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Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation.

Chen JJ, Nathaniel DL, Raghavan P, Nelson M, Tian R, Tse E, Hong JY, See SK, Mok SA, Hein MY, Southworth DR, Grinberg LT, Gestwicki JE, Leonetti MD, Kampmann M.

J Biol Chem. 2019 Oct 2. pii: jbc.RA119.009432. doi: 10.1074/jbc.RA119.009432. [Epub ahead of print]


Chromatin-informed inference of transcriptional programs in gynecologic and basal breast cancers.

Osmanbeyoglu HU, Shimizu F, Rynne-Vidal A, Alonso-Curbelo D, Chen HA, Wen HY, Yeung TL, Jelinic P, Razavi P, Lowe SW, Mok SC, Chiosis G, Levine DA, Leslie CS.

Nat Commun. 2019 Sep 25;10(1):4369. doi: 10.1038/s41467-019-12291-6.


A Novel Drug Resistance Mechanism: Genetic Loss of Xeroderma Pigmentosum Complementation Group C (XPC) Enhances Glycolysis-Mediated Drug Resistance in DLD-1 Colon Cancer Cells.

Han Y, Qu YQ, Mok SWF, Chen J, Xia CL, He HQ, Li Z, Zhang W, Qiu CL, Liu L, Law BYK, Wong VKW.

Front Pharmacol. 2019 Sep 10;10:912. doi: 10.3389/fphar.2019.00912. eCollection 2019.


Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis.

Sohn PD, Huang CT, Yan R, Fan L, Tracy TE, Camargo CM, Montgomery KM, Arhar T, Mok SA, Freilich R, Baik J, He M, Gong S, Roberson ED, Karch CM, Gestwicki JE, Xu K, Kosik KS, Gan L.

Neuron. 2019 Sep 4. pii: S0896-6273(19)30692-0. doi: 10.1016/j.neuron.2019.08.008. [Epub ahead of print]


Intra-articular injection of magnesium chloride attenuates osteoarthritis progression in rats.

Yao H, Xu JK, Zheng NY, Wang JL, Mok SW, Lee YW, Shi L, Wang JY, Yue J, Yung SH, Hu PJ, Ruan YC, Zhang YF, Ho KW, Qin L.

Osteoarthritis Cartilage. 2019 Sep 16. pii: S1063-4584(19)31203-8. doi: 10.1016/j.joca.2019.08.007. [Epub ahead of print]


Lymphocyte-specific kinase expression is a prognostic indicator in ovarian cancer and correlates with a prominent B cell transcriptional signature.

Hinchcliff E, Paquette C, Roszik J, Kelting S, Stoler MH, Mok SC, Yeung TL, Zhang Q, Yates M, Peng W, Hwu P, Jazaeri A.

Cancer Immunol Immunother. 2019 Sep;68(9):1515-1526. doi: 10.1007/s00262-019-02385-x. Epub 2019 Sep 12.


Perceptions of a night float system for intern doctors in an internal medicine program: an Asian perspective.

Tan BY, Ngiam NJ, Chang ZY, Tan SMY, Shen X, Mok SF, Subramanian S, Ooi SBS, Kee AC.

Korean J Med Educ. 2019 Sep;31(3):271-276. doi: 10.3946/kjme.2019.137. Epub 2019 Aug 26.


Testosterone for Androgen Deficiency-Like Symptoms in Men Without Pathologic Hypogonadism: A Randomized, Placebo-Controlled Cross-Over with Masked Choice Extension Clinical Trial.

Mok SF, Fennell C, Savkovic S, Turner L, Jayadev V, Conway A, Handelsman DJ.

J Gerontol A Biol Sci Med Sci. 2019 Aug 19. pii: glz195. doi: 10.1093/gerona/glz195. [Epub ahead of print]


Anticancer Immunotherapy by MFAP5 Blockade Inhibits Fibrosis and Enhances Chemosensitivity in Ovarian and Pancreatic Cancer.

Yeung TL, Leung CS, Yip KP, Sheng J, Vien L, Bover LC, Birrer MJ, Wong STC, Mok SC.

Clin Cancer Res. 2019 Jul 22. doi: 10.1158/1078-0432.CCR-19-0187. [Epub ahead of print]


Micropocket hydrogel devices for all-in-one formation, assembly, and analysis of aggregate-based tissues.

Zhao L, Mok S, Moraes C.

Biofabrication. 2019 Aug 13;11(4):045013. doi: 10.1088/1758-5090/ab30b4.


Antimicrobial Susceptibility of Clinical and Environmental Mycobacterium chimaera Isolates.

Mok S, Hannan MM, Nölke L, Stapleton P, O'Sullivan N, Murphy P, McLaughlin AM, McNamara E, Fitzgibbon MM, Rogers TR.

Antimicrob Agents Chemother. 2019 Aug 23;63(9). pii: e00755-19. doi: 10.1128/AAC.00755-19. Print 2019 Sep.


Management and clinical outcomes of periprosthetic fractures after total knee arthroplasty with a stem extension.

Shin JH, Chang MJ, Kang SB, Chang CB, Kim DH, Lee SA, Mok SJ.

Medicine (Baltimore). 2019 Jun;98(25):e16088. doi: 10.1097/MD.0000000000016088.


Effectiveness of near-peer simulation for managing the acutely deteriorating patient among residents of an internal medicine junior residency programme.

Shen X, Tay BWR, Tan BY, Ngiam NJ, Mok JSR, Mok SF, Yap ES, Khoo SM.

Singapore Med J. 2019 Jun 14. doi: 10.11622/smedj.2019056. [Epub ahead of print]


Ca2+ signalling plays a role in celastrol-mediated suppression of synovial fibroblasts of rheumatoid arthritis patients and experimental arthritis in rats.

Wong VKW, Qiu C, Xu SW, Law BYK, Zeng W, Wang H, Michelangeli F, Dias IRSR, Qu YQ, Chan TW, Han Y, Zhang N, Mok SWF, Chen X, Yu L, Pan H, Hamdoun S, Efferth T, Yu WJ, Zhang W, Li Z, Xie Y, Luo R, Jiang Q, Liu L.

Br J Pharmacol. 2019 Aug;176(16):2922-2944. doi: 10.1111/bph.14718. Epub 2019 Jul 4.


Global Spread of Mutant PfCRT and Its Pleiotropic Impact on Plasmodium falciparum Multidrug Resistance and Fitness.

Dhingra SK, Gabryszewski SJ, Small-Saunders JL, Yeo T, Henrich PP, Mok S, Fidock DA.

MBio. 2019 Apr 30;10(2). pii: e02731-18. doi: 10.1128/mBio.02731-18.


Extensive unroofing of myocardial bridge: A case report and literature review.

Mok S, Majdalany D, Pettersson GB.

SAGE Open Med Case Rep. 2019 Jan 16;7:2050313X18823380. doi: 10.1177/2050313X18823380. eCollection 2019.


Remote Antimicrobial Stewardship: A Solution for Meeting The Joint Commission Stewardship Standard?

Howell CK, Jacob J, Mok S.

Hosp Pharm. 2019 Feb;54(1):51-56. doi: 10.1177/0018578718769240. Epub 2018 Apr 10.


Advances in managing the noninfected open chest after cardiac surgery: Negative-pressure wound therapy.

Bakaeen FG, Haddad O, Ibrahim M, Pasadyn SR, Germano E, Mok S, Halbreiner MS, McCurry KR, Johnston DR, Mick SL, Navia JL, Roselli EE, Smedira NG, Soltesz EG, Tong MZ, Wierup P, Gillinov AM, Svensson LG, Houghtaling PL, Blackstone EH, Pettersson GB.

J Thorac Cardiovasc Surg. 2019 May;157(5):1891-1903.e9. doi: 10.1016/j.jtcvs.2018.10.152. Epub 2018 Nov 27.


The Role of EUS in Liver Biopsy.

Mok SRS, Diehl DL.

Curr Gastroenterol Rep. 2019 Jan 31;21(2):6. doi: 10.1007/s11894-019-0675-8. Review.


Endoscopic ultrasound-guided biopsy in chronic liver disease: a randomized comparison of 19-G FNA and 22-G FNB needles.

Mok SRS, Diehl DL, Johal AS, Khara HS, Confer BD, Mudireddy PR, Kovach AH, Diehl MM, Kirchner HL, Chen ZE.

Endosc Int Open. 2019 Jan;7(1):E62-E71. doi: 10.1055/a-0655-7462. Epub 2019 Jan 4.


Dispersible hydrogel force sensors reveal patterns of solid mechanical stress in multicellular spheroid cultures.

Lee W, Kalashnikov N, Mok S, Halaoui R, Kuzmin E, Putnam AJ, Takayama S, Park M, McCaffrey L, Zhao R, Leask RL, Moraes C.

Nat Commun. 2019 Jan 11;10(1):144. doi: 10.1038/s41467-018-07967-4.


Health professionals' involvement and information provision in genetic counseling following prenatal diagnosis of sex chromosome aneuploidy in Hong Kong.

So PL, Cheng YKY, Cheuk KY, Chiu WK, Mak SL, Mok SL, Lo TK, Yung WK, Lo FM, Chung BHY, Kan ASY, Lee CP, Tang MHY.

Int J Gynaecol Obstet. 2019 Mar;144(3):314-316. doi: 10.1002/ijgo.12737. Epub 2018 Dec 19.


The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background.

Zhu L, Tripathi J, Rocamora FM, Miotto O, van der Pluijm R, Voss TS, Mok S, Kwiatkowski DP, Nosten F, Day NPJ, White NJ, Dondorp AM, Bozdech Z; Tracking Resistance to Artemisinin Collaboration I.

Nat Commun. 2018 Dec 4;9(1):5158. doi: 10.1038/s41467-018-07588-x.


ISG15 Promotes ERK1 ISGylation, CD8+ T Cell Activation and Suppresses Ovarian Cancer Progression.

Yeung TL, Tsai CC, Leung CS, Au Yeung CL, Thompson MS, Lu KH, Freedman RS, Birrer MJ, Wong KK, Mok SC.

Cancers (Basel). 2018 Nov 22;10(12). pii: E464. doi: 10.3390/cancers10120464.


Novel dauricine derivatives suppress cancer via autophagy-dependent cell death.

Zhou X, Qu YQ, Zheng Z, Law BYK, Mok SWF, Jiang ZH, Wong VKW, Bai LP.

Bioorg Chem. 2019 Mar;83:450-460. doi: 10.1016/j.bioorg.2018.10.074. Epub 2018 Nov 2.


Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau.

Freilich R, Betegon M, Tse E, Mok SA, Julien O, Agard DA, Southworth DR, Takeuchi K, Gestwicki JE.

Nat Commun. 2018 Nov 1;9(1):4563. doi: 10.1038/s41467-018-07012-4.


Corrigendum: Novel Peroxides as Promising Anticancer Agents with Unexpected Depressed Antimalarial Activity.

Coghi P, Yaremenko IA, Prommana P, Radulov PS, Syroeshkin MA, Wu YJ, Gao JY, Gordillo FM, Mok S, Wong VKW, Uthaipibull C, Terent'ev AO.

ChemMedChem. 2018 Oct 22;13(20):2249. doi: 10.1002/cmdc.201800618. Epub 2018 Sep 25. No abstract available.


Endoscopic treatment of internal hemorrhoids by use of a bipolar system.

Mok SRS, Khara HS, Johal AS, Confer BD, Diehl DL.

VideoGIE. 2017 Aug 12;2(10):290-292. doi: 10.1016/j.vgie.2017.07.004. eCollection 2017 Oct. No abstract available.


Cholangioscopic appearance after radiofrequency ablation of cholangiocarcinoma.

Mok SRS, Khara HS, Johal AS, Confer BD, Diehl DL.

VideoGIE. 2017 Aug 12;2(10):279-283. doi: 10.1016/j.vgie.2017.07.005. eCollection 2017 Oct. No abstract available.


Intra-Articular Delivery of Quercetin Using Thermosensitive Hydrogel Attenuate Cartilage Degradation in an Osteoarthritis Rat Model.

Mok SW, Fu SC, Cheuk YC, Chu IM, Chan KM, Qin L, Yung SH, Kevin Ho KW.

Cartilage. 2018 Aug 30:1947603518796550. doi: 10.1177/1947603518796550. [Epub ahead of print]


A prospective pilot comparison of wet and dry heparinized suction for EUS-guided liver biopsy (with videos).

Mok SRS, Diehl DL, Johal AS, Khara HS, Confer BD, Mudireddy PR, Kirchner HL, Chen ZE.

Gastrointest Endosc. 2018 Dec;88(6):919-925. doi: 10.1016/j.gie.2018.07.036. Epub 2018 Aug 16.


Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine.

Ross LS, Dhingra SK, Mok S, Yeo T, Wicht KJ, Kümpornsin K, Takala-Harrison S, Witkowski B, Fairhurst RM, Ariey F, Menard D, Fidock DA.

Nat Commun. 2018 Aug 17;9(1):3314. doi: 10.1038/s41467-018-05652-0.


A Method for Rapid Screening of Anilide-Containing AMPK Modulators Based on Computational Docking and Biological Validation.

Mok SWF, Zeng W, Niu Y, Coghi P, Wu Y, Sin WM, Ng SI, Gordillo-Martínez F, Gao JY, Law BYK, Liu L, Yao X, Wong VKW.

Front Pharmacol. 2018 Jul 3;9:710. doi: 10.3389/fphar.2018.00710. eCollection 2018.


Selective Inhibition of Lysine-Specific Demethylase 5A (KDM5A) Using a Rhodium(III) Complex for Triple-Negative Breast Cancer Therapy.

Yang GJ, Wang W, Mok SWF, Wu C, Law BYK, Miao XM, Wu KJ, Zhong HJ, Wong CY, Wong VKW, Ma DL, Leung CH.

Angew Chem Int Ed Engl. 2018 Oct 1;57(40):13091-13095. doi: 10.1002/anie.201807305. Epub 2018 Jul 19.


Adrenergic-mediated increases in INHBA drive CAF phenotype and collagens.

Nagaraja AS, Dood RL, Armaiz-Pena G, Kang Y, Wu SY, Allen JK, Jennings NB, Mangala LS, Pradeep S, Lyons Y, Haemmerle M, Gharpure KM, Sadaoui NC, Rodriguez-Aguayo C, Ivan C, Wang Y, Baggerly K, Ram P, Lopez-Berestein G, Liu J, Mok SC, Cohen L, Lutgendorf SK, Cole SW, Sood AK.

JCI Insight. 2018 Jun 7;3(11). pii: 122389. doi: 10.1172/jci.insight.122389. eCollection 2018 Jun 7. No abstract available.


Systematic Identification of Druggable Epithelial-Stromal Crosstalk Signaling Networks in Ovarian Cancer.

Yeung TL, Sheng J, Leung CS, Li F, Kim J, Ho SY, Matzuk MM, Lu KH, Wong STC, Mok SC.

J Natl Cancer Inst. 2019 Mar 1;111(3):272-282. doi: 10.1093/jnci/djy097. Erratum in: J Natl Cancer Inst. 2018 Oct 1;110(10):1146.


Role of Nonsteroidal Anti-inflammatory Drug in Treatment of Extra-abdominal Desmoid Tumors.

Cho JY, Gupta S, Cho HS, Park MS, Mok SJ, Han I, Kim HS.

Clin Orthop Surg. 2018 Jun;10(2):225-233. doi: 10.4055/cios.2018.10.2.225. Epub 2018 May 18.


Gene copy number variation in natural populations of Plasmodium falciparum in Eastern Africa.

Simam J, Rono M, Ngoi J, Nyonda M, Mok S, Marsh K, Bozdech Z, Mackinnon M.

BMC Genomics. 2018 May 21;19(1):372. doi: 10.1186/s12864-018-4689-7.


Mapping interactions with the chaperone network reveals factors that protect against tau aggregation.

Mok SA, Condello C, Freilich R, Gillies A, Arhar T, Oroz J, Kadavath H, Julien O, Assimon VA, Rauch JN, Dunyak BM, Lee J, Tsai FTF, Wilson MR, Zweckstetter M, Dickey CA, Gestwicki JE.

Nat Struct Mol Biol. 2018 May;25(5):384-393. doi: 10.1038/s41594-018-0057-1. Epub 2018 Apr 30.


[Guidenline for diagnosis and treatment of Alk and Ros1 positive non-small cell lung cancer in China].

Zhang XC, Lu S, Zhang L, Liao ML, Wang CL, Cheng Y, Li GD, Mok SJ, Huang C, Liu XQ, Wang J, Wang MZ, Zhang YP, Zhou JY, Zhou XJ, Zhou XY, Lin DM, Yang JJ, Song Y, Hu CP, Wang K, He Y, Li H, Zhong WZ, Wu YL; Tumor Marker Committee of Chinese Society of Clinical Oncology.

Zhonghua Bing Li Xue Za Zhi. 2018 Apr 8;47(4):241-247. doi: 10.3760/cma.j.issn.0529-5807.2018.04.003. Chinese. No abstract available.


SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy.

Min SW, Sohn PD, Li Y, Devidze N, Johnson JR, Krogan NJ, Masliah E, Mok SA, Gestwicki JE, Gan L.

J Neurosci. 2018 Apr 11;38(15):3680-3688. doi: 10.1523/JNEUROSCI.2369-17.2018. Epub 2018 Mar 14.


Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites.

Rocamora F, Zhu L, Liong KY, Dondorp A, Miotto O, Mok S, Bozdech Z.

PLoS Pathog. 2018 Mar 14;14(3):e1006930. doi: 10.1371/journal.ppat.1006930. eCollection 2018 Mar.


Heparin priming of EUS-FNA needles does not adversely affect tissue cytology or immunohistochemical staining.

Diehl DL, Mok SRS, Khara HS, Johal AS, Kirchner HL, Lin F.

Endosc Int Open. 2018 Mar;6(3):E356-E362. doi: 10.1055/s-0043-121880. Epub 2018 Mar 7.


2-Aminoethoxydiphenylborane sensitizes anti-tumor effect of bortezomib via suppression of calcium-mediated autophagy.

Qu YQ, Gordillo-Martinez F, Law BYK, Han Y, Wu A, Zeng W, Lam WK, Ho C, Mok SWF, He HQ, Wong VKW, Wang R.

Cell Death Dis. 2018 Mar 2;9(3):361. doi: 10.1038/s41419-018-0397-0.


Hospitalized Patients With and Without Hemodialysis Have Markedly Different Vancomycin Pharmacokinetics: A Population Pharmacokinetic Model-Based Analysis.

Goti V, Chaturvedula A, Fossler MJ, Mok S, Jacob JT.

Ther Drug Monit. 2018 Apr;40(2):212-221. doi: 10.1097/FTD.0000000000000490. Erratum in: Ther Drug Monit. 2019 Aug;41(4):549.


Novel Peroxides as Promising Anticancer Agents with Unexpected Depressed Antimalarial Activity.

Coghi P, Yaremenko IA, Prommana P, Radulov PS, Syroeshkin MA, Wu YJ, Gao JY, Gordillo FM, Mok S, Wong VKW, Uthaipibull C, Terent'ev AO.

ChemMedChem. 2018 May 8;13(9):902-908. doi: 10.1002/cmdc.201700804. Epub 2018 Mar 15. Erratum in: ChemMedChem. 2018 Oct 22;13(20):2249.


Recommendations and Choices for BRCA Mutation Carriers at Risk for Ovarian Cancer: A Complicated Decision.

Lewis KE, Lu KH, Klimczak AM, Mok SC.

Cancers (Basel). 2018 Feb 21;10(2). pii: E57. doi: 10.3390/cancers10020057. Review.


The Calcium-Induced Regulation in the Molecular and Transcriptional Circuitry of Human Inflammatory Response and Autoimmunity.

de Seabra Rodrigues Dias IR, Mok SWF, Gordillo-Martínez F, Khan I, Hsiao WWL, Law BYK, Wong VKW, Liu L.

Front Pharmacol. 2018 Jan 8;8:962. doi: 10.3389/fphar.2017.00962. eCollection 2017.

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