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Gastroenterol Hepatol Bed Bench. 2019 Spring;12(2):124-130.

Pro-oxidant antioxidant balance in patients with non-alcoholic fatty liver disease.

Author information

1
Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.
2
Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran.
3
22 Bahman hospital, Neyshabur University of Medical Sciences, Neyshabur, Iran.
4
Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Aim:

We aimed to determine these parameters in patients with non-alcoholic fatty liver disease using pro-oxidant antioxidant balance assay.

Background:

In human, pro-oxidants and antioxidants are normally produced and there is a balance between production and deletion of them. When the balance between oxidants and antioxidants are disrupted oxidative stress occurs. Oxidative stress is known one of the main mechanisms for the development of nonalcoholic fatty liver disease. Many investigations have evaluated some oxidants and/or antioxidant status in these patients. However, studies explaining the antioxidant status and the oxidant burden in these patients are lacking.

Methods:

Sera from 35 healthy subjects and 38 patients with non-alcoholic fatty liver disease were recruited. Then, the pro-oxidant burden and the antioxidants capacity were measured by pro-oxidant antioxidant balance assay.

Results:

There was no significant difference in the mean pro-oxidant antioxidant balance values between the two study groups. The results demonstrated that serum pro-oxidant antioxidant balance values were positively correlated with BMI and age in the patient group. Furthermore, the pro-oxidant antioxidant balance significantly increased in women when compared with men in all participants.

Conclusion:

It demonstrated that increased antioxidant status could be as a response reflecting of the organism to elevated oxidants in NAFLD patients which may lead to unchanged PAB values.

KEYWORDS:

NAFLD; Oxidative stress; Pro-oxidants/ antioxidants balance

PMID:
31191836
PMCID:
PMC6536017

Conflict of interest statement

The authors declare that they have no conflict of interest.

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