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Items: 44

1.

A mutagenesis analysis of Tim50, the major receptor of the TIM23 complex, identifies regions that affect its interaction with Tim23.

Dayan D, Bandel M, Günsel U, Nussbaum I, Prag G, Mokranjac D, Neupert W, Azem A.

Sci Rep. 2019 Feb 14;9(1):2012. doi: 10.1038/s41598-018-38353-1.

2.

MICU1 Confers Protection from MCU-Dependent Manganese Toxicity.

Wettmarshausen J, Goh V, Huang KT, Arduino DM, Tripathi U, Leimpek A, Cheng Y, Pittis AA, Gabaldón T, Mokranjac D, Hajnóczky G, Perocchi F.

Cell Rep. 2018 Nov 6;25(6):1425-1435.e7. doi: 10.1016/j.celrep.2018.10.037.

3.

Cardiolipin mediates membrane and channel interactions of the mitochondrial TIM23 protein import complex receptor Tim50.

Malhotra K, Modak A, Nangia S, Daman TH, Gunsel U, Robinson VL, Mokranjac D, May ER, Alder NN.

Sci Adv. 2017 Sep 1;3(9):e1700532. doi: 10.1126/sciadv.1700532. eCollection 2017 Sep.

4.

Systematic Identification of MCU Modulators by Orthogonal Interspecies Chemical Screening.

Arduino DM, Wettmarshausen J, Vais H, Navas-Navarro P, Cheng Y, Leimpek A, Ma Z, Delrio-Lorenzo A, Giordano A, Garcia-Perez C, Médard G, Kuster B, García-Sancho J, Mokranjac D, Foskett JK, Alonso MT, Perocchi F.

Mol Cell. 2017 Aug 17;67(4):711-723.e7. doi: 10.1016/j.molcel.2017.07.019.

5.

Chemical Crosslinking in Intact Mitochondria.

Banerjee R, Günsel U, Mokranjac D.

Methods Mol Biol. 2017;1567:139-154. doi: 10.1007/978-1-4939-6824-4_9.

PMID:
28276017
6.

Role of Tim17 in coupling the import motor to the translocation channel of the mitochondrial presequence translocase.

Demishtein-Zohary K, Günsel U, Marom M, Banerjee R, Neupert W, Azem A, Mokranjac D.

Elife. 2017 Feb 6;6. pii: e22696. doi: 10.7554/eLife.22696.

7.

Mitochondrial protein import: An unexpected disulfide bond.

Mokranjac D.

J Cell Biol. 2016 Aug 15;214(4):363-5. doi: 10.1083/jcb.201607117. Epub 2016 Aug 8.

8.

Protein translocation channel of mitochondrial inner membrane and matrix-exposed import motor communicate via two-domain coupling protein.

Banerjee R, Gladkova C, Mapa K, Witte G, Mokranjac D.

Elife. 2015 Dec 29;4:e11897. doi: 10.7554/eLife.11897.

9.

Cell biology: Architecture of a protein entry gate.

Mokranjac D, Neupert W.

Nature. 2015 Dec 10;528(7581):201-2. doi: 10.1038/nature16318. Epub 2015 Nov 25. No abstract available.

PMID:
26605527
10.

Nucleotides regulate the mechanical hierarchy between subdomains of the nucleotide binding domain of the Hsp70 chaperone DnaK.

Bauer D, Merz DR, Pelz B, Theisen KE, Yacyshyn G, Mokranjac D, Dima RI, Rief M, Žoldák G.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10389-94. doi: 10.1073/pnas.1504625112. Epub 2015 Aug 3.

11.

GxxxG motifs hold the TIM23 complex together.

Demishtein-Zohary K, Marom M, Neupert W, Mokranjac D, Azem A.

FEBS J. 2015 Jun;282(11):2178-86. doi: 10.1111/febs.13266. Epub 2015 Apr 10.

12.

Editorial overview: elucidation of protein translocation pathways, part II.

Mokranjac D, High S.

J Mol Biol. 2015 Mar 27;427(6 Pt A):1133-4. doi: 10.1016/j.jmb.2015.02.020. No abstract available.

PMID:
25755004
13.

Functional complementation analyses reveal that the single PRAT family protein of trypanosoma brucei is a divergent homolog of Tim17 in saccharomyces cerevisiae.

Weems E, Singha UK, Hamilton V, Smith JT, Waegemann K, Mokranjac D, Chaudhuri M.

Eukaryot Cell. 2015 Mar;14(3):286-96. doi: 10.1128/EC.00203-14. Epub 2015 Jan 9.

14.

Cooperation of TOM and TIM23 complexes during translocation of proteins into mitochondria.

Waegemann K, Popov-Čeleketić D, Neupert W, Azem A, Mokranjac D.

J Mol Biol. 2015 Mar 13;427(5):1075-84. doi: 10.1016/j.jmb.2014.07.015. Epub 2014 Jul 30.

PMID:
25083920
15.

Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1.

Burbulla LF, Fitzgerald JC, Stegen K, Westermeier J, Thost AK, Kato H, Mokranjac D, Sauerwald J, Martins LM, Woitalla D, Rapaport D, Riess O, Proikas-Cezanne T, Rasse TM, Krüger R.

Cell Death Dis. 2014 Apr 17;5:e1180. doi: 10.1038/cddis.2014.103.

16.

Real-time observation of the conformational dynamics of mitochondrial Hsp70 by spFRET.

Sikor M, Mapa K, von Voithenberg LV, Mokranjac D, Lamb DC.

EMBO J. 2013 May 29;32(11):1639-49. doi: 10.1038/emboj.2013.89. Epub 2013 Apr 26.

17.

Role of the AAA protease Yme1 in folding of proteins in the intermembrane space of mitochondria.

Schreiner B, Westerburg H, Forné I, Imhof A, Neupert W, Mokranjac D.

Mol Biol Cell. 2012 Nov;23(22):4335-46. doi: 10.1091/mbc.E12-05-0420. Epub 2012 Sep 19.

18.

Combining MFD and PIE for accurate single-pair Förster resonance energy transfer measurements.

Kudryavtsev V, Sikor M, Kalinin S, Mokranjac D, Seidel CA, Lamb DC.

Chemphyschem. 2012 Mar;13(4):1060-78. doi: 10.1002/cphc.201100822. Epub 2012 Mar 1.

19.

The mitochondrial contact site complex, a determinant of mitochondrial architecture.

Harner M, Körner C, Walther D, Mokranjac D, Kaesmacher J, Welsch U, Griffith J, Mann M, Reggiori F, Neupert W.

EMBO J. 2011 Oct 18;30(21):4356-70. doi: 10.1038/emboj.2011.379.

20.

Direct interaction of mitochondrial targeting presequences with purified components of the TIM23 protein complex.

Marom M, Dayan D, Demishtein-Zohary K, Mokranjac D, Neupert W, Azem A.

J Biol Chem. 2011 Dec 23;286(51):43809-15. doi: 10.1074/jbc.M111.261040. Epub 2011 Oct 3.

21.

Role of the import motor in insertion of transmembrane segments by the mitochondrial TIM23 complex.

Popov-Čeleketić D, Waegemann K, Mapa K, Neupert W, Mokranjac D.

EMBO Rep. 2011 Jun;12(6):542-8. doi: 10.1038/embor.2011.72. Epub 2011 May 6.

22.

Understanding the molecular mechanism of protein translocation across the mitochondrial inner membrane: still a long way to go.

Marom M, Azem A, Mokranjac D.

Biochim Biophys Acta. 2011 Mar;1808(3):990-1001. doi: 10.1016/j.bbamem.2010.07.011. Epub 2010 Jul 18. Review.

23.

The conformational dynamics of the mitochondrial Hsp70 chaperone.

Mapa K, Sikor M, Kudryavtsev V, Waegemann K, Kalinin S, Seidel CA, Neupert W, Lamb DC, Mokranjac D.

Mol Cell. 2010 Apr 9;38(1):89-100. doi: 10.1016/j.molcel.2010.03.010.

24.

The many faces of the mitochondrial TIM23 complex.

Mokranjac D, Neupert W.

Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):1045-54. doi: 10.1016/j.bbabio.2010.01.026. Epub 2010 Jan 28. Review.

25.

ATPase domain and interdomain linker play a key role in aggregation of mitochondrial Hsp70 chaperone Ssc1.

Blamowska M, Sichting M, Mapa K, Mokranjac D, Neupert W, Hell K.

J Biol Chem. 2010 Feb 12;285(7):4423-31. doi: 10.1074/jbc.M109.061697. Epub 2009 Dec 10.

26.

Role of Tim50 in the transfer of precursor proteins from the outer to the inner membrane of mitochondria.

Mokranjac D, Sichting M, Popov-Celeketić D, Mapa K, Gevorkyan-Airapetov L, Zohary K, Hell K, Azem A, Neupert W.

Mol Biol Cell. 2009 Mar;20(5):1400-7. doi: 10.1091/mbc.E08-09-0934. Epub 2009 Jan 14.

27.

Interaction of Tim23 with Tim50 Is essential for protein translocation by the mitochondrial TIM23 complex.

Gevorkyan-Airapetov L, Zohary K, Popov-Celeketic D, Mapa K, Hell K, Neupert W, Azem A, Mokranjac D.

J Biol Chem. 2009 Feb 20;284(8):4865-72. doi: 10.1074/jbc.M807041200. Epub 2008 Nov 18.

28.

Thirty years of protein translocation into mitochondria: unexpectedly complex and still puzzling.

Mokranjac D, Neupert W.

Biochim Biophys Acta. 2009 Jan;1793(1):33-41. doi: 10.1016/j.bbamcr.2008.06.021. Epub 2008 Jul 12. Review.

29.

Energetics of protein translocation into mitochondria.

Mokranjac D, Neupert W.

Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):758-62. doi: 10.1016/j.bbabio.2008.04.009. Epub 2008 Apr 12. Review.

30.

Active remodelling of the TIM23 complex during translocation of preproteins into mitochondria.

Popov-Celeketić D, Mapa K, Neupert W, Mokranjac D.

EMBO J. 2008 May 21;27(10):1469-80. doi: 10.1038/emboj.2008.79. Epub 2008 Apr 17.

31.

Protein import into isolated mitochondria.

Mokranjac D, Neupert W.

Methods Mol Biol. 2007;372:277-86. doi: 10.1007/978-1-59745-365-3_20.

PMID:
18314733
32.

Association of the Tim14.Tim16 subcomplex with the TIM23 translocase is crucial for function of the mitochondrial protein import motor.

Mokranjac D, Berg A, Adam A, Neupert W, Hell K.

J Biol Chem. 2007 Jun 22;282(25):18037-45. Epub 2007 Apr 23.

33.

Characterization of the preprotein and amino acid transporter gene family in Arabidopsis.

Murcha MW, Elhafez D, Lister R, Tonti-Filippini J, Baumgartner M, Philippar K, Carrie C, Mokranjac D, Soll J, Whelan J.

Plant Physiol. 2007 Jan;143(1):199-212. Epub 2006 Nov 10.

34.

Structure and function of Tim14 and Tim16, the J and J-like components of the mitochondrial protein import motor.

Mokranjac D, Bourenkov G, Hell K, Neupert W, Groll M.

EMBO J. 2006 Oct 4;25(19):4675-85. Epub 2006 Sep 14.

35.

Protein import into mitochondria.

Mokranjac D, Neupert W.

Biochem Soc Trans. 2005 Nov;33(Pt 5):1019-23. Review.

PMID:
16246036
36.

The import motor of the yeast mitochondrial TIM23 preprotein translocase contains two different J proteins, Tim14 and Mdj2.

Mokranjac D, Sichting M, Popov-Celeketić D, Berg A, Hell K, Neupert W.

J Biol Chem. 2005 Sep 9;280(36):31608-14. Epub 2005 Jul 18.

37.

Role of Tim21 in mitochondrial translocation contact sites.

Mokranjac D, Popov-Celeketić D, Hell K, Neupert W.

J Biol Chem. 2005 Jun 24;280(25):23437-40. Epub 2005 May 4.

38.

Maintenance of structure and function of mitochondrial Hsp70 chaperones requires the chaperone Hep1.

Sichting M, Mokranjac D, Azem A, Neupert W, Hell K.

EMBO J. 2005 Mar 9;24(5):1046-56. Epub 2005 Feb 17.

39.

Mia40, a novel factor for protein import into the intermembrane space of mitochondria is able to bind metal ions.

Terziyska N, Lutz T, Kozany C, Mokranjac D, Mesecke N, Neupert W, Herrmann JM, Hell K.

FEBS Lett. 2005 Jan 3;579(1):179-84.

40.

Tob38, a novel essential component in the biogenesis of beta-barrel proteins of mitochondria.

Waizenegger T, Habib SJ, Lech M, Mokranjac D, Paschen SA, Hell K, Neupert W, Rapaport D.

EMBO Rep. 2004 Jul;5(7):704-9. Epub 2004 Jun 18.

41.

The J domain-related cochaperone Tim16 is a constituent of the mitochondrial TIM23 preprotein translocase.

Kozany C, Mokranjac D, Sichting M, Neupert W, Hell K.

Nat Struct Mol Biol. 2004 Mar;11(3):234-41. Epub 2004 Feb 15.

PMID:
14981506
42.

Tim14, a novel key component of the import motor of the TIM23 protein translocase of mitochondria.

Mokranjac D, Sichting M, Neupert W, Hell K.

EMBO J. 2003 Oct 1;22(19):4945-56.

43.

Tim50, a novel component of the TIM23 preprotein translocase of mitochondria.

Mokranjac D, Paschen SA, Kozany C, Prokisch H, Hoppins SC, Nargang FE, Neupert W, Hell K.

EMBO J. 2003 Feb 17;22(4):816-25.

44.

Systematic screen for human disease genes in yeast.

Steinmetz LM, Scharfe C, Deutschbauer AM, Mokranjac D, Herman ZS, Jones T, Chu AM, Giaever G, Prokisch H, Oefner PJ, Davis RW.

Nat Genet. 2002 Aug;31(4):400-4. Epub 2002 Jul 22.

PMID:
12134146

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