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Items: 40

1.

Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists.

Asano M, Hashimoto K, Saito B, Shiokawa Z, Sumi H, Yabuki M, Yoshimatsu M, Aoyama K, Hamada T, Morishita N, Dougan DR, Mol CD, Yoshida S, Ishikawa T.

Bioorg Med Chem. 2013 Sep 15;21(18):5725-37. doi: 10.1016/j.bmc.2013.07.020. Epub 2013 Jul 18.

PMID:
23928071
2.

Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes.

Tsutakawa SE, Shin DS, Mol CD, Izumi T, Arvai AS, Mantha AK, Szczesny B, Ivanov IN, Hosfield DJ, Maiti B, Pique ME, Frankel KA, Hitomi K, Cunningham RP, Mitra S, Tainer JA.

J Biol Chem. 2013 Mar 22;288(12):8445-55. doi: 10.1074/jbc.M112.422774. Epub 2013 Jan 25.

3.

Structure-activity relationships and key structural feature of pyridyloxybenzene-acylsulfonamides as new, potent, and selective peroxisome proliferator-activated receptor (PPAR) γ Agonists.

Rikimaru K, Wakabayashi T, Abe H, Tawaraishi T, Imoto H, Yonemori J, Hirose H, Murase K, Matsuo T, Matsumoto M, Nomura C, Tsuge H, Arimura N, Kawakami K, Sakamoto J, Funami M, Mol CD, Snell GP, Bragstad KA, Sang BC, Dougan DR, Tanaka T, Katayama N, Horiguchi Y, Momose Y.

Bioorg Med Chem. 2012 May 15;20(10):3332-58. doi: 10.1016/j.bmc.2012.03.036. Epub 2012 Mar 23.

PMID:
22503460
4.

A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR) γ agonists: design and synthesis of benzylpyrazole acylsulfonamides.

Rikimaru K, Wakabayashi T, Abe H, Imoto H, Maekawa T, Ujikawa O, Murase K, Matsuo T, Matsumoto M, Nomura C, Tsuge H, Arimura N, Kawakami K, Sakamoto J, Funami M, Mol CD, Snell GP, Bragstad KA, Sang BC, Dougan DR, Tanaka T, Katayama N, Horiguchi Y, Momose Y.

Bioorg Med Chem. 2012 Jan 15;20(2):714-33. doi: 10.1016/j.bmc.2011.12.008. Epub 2011 Dec 13.

PMID:
22209730
5.

Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors.

Yamashita T, Kamata M, Endo S, Yamamoto M, Kakegawa K, Watanabe H, Miwa K, Yamano T, Funata M, Sakamoto J, Tani A, Mol CD, Zou H, Dougan DR, Sang B, Snell G, Fukatsu K.

Bioorg Med Chem Lett. 2011 Nov 1;21(21):6314-8. doi: 10.1016/j.bmcl.2011.08.117. Epub 2011 Sep 6.

PMID:
21944854
6.

Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists.

Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC, Hamel DJ, Kuhn P, Handel TM, Cherezov V, Stevens RC.

Science. 2010 Nov 19;330(6007):1066-71. doi: 10.1126/science.1194396. Epub 2010 Oct 7.

7.

Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors.

Wallace MB, Adams ME, Kanouni T, Mol CD, Dougan DR, Feher VA, O'Connell SM, Shi L, Halkowycz P, Dong Q.

Bioorg Med Chem Lett. 2010 Jul 15;20(14):4156-8. doi: 10.1016/j.bmcl.2010.05.058. Epub 2010 May 20.

PMID:
20621728
8.

2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta with good brain permeability.

Saitoh M, Kunitomo J, Kimura E, Iwashita H, Uno Y, Onishi T, Uchiyama N, Kawamoto T, Tanaka T, Mol CD, Dougan DR, Textor GP, Snell GP, Takizawa M, Itoh F, Kori M.

J Med Chem. 2009 Oct 22;52(20):6270-86. doi: 10.1021/jm900647e.

PMID:
19775160
9.

Design, synthesis and structure-activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta.

Saitoh M, Kunitomo J, Kimura E, Hayase Y, Kobayashi H, Uchiyama N, Kawamoto T, Tanaka T, Mol CD, Dougan DR, Textor GS, Snell GP, Itoh F.

Bioorg Med Chem. 2009 Mar 1;17(5):2017-29. doi: 10.1016/j.bmc.2009.01.019. Epub 2009 Jan 15.

PMID:
19200745
10.

Structural insights into the conformational selectivity of STI-571 and related kinase inhibitors.

Mol CD, Fabbro D, Hosfield DJ.

Curr Opin Drug Discov Devel. 2004 Sep;7(5):639-48. Review.

PMID:
15503866
11.

Switching on kinases: oncogenic activation of BRAF and the PDGFR family.

Dibb NJ, Dilworth SM, Mol CD.

Nat Rev Cancer. 2004 Sep;4(9):718-27. doi: 10.1038/nrc1434. Review.

PMID:
15343278
12.

Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase.

Mol CD, Dougan DR, Schneider TR, Skene RJ, Kraus ML, Scheibe DN, Snell GP, Zou H, Sang BC, Wilson KP.

J Biol Chem. 2004 Jul 23;279(30):31655-63. Epub 2004 Apr 29.

13.

Crystal structures of active fully assembled substrate- and product-bound complexes of UDP-N-acetylmuramic acid:L-alanine ligase (MurC) from Haemophilus influenzae.

Mol CD, Brooun A, Dougan DR, Hilgers MT, Tari LW, Wijnands RA, Knuth MW, McRee DE, Swanson RV.

J Bacteriol. 2003 Jul;185(14):4152-62.

14.

Structure of a c-kit product complex reveals the basis for kinase transactivation.

Mol CD, Lim KB, Sridhar V, Zou H, Chien EY, Sang BC, Nowakowski J, Kassel DB, Cronin CN, McRee DE.

J Biol Chem. 2003 Aug 22;278(34):31461-4. Epub 2003 Jun 24.

15.

Structure and activity of a thermostable thymine-DNA glycosylase: evidence for base twisting to remove mismatched normal DNA bases.

Mol CD, Arvai AS, Begley TJ, Cunningham RP, Tainer JA.

J Mol Biol. 2002 Jan 18;315(3):373-84.

PMID:
11786018
16.

DNA damage recognition and repair pathway coordination revealed by the structural biochemistry of DNA repair enzymes.

Hosfield DJ, Daniels DS, Mol CD, Putnam CD, Parikh SS, Tainer JA.

Prog Nucleic Acid Res Mol Biol. 2001;68:315-47. Review.

PMID:
11554309
17.
18.

Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding.

Daniels DS, Mol CD, Arvai AS, Kanugula S, Pegg AE, Tainer JA.

EMBO J. 2000 Apr 3;19(7):1719-30.

19.

DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected].

Mol CD, Izumi T, Mitra S, Tainer JA.

Nature. 2000 Jan 27;403(6768):451-6. Erratum in: Nature 2000 Mar 30;404(6777.

PMID:
10667800
20.

DNA repair mechanisms for the recognition and removal of damaged DNA bases.

Mol CD, Parikh SS, Putnam CD, Lo TP, Tainer JA.

Annu Rev Biophys Biomol Struct. 1999;28:101-28. Review.

PMID:
10410797
21.

Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with Escherichia coli uracil-DNA glycosylase.

Putnam CD, Shroyer MJ, Lundquist AJ, Mol CD, Arvai AS, Mosbaugh DW, Tainer JA.

J Mol Biol. 1999 Mar 26;287(2):331-46.

PMID:
10080896
22.

Envisioning the molecular choreography of DNA base excision repair.

Parikh SS, Mol CD, Hosfield DJ, Tainer JA.

Curr Opin Struct Biol. 1999 Feb;9(1):37-47. Review.

PMID:
10047578
23.

MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily.

Guan Y, Manuel RC, Arvai AS, Parikh SS, Mol CD, Miller JH, Lloyd S, Tainer JA.

Nat Struct Biol. 1998 Dec;5(12):1058-64.

PMID:
9846876
24.
25.

Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.

Parikh SS, Mol CD, Slupphaug G, Bharati S, Krokan HE, Tainer JA.

EMBO J. 1998 Sep 1;17(17):5214-26.

26.
27.

The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites.

Gorman MA, Morera S, Rothwell DG, de La Fortelle E, Mol CD, Tainer JA, Hickson ID, Freemont PS.

EMBO J. 1997 Nov 3;16(21):6548-58.

28.

A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA.

Slupphaug G, Mol CD, Kavli B, Arvai AS, Krokan HE, Tainer JA.

Nature. 1996 Nov 7;384(6604):87-92.

PMID:
8900285
29.
30.

Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase.

Kavli B, Slupphaug G, Mol CD, Arvai AS, Peterson SB, Tainer JA, Krokan HE.

EMBO J. 1996 Jul 1;15(13):3442-7.

31.

Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: protein mimicry of DNA.

Mol CD, Arvai AS, Sanderson RJ, Slupphaug G, Kavli B, Krokan HE, Mosbaugh DW, Tainer JA.

Cell. 1995 Sep 8;82(5):701-8.

32.

Identification of critical active-site residues in the multifunctional human DNA repair enzyme HAP1.

Barzilay G, Mol CD, Robson CN, Walker LJ, Cunningham RP, Tainer JA, Hickson ID.

Nat Struct Biol. 1995 Jul;2(7):561-8.

PMID:
7664124
33.

Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis.

Mol CD, Arvai AS, Slupphaug G, Kavli B, Alseth I, Krokan HE, Tainer JA.

Cell. 1995 Mar 24;80(6):869-78.

34.

Structure and function of the multifunctional DNA-repair enzyme exonuclease III.

Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA.

Nature. 1995 Mar 23;374(6520):381-6.

PMID:
7885481
35.

Structure and function of the DNA repair enzyme exonuclease III from E. coli.

Kuo CF, Mol CD, Thayer MM, Cunningham RP, Tainer JA.

Ann N Y Acad Sci. 1994 Jul 29;726:223-34; discussion 234-5. Review.

PMID:
8092679
36.

Sequencing and modeling of anti-DNA immunoglobulin Fv domains. Comparison with crystal structures.

Barry MM, Mol CD, Anderson WF, Lee JS.

J Biol Chem. 1994 Feb 4;269(5):3623-32.

37.

Structure of an immunoglobulin Fab fragment specific for triple-stranded DNA.

Mol CD, Muir AK, Cygler M, Lee JS, Anderson WF.

J Biol Chem. 1994 Feb 4;269(5):3615-22.

38.

Structure of an immunoglobulin Fab fragment specific for poly(dG).poly(dC).

Mol CD, Muir AK, Lee JS, Anderson WF.

J Biol Chem. 1994 Feb 4;269(5):3605-14.

39.

Crystallization of immunoglobulin Fab fragments specific for DNA.

Boodhoo A, Mol CD, Lee JS, Anderson WF.

J Biol Chem. 1988 Dec 5;263(34):18578-81.

40.

Structural and functional homology of parvovirus and papovavirus polypeptides.

Astell CR, Mol CD, Anderson WF.

J Gen Virol. 1987 Mar;68 ( Pt 3):885-93.

PMID:
3819702

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