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Items: 20

1.

Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity.

Lotta LA, Mokrosiński J, Mendes de Oliveira E, Li C, Sharp SJ, Luan J, Brouwers B, Ayinampudi V, Bowker N, Kerrison N, Kaimakis V, Hoult D, Stewart ID, Wheeler E, Day FR, Perry JRB, Langenberg C, Wareham NJ, Farooqi IS.

Cell. 2019 Apr 18;177(3):597-607.e9. doi: 10.1016/j.cell.2019.03.044.

2.

The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones.

Rudenko O, Shang J, Munk A, Ekberg JP, Petersen N, Engelstoft MS, Egerod KL, Hjorth SA, Wu M, Feng Y, Zhou YP, Mokrosinski J, Thams P, Reimann F, Gribble F, Rehfeld JF, Holst JJ, Treebak JT, Howard AD, Schwartz TW.

Mol Metab. 2019 Jan;19:49-64. doi: 10.1016/j.molmet.2018.10.012. Epub 2018 Nov 5.

3.

MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency.

Clément K, Biebermann H, Farooqi IS, Van der Ploeg L, Wolters B, Poitou C, Puder L, Fiedorek F, Gottesdiener K, Kleinau G, Heyder N, Scheerer P, Blume-Peytavi U, Jahnke I, Sharma S, Mokrosinski J, Wiegand S, Müller A, Weiß K, Mai K, Spranger J, Grüters A, Blankenstein O, Krude H, Kühnen P.

Nat Med. 2018 May;24(5):551-555. doi: 10.1038/s41591-018-0015-9. Epub 2018 May 7.

PMID:
29736023
4.

Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis.

Syed I, Lee J, Moraes-Vieira PM, Donaldson CJ, Sontheimer A, Aryal P, Wellenstein K, Kolar MJ, Nelson AT, Siegel D, Mokrosinski J, Farooqi IS, Zhao JJ, Yore MM, Peroni OD, Saghatelian A, Kahn BB.

Cell Metab. 2018 Feb 6;27(2):419-427.e4. doi: 10.1016/j.cmet.2018.01.001.

5.

Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency.

Collet TH, Dubern B, Mokrosinski J, Connors H, Keogh JM, Mendes de Oliveira E, Henning E, Poitou-Bernert C, Oppert JM, Tounian P, Marchelli F, Alili R, Le Beyec J, Pépin D, Lacorte JM, Gottesdiener A, Bounds R, Sharma S, Folster C, Henderson B, O'Rahilly S, Stoner E, Gottesdiener K, Panaro BL, Cone RD, Clément K, Farooqi IS, Van der Ploeg LHT.

Mol Metab. 2017 Oct;6(10):1321-1329. doi: 10.1016/j.molmet.2017.06.015. Epub 2017 Jul 8.

6.

The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW.

Nøhr AC, Shehata MA, Hauser AS, Isberg V, Mokrosinski J, Andersen KB, Farooqi IS, Pedersen DS, Gloriam DE, Bräuner-Osborne H.

Neurochem Int. 2017 Jan;102:105-113. doi: 10.1016/j.neuint.2016.11.012. Epub 2016 Dec 1.

7.

A Novel Thyrotropin-Releasing Hormone Receptor Missense Mutation (P81R) in Central Congenital Hypothyroidism.

Koulouri O, Nicholas AK, Schoenmakers E, Mokrosinski J, Lane F, Cole T, Kirk J, Farooqi IS, Chatterjee VK, Gurnell M, Schoenmakers N.

J Clin Endocrinol Metab. 2016 Mar;101(3):847-51. doi: 10.1210/jc.2015-3916. Epub 2016 Jan 6.

8.

Biased Gs versus Gq proteins and β-arrestin signaling in the NK1 receptor determined by interactions in the water hydrogen bond network.

Valentin-Hansen L, Frimurer TM, Mokrosinski J, Holliday ND, Schwartz TW.

J Biol Chem. 2015 Oct 2;290(40):24495-508. doi: 10.1074/jbc.M115.641944. Epub 2015 Aug 12.

9.

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes.

Albrechtsen A, Grarup N, Li Y, Sparsø T, Tian G, Cao H, Jiang T, Kim SY, Korneliussen T, Li Q, Nie C, Wu R, Skotte L, Morris AP, Ladenvall C, Cauchi S, Stančáková A, Andersen G, Astrup A, Banasik K, Bennett AJ, Bolund L, Charpentier G, Chen Y, Dekker JM, Doney AS, Dorkhan M, Forsen T, Frayling TM, Groves CJ, Gui Y, Hallmans G, Hattersley AT, He K, Hitman GA, Holmkvist J, Huang S, Jiang H, Jin X, Justesen JM, Kristiansen K, Kuusisto J, Lajer M, Lantieri O, Li W, Liang H, Liao Q, Liu X, Ma T, Ma X, Manijak MP, Marre M, Mokrosiński J, Morris AD, Mu B, Nielsen AA, Nijpels G, Nilsson P, Palmer CN, Rayner NW, Renström F, Ribel-Madsen R, Robertson N, Rolandsson O, Rossing P, Schwartz TW; D.E.S.I.R. Study Group, Slagboom PE, Sterner M; DIAGRAM Consortium, Tang M, Tarnow L, Tuomi T, van't Riet E, van Leeuwen N, Varga TV, Vestmar MA, Walker M, Wang B, Wang Y, Wu H, Xi F, Yengo L, Yu C, Zhang X, Zhang J, Zhang Q, Zhang W, Zheng H, Zhou Y, Altshuler D, 't Hart LM, Franks PW, Balkau B, Froguel P, McCarthy MI, Laakso M, Groop L, Christensen C, Brandslund I, Lauritzen T, Witte DR, Linneberg A, Jørgensen T, Hansen T, Wang J, Nielsen R, Pedersen O.

Diabetologia. 2013 Feb;56(2):298-310. doi: 10.1007/s00125-012-2756-1. Epub 2012 Nov 19.

10.

An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor.

Els S, Schild E, Petersen PS, Kilian TM, Mokrosinski J, Frimurer TM, Chollet C, Schwartz TW, Holst B, Beck-Sickinger AG.

J Med Chem. 2012 Sep 13;55(17):7437-49. doi: 10.1021/jm300414b. Epub 2012 Sep 5.

PMID:
22920150
11.

Modulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop.

Mokrosiński J, Frimurer TM, Sivertsen B, Schwartz TW, Holst B.

J Biol Chem. 2012 Sep 28;287(40):33488-502. Epub 2012 Jul 30.

12.

Expression of endoglin in primary endometrial cancer.

Zakrzewski PK, Cygankiewicz AI, Mokrosiński J, Nowacka-Zawisza M, Semczuk A, Rechberger T, Krajewska WM.

Oncology. 2011;81(3-4):243-50. doi: 10.1159/000334240. Epub 2011 Nov 22.

PMID:
22116456
13.

The E92K melanocortin 1 receptor mutant induces cAMP production and arrestin recruitment but not ERK activity indicating biased constitutive signaling.

Benned-Jensen T, Mokrosinski J, Rosenkilde MM.

PLoS One. 2011;6(9):e24644. doi: 10.1371/journal.pone.0024644. Epub 2011 Sep 13.

14.

Allosteric and orthosteric sites in CC chemokine receptor (CCR5), a chimeric receptor approach.

Thiele S, Steen A, Jensen PC, Mokrosinski J, Frimurer TM, Rosenkilde MM.

J Biol Chem. 2011 Oct 28;286(43):37543-54. doi: 10.1074/jbc.M111.243808. Epub 2011 Aug 30.

15.

Dysregulation of betaglycan expression in primary human endometrial carcinomas.

Zakrzewski PK, Mokrosinski J, Cygankiewicz AI, Semczuk A, Rechberger T, Skomra D, Krajewska WM.

Cancer Invest. 2011 Feb;29(2):137-44. doi: 10.3109/07357907.2010.543213.

PMID:
21261473
16.

Modulation of the constitutive activity of the ghrelin receptor by use of pharmacological tools and mutagenesis.

Mokrosiński J, Holst B.

Methods Enzymol. 2010;484:53-73. doi: 10.1016/B978-0-12-381298-8.00003-4.

PMID:
21036226
17.

Conserved water-mediated hydrogen bond network between TM-I, -II, -VI, and -VII in 7TM receptor activation.

Nygaard R, Valentin-Hansen L, Mokrosinski J, Frimurer TM, Schwartz TW.

J Biol Chem. 2010 Jun 18;285(25):19625-36. doi: 10.1074/jbc.M110.106021. Epub 2010 Apr 15.

18.

[TGF beta signalling accessory receptors].

Mokrosiński J, Krajewska WM.

Postepy Biochem. 2008;54(3):264-73. Review. Polish.

PMID:
19112825
19.

Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor.

Holst B, Frimurer TM, Mokrosinski J, Halkjaer T, Cullberg KB, Underwood CR, Schwartz TW.

Mol Pharmacol. 2009 Jan;75(1):44-59. doi: 10.1124/mol.108.049189. Epub 2008 Oct 15.

PMID:
18923064
20.

Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism.

Holst B, Mokrosinski J, Lang M, Brandt E, Nygaard R, Frimurer TM, Beck-Sickinger AG, Schwartz TW.

J Biol Chem. 2007 May 25;282(21):15799-811. Epub 2007 Mar 19.

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