Brumback BA, Baker HV, Efron PA, Brakenridge SC, Xiao W, Tompkins RG, Cuschieri J, Moore FA, Maier RV, Moldawer LL.

Ann Surg. 2019 Jan 24. doi: 10.1097/SLA.0000000000003204. [Epub ahead of print]

PMID:
30688688
13.

What's New in Shock, February 2019?

Moldawer LL.

Shock. 2019 Feb;51(2):143-146. doi: 10.1097/SHK.0000000000001292. No abstract available.

PMID:
30640890
14.

A checkpoint on innate myeloid cells in pulmonary arterial hypertension.

Bryant AJ, Fu C, Lu Y, Brantly ML, Mehrad B, Moldawer LL, Brusko TM, Brittain EL, West JD, Austin ED, Hamid R.

Pulm Circ. 2019 Jan-Mar;9(1):2045894018823528. doi: 10.1177/2045894018823528. Epub 2018 Dec 18. No abstract available.

15.

Persistent inflammation and anemia among critically ill septic patients.

Loftus TJ, Mira JC, Stortz JA, Ozrazgat-Baslanti T, Ghita GL, Wang Z, Brumback BA, Ungaro RF, Bihorac A, Leeuwenburgh C, Moore FA, Moldawer LL, Brakenridge SC, Efron PA, Mohr AM.

J Trauma Acute Care Surg. 2019 Feb;86(2):260-267. doi: 10.1097/TA.0000000000002147.

PMID:
30489504
16.

Sepsis is associated with reduced spontaneous neutrophil migration velocity in human adults.

Raymond SL, Hawkins RB, Stortz JA, Murphy TJ, Ungaro R, Dirain ML, Nacionales DC, Hollen MK, Rincon JC, Larson SD, Brakenridge SC, Moore FA, Irimia D, Efron PA, Moldawer LL.

PLoS One. 2018 Oct 9;13(10):e0205327. doi: 10.1371/journal.pone.0205327. eCollection 2018.

17.

Correction to: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis.

Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon JM, Chaudry IH, Coopersmith CM, Deutschman C, Drechsler S, Efron P, Frostell C, Fritsch G, Gozdzik W, Hellman J, Huber-Lang M, Inoue S, Knapp S, Kozlov AV, Libert C, Marshall JC, Moldawer LL, Radermacher P, Redl H, Remick DG, Singer M, Thiemermann C, Wang P, Wiersinga WJ, Xiao X, Zingarelli B.

Infection. 2018 Oct;46(5):745-747. doi: 10.1007/s15010-018-1197-2.

18.

Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis.

Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon JM, Chaudry IH, Coopersmith CM, Deutschman C, Drechsler S, Efron P, Frostell C, Fritsch G, Gozdzik W, Hellman J, Huber-Lang M, Inoue S, Knapp S, Kozlov AV, Libert C, Marshall JC, Moldawer LL, Radermacher P, Redl H, Remick DG, Singer M, Thiemermann C, Wang P, Wiersinga WJ, Xiao X, Zingarelli B.

Intensive Care Med Exp. 2018 Aug 14;6(1):26. doi: 10.1186/s40635-018-0189-y. Review.

19.

Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis.

Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon JM, Chaudry IH, Coopersmith CM, Deutschman CS, Drechsler S, Efron P, Frostell C, Fritsch G, Gozdzik W, Hellman J, Huber-Lang M, Inoue S, Knapp S, Kozlov AV, Libert C, Marshall JC, Moldawer LL, Radermacher P, Redl H, Remick DG, Singer M, Thiemermann C, Wang P, Wiersinga WJ, Xiao X, Zingarelli B.

Shock. 2018 Oct;50(4):377-380. doi: 10.1097/SHK.0000000000001212.

20.

Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis.

Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon JM, Chaudry IH, Coopersmith CM, Deutschman C, Drechsler S, Efron P, Frostell C, Fritsch G, Gozdzik W, Hellman J, Huber-Lang M, Inoue S, Knapp S, Kozlov AV, Libert C, Marshall JC, Moldawer LL, Radermacher P, Redl H, Remick DG, Singer M, Thiemermann C, Wang P, Wiersinga WJ, Xiao X, Zingarelli B.

Infection. 2018 Oct;46(5):687-691. doi: 10.1007/s15010-018-1183-8. Review. Erratum in: Infection. 2018 Sep 17;:.

21.

Myeloid-Derived Suppressor Cells and Pulmonary Hypertension.

Bryant AJ, Mehrad B, Brusko TM, West JD, Moldawer LL.

Int J Mol Sci. 2018 Aug 3;19(8). pii: E2277. doi: 10.3390/ijms19082277. Review.

22.

Chronic Critical Illness and the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome.

Hawkins RB, Raymond SL, Stortz JA, Horiguchi H, Brakenridge SC, Gardner A, Efron PA, Bihorac A, Segal M, Moore FA, Moldawer LL.

Front Immunol. 2018 Jul 2;9:1511. doi: 10.3389/fimmu.2018.01511. eCollection 2018. Review.

23.

Impact of toll-like receptor 4 stimulation on human neonatal neutrophil spontaneous migration, transcriptomics, and cytokine production.

Raymond SL, Hawkins RB, Murphy TJ, Rincon JC, Stortz JA, López MC, Ungaro R, Ellett F, Baker HV, Wynn JL, Moldawer LL, Irimia D, Larson SD.

J Mol Med (Berl). 2018 Jul;96(7):673-684. doi: 10.1007/s00109-018-1646-5. Epub 2018 May 28.

24.

Persistent inflammation, immunosuppression, and catabolism and the development of chronic critical illness after surgery.

Efron PA, Mohr AM, Bihorac A, Horiguchi H, Hollen MK, Segal MS, Baker HV, Leeuwenburgh C, Moldawer LL, Moore FA, Brakenridge SC.

Surgery. 2018 Aug;164(2):178-184. doi: 10.1016/j.surg.2018.04.011. Epub 2018 May 26. Review.

25.

The Postinjury Inflammatory State and the Bone Marrow Response to Anemia.

Loftus TJ, Mira JC, Miller ES, Kannan KB, Plazas JM, Delitto D, Stortz JA, Hagen JE, Parvataneni HK, Sadasivan KK, Brakenridge SC, Moore FA, Moldawer LL, Efron PA, Mohr AM.

Am J Respir Crit Care Med. 2018 Sep 1;198(5):629-638. doi: 10.1164/rccm.201712-2536OC.

26.

Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy.

Horiguchi H, Loftus TJ, Hawkins RB, Raymond SL, Stortz JA, Hollen MK, Weiss BP, Miller ES, Bihorac A, Larson SD, Mohr AM, Brakenridge SC, Tsujimoto H, Ueno H, Moore FA, Moldawer LL, Efron PA; Sepsis and Critical Illness Research Center Investigators.

Front Immunol. 2018 Apr 4;9:595. doi: 10.3389/fimmu.2018.00595. eCollection 2018. Review.

27.

The impact of age on the innate immune response and outcomes after severe sepsis/septic shock in trauma and surgical intensive care unit patients.

Brakenridge SC, Efron PA, Stortz JA, Ozrazgat-Baslanti T, Ghita G, Wang Z, Bihorac A, Mohr AM, Brumback BA, Moldawer LL, Moore FA.

J Trauma Acute Care Surg. 2018 Aug;85(2):247-255. doi: 10.1097/TA.0000000000001921.

28.

Hyperacute Monocyte Gene Response Patterns Are Associated With Lower Extremity Vein Bypass Graft Failure.

Rehfuss JP, DeSart KM, Rozowsky JM, O'Malley KA, Moldawer LL, Baker HV, Wang Y, Wu R, Nelson PR, Berceli SA.

Circ Genom Precis Med. 2018 Mar;11(3):e001970. doi: 10.1161/CIRCGEN.117.001970.

29.

MySurgeryRisk: Development and Validation of a Machine-learning Risk Algorithm for Major Complications and Death After Surgery.

Bihorac A, Ozrazgat-Baslanti T, Ebadi A, Motaei A, Madkour M, Pardalos PM, Lipori G, Hogan WR, Efron PA, Moore F, Moldawer LL, Wang DZ, Hobson CE, Rashidi P, Li X, Momcilovic P.

Ann Surg. 2019 Apr;269(4):652-662. doi: 10.1097/SLA.0000000000002706.

PMID:
29489489
30.

Mouse Injury Model of Polytrauma and Shock.

Mira JC, Nacionales DC, Loftus TJ, Ungaro R, Mathias B, Mohr AM, Moldawer LL, Efron PA.

Methods Mol Biol. 2018;1717:1-15. doi: 10.1007/978-1-4939-7526-6_1. Review.

31.

A community approach to mortality prediction in sepsis via gene expression analysis.

Sweeney TE, Perumal TM, Henao R, Nichols M, Howrylak JA, Choi AM, Bermejo-Martin JF, Almansa R, Tamayo E, Davenport EE, Burnham KL, Hinds CJ, Knight JC, Woods CW, Kingsmore SF, Ginsburg GS, Wong HR, Parnell GP, Tang B, Moldawer LL, Moore FE, Omberg L, Khatri P, Tsalik EL, Mangravite LM, Langley RJ.

Nat Commun. 2018 Feb 15;9(1):694. doi: 10.1038/s41467-018-03078-2.

32.

Immunotherapy: It is not just for cancer anymore.

Moldawer LL, Hotchkiss R.

J Leukoc Biol. 2018 Jan;103(1):9-11. doi: 10.1002/JLB.4CE1117-447. Epub 2018 Jan 3. No abstract available.

PMID:
29345063
33.

Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients.

Stortz JA, Mira JC, Raymond SL, Loftus TJ, Ozrazgat-Baslanti T, Wang Z, Ghita GL, Leeuwenburgh C, Segal MS, Bihorac A, Brumback BA, Mohr AM, Efron PA, Moldawer LL, Moore FA, Brakenridge SC.

J Trauma Acute Care Surg. 2018 Feb;84(2):342-349. doi: 10.1097/TA.0000000000001758.

34.

Adjuvant pretreatment with alum protects neonatal mice in sepsis through myeloid cell activation.

Rincon JC, Cuenca AL, Raymond SL, Mathias B, Nacionales DC, Ungaro R, Efron PA, Wynn JL, Moldawer LL, Larson SD.

Clin Exp Immunol. 2018 Mar;191(3):268-278. doi: 10.1111/cei.13072. Epub 2017 Nov 16.

35.

Dysregulated myelopoiesis and hematopoietic function following acute physiologic insult.

Loftus TJ, Mohr AM, Moldawer LL.

Curr Opin Hematol. 2018 Jan;25(1):37-43. doi: 10.1097/MOH.0000000000000395. Review.

36.

ICU-Acquired Weakness, Chronic Critical Illness, and the Persistent Inflammation-Immunosuppression and Catabolism Syndrome.

Loftus TJ, Moore FA, Moldawer LL.

Crit Care Med. 2017 Nov;45(11):e1184. doi: 10.1097/CCM.0000000000002576. No abstract available.

37.

Unique transcriptomic response to sepsis is observed among patients of different age groups.

Raymond SL, López MC, Baker HV, Larson SD, Efron PA, Sweeney TE, Khatri P, Moldawer LL, Wynn JL.

PLoS One. 2017 Sep 8;12(9):e0184159. doi: 10.1371/journal.pone.0184159. eCollection 2017.

38.

Evidence for Persistent Immune Suppression in Patients Who Develop Chronic Critical Illness After Sepsis.

Stortz JA, Murphy TJ, Raymond SL, Mira JC, Ungaro R, Dirain ML, Nacionales DC, Loftus TJ, Wang Z, Ozrazgat-Baslanti T, Ghita GL, Brumback BA, Mohr AM, Bihorac A, Efron PA, Moldawer LL, Moore FA, Brakenridge SC.

Shock. 2018 Mar;49(3):249-258. doi: 10.1097/SHK.0000000000000981.

39.

Neutrophil chemotaxis and transcriptomics in term and preterm neonates.

Raymond SL, Mathias BJ, Murphy TJ, Rincon JC, López MC, Ungaro R, Ellett F, Jorgensen J, Wynn JL, Baker HV, Moldawer LL, Irimia D, Larson SD.

Transl Res. 2017 Dec;190:4-15. doi: 10.1016/j.trsl.2017.08.003. Epub 2017 Sep 1.

40.

The Epidemiology of Chronic Critical Illness After Severe Traumatic Injury at Two Level-One Trauma Centers.

Mira JC, Cuschieri J, Ozrazgat-Baslanti T, Wang Z, Ghita GL, Loftus TJ, Stortz JA, Raymond SL, Lanz JD, Hennessy LV, Brumback B, Efron PA, Baker HV, Moore FA, Maier RV, Moldawer LL, Brakenridge SC.

Crit Care Med. 2017 Dec;45(12):1989-1996. doi: 10.1097/CCM.0000000000002697.

41.

Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients.

Loftus TJ, Mira JC, Ozrazgat-Baslanti T, Ghita GL, Wang Z, Stortz JA, Brumback BA, Bihorac A, Segal MS, Anton SD, Leeuwenburgh C, Mohr AM, Efron PA, Moldawer LL, Moore FA, Brakenridge SC.

BMJ Open. 2017 Aug 1;7(7):e015136. doi: 10.1136/bmjopen-2016-015136.

42.

Impact of Early-Life Exposures to Infections, Antibiotics, and Vaccines on Perinatal and Long-term Health and Disease.

Raymond SL, Rincon JC, Wynn JL, Moldawer LL, Larson SD.

Front Immunol. 2017 Jun 23;8:729. doi: 10.3389/fimmu.2017.00729. eCollection 2017. Review.

43.

The authors reply.

Moldawer LL, Efron PA, Brakenridge S, Moore FA.

Crit Care Med. 2017 Jul;45(7):e740-e741. doi: 10.1097/CCM.0000000000002469. No abstract available.

44.

The role of NIGMS P50 sponsored team science in our understanding of multiple organ failure.

Moore FA, Moore EE, Billiar TR, Vodovotz Y, Banerjee A, Moldawer LL.

J Trauma Acute Care Surg. 2017 Sep;83(3):520-531. doi: 10.1097/TA.0000000000001587.

45.

Murine Models of Sepsis and Trauma: Can We Bridge the Gap?

Stortz JA, Raymond SL, Mira JC, Moldawer LL, Mohr AM, Efron PA.

ILAR J. 2017 Jul 1;58(1):90-105. doi: 10.1093/ilar/ilx007. Review.

46.

LPS Stimulation of Cord Blood Reveals a Newborn-Specific Neutrophil Transcriptomic Response and Cytokine Production.

Mathias B, Mira JC, Rehfuss JP, Rincon JC, Ungaro R, Nacionales DC, Lopez MC, Baker HV, Moldawer LL, Larson SD.

Shock. 2017 May;47(5):606-614. doi: 10.1097/SHK.0000000000000800.

47.

Persistent Inflammation, Immunosuppression and Catabolism Syndrome.

Mira JC, Brakenridge SC, Moldawer LL, Moore FA.

Crit Care Clin. 2017 Apr;33(2):245-258. doi: 10.1016/j.ccc.2016.12.001. Review.

48.

Immunological Defects in Neonatal Sepsis and Potential Therapeutic Approaches.

Raymond SL, Stortz JA, Mira JC, Larson SD, Wynn JL, Moldawer LL.

Front Pediatr. 2017 Feb 7;5:14. doi: 10.3389/fped.2017.00014. eCollection 2017. Review.

49.

Sepsis and septic shock.

Hotchkiss RS, Moldawer LL, Opal SM, Reinhart K, Turnbull IR, Vincent JL.

Nat Rev Dis Primers. 2016 Jun 30;2:16045. doi: 10.1038/nrdp.2016.45. Review.

50.

Microbial recognition and danger signals in sepsis and trauma.

Raymond SL, Holden DC, Mira JC, Stortz JA, Loftus TJ, Mohr AM, Moldawer LL, Moore FA, Larson SD, Efron PA.

Biochim Biophys Acta Mol Basis Dis. 2017 Oct;1863(10 Pt B):2564-2573. doi: 10.1016/j.bbadis.2017.01.013. Epub 2017 Jan 20. Review.

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