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The MBOAT7 rs641738 variant is associated with an improved outcome in primary sclerosing cholangitis.

Freund C, Wahlers A, Begli NH, Leopold Y, Klöters-Plachky P, Mehrabi A, Mohr I, Sander J, Rupp C, Gotthardt DN, Weiss KH.

Clin Res Hepatol Gastroenterol. 2020 Jan 9. pii: S2210-7401(19)30268-2. doi: 10.1016/j.clinre.2019.12.006. [Epub ahead of print]


Mobility and localization of the iron deficiency-induced transcription factor bHLH039 change in the presence of FIT.

Trofimov K, Ivanov R, Eutebach M, Acaroglu B, Mohr I, Bauer P, Brumbarova T.

Plant Direct. 2019 Dec 23;3(12):e00190. doi: 10.1002/pld3.190. eCollection 2019 Dec.


Inhibition of ULK1 and Beclin1 by an α-herpesvirus Akt-like Ser/Thr kinase limits autophagy to stimulate virus replication.

Rubio RM, Mohr I.

Proc Natl Acad Sci U S A. 2019 Dec 16. pii: 201915139. doi: 10.1073/pnas.1915139116. [Epub ahead of print]


Ribosome biogenesis restricts innate immune responses to virus infection and DNA.

Bianco C, Mohr I.

Elife. 2019 Dec 16;8. pii: e49551. doi: 10.7554/eLife.49551.


Repression of eEF2K transcription by NF-κB tunes translation elongation to inflammation and dsDNA-sensing.

Bianco C, Thompson L, Mohr I.

Proc Natl Acad Sci U S A. 2019 Nov 5;116(45):22583-22590. doi: 10.1073/pnas.1909143116. Epub 2019 Oct 21.


Using Primary SCG Neuron Cultures to Study Molecular Determinants of HSV-1 Latency and Reactivation.

Hu HL, Srinivas KP, Mohr I, Huang TT, Wilson AC.

Methods Mol Biol. 2020;2060:263-277. doi: 10.1007/978-1-4939-9814-2_14.


An ultra-sensitive UHPLC-MS/MS assay for the quantification of orally administered vancomycin in plasma.

Sauter M, Uhl P, Foerster KI, Mohr I, Höne RT, Merle U, Burhenne J, Haefeli WE.

J Pharm Biomed Anal. 2019 Sep 10;174:633-638. doi: 10.1016/j.jpba.2019.06.015. Epub 2019 Jun 27.


Biochemical Markers for the Diagnosis and Monitoring of Wilson Disease.

Mohr I, Weiss KH.

Clin Biochem Rev. 2019 May;40(2):59-77. doi: 10.33176/AACB-18-00014. Review.


Current anti-copper therapies in management of Wilson disease.

Mohr I, Weiss KH.

Ann Transl Med. 2019 Apr;7(Suppl 2):S69. doi: 10.21037/atm.2019.02.48. Review.


TOP2β-Dependent Nuclear DNA Damage Shapes Extracellular Growth Factor Responses via Dynamic AKT Phosphorylation to Control Virus Latency.

Hu HL, Shiflett LA, Kobayashi M, Chao MV, Wilson AC, Mohr I, Huang TT.

Mol Cell. 2019 May 2;74(3):466-480.e4. doi: 10.1016/j.molcel.2019.02.032. Epub 2019 Mar 28.


Direct RNA sequencing on nanopore arrays redefines the transcriptional complexity of a viral pathogen.

Depledge DP, Srinivas KP, Sadaoka T, Bready D, Mori Y, Placantonakis DG, Mohr I, Wilson AC.

Nat Commun. 2019 Feb 14;10(1):754. doi: 10.1038/s41467-019-08734-9.


CIPK11-Dependent Phosphorylation Modulates FIT Activity to Promote Arabidopsis Iron Acquisition in Response to Calcium Signaling.

Gratz R, Manishankar P, Ivanov R, Köster P, Mohr I, Trofimov K, Steinhorst L, Meiser J, Mai HJ, Drerup M, Arendt S, Holtkamp M, Karst U, Kudla J, Bauer P, Brumbarova T.

Dev Cell. 2019 Mar 11;48(5):726-740.e10. doi: 10.1016/j.devcel.2019.01.006. Epub 2019 Jan 31.


RNA m6 A modification enzymes shape innate responses to DNA by regulating interferon β.

Rubio RM, Depledge DP, Bianco C, Thompson L, Mohr I.

Genes Dev. 2018 Dec 1;32(23-24):1472-1484. doi: 10.1101/gad.319475.118. Epub 2018 Nov 21.


Going the Distance: Optimizing RNA-Seq Strategies for Transcriptomic Analysis of Complex Viral Genomes.

Depledge DP, Mohr I, Wilson AC.

J Virol. 2018 Dec 10;93(1). pii: e01342-18. doi: 10.1128/JVI.01342-18. Print 2019 Jan 1. Review.


Remodeling mTORC1 Responsiveness to Amino Acids by the Herpes Simplex Virus UL46 and Us3 Gene Products Supports Replication during Nutrient Insufficiency.

Vink EI, Lee S, Smiley JR, Mohr I.

J Virol. 2018 Nov 27;92(24). pii: e01377-18. doi: 10.1128/JVI.01377-18. Print 2018 Dec 15.


Translational Control in Virus-Infected Cells.

Stern-Ginossar N, Thompson SR, Mathews MB, Mohr I.

Cold Spring Harb Perspect Biol. 2019 Mar 1;11(3). pii: a033001. doi: 10.1101/cshperspect.a033001. Review.


Targeting Poxvirus Decapping Enzymes and mRNA Decay to Generate an Effective Oncolytic Virus.

Burgess HM, Pourchet A, Hajdu CH, Chiriboga L, Frey AB, Mohr I.

Mol Ther Oncolytics. 2018 Jan 31;8:71-81. doi: 10.1016/j.omto.2018.01.001. eCollection 2018 Mar 30.


Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS.

Burgess HM, Mohr I.

J Virol. 2018 Jul 17;92(15). pii: e00829-18. doi: 10.1128/JVI.00829-18. Print 2018 Aug 1.


Shared ancestry of herpes simplex virus 1 strain Patton with recent clinical isolates from Asia and with strain KOS63.

Pourchet A, Copin R, Mulvey MC, Shopsin B, Mohr I, Wilson AC.

Virology. 2017 Dec;512:124-131. doi: 10.1016/j.virol.2017.09.016.


Modeling HSV-1 Latency in Human Embryonic Stem Cell-Derived Neurons.

Pourchet A, Modrek AS, Placantonakis DG, Mohr I, Wilson AC.

Pathogens. 2017 Jun 8;6(2). pii: E24. doi: 10.3390/pathogens6020024.


Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.

Vink EI, Smiley JR, Mohr I.

J Virol. 2017 Jun 26;91(14). pii: e00295-17. doi: 10.1128/JVI.00295-17. Print 2017 Jul 15.


Restriction of Human Cytomegalovirus Replication by ISG15, a Host Effector Regulated by cGAS-STING Double-Stranded-DNA Sensing.

Bianco C, Mohr I.

J Virol. 2017 Apr 13;91(9). pii: e02483-16. doi: 10.1128/JVI.02483-16. Print 2017 May 1.


Immune Escape via a Transient Gene Expression Program Enables Productive Replication of a Latent Pathogen.

Linderman JA, Kobayashi M, Rayannavar V, Fak JJ, Darnell RB, Chao MV, Wilson AC, Mohr I.

Cell Rep. 2017 Jan 31;18(5):1312-1323. doi: 10.1016/j.celrep.2017.01.017.


Closing in on the causes of host shutoff.

Mohr I.

Elife. 2016 Sep 19;5. pii: e20755. doi: 10.7554/eLife.20755.


A Cap-to-Tail Guide to mRNA Translation Strategies in Virus-Infected Cells.

Jan E, Mohr I, Walsh D.

Annu Rev Virol. 2016 Sep 29;3(1):283-307. Epub 2016 Aug 3. Review.


CD8(+) T-cell Immune Evasion Enables Oncolytic Virus Immunotherapy.

Pourchet A, Fuhrmann SR, Pilones KA, Demaria S, Frey AB, Mulvey M, Mohr I.

EBioMedicine. 2016 Jan 19;5:59-67. doi: 10.1016/j.ebiom.2016.01.022. eCollection 2016 Mar.


Evolutionary clash between myxoma virus and rabbit PKR in Australia.

Burgess HM, Mohr I.

Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):3912-4. doi: 10.1073/pnas.1602063113. Epub 2016 Mar 31. No abstract available.


An investigation of herpes simplex virus type 1 latency in a novel mouse dorsal root ganglion model suggests a role for ICP34.5 in reactivation.

Mattila RK, Harila K, Kangas SM, Paavilainen H, Heape AM, Mohr IJ, Hukkanen V.

J Gen Virol. 2015 Aug;96(8):2304-13. doi: 10.1099/vir.0.000138. Epub 2015 Apr 8.


Cellular 5'-3' mRNA exonuclease Xrn1 controls double-stranded RNA accumulation and anti-viral responses.

Burgess HM, Mohr I.

Cell Host Microbe. 2015 Mar 11;17(3):332-344. doi: 10.1016/j.chom.2015.02.003.


Co-opting the Fanconi anemia genomic stability pathway enables herpesvirus DNA synthesis and productive growth.

Karttunen H, Savas JN, McKinney C, Chen YH, Yates JR 3rd, Hukkanen V, Huang TT, Mohr I.

Mol Cell. 2014 Jul 3;55(1):111-22. doi: 10.1016/j.molcel.2014.05.020. Epub 2014 Jun 19.


Coupling 40S ribosome recruitment to modification of a cap-binding initiation factor by eIF3 subunit e.

Walsh D, Mohr I.

Genes Dev. 2014 Apr 15;28(8):835-40. doi: 10.1101/gad.236752.113.


Using homogeneous primary neuron cultures to study fundamental aspects of HSV-1 latency and reactivation.

Kim JY, Shiflett LA, Linderman JA, Mohr I, Wilson AC.

Methods Mol Biol. 2014;1144:167-79. doi: 10.1007/978-1-4939-0428-0_11.


Global Reprogramming of the Cellular Translational Landscape Facilitates Cytomegalovirus Replication.

McKinney C, Zavadil J, Bianco C, Shiflett L, Brown S, Mohr I.

Cell Rep. 2014 Mar 27;6(6):1175. doi: 10.1016/j.celrep.2014.03.002. Epub 2014 Mar 27. No abstract available.


Global reprogramming of the cellular translational landscape facilitates cytomegalovirus replication.

McKinney C, Zavadil J, Bianco C, Shiflett L, Brown S, Mohr I.

Cell Rep. 2014 Jan 16;6(1):9-17. doi: 10.1016/j.celrep.2013.11.045. Epub 2013 Dec 27.


Suppression of PACT-induced type I interferon production by herpes simplex virus 1 Us11 protein.

Kew C, Lui PY, Chan CP, Liu X, Au SW, Mohr I, Jin DY, Kok KH.

J Virol. 2013 Dec;87(24):13141-9. doi: 10.1128/JVI.02564-13. Epub 2013 Sep 25.


Tinkering with translation: protein synthesis in virus-infected cells.

Walsh D, Mathews MB, Mohr I.

Cold Spring Harb Perspect Biol. 2013 Jan 1;5(1):a012351. doi: 10.1101/cshperspect.a012351. Review.


Host translation at the nexus of infection and immunity.

Mohr I, Sonenberg N.

Cell Host Microbe. 2012 Oct 18;12(4):470-83. doi: 10.1016/j.chom.2012.09.006. Review.


A cultured affair: HSV latency and reactivation in neurons.

Wilson AC, Mohr I.

Trends Microbiol. 2012 Dec;20(12):604-11. doi: 10.1016/j.tim.2012.08.005. Epub 2012 Sep 7. Review.


Site-specific cleavage of the host poly(A) binding protein by the encephalomyocarditis virus 3C proteinase stimulates viral replication.

Kobayashi M, Arias C, Garabedian A, Palmenberg AC, Mohr I.

J Virol. 2012 Oct;86(19):10686-94. doi: 10.1128/JVI.00896-12. Epub 2012 Jul 25.


Control of viral latency in neurons by axonal mTOR signaling and the 4E-BP translation repressor.

Kobayashi M, Wilson AC, Chao MV, Mohr I.

Genes Dev. 2012 Jul 15;26(14):1527-32. doi: 10.1101/gad.190157.112.


Suppression of extracellular signal-regulated kinase activity in herpes simplex virus 1-infected cells by the Us3 protein kinase.

Chuluunbaatar U, Roller R, Mohr I.

J Virol. 2012 Aug;86(15):7771-6. doi: 10.1128/JVI.00622-12. Epub 2012 May 16.


Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E.

Herdy B, Jaramillo M, Svitkin YV, Rosenfeld AB, Kobayashi M, Walsh D, Alain T, Sean P, Robichaud N, Topisirovic I, Furic L, Dowling RJO, Sylvestre A, Rong L, Colina R, Costa-Mattioli M, Fritz JH, Olivier M, Brown E, Mohr I, Sonenberg N.

Nat Immunol. 2012 Apr 29;13(6):543-550. doi: 10.1038/ni.2291.


A primary neuron culture system for the study of herpes simplex virus latency and reactivation.

Kobayashi M, Kim JY, Camarena V, Roehm PC, Chao MV, Wilson AC, Mohr I.

J Vis Exp. 2012 Apr 2;(62). pii: 3823. doi: 10.3791/3823.


Poly(A) binding protein abundance regulates eukaryotic translation initiation factor 4F assembly in human cytomegalovirus-infected cells.

McKinney C, Perez C, Mohr I.

Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5627-32. doi: 10.1073/pnas.1202829109. Epub 2012 Mar 19.


Transient reversal of episome silencing precedes VP16-dependent transcription during reactivation of latent HSV-1 in neurons.

Kim JY, Mandarino A, Chao MV, Mohr I, Wilson AC.

PLoS Pathog. 2012 Feb;8(2):e1002540. doi: 10.1371/journal.ppat.1002540. Epub 2012 Feb 23.


Urothelial tumor initiation requires deregulation of multiple signaling pathways: implications in target-based therapies.

Zhou H, Huang HY, Shapiro E, Lepor H, Huang WC, Mohammadi M, Mohr I, Tang MS, Huang C, Wu XR.

Carcinogenesis. 2012 Apr;33(4):770-80. doi: 10.1093/carcin/bgs025. Epub 2012 Jan 27.


A cell culture model of facial palsy resulting from reactivation of latent herpes simplex type 1.

Kuhn MA, Nayak S, Camarena V, Gardner J, Wilson A, Mohr I, Chao MV, Roehm PC.

Otol Neurotol. 2012 Jan;33(1):87-92. doi: 10.1097/MAO.0b013e31823dbb20.


Cooperation between viral interferon regulatory factor 4 and RTA to activate a subset of Kaposi's sarcoma-associated herpesvirus lytic promoters.

Xi X, Persson LM, O'Brien MW, Mohr I, Wilson AC.

J Virol. 2012 Jan;86(2):1021-33. doi: 10.1128/JVI.00694-11. Epub 2011 Nov 16.


Viral subversion of the host protein synthesis machinery.

Walsh D, Mohr I.

Nat Rev Microbiol. 2011 Oct 17;9(12):860-75. doi: 10.1038/nrmicro2655. Review.


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