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Items: 1 to 50 of 87

1.

ODM-203 a selective inhibitor of FGFR and VEGFR, shows strong anti-tumor activity, and induces anti-tumor immunity.

Holmström TH, Moilanen AM, Ikonen T, Björkman ML, Linnanen T, Wohlfahrt G, Karlsson S, Oksala R, Korjamo T, Samajdar S, Rajagopalan S, Chelur S, Narayan K, Ramachandra RK, Mani J, Nair R, Gowda N, Anthony T, Dhodheri S, Mukherjee S, Ujjinamatada RK, Srinivas N, Ramachandra M, Kallio PJ.

Mol Cancer Ther. 2018 Oct 9. pii: molcanther.0204.2018. doi: 10.1158/1535-7163.MCT-18-0204. [Epub ahead of print]

PMID:
30301864
2.

Discovery and development of ODM-204: A Novel nonsteroidal compound for the treatment of castration-resistant prostate cancer by blocking the androgen receptor and inhibiting CYP17A1.

Oksala R, Moilanen A, Riikonen R, Rummakko P, Karjalainen A, Passiniemi M, Wohlfahrt G, Taavitsainen P, Malmström C, Ramela M, Metsänkylä HM, Huhtaniemi R, Kallio PJ, Mustonen MV.

J Steroid Biochem Mol Biol. 2018 Feb 10. pii: S0960-0760(18)30078-5. doi: 10.1016/j.jsbmb.2018.02.004. [Epub ahead of print] Review.

3.

Threats from urban expansion, agricultural transformation and forest loss on global conservation priority areas.

Veach V, Moilanen A, Di Minin E.

PLoS One. 2017 Nov 28;12(11):e0188397. doi: 10.1371/journal.pone.0188397. eCollection 2017.

4.

Exposing ecological and economic costs of the research-implementation gap and compromises in decision making.

Kareksela S, Moilanen A, Ristaniemi O, Välivaara R, Kotiaho JS.

Conserv Biol. 2018 Feb;32(1):9-17. doi: 10.1111/cobi.13054.

PMID:
29139572
5.

Examining current or future trade-offs for biodiversity conservation in north-eastern Australia.

Reside AE, VanDerWal J, Moilanen A, Graham EM.

PLoS One. 2017 Feb 21;12(2):e0172230. doi: 10.1371/journal.pone.0172230. eCollection 2017.

6.

Coupled dipole approximation across the Γ-point in a finite-sized nanoparticle array.

Martikainen JP, Moilanen AJ, Törmä P.

Philos Trans A Math Phys Eng Sci. 2017 Mar 28;375(2090). pii: 20160316. doi: 10.1098/rsta.2016.0316.

7.

Lasing in dark and bright modes of a finite-sized plasmonic lattice.

Hakala TK, Rekola HT, Väkeväinen AI, Martikainen JP, Nečada M, Moilanen AJ, Törmä P.

Nat Commun. 2017 Jan 3;8:13687. doi: 10.1038/ncomms13687.

8.

Use of demand for and spatial flow of ecosystem services to identify priority areas.

Verhagen W, Kukkala AS, Moilanen A, van Teeffelen AJA, Verburg PH.

Conserv Biol. 2017 Aug;31(4):860-871. doi: 10.1111/cobi.12872. Epub 2017 Apr 20.

PMID:
27943463
9.

Transcription factor PEX1 modulates extracellular matrix turnover through regulation of MMP-9 expression.

Jurado Acosta A, Rysä J, Szabo Z, Moilanen AM, Komati H, Nemer M, Ruskoaho H.

Cell Tissue Res. 2017 Feb;367(2):369-385. doi: 10.1007/s00441-016-2527-2. Epub 2016 Nov 8.

PMID:
27826738
10.

Optimal conservation resource allocation under variable economic and ecological time discounting rates in boreal forest.

Mazziotta A, Pouzols FM, Mönkkönen M, Kotiaho JS, Strandman H, Moilanen A.

J Environ Manage. 2016 Sep 15;180:366-74. doi: 10.1016/j.jenvman.2016.05.057. Epub 2016 Jun 1.

PMID:
27262031
11.

Global priorities for national carnivore conservation under land use change.

Di Minin E, Slotow R, Hunter LT, Montesino Pouzols F, Toivonen T, Verburg PH, Leader-Williams N, Petracca L, Moilanen A.

Sci Rep. 2016 Apr 1;6:23814. doi: 10.1038/srep23814.

12.

FORUM: Indirect leakage leads to a failure of avoided loss biodiversity offsetting.

Moilanen A, Laitila J.

J Appl Ecol. 2016 Feb;53(1):106-111. Epub 2015 Nov 27.

13.

Complementarity and Area-Efficiency in the Prioritization of the Global Protected Area Network.

Kullberg P, Toivonen T, Montesino Pouzols F, Lehtomäki J, Di Minin E, Moilanen A.

PLoS One. 2015 Dec 17;10(12):e0145231. doi: 10.1371/journal.pone.0145231. eCollection 2015.

14.

Structure-guided discovery of 2-aryl/pyridin-2-yl-1H-indole derivatives as potent and selective hepsin inhibitors.

Goswami R, Wohlfahrt G, Törmäkangas O, Moilanen A, Lakshminarasimhan A, Nagaraj J, Arumugam KN, Mukherjee S, Chacko AR, Krishnamurthy NR, Jaleel M, Palakurthy RK, Samiulla DS, Ramachandra M.

Bioorg Med Chem Lett. 2015 Nov 15;25(22):5309-14. doi: 10.1016/j.bmcl.2015.09.042. Epub 2015 Sep 21.

PMID:
26421993
15.

Green Infrastructure Design Based on Spatial Conservation Prioritization and Modeling of Biodiversity Features and Ecosystem Services.

Snäll T, Lehtomäki J, Arponen A, Elith J, Moilanen A.

Environ Manage. 2016 Feb;57(2):251-6. doi: 10.1007/s00267-015-0613-y. Epub 2015 Sep 22.

16.

Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion.

Tervonen TA, Belitškin D, Pant SM, Englund JI, Marques E, Ala-Hongisto H, Nevalaita L, Sihto H, Heikkilä P, Leidenius M, Hewitson K, Ramachandra M, Moilanen A, Joensuu H, Kovanen PE, Poso A, Klefström J.

Oncogene. 2016 Apr 7;35(14):1832-46. doi: 10.1038/onc.2015.248. Epub 2015 Jul 13.

PMID:
26165838
17.

Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies.

Moilanen AM, Riikonen R, Oksala R, Ravanti L, Aho E, Wohlfahrt G, Nykänen PS, Törmäkangas OP, Palvimo JJ, Kallio PJ.

Sci Rep. 2015 Jul 3;5:12007. doi: 10.1038/srep12007.

18.

The Minor Capsid Protein VP11 of Thermophilic Bacteriophage P23-77 Facilitates Virus Assembly by Using Lipid-Protein Interactions.

Pawlowski A, Moilanen AM, Rissanen IA, Määttä JA, Hytönen VP, Ihalainen JA, Bamford JK.

J Virol. 2015 Aug;89(15):7593-603. doi: 10.1128/JVI.00262-15. Epub 2015 May 13.

19.

WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function.

Moilanen AM, Rysä J, Kaikkonen L, Karvonen T, Mustonen E, Serpi R, Szabó Z, Tenhunen O, Bagyura Z, Näpänkangas J, Ohukainen P, Tavi P, Kerkelä R, Leósdóttir M, Wahlstrand B, Hedner T, Melander O, Ruskoaho H.

PLoS One. 2015 Apr 27;10(4):e0124907. doi: 10.1371/journal.pone.0124907. eCollection 2015.

20.

A method for calculating minimum biodiversity offset multipliers accounting for time discounting, additionality and permanence.

Laitila J, Moilanen A, Pouzols FM.

Methods Ecol Evol. 2014 Nov;5(11):1247-1254. Epub 2014 Nov 29.

21.

Inhibition of Let-7 microRNA attenuates myocardial remodeling and improves cardiac function postinfarction in mice.

Tolonen AM, Magga J, Szabó Z, Viitala P, Gao E, Moilanen AM, Ohukainen P, Vainio L, Koch WJ, Kerkelä R, Ruskoaho H, Serpi R.

Pharmacol Res Perspect. 2014 Aug;2(4):e00056. doi: 10.1002/prp2.56. Epub 2014 Jun 12.

22.

Global protected area expansion is compromised by projected land-use and parochialism.

Montesino Pouzols F, Toivonen T, Di Minin E, Kukkala AS, Kullberg P, Kuusterä J, Lehtomäki J, Tenkanen H, Verburg PH, Moilanen A.

Nature. 2014 Dec 18;516(7531):383-6. doi: 10.1038/nature14032. Epub 2014 Nov 14.

PMID:
25494203
23.

Identification of policies for a sustainable legal trade in rhinoceros horn based on population projection and socioeconomic models.

Di Minin E, Laitila J, Montesino-Pouzols F, Leader-Williams N, Slotow R, Goodman PS, Conway AJ, Moilanen A.

Conserv Biol. 2015 Apr;29(2):545-55. doi: 10.1111/cobi.12412. Epub 2014 Oct 20.

24.

Characterization of the regulatory mechanisms of activating transcription factor 3 by hypertrophic stimuli in rat cardiomyocytes.

Koivisto E, Jurado Acosta A, Moilanen AM, Tokola H, Aro J, Pennanen H, Säkkinen H, Kaikkonen L, Ruskoaho H, Rysä J.

PLoS One. 2014 Aug 19;9(8):e105168. doi: 10.1371/journal.pone.0105168. eCollection 2014.

25.

Discovery of Pyridyl Bis(oxy)dibenzimidamide Derivatives as Selective Matriptase Inhibitors.

Goswami R, Mukherjee S, Wohlfahrt G, Ghadiyaram C, Nagaraj J, Chandra BR, Sistla RK, Satyam LK, Samiulla DS, Moilanen A, Subramanya HS, Ramachandra M.

ACS Med Chem Lett. 2013 Oct 7;4(12):1152-7. doi: 10.1021/ml400213v. eCollection 2013 Dec 12.

26.

Structure-guided discovery of 1,3,5 tri-substituted benzenes as potent and selective matriptase inhibitors exhibiting in vivo antitumor efficacy.

Goswami R, Mukherjee S, Ghadiyaram C, Wohlfahrt G, Sistla RK, Nagaraj J, Satyam LK, Subbarao K, Palakurthy RK, Gopinath S, Krishnamurthy NR, Ikonen T, Moilanen A, Subramanya HS, Kallio P, Ramachandra M.

Bioorg Med Chem. 2014 Jun 15;22(12):3187-203. doi: 10.1016/j.bmc.2014.04.013. Epub 2014 Apr 18.

PMID:
24794746
27.

Use of inverse spatial conservation prioritization to avoid biological diversity loss outside protected areas.

Kareksela S, Moilanen A, Tuominen S, Kotiaho JS.

Conserv Biol. 2013 Dec;27(6):1294-303. doi: 10.1111/cobi.12146. Epub 2013 Sep 4.

PMID:
24033397
28.

Conservation businesses and conservation planning in a biological diversity hotspot.

Di Minin E, Macmillan DC, Goodman PS, Escott B, Slotow R, Moilanen A.

Conserv Biol. 2013 Aug;27(4):808-20. doi: 10.1111/cobi.12048. Epub 2013 Apr 8.

PMID:
23565917
29.

Conservation planning with uncertain climate change projections.

Kujala H, Moilanen A, Araújo MB, Cabeza M.

PLoS One. 2013;8(2):e53315. doi: 10.1371/journal.pone.0053315. Epub 2013 Feb 6.

30.

Reconciling biodiversity and carbon conservation.

Thomas CD, Anderson BJ, Moilanen A, Eigenbrod F, Heinemeyer A, Quaife T, Roy DB, Gillings S, Armsworth PR, Gaston KJ.

Ecol Lett. 2013 May;16 Suppl 1:39-47. doi: 10.1111/ele.12054. Epub 2012 Dec 20.

PMID:
23279784
31.

Core concepts of spatial prioritisation in systematic conservation planning.

Kukkala AS, Moilanen A.

Biol Rev Camb Philos Soc. 2013 May;88(2):443-64. doi: 10.1111/brv.12008. Epub 2012 Dec 22. Review.

32.

Genetic diversity in widespread species is not congruent with species richness in alpine plant communities.

Taberlet P, Zimmermann NE, Englisch T, Tribsch A, Holderegger R, Alvarez N, Niklfeld H, Coldea G, Mirek Z, Moilanen A, Ahlmer W, Marsan PA, Bona E, Bovio M, Choler P, Cieślak E, Colli L, Cristea V, Dalmas JP, Frajman B, Garraud L, Gaudeul M, Gielly L, Gutermann W, Jogan N, Kagalo AA, Korbecka G, Küpfer P, Lequette B, Letz DR, Manel S, Mansion G, Marhold K, Martini F, Negrini R, Niño F, Paun O, Pellecchia M, Perico G, Piękoś-Mirkowa H, Prosser F, Puşcaş M, Ronikier M, Scheuerer M, Schneeweiss GM, Schönswetter P, Schratt-Ehrendorfer L, Schüpfer F, Selvaggi A, Steinmann K, Thiel-Egenter C, van Loo M, Winkler M, Wohlgemuth T, Wraber T, Gugerli F; IntraBioDiv Consortium, Vellend M.

Ecol Lett. 2012 Dec;15(12):1439-48. doi: 10.1111/ele.12004. Epub 2012 Sep 25.

33.

Integrating environmental gap analysis with spatial conservation prioritization: a case study from Victoria, Australia.

Sharafi SM, Moilanen A, White M, Burgman M.

J Environ Manage. 2012 Dec 15;112:240-51. doi: 10.1016/j.jenvman.2012.07.010. Epub 2012 Aug 28.

PMID:
22935646
34.

(Pro)renin receptor triggers distinct angiotensin II-independent extracellular matrix remodeling and deterioration of cardiac function.

Moilanen AM, Rysä J, Serpi R, Mustonen E, Szabò Z, Aro J, Näpänkangas J, Tenhunen O, Sutinen M, Salo T, Ruskoaho H.

PLoS One. 2012;7(7):e41404. doi: 10.1371/journal.pone.0041404. Epub 2012 Jul 23.

35.

Effects of connectivity and spatial resolution of analyses on conservation prioritization across large extents.

Arponen A, Lehtomäki J, Leppänen J, Tomppo E, Moilanen A.

Conserv Biol. 2012 Apr;26(2):294-304. doi: 10.1111/j.1523-1739.2011.01814.x. Epub 2012 Jan 23.

PMID:
22268786
36.

Balancing alternative land uses in conservation prioritization.

Moilanen A, Anderson BJ, Eigenbrod F, Heinemeyer A, Roy DB, Gillings S, Armsworth PR, Gaston KJ, Thomas CD.

Ecol Appl. 2011 Jul;21(5):1419-26.

PMID:
21830691
37.

Faulty epithelial polarity genes and cancer.

Tervonen TA, Partanen JI, Saarikoski ST, Myllynen M, Marques E, Paasonen K, Moilanen A, Wohlfahrt G, Kovanen PE, Klefstrom J.

Adv Cancer Res. 2011;111:97-161. doi: 10.1016/B978-0-12-385524-4.00003-9. Review.

PMID:
21704831
38.

Intramyocardial BNP gene delivery improves cardiac function through distinct context-dependent mechanisms.

Moilanen AM, Rysä J, Mustonen E, Serpi R, Aro J, Tokola H, Leskinen H, Manninen A, Levijoki J, Vuolteenaho O, Ruskoaho H.

Circ Heart Fail. 2011 Jul;4(4):483-95. doi: 10.1161/CIRCHEARTFAILURE.110.958033. Epub 2011 May 10.

PMID:
21558448
39.

Characterization of molecular forms of N-terminal B-type natriuretic peptide in vitro.

Ala-Kopsala M, Moilanen AM, Rysä J, Ruskoaho H, Vuolteenaho O.

Clin Chem. 2010 Dec;56(12):1822-9. doi: 10.1373/clinchem.2010.148775. Epub 2010 Oct 6.

40.

Sorbitol dehydrogenase expression is regulated by androgens in the human prostate.

Szabó Z, Hämäläinen J, Loikkanen I, Moilanen AM, Hirvikoski P, Väisänen T, Paavonen TK, Vaarala MH.

Oncol Rep. 2010 May;23(5):1233-9.

PMID:
20372835
41.

Reconciling uncertain costs and benefits in Bayes nets for invasive species management.

Burgman MA, Wintle BA, Thompson CA, Moilanen A, Runge MC, Ben-Haim Y.

Risk Anal. 2010 Feb;30(2):277-84. doi: 10.1111/j.1539-6924.2009.01273.x. Epub 2009 Jul 30.

PMID:
19659556
42.

Metapopulation responses to patch connectivity and quality are masked by successional habitat dynamics.

Hodgson JA, Moilanen A, Thomas CD.

Ecology. 2009 Jun;90(6):1608-19.

PMID:
19569375
43.

Where and when to revegetate: a quantitative method for scheduling landscape reconstruction.

Thomson JR, Moilanen AJ, Vesk PA, Bennett AF, Nally RM.

Ecol Appl. 2009 Jun;19(4):817-28.

PMID:
19544726
44.

Delaying conservation actions for improved knowledge: how long should we wait?

Grantham HS, Wilson KA, Moilanen A, Rebelo T, Possingham HP.

Ecol Lett. 2009 Apr;12(4):293-301. doi: 10.1111/j.1461-0248.2009.01287.x. Epub 2009 Feb 20.

PMID:
19243409
45.

Long-term dynamics in a metapopulation of the American pika.

Moilanen A, Smith AT, Hanski I.

Am Nat. 1998 Oct;152(4):530-42. doi: 10.1086/286188.

PMID:
18811362
46.

Generalized complementarity and mapping of the concepts of systematic conservation planning.

Moilanen A.

Conserv Biol. 2008 Dec;22(6):1655-8. doi: 10.1111/j.1523-1739.2008.01043.x. Epub 2008 Sep 4. No abstract available.

PMID:
18778265
47.

Aligning conservation priorities across taxa in Madagascar with high-resolution planning tools.

Kremen C, Cameron A, Moilanen A, Phillips SJ, Thomas CD, Beentje H, Dransfield J, Fisher BL, Glaw F, Good TC, Harper GJ, Hijmans RJ, Lees DC, Louis E Jr, Nussbaum RA, Raxworthy CJ, Razafimpahanana A, Schatz GE, Vences M, Vieites DR, Wright PC, Zjhra ML.

Science. 2008 Apr 11;320(5873):222-6. doi: 10.1126/science.1155193.

48.

Conservation planning in forest landscapes of Fennoscandia and an approach to the challenge of countdown 2010.

Mikusiński G, Pressey RL, Edenius L, Kujala H, Moilanen A, Niemelä J, Ranius T.

Conserv Biol. 2007 Dec;21(6):1445-54. doi: 10.1111/j.1523-1739.2007.00833.x.

PMID:
18173468
49.

Area-based refinement for selection of reserve sites with the benefit-function approach.

Arponen A, Kondelin H, Moilanen A.

Conserv Biol. 2007 Apr;21(2):527-33.

PMID:
17391202
50.

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