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Items: 1 to 50 of 124

1.

Alzheimer's Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection.

Eimer WA, Vijaya Kumar DK, Navalpur Shanmugam NK, Rodriguez AS, Mitchell T, Washicosky KJ, György B, Breakefield XO, Tanzi RE, Moir RD.

Neuron. 2018 Jul 11;99(1):56-63.e3. doi: 10.1016/j.neuron.2018.06.030.

2.

Enhanced Isotopic Ratio Outlier Analysis (IROA) Peak Detection and Identification with Ultra-High Resolution GC-Orbitrap/MS: Potential Application for Investigation of Model Organism Metabolomes.

Qiu Y, Moir RD, Willis IM, Seethapathy S, Biniakewitz RC, Kurland IJ.

Metabolites. 2018 Jan 18;8(1). pii: E9. doi: 10.3390/metabo8010009.

3.

Signaling to and from the RNA Polymerase III Transcription and Processing Machinery.

Willis IM, Moir RD.

Annu Rev Biochem. 2018 Jun 20;87:75-100. doi: 10.1146/annurev-biochem-062917-012624. Epub 2018 Jan 12.

PMID:
29328783
4.

Absence of neurological abnormalities in mice homozygous for the Polr3a G672E hypomyelinating leukodystrophy mutation.

Choquet K, Yang S, Moir RD, Forget D, Larivière R, Bouchard A, Poitras C, Sgarioto N, Dicaire MJ, Noohi F, Kennedy TE, Rochford J, Bernard G, Teichmann M, Coulombe B, Willis IM, Kleinman CL, Brais B.

Mol Brain. 2017 Apr 13;10(1):13. doi: 10.1186/s13041-017-0294-y.

5.

The Emerging Role of Innate Immunity in Alzheimer's Disease.

Vijaya Kumar DK, Moir RD.

Neuropsychopharmacology. 2017 Jan;42(1):362. doi: 10.1038/npp.2016.226. No abstract available.

6.

Analysis of the Yeast Peptidome and Comparison with the Human Peptidome.

Dasgupta S, Yang C, Castro LM, Tashima AK, Ferro ES, Moir RD, Willis IM, Fricker LD.

PLoS One. 2016 Sep 29;11(9):e0163312. doi: 10.1371/journal.pone.0163312. eCollection 2016.

7.

Alzheimer's disease: the potential therapeutic role of the natural antibiotic amyloid-β peptide.

Kumar DK, Eimer WA, Tanzi RE, Moir RD.

Neurodegener Dis Manag. 2016 Oct;6(5):345-8. doi: 10.2217/nmt-2016-0035. Epub 2016 Sep 7. Review. No abstract available.

8.

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease.

Kumar DK, Choi SH, Washicosky KJ, Eimer WA, Tucker S, Ghofrani J, Lefkowitz A, McColl G, Goldstein LE, Tanzi RE, Moir RD.

Sci Transl Med. 2016 May 25;8(340):340ra72. doi: 10.1126/scitranslmed.aaf1059.

9.

Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer's disease.

Zhang X, Tian Y, Zhang C, Tian X, Ross AW, Moir RD, Sun H, Tanzi RE, Moore A, Ran C.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9734-9. doi: 10.1073/pnas.1505420112. Epub 2015 Jul 21.

10.

Differential Phosphorylation of RNA Polymerase III and the Initiation Factor TFIIIB in Saccharomyces cerevisiae.

Lee J, Moir RD, Willis IM.

PLoS One. 2015 May 13;10(5):e0127225. doi: 10.1371/journal.pone.0127225. eCollection 2015.

11.

Loss of the RNA polymerase III repressor MAF1 confers obesity resistance.

Bonhoure N, Byrnes A, Moir RD, Hodroj W, Preitner F, Praz V, Marcelin G, Chua SC Jr, Martinez-Lopez N, Singh R, Moullan N, Auwerx J, Willemin G, Shah H, Hartil K, Vaitheesvaran B, Kurland I, Hernandez N, Willis IM.

Genes Dev. 2015 May 1;29(9):934-47. doi: 10.1101/gad.258350.115.

12.

Differential phosphorylation of a regulatory subunit of protein kinase CK2 by target of rapamycin complex 1 signaling and the Cdc-like kinase Kns1.

Sanchez-Casalongue ME, Lee J, Diamond A, Shuldiner S, Moir RD, Willis IM.

J Biol Chem. 2015 Mar 13;290(11):7221-33. doi: 10.1074/jbc.M114.626523. Epub 2015 Jan 28.

13.

Yeast-based high-throughput screen identifies Plasmodium falciparum equilibrative nucleoside transporter 1 inhibitors that kill malaria parasites.

Frame IJ, Deniskin R, Rinderspacher A, Katz F, Deng SX, Moir RD, Adjalley SH, Coburn-Flynn O, Fidock DA, Willis IM, Landry DW, Akabas MH.

ACS Chem Biol. 2015 Mar 20;10(3):775-83. doi: 10.1021/cb500981y. Epub 2015 Jan 30.

14.

Regulating maf1 expression and its expanding biological functions.

Moir RD, Willis IM.

PLoS Genet. 2015 Jan 8;11(1):e1004896. doi: 10.1371/journal.pgen.1004896. eCollection 2015 Jan. No abstract available.

15.

Synaptic abnormalities in a Drosophila model of Alzheimer's disease.

Mhatre SD, Satyasi V, Killen M, Paddock BE, Moir RD, Saunders AJ, Marenda DR.

Dis Model Mech. 2014 Mar;7(3):373-85. doi: 10.1242/dmm.012104. Epub 2014 Jan 30.

16.

Regulation of pol III transcription by nutrient and stress signaling pathways.

Moir RD, Willis IM.

Biochim Biophys Acta. 2013 Mar-Apr;1829(3-4):361-75. doi: 10.1016/j.bbagrm.2012.11.001. Epub 2012 Nov 16. Review.

17.

SCS3 and YFT2 link transcription of phospholipid biosynthetic genes to ER stress and the UPR.

Moir RD, Gross DA, Silver DL, Willis IM.

PLoS Genet. 2012 Aug;8(8):e1002890. doi: 10.1371/journal.pgen.1002890. Epub 2012 Aug 23.

18.

Recovery of RNA polymerase III transcription from the glycerol-repressed state: revisiting the role of protein kinase CK2 in Maf1 phosphoregulation.

Moir RD, Lee J, Willis IM.

J Biol Chem. 2012 Aug 31;287(36):30833-41. doi: 10.1074/jbc.M112.378828. Epub 2012 Jul 18.

19.

Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model.

Goldstein LE, Fisher AM, Tagge CA, Zhang XL, Velisek L, Sullivan JA, Upreti C, Kracht JM, Ericsson M, Wojnarowicz MW, Goletiani CJ, Maglakelidze GM, Casey N, Moncaster JA, Minaeva O, Moir RD, Nowinski CJ, Stern RA, Cantu RC, Geiling J, Blusztajn JK, Wolozin BL, Ikezu T, Stein TD, Budson AE, Kowall NW, Chargin D, Sharon A, Saman S, Hall GF, Moss WC, Cleveland RO, Tanzi RE, Stanton PK, McKee AC.

Sci Transl Med. 2012 May 16;4(134):134ra60. doi: 10.1126/scitranslmed.3003716.

20.

TOR signaling regulates ribosome and tRNA synthesis via LAMMER/Clk and GSK-3 family kinases.

Lee J, Moir RD, McIntosh KB, Willis IM.

Mol Cell. 2012 Mar 30;45(6):836-43. doi: 10.1016/j.molcel.2012.01.018. Epub 2012 Feb 23.

21.

Kar2p availability defines distinct forms of endoplasmic reticulum stress in living cells.

Lajoie P, Moir RD, Willis IM, Snapp EL.

Mol Biol Cell. 2012 Mar;23(5):955-64. doi: 10.1091/mbc.E11-12-0995. Epub 2012 Jan 4.

22.

Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Aβ oligomerization.

Zhang Y, Zhen Y, Dong Y, Xu Z, Yue Y, Golde TE, Tanzi RE, Moir RD, Xie Z.

PLoS One. 2011;6(11):e27019. doi: 10.1371/journal.pone.0027019. Epub 2011 Nov 1.

23.

Does casein kinase II phosphorylation of Maf1 trigger RNA polymerase III activation?

Willis IM, Moir RD, Lee J.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):E300; author reply E301. doi: 10.1073/pnas.1107306108. Epub 2011 Jul 6. No abstract available.

24.

Characterization of a Drosophila Alzheimer's disease model: pharmacological rescue of cognitive defects.

Chakraborty R, Vepuri V, Mhatre SD, Paddock BE, Miller S, Michelson SJ, Delvadia R, Desai A, Vinokur M, Melicharek DJ, Utreja S, Khandelwal P, Ansaloni S, Goldstein LE, Moir RD, Lee JC, Tabb LP, Saunders AJ, Marenda DR.

PLoS One. 2011;6(6):e20799. doi: 10.1371/journal.pone.0020799. Epub 2011 Jun 6.

25.

Non-conjugated small molecule FRET for differentiating monomers from higher molecular weight amyloid beta species.

Ran C, Zhao W, Moir RD, Moore A.

PLoS One. 2011 Apr 29;6(4):e19362. doi: 10.1371/journal.pone.0019362.

26.

Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease.

Duce JA, Tsatsanis A, Cater MA, James SA, Robb E, Wikhe K, Leong SL, Perez K, Johanssen T, Greenough MA, Cho HH, Galatis D, Moir RD, Masters CL, McLean C, Tanzi RE, Cappai R, Barnham KJ, Ciccotosto GD, Rogers JT, Bush AI.

Cell. 2010 Sep 17;142(6):857-67. doi: 10.1016/j.cell.2010.08.014.

27.

Alzheimer's disease amyloid-beta links lens and brain pathology in Down syndrome.

Moncaster JA, Pineda R, Moir RD, Lu S, Burton MA, Ghosh JG, Ericsson M, Soscia SJ, Mocofanescu A, Folkerth RD, Robb RM, Kuszak JR, Clark JI, Tanzi RE, Hunter DG, Goldstein LE.

PLoS One. 2010 May 20;5(5):e10659. doi: 10.1371/journal.pone.0010659.

28.

The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide.

Soscia SJ, Kirby JE, Washicosky KJ, Tucker SM, Ingelsson M, Hyman B, Burton MA, Goldstein LE, Duong S, Tanzi RE, Moir RD.

PLoS One. 2010 Mar 3;5(3):e9505. doi: 10.1371/journal.pone.0009505.

29.

Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity.

Kim M, Suh J, Romano D, Truong MH, Mullin K, Hooli B, Norton D, Tesco G, Elliott K, Wagner SL, Moir RD, Becker KD, Tanzi RE.

Hum Mol Genet. 2009 Oct 15;18(20):3987-96. doi: 10.1093/hmg/ddp323. Epub 2009 Jul 15.

30.

The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels.

Dong Y, Zhang G, Zhang B, Moir RD, Xia W, Marcantonio ER, Culley DJ, Crosby G, Tanzi RE, Xie Z.

Arch Neurol. 2009 May;66(5):620-31. doi: 10.1001/archneurol.2009.48.

31.

Regulation of RNA polymerase III transcription involves SCH9-dependent and SCH9-independent branches of the target of rapamycin (TOR) pathway.

Lee J, Moir RD, Willis IM.

J Biol Chem. 2009 May 8;284(19):12604-8. doi: 10.1074/jbc.C900020200. Epub 2009 Mar 19.

32.

Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1.

Myre MA, Washicosky K, Moir RD, Tesco G, Tanzi RE, Wasco W.

Cell Signal. 2009 Apr;21(4):567-76. doi: 10.1016/j.cellsig.2008.12.008. Epub 2008 Dec 25.

33.

The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo.

Xie Z, Culley DJ, Dong Y, Zhang G, Zhang B, Moir RD, Frosch MP, Crosby G, Tanzi RE.

Ann Neurol. 2008 Dec;64(6):618-27. doi: 10.1002/ana.21548.

34.

Genetic interactions of MAF1 identify a role for Med20 in transcriptional repression of ribosomal protein genes.

Willis IM, Chua G, Tong AH, Brost RL, Hughes TR, Boone C, Moir RD.

PLoS Genet. 2008 Jul 4;4(7):e1000112. doi: 10.1371/journal.pgen.1000112.

35.

The inhalation anesthetic desflurane induces caspase activation and increases amyloid beta-protein levels under hypoxic conditions.

Zhang B, Dong Y, Zhang G, Moir RD, Xia W, Yue Y, Tian M, Culley DJ, Crosby G, Tanzi RE, Xie Z.

J Biol Chem. 2008 May 2;283(18):11866-75. doi: 10.1074/jbc.M800199200. Epub 2008 Mar 6.

36.

The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation.

Xie Z, Dong Y, Maeda U, Moir RD, Xia W, Culley DJ, Crosby G, Tanzi RE.

J Neurosci. 2007 Feb 7;27(6):1247-54.

37.

Integration of nutritional and stress signaling pathways by Maf1.

Willis IM, Moir RD.

Trends Biochem Sci. 2007 Feb;32(2):51-3. Epub 2006 Dec 14. Review.

PMID:
17174096
38.

Protein kinase A regulates RNA polymerase III transcription through the nuclear localization of Maf1.

Moir RD, Lee J, Haeusler RA, Desai N, Engelke DR, Willis IM.

Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15044-9. Epub 2006 Sep 27.

39.

Hypocapnia induces caspase-3 activation and increases Abeta production.

Xie Z, Moir RD, Romano DM, Tesco G, Kovacs DM, Tanzi RE.

Neurodegener Dis. 2004;1(1):29-37.

41.

Metal exposure and Alzheimer's pathogenesis.

Liu G, Huang W, Moir RD, Vanderburg CR, Lai B, Peng Z, Tanzi RE, Rogers JT, Huang X.

J Struct Biol. 2006 Jul;155(1):45-51. Epub 2006 Feb 9. Review.

PMID:
16503166
42.

Functions and dysfunctions of the nuclear lamin Ig-fold domain in nuclear assembly, growth, and Emery-Dreifuss muscular dystrophy.

Shumaker DK, Lopez-Soler RI, Adam SA, Herrmann H, Moir RD, Spann TP, Goldman RD.

Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15494-9. Epub 2005 Oct 14.

43.

LRP-mediated clearance of Abeta is inhibited by KPI-containing isoforms of APP.

Moir RD, Tanzi RE.

Curr Alzheimer Res. 2005 Apr;2(2):269-73.

PMID:
15974929
44.

Autoantibodies to redox-modified oligomeric Abeta are attenuated in the plasma of Alzheimer's disease patients.

Moir RD, Tseitlin KA, Soscia S, Hyman BT, Irizarry MC, Tanzi RE.

J Biol Chem. 2005 Apr 29;280(17):17458-63. Epub 2005 Feb 21.

45.

Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition.

Sauve AA, Moir RD, Schramm VL, Willis IM.

Mol Cell. 2005 Feb 18;17(4):595-601.

46.

Two steps in Maf1-dependent repression of transcription by RNA polymerase III.

Desai N, Lee J, Upadhya R, Chu Y, Moir RD, Willis IM.

J Biol Chem. 2005 Feb 25;280(8):6455-62. Epub 2004 Dec 8.

47.

Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis.

Dedeoglu A, Cormier K, Payton S, Tseitlin KA, Kremsky JN, Lai L, Li X, Moir RD, Tanzi RE, Bush AI, Kowall NW, Rogers JT, Huang X.

Exp Gerontol. 2004 Nov-Dec;39(11-12):1641-9.

PMID:
15582280
48.

Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides.

Huang X, Atwood CS, Moir RD, Hartshorn MA, Tanzi RE, Bush AI.

J Biol Inorg Chem. 2004 Dec;9(8):954-60. Epub 2004 Nov 3.

PMID:
15578276
49.

The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease.

Hutter-Paier B, Huttunen HJ, Puglielli L, Eckman CB, Kim DY, Hofmeister A, Moir RD, Domnitz SB, Frosch MP, Windisch M, Kovacs DM.

Neuron. 2004 Oct 14;44(2):227-38. Erratum in: Neuron. 2010 Dec 9;68(5):1014.

50.

Clearance of Alzheimer's Abeta peptide: the many roads to perdition.

Tanzi RE, Moir RD, Wagner SL.

Neuron. 2004 Sep 2;43(5):605-8. Review.

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