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Structural basis for RNA polymerase III transcription repression by Maf1.

Vorländer MK, Baudin F, Moir RD, Wetzel R, Hagen WJH, Willis IM, Müller CW.

Nat Struct Mol Biol. 2020 Feb 17. doi: 10.1038/s41594-020-0383-y. [Epub ahead of print]


The oral health of Indigenous pregnant women: A mixed-methods systematic review.

Kong AC, Ramjan L, Sousa MS, Gwynne K, Goulding J, Jones N, Srinivas R, Rambaldini B, Moir R, George A.

Women Birth. 2019 Sep 6. pii: S1871-5192(19)30429-9. doi: 10.1016/j.wombi.2019.08.007. [Epub ahead of print] Review.


The leukodystrophy mutation Polr3b R103H causes homozygote mouse embryonic lethality and impairs RNA polymerase III biogenesis.

Choquet K, Pinard M, Yang S, Moir RD, Poitras C, Dicaire MJ, Sgarioto N, Larivière R, Kleinman CL, Willis IM, Gauthier MS, Coulombe B, Brais B.

Mol Brain. 2019 Jun 20;12(1):59. doi: 10.1186/s13041-019-0479-7.


Low Evolutionary Selection Pressure in Senescence Does Not Explain the Persistence of Aβ in the Vertebrate Genome.

Moir RD, Tanzi RE.

Front Aging Neurosci. 2019 Mar 28;11:70. doi: 10.3389/fnagi.2019.00070. eCollection 2019. Review.


Annexin II Light Chain p11 Interacts With ENaC to Increase Functional Activity at the Membrane.

Cheung TT, Ismail NAS, Moir R, Arora N, McDonald FJ, Condliffe SB.

Front Physiol. 2019 Feb 8;10:7. doi: 10.3389/fphys.2019.00007. eCollection 2019.


Alzheimer's Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection.

Eimer WA, Vijaya Kumar DK, Navalpur Shanmugam NK, Rodriguez AS, Mitchell T, Washicosky KJ, György B, Breakefield XO, Tanzi RE, Moir RD.

Neuron. 2018 Dec 19;100(6):1527-1532. doi: 10.1016/j.neuron.2018.11.043. No abstract available.


Metabolic programming a lean phenotype by deregulation of RNA polymerase III.

Willis IM, Moir RD, Hernandez N.

Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):12182-12187. doi: 10.1073/pnas.1815590115. Epub 2018 Nov 14.


The antimicrobial protection hypothesis of Alzheimer's disease.

Moir RD, Lathe R, Tanzi RE.

Alzheimers Dement. 2018 Dec;14(12):1602-1614. doi: 10.1016/j.jalz.2018.06.3040. Epub 2018 Oct 9.


Results of a two year dental health education program to reduce dental caries in young Aboriginal children in New South Wales, Australia.

Smith L, Blinkhorn F, Moir R, Blinkhorn A.

Community Dent Health. 2018 Nov 29;35(4):211-216. doi: 10.1922/CDH_4293Smith06.


Alzheimer's Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection.

Eimer WA, Vijaya Kumar DK, Navalpur Shanmugam NK, Rodriguez AS, Mitchell T, Washicosky KJ, György B, Breakefield XO, Tanzi RE, Moir RD.

Neuron. 2018 Jul 11;99(1):56-63.e3. doi: 10.1016/j.neuron.2018.06.030. Erratum in: Neuron. 2018 Dec 19;100(6):1527-1532.


Enhanced Isotopic Ratio Outlier Analysis (IROA) Peak Detection and Identification with Ultra-High Resolution GC-Orbitrap/MS: Potential Application for Investigation of Model Organism Metabolomes.

Qiu Y, Moir RD, Willis IM, Seethapathy S, Biniakewitz RC, Kurland IJ.

Metabolites. 2018 Jan 18;8(1). pii: E9. doi: 10.3390/metabo8010009.


Signaling to and from the RNA Polymerase III Transcription and Processing Machinery.

Willis IM, Moir RD.

Annu Rev Biochem. 2018 Jun 20;87:75-100. doi: 10.1146/annurev-biochem-062917-012624. Epub 2018 Jan 12. Review.


Absence of neurological abnormalities in mice homozygous for the Polr3a G672E hypomyelinating leukodystrophy mutation.

Choquet K, Yang S, Moir RD, Forget D, Larivière R, Bouchard A, Poitras C, Sgarioto N, Dicaire MJ, Noohi F, Kennedy TE, Rochford J, Bernard G, Teichmann M, Coulombe B, Willis IM, Kleinman CL, Brais B.

Mol Brain. 2017 Apr 13;10(1):13. doi: 10.1186/s13041-017-0294-y.


KOtBu-Catalyzed lithiation of PMDTA and the direct functionalization of bridged alkenes under mild conditions.

Wang Y, Liu J, Huang L, Zhu R, Huang X, Moir R, Huang J.

Chem Commun (Camb). 2017 Apr 20;53(33):4589-4592. doi: 10.1039/c7cc02006f.


The Emerging Role of Innate Immunity in Alzheimer's Disease.

Vijaya Kumar DK, Moir RD.

Neuropsychopharmacology. 2017 Jan;42(1):362. doi: 10.1038/npp.2016.226. No abstract available.


Analysis of the Yeast Peptidome and Comparison with the Human Peptidome.

Dasgupta S, Yang C, Castro LM, Tashima AK, Ferro ES, Moir RD, Willis IM, Fricker LD.

PLoS One. 2016 Sep 29;11(9):e0163312. doi: 10.1371/journal.pone.0163312. eCollection 2016.


Alzheimer's disease: the potential therapeutic role of the natural antibiotic amyloid-β peptide.

Kumar DK, Eimer WA, Tanzi RE, Moir RD.

Neurodegener Dis Manag. 2016 Oct;6(5):345-8. doi: 10.2217/nmt-2016-0035. Epub 2016 Sep 7. Review. No abstract available.


Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease.

Kumar DK, Choi SH, Washicosky KJ, Eimer WA, Tucker S, Ghofrani J, Lefkowitz A, McColl G, Goldstein LE, Tanzi RE, Moir RD.

Sci Transl Med. 2016 May 25;8(340):340ra72. doi: 10.1126/scitranslmed.aaf1059.


Isotopic Ratio Outlier Analysis of the S. cerevisiae Metabolome Using Accurate Mass Gas Chromatography/Time-of-Flight Mass Spectrometry: A New Method for Discovery.

Qiu Y, Moir R, Willis I, Beecher C, Tsai YH, Garrett TJ, Yost RA, Kurland IJ.

Anal Chem. 2016 Mar 1;88(5):2747-54. doi: 10.1021/acs.analchem.5b04263. Epub 2016 Feb 17.


An assessment of dental caries among young Aboriginal children in New South Wales, Australia: a cross-sectional study.

Smith L, Blinkhorn A, Moir R, Brown N, Blinkhorn F.

BMC Public Health. 2015 Dec 29;15:1314. doi: 10.1186/s12889-015-2673-6.


Synergies and challenges in tackling disease issues and emergency events.

Cook C, Moir R.

Vet Rec. 2015 Aug 15;177(7):166-7. doi: 10.1136/vr.h3797. No abstract available.


Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer's disease.

Zhang X, Tian Y, Zhang C, Tian X, Ross AW, Moir RD, Sun H, Tanzi RE, Moore A, Ran C.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9734-9. doi: 10.1073/pnas.1505420112. Epub 2015 Jul 21.


Differential Phosphorylation of RNA Polymerase III and the Initiation Factor TFIIIB in Saccharomyces cerevisiae.

Lee J, Moir RD, Willis IM.

PLoS One. 2015 May 13;10(5):e0127225. doi: 10.1371/journal.pone.0127225. eCollection 2015.


Loss of the RNA polymerase III repressor MAF1 confers obesity resistance.

Bonhoure N, Byrnes A, Moir RD, Hodroj W, Preitner F, Praz V, Marcelin G, Chua SC Jr, Martinez-Lopez N, Singh R, Moullan N, Auwerx J, Willemin G, Shah H, Hartil K, Vaitheesvaran B, Kurland I, Hernandez N, Willis IM.

Genes Dev. 2015 May 1;29(9):934-47. doi: 10.1101/gad.258350.115.


Differential phosphorylation of a regulatory subunit of protein kinase CK2 by target of rapamycin complex 1 signaling and the Cdc-like kinase Kns1.

Sanchez-Casalongue ME, Lee J, Diamond A, Shuldiner S, Moir RD, Willis IM.

J Biol Chem. 2015 Mar 13;290(11):7221-33. doi: 10.1074/jbc.M114.626523. Epub 2015 Jan 28.


Yeast-based high-throughput screen identifies Plasmodium falciparum equilibrative nucleoside transporter 1 inhibitors that kill malaria parasites.

Frame IJ, Deniskin R, Rinderspacher A, Katz F, Deng SX, Moir RD, Adjalley SH, Coburn-Flynn O, Fidock DA, Willis IM, Landry DW, Akabas MH.

ACS Chem Biol. 2015 Mar 20;10(3):775-83. doi: 10.1021/cb500981y. Epub 2015 Jan 30.


Regulating maf1 expression and its expanding biological functions.

Moir RD, Willis IM.

PLoS Genet. 2015 Jan 8;11(1):e1004896. doi: 10.1371/journal.pgen.1004896. eCollection 2015 Jan. No abstract available.


Anion effects to deliver enhanced iridium catalysts for hydrogen isotope exchange processes.

Kennedy AR, Kerr WJ, Moir R, Reid M.

Org Biomol Chem. 2014 Oct 28;12(40):7927-31. doi: 10.1039/c4ob01570c.


Synaptic abnormalities in a Drosophila model of Alzheimer's disease.

Mhatre SD, Satyasi V, Killen M, Paddock BE, Moir RD, Saunders AJ, Marenda DR.

Dis Model Mech. 2014 Mar;7(3):373-85. doi: 10.1242/dmm.012104. Epub 2014 Jan 30.


Regulation of pol III transcription by nutrient and stress signaling pathways.

Moir RD, Willis IM.

Biochim Biophys Acta. 2013 Mar-Apr;1829(3-4):361-75. doi: 10.1016/j.bbagrm.2012.11.001. Epub 2012 Nov 16. Review.


SCS3 and YFT2 link transcription of phospholipid biosynthetic genes to ER stress and the UPR.

Moir RD, Gross DA, Silver DL, Willis IM.

PLoS Genet. 2012 Aug;8(8):e1002890. doi: 10.1371/journal.pgen.1002890. Epub 2012 Aug 23.


Recovery of RNA polymerase III transcription from the glycerol-repressed state: revisiting the role of protein kinase CK2 in Maf1 phosphoregulation.

Moir RD, Lee J, Willis IM.

J Biol Chem. 2012 Aug 31;287(36):30833-41. doi: 10.1074/jbc.M112.378828. Epub 2012 Jul 18.


The yeast magmas ortholog pam16 has an essential function in fermentative growth that involves sphingolipid metabolism.

Short MK, Hallett JP, Tar K, Dange T, Schmidt M, Moir R, Willis IM, Jubinsky PT.

PLoS One. 2012;7(7):e39428. doi: 10.1371/journal.pone.0039428. Epub 2012 Jul 10.


Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model.

Goldstein LE, Fisher AM, Tagge CA, Zhang XL, Velisek L, Sullivan JA, Upreti C, Kracht JM, Ericsson M, Wojnarowicz MW, Goletiani CJ, Maglakelidze GM, Casey N, Moncaster JA, Minaeva O, Moir RD, Nowinski CJ, Stern RA, Cantu RC, Geiling J, Blusztajn JK, Wolozin BL, Ikezu T, Stein TD, Budson AE, Kowall NW, Chargin D, Sharon A, Saman S, Hall GF, Moss WC, Cleveland RO, Tanzi RE, Stanton PK, McKee AC.

Sci Transl Med. 2012 May 16;4(134):134ra60. doi: 10.1126/scitranslmed.3003716.


Geneious Basic: an integrated and extendable desktop software platform for the organization and analysis of sequence data.

Kearse M, Moir R, Wilson A, Stones-Havas S, Cheung M, Sturrock S, Buxton S, Cooper A, Markowitz S, Duran C, Thierer T, Ashton B, Meintjes P, Drummond A.

Bioinformatics. 2012 Jun 15;28(12):1647-9. doi: 10.1093/bioinformatics/bts199. Epub 2012 Apr 27.


Role of common and rare APP DNA sequence variants in Alzheimer disease.

Hooli BV, Mohapatra G, Mattheisen M, Parrado AR, Roehr JT, Shen Y, Gusella JF, Moir R, Saunders AJ, Lange C, Tanzi RE, Bertram L.

Neurology. 2012 Apr 17;78(16):1250-7. doi: 10.1212/WNL.0b013e3182515972. Epub 2012 Apr 4.


TOR signaling regulates ribosome and tRNA synthesis via LAMMER/Clk and GSK-3 family kinases.

Lee J, Moir RD, McIntosh KB, Willis IM.

Mol Cell. 2012 Mar 30;45(6):836-43. doi: 10.1016/j.molcel.2012.01.018. Epub 2012 Feb 23.


Kar2p availability defines distinct forms of endoplasmic reticulum stress in living cells.

Lajoie P, Moir RD, Willis IM, Snapp EL.

Mol Biol Cell. 2012 Mar;23(5):955-64. doi: 10.1091/mbc.E11-12-0995. Epub 2012 Jan 4.


Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Aβ oligomerization.

Zhang Y, Zhen Y, Dong Y, Xu Z, Yue Y, Golde TE, Tanzi RE, Moir RD, Xie Z.

PLoS One. 2011;6(11):e27019. doi: 10.1371/journal.pone.0027019. Epub 2011 Nov 1.


Does casein kinase II phosphorylation of Maf1 trigger RNA polymerase III activation?

Willis IM, Moir RD, Lee J.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):E300; author reply E301. doi: 10.1073/pnas.1107306108. Epub 2011 Jul 6. No abstract available.


Characterization of a Drosophila Alzheimer's disease model: pharmacological rescue of cognitive defects.

Chakraborty R, Vepuri V, Mhatre SD, Paddock BE, Miller S, Michelson SJ, Delvadia R, Desai A, Vinokur M, Melicharek DJ, Utreja S, Khandelwal P, Ansaloni S, Goldstein LE, Moir RD, Lee JC, Tabb LP, Saunders AJ, Marenda DR.

PLoS One. 2011;6(6):e20799. doi: 10.1371/journal.pone.0020799. Epub 2011 Jun 6.


Non-conjugated small molecule FRET for differentiating monomers from higher molecular weight amyloid beta species.

Ran C, Zhao W, Moir RD, Moore A.

PLoS One. 2011 Apr 29;6(4):e19362. doi: 10.1371/journal.pone.0019362.


Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease.

Duce JA, Tsatsanis A, Cater MA, James SA, Robb E, Wikhe K, Leong SL, Perez K, Johanssen T, Greenough MA, Cho HH, Galatis D, Moir RD, Masters CL, McLean C, Tanzi RE, Cappai R, Barnham KJ, Ciccotosto GD, Rogers JT, Bush AI.

Cell. 2010 Sep 17;142(6):857-67. doi: 10.1016/j.cell.2010.08.014.


Alzheimer's disease amyloid-beta links lens and brain pathology in Down syndrome.

Moncaster JA, Pineda R, Moir RD, Lu S, Burton MA, Ghosh JG, Ericsson M, Soscia SJ, Mocofanescu A, Folkerth RD, Robb RM, Kuszak JR, Clark JI, Tanzi RE, Hunter DG, Goldstein LE.

PLoS One. 2010 May 20;5(5):e10659. doi: 10.1371/journal.pone.0010659.


The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide.

Soscia SJ, Kirby JE, Washicosky KJ, Tucker SM, Ingelsson M, Hyman B, Burton MA, Goldstein LE, Duong S, Tanzi RE, Moir RD.

PLoS One. 2010 Mar 3;5(3):e9505. doi: 10.1371/journal.pone.0009505.


Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity.

Kim M, Suh J, Romano D, Truong MH, Mullin K, Hooli B, Norton D, Tesco G, Elliott K, Wagner SL, Moir RD, Becker KD, Tanzi RE.

Hum Mol Genet. 2009 Oct 15;18(20):3987-96. doi: 10.1093/hmg/ddp323. Epub 2009 Jul 15.


The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels.

Dong Y, Zhang G, Zhang B, Moir RD, Xia W, Marcantonio ER, Culley DJ, Crosby G, Tanzi RE, Xie Z.

Arch Neurol. 2009 May;66(5):620-31. doi: 10.1001/archneurol.2009.48.


Regulation of RNA polymerase III transcription involves SCH9-dependent and SCH9-independent branches of the target of rapamycin (TOR) pathway.

Lee J, Moir RD, Willis IM.

J Biol Chem. 2009 May 8;284(19):12604-8. doi: 10.1074/jbc.C900020200. Epub 2009 Mar 19.


Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1.

Myre MA, Washicosky K, Moir RD, Tesco G, Tanzi RE, Wasco W.

Cell Signal. 2009 Apr;21(4):567-76. doi: 10.1016/j.cellsig.2008.12.008. Epub 2008 Dec 25.


The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo.

Xie Z, Culley DJ, Dong Y, Zhang G, Zhang B, Moir RD, Frosch MP, Crosby G, Tanzi RE.

Ann Neurol. 2008 Dec;64(6):618-27. doi: 10.1002/ana.21548.

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