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Items: 1 to 50 of 217

1.

Plakophilin-2 Haploinsufficiency Causes Calcium Handling Deficits and Modulates the Cardiac Response Towards Stress.

van Opbergen CJM, Noorman M, Pfenniger A, Copier JS, Vermij SH, Li Z, van der Nagel R, Zhang M, de Bakker JMT, Glass AM, Mohler PJ, Taffet SM, Vos MA, van Rijen HVM, Delmar M, van Veen TAB.

Int J Mol Sci. 2019 Aug 21;20(17). pii: E4076. doi: 10.3390/ijms20174076.

2.

Impact of heart rate on cross-bridge cycling kinetics in failing and non-failing human myocardium.

Chung JH, Milani-Nejad N, Davis JP, Weisleder N, Whitson BA, Mohler PJ, Janssen PML.

Am J Physiol Heart Circ Physiol. 2019 Jul 26. doi: 10.1152/ajpheart.00163.2019. [Epub ahead of print]

PMID:
31347914
3.

Ankyrin-B dysfunction predisposes to arrhythmogenic cardiomyopathy and is amenable to therapy.

Roberts JD, Murphy NP, Hamilton RM, Lubbers ER, James CA, Kline CF, Gollob MH, Krahn AD, Sturm AC, Musa H, El-Refaey M, Koenig S, Aneq MÅ, Hoorntje ET, Graw SL, Davies RW, Rafiq MA, Koopmann TT, Aafaqi S, Fatah M, Chiasson DA, Taylor MR, Simmons SL, Han M, van Opbergen CJ, Wold LE, Sinagra G, Mittal K, Tichnell C, Murray B, Codima A, Nazer B, Nguyen DT, Marcus FI, Sobriera N, Lodder EM, van den Berg MP, Spears DA, Robinson JF, Ursell PC, Green AK, Skanes AC, Tang AS, Gardner MJ, Hegele RA, van Veen TA, Wilde AA, Healey JS, Janssen PM, Mestroni L, van Tintelen JP, Calkins H, Judge DP, Hund TJ, Scheinman MM, Mohler PJ.

J Clin Invest. 2019 Jul 2;129(8):3171-3184. doi: 10.1172/JCI125538. eCollection 2019 Jul 2.

4.

βII-spectrin promotes mouse brain connectivity through stabilizing axonal plasma membranes and enabling axonal organelle transport.

Lorenzo DN, Badea A, Zhou R, Mohler PJ, Zhuang X, Bennett V.

Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15686-15695. doi: 10.1073/pnas.1820649116. Epub 2019 Jun 17.

PMID:
31209033
5.

Defining new mechanistic roles for αII spectrin in cardiac function.

Lubbers ER, Murphy NP, Musa H, Huang CY, Gupta R, Price MV, Han M, Daoud G, Gratz D, El Refaey M, Xu X, Hoeflinger NK, Friel EL, Lancione P, Wallace MJ, Cavus O, Simmons SL, Williams JL, Skaf M, Koenig SN, Janssen PML, Rasband MN, Hund TJ, Mohler PJ.

J Biol Chem. 2019 Jun 14;294(24):9576-9591. doi: 10.1074/jbc.RA119.007714. Epub 2019 May 7.

PMID:
31064843
6.

Response by El Refaey et al to Letter Regarding Article, "Protein Phosphatase 2A Regulates Cardiac Na+ Channels".

El Refaey M, Musa H, Smith SA, Binkley PF, Bradley E, Hund TJ, Mohler PJ.

Circ Res. 2019 Apr 12;124(8):e60-e61. doi: 10.1161/CIRCRESAHA.119.314938. No abstract available.

PMID:
30973807
7.

Stretching Single Titin Molecules from Failing Human Hearts Reveals Titin's Role in Blunting Cardiac Kinetic Reserve.

Chen MP, Kiduko SA, Saad NS, Canan BD, Kilic A, Mohler PJ, Janssen PML.

Cardiovasc Res. 2019 Feb 18. pii: cvz043. doi: 10.1093/cvr/cvz043. [Epub ahead of print]

PMID:
30778519
8.

Protein Phosphatase 2A Regulates Cardiac Na+ Channels.

El Refaey M, Musa H, Murphy NP, Lubbers ER, Skaf M, Han M, Cavus O, Koenig SN, Wallace MJ, Gratz D, Bradley E, Alsina KM, Wehrens XHT, Hund TJ, Mohler PJ.

Circ Res. 2019 Mar;124(5):737-746. doi: 10.1161/CIRCRESAHA.118.314350.

PMID:
30602331
9.

Human Atrial Fibrillation Drivers Resolved With Integrated Functional and Structural Imaging to Benefit Clinical Mapping.

Hansen BJ, Zhao J, Li N, Zolotarev A, Zakharkin S, Wang Y, Atwal J, Kalyanasundaram A, Abudulwahed SH, Helfrich KM, Bratasz A, Powell KA, Whitson B, Mohler PJ, Janssen PML, Simonetti OP, Hummel JD, Fedorov VV.

JACC Clin Electrophysiol. 2018 Dec;4(12):1501-1515. doi: 10.1016/j.jacep.2018.08.024. Epub 2018 Nov 1.

PMID:
30573112
10.

Ankyrin-B Q1283H Variant Linked to Arrhythmias Via Loss of Local Protein Phosphatase 2A Activity Causes Ryanodine Receptor Hyperphosphorylation.

Zhu W, Wang C, Hu J, Wan R, Yu J, Xie J, Ma J, Guo L, Ge J, Qiu Y, Chen L, Liu H, Yan X, Liu X, Ye J, He W, Shen Y, Wang C, Mohler PJ, Hong K.

Circulation. 2018 Dec 4;138(23):2682-2697. doi: 10.1161/CIRCULATIONAHA.118.034541.

11.

First In Vivo Use of High-Resolution Near-Infrared Optical Mapping to Assess Atrial Activation During Sinus Rhythm and Atrial Fibrillation in a Large Animal Model.

Hansen BJ, Li N, Helfrich KM, Abudulwahed SH, Artiga EJ, Joseph ME, Mohler PJ, Hummel JD, Fedorov VV.

Circ Arrhythm Electrophysiol. 2018 Dec;11(12):e006870. doi: 10.1161/CIRCEP.118.006870. No abstract available.

PMID:
30562105
12.

Novel Mechanistic Roles for Ankyrin-G in Cardiac Remodeling and Heart Failure.

Makara MA, Curran J, Lubbers ER, Murphy NP, Little SC, Musa H, Smith SA, Unudurthi SD, Rajaram MVS, Janssen PML, Boyden PA, Bradley EA, Hund TJ, Mohler PJ.

JACC Basic Transl Sci. 2018 Nov 12;3(5):675-689. doi: 10.1016/j.jacbts.2018.07.008. eCollection 2018 Oct.

13.

Potential use of ivabradine for treatment of atrial fibrillation.

Koenig SN, Mohler PJ.

J Cardiovasc Electrophysiol. 2019 Feb;30(2):253-254. doi: 10.1111/jce.13788. Epub 2018 Nov 28. No abstract available.

PMID:
30427090
14.

Arrhythmogenic Substrates for Atrial Fibrillation in Obesity.

Lubbers ER, Price MV, Mohler PJ.

Front Physiol. 2018 Oct 22;9:1482. doi: 10.3389/fphys.2018.01482. eCollection 2018. Review.

15.

Assessment of PKA and PKC inhibitors on force and kinetics of non-failing and failing human myocardium.

Saad NS, Elnakish MT, Brundage EA, Biesiadecki BJ, Kilic A, Ahmed AAE, Mohler PJ, Janssen PML.

Life Sci. 2018 Dec 15;215:119-127. doi: 10.1016/j.lfs.2018.10.065. Epub 2018 Nov 3.

PMID:
30399377
16.

Oxidative stress creates a unique, CaMKII-mediated substrate for atrial fibrillation in heart failure.

Yoo S, Aistrup G, Shiferaw Y, Ng J, Mohler PJ, Hund TJ, Waugh T, Browne S, Gussak G, Gilani M, Knight BP, Passman R, Goldberger JJ, Wasserstrom JA, Arora R.

JCI Insight. 2018 Nov 2;3(21). pii: 120728. doi: 10.1172/jci.insight.120728.

17.

βIV-Spectrin regulates STAT3 targeting to tune cardiac response to pressure overload.

Unudurthi SD, Nassal D, Greer-Short A, Patel N, Howard T, Xu X, Onal B, Satroplus T, Hong D, Lane C, Dalic A, Koenig SN, Lehnig AC, Baer LA, Musa H, Stanford KI, Smith S, Mohler PJ, Hund TJ.

J Clin Invest. 2018 Dec 3;128(12):5561-5572. doi: 10.1172/JCI99245. Epub 2018 Nov 12.

18.

Etiology-dependent impairment of relaxation kinetics in right ventricular end-stage failing human myocardium.

Chung JH, Martin BL, Canan BD, Elnakish MT, Milani-Nejad N, Saad NS, Repas SJ, Schultz JEJ, Murray JD, Slabaugh JL, Gearinger RL, Conkle J, Karaze T, Rastogi N, Chen MP, Crecelius W, Peczkowski KK, Ziolo MT, Fedorov VV, Kilic A, Whitson BA, Higgins RSD, Smith SA, Mohler PJ, Binkley PF, Janssen PML.

J Mol Cell Cardiol. 2018 Aug;121:81-93. doi: 10.1016/j.yjmcc.2018.07.005. Epub 2018 Jul 5.

19.

CaMKII-dependent late Na+ current increases electrical dispersion and arrhythmia in ischemia-reperfusion.

Howard T, Greer-Short A, Satroplus T, Patel N, Nassal D, Mohler PJ, Hund TJ.

Am J Physiol Heart Circ Physiol. 2018 Oct 1;315(4):H794-H801. doi: 10.1152/ajpheart.00197.2018. Epub 2018 Jun 22.

PMID:
29932771
20.

Common Coding Variants in SCN10A Are Associated With the Nav1.8 Late Current and Cardiac Conduction.

Macri V, Brody JA, Arking DE, Hucker WJ, Yin X, Lin H, Mills RW, Sinner MF, Lubitz SA, Liu CT, Morrison AC, Alonso A, Li N, Fedorov VV, Janssen PM, Bis JC, Heckbert SR, Dolmatova EV, Lumley T, Sitlani CM, Cupples LA, Pulit SL, Newton-Cheh C, Barnard J, Smith JD, Van Wagoner DR, Chung MK, Vlahakes GJ, O'Donnell CJ, Rotter JI, Margulies KB, Morley MP, Cappola TP, Benjamin EJ, Muzny D, Gibbs RA, Jackson RD, Magnani JW, Herndon CN, Rich SS, Psaty BM, Milan DJ, Boerwinkle E, Mohler PJ, Sotoodehnia N, Ellinor PT.

Circ Genom Precis Med. 2018 May;11(5):e001663. doi: 10.1161/CIRCGEN.116.001663.

21.

Altered regulation of cardiac ankyrin repeat protein in heart failure.

Kempton A, Cefalu M, Justice C, Baich T, Derbala M, Canan B, Janssen PML, Mohler PJ, Smith SA.

Heliyon. 2018 Feb 1;4(1):e00514. doi: 10.1016/j.heliyon.2018.e00514. eCollection 2018 Jan.

22.

Microtubular remodeling and decreased expression of Nav1.5 with enhanced EHD4 in cells from the infarcted heart.

Dun W, Danilo P Jr, Mohler PJ, Boyden PA.

Life Sci. 2018 May 15;201:72-80. doi: 10.1016/j.lfs.2018.03.024. Epub 2018 Mar 10.

23.

Defining the molecular signatures of human right heart failure.

Williams JL, Cavus O, Loccoh EC, Adelman S, Daugherty JC, Smith SA, Canan B, Janssen PML, Koenig S, Kline CF, Mohler PJ, Bradley EA.

Life Sci. 2018 Mar 1;196:118-126. doi: 10.1016/j.lfs.2018.01.021. Epub 2018 Jan 31.

24.

Ankyrins and Spectrins in Cardiovascular Biology and Disease.

El Refaey MM, Mohler PJ.

Front Physiol. 2017 Oct 27;8:852. doi: 10.3389/fphys.2017.00852. eCollection 2017. Review.

25.

Increased cross-bridge recruitment contributes to transient increase in force generation beyond maximal capacity in human myocardium.

Milani-Nejad N, Chung JH, Canan BD, Fedorov VV, Whitson BA, Kilic A, Mohler PJ, Janssen PML.

J Mol Cell Cardiol. 2018 Jan;114:116-123. doi: 10.1016/j.yjmcc.2017.11.007. Epub 2017 Nov 12.

26.

The role of βII spectrin in cardiac health and disease.

Derbala MH, Guo AS, Mohler PJ, Smith SA.

Life Sci. 2018 Jan 1;192:278-285. doi: 10.1016/j.lfs.2017.11.009. Epub 2017 Nov 9. Review.

27.

Novel Pathways for Regulation of Sinoatrial Node Plasticity and Heart Rate.

Mohler PJ, Hund TJ.

Circ Res. 2017 Oct 13;121(9):1027-1028. doi: 10.1161/CIRCRESAHA.117.311922. No abstract available.

28.

Three-dimensional Integrated Functional, Structural, and Computational Mapping to Define the Structural "Fingerprints" of Heart-Specific Atrial Fibrillation Drivers in Human Heart Ex Vivo.

Zhao J, Hansen BJ, Wang Y, Csepe TA, Sul LV, Tang A, Yuan Y, Li N, Bratasz A, Powell KA, Kilic A, Mohler PJ, Janssen PML, Weiss R, Simonetti OP, Hummel JD, Fedorov VV.

J Am Heart Assoc. 2017 Aug 22;6(8). pii: e005922. doi: 10.1161/JAHA.117.005922.

29.

In Vivo Genome Editing Restores Dystrophin Expression and Cardiac Function in Dystrophic Mice.

El Refaey M, Xu L, Gao Y, Canan BD, Adesanya TMA, Warner SC, Akagi K, Symer DE, Mohler PJ, Ma J, Janssen PML, Han R.

Circ Res. 2017 Sep 29;121(8):923-929. doi: 10.1161/CIRCRESAHA.117.310996. Epub 2017 Aug 8.

30.

The evolving role of ankyrin-B in cardiovascular disease.

Koenig SN, Mohler PJ.

Heart Rhythm. 2017 Dec;14(12):1884-1889. doi: 10.1016/j.hrthm.2017.07.032. Epub 2017 Jul 29. Review.

31.

Redundant and diverse intranodal pacemakers and conduction pathways protect the human sinoatrial node from failure.

Li N, Hansen BJ, Csepe TA, Zhao J, Ignozzi AJ, Sul LV, Zakharkin SO, Kalyanasundaram A, Davis JP, Biesiadecki BJ, Kilic A, Janssen PML, Mohler PJ, Weiss R, Hummel JD, Fedorov VV.

Sci Transl Med. 2017 Jul 26;9(400). pii: eaam5607. doi: 10.1126/scitranslmed.aam5607.

32.

Treat the Patient, Not Just the Cell!

Boyden PA, Mohler PJ.

Circ Res. 2017 Apr 28;120(9):1390-1392. doi: 10.1161/CIRCRESAHA.116.310427. Review. No abstract available.

33.

Advancements in the use of gene therapy for cardiac arrhythmia.

Murphy NP, Lubbers ER, Mohler PJ.

Heart Rhythm. 2017 Jul;14(7):1061-1062. doi: 10.1016/j.hrthm.2017.03.041. Epub 2017 Apr 4. No abstract available.

34.

The Davis Heart and Lung Research Institute: Building a Sustainable Platform for Translation.

Mohler PJ, Fowler LA, Abraham WT, Ryan T.

Circ Res. 2017 Mar 31;120(7):1068-1071. doi: 10.1161/CIRCRESAHA.117.310399. No abstract available.

PMID:
28360344
35.

Novel Variant in the ANK2 Membrane-Binding Domain Is Associated With Ankyrin-B Syndrome and Structural Heart Disease in a First Nations Population With a High Rate of Long QT Syndrome.

Swayne LA, Murphy NP, Asuri S, Chen L, Xu X, McIntosh S, Wang C, Lancione PJ, Roberts JD, Kerr C, Sanatani S, Sherwin E, Kline CF, Zhang M, Mohler PJ, Arbour LT.

Circ Cardiovasc Genet. 2017 Jan;10(1). pii: e001537. doi: 10.1161/CIRCGENETICS.116.001537.

36.

Novel application of 3D contrast-enhanced CMR to define fibrotic structure of the human sinoatrial node in vivo.

Csepe TA, Zhao J, Sul LV, Wang Y, Hansen BJ, Li N, Ignozzi AJ, Bratasz A, Powell KA, Kilic A, Mohler PJ, Janssen PML, Hummel JD, Simonetti OP, Fedorov VV.

Eur Heart J Cardiovasc Imaging. 2017 May 1;18(8):862-869. doi: 10.1093/ehjci/jew304.

37.

A Novel Mechanism for Human Cardiac Ankyrin-B Syndrome due to Reciprocal Chromosomal Translocation.

Huq AJ, Pertile MD, Davis AM, Landon H, James PA, Kline CF, Vohra J, Mohler PJ, Delatycki MB.

Heart Lung Circ. 2017 Jun;26(6):612-618. doi: 10.1016/j.hlc.2016.09.013. Epub 2016 Nov 16.

38.

Effects of zacopride, a moderate IK1 channel agonist, on triggered arrhythmia and contractility in human ventricular myocardium.

Elnakish MT, Canan BD, Kilic A, Mohler PJ, Janssen PM.

Pharmacol Res. 2017 Jan;115:309-318. doi: 10.1016/j.phrs.2016.11.033. Epub 2016 Nov 30.

39.

Roles and regulation of protein phosphatase 2A (PP2A) in the heart.

Lubbers ER, Mohler PJ.

J Mol Cell Cardiol. 2016 Dec;101:127-133. doi: 10.1016/j.yjmcc.2016.11.003. Epub 2016 Nov 8. Review.

40.

Neuronal Na+ Channels Are Integral Components of Pro-arrhythmic Na+/Ca2+ Signaling Nanodomain That Promotes Cardiac Arrhythmias During β-adrenergic Stimulation.

Radwański PB, Ho HT, Veeraraghavan R, Brunello L, Liu B, Belevych AE, Unudurthi SD, Makara MA, Priori SG, Volpe P, Armoundas AA, Dillmann WH, Knollmann BC, Mohler PJ, Hund TJ, Györke S.

JACC Basic Transl Sci. 2016 Jun;1(4):251-266.

41.

Atrial-specific pathways for control of intracellular signaling and myocyte function.

Hund TJ, Mohler PJ.

J Clin Invest. 2016 Oct 3;126(10):3731-3734. doi: 10.1172/JCI90348. Epub 2016 Sep 19.

42.

Cardiac Electrical and Structural Changes During Bacterial Infection: An Instructive Model to Study Cardiac Dysfunction in Sepsis.

Makara MA, Hoang KV, Ganesan LP, Crouser ED, Gunn JS, Turner J, Schlesinger LS, Mohler PJ, Rajaram MV.

J Am Heart Assoc. 2016 Sep 12;5(9). pii: e003820. doi: 10.1161/JAHA.116.003820.

43.

Whole Exome Sequencing in Atrial Fibrillation.

Lubitz SA, Brody JA, Bihlmeyer NA, Roselli C, Weng LC, Christophersen IE, Alonso A, Boerwinkle E, Gibbs RA, Bis JC; NHLBI GO Exome Sequencing Project, Cupples LA, Mohler PJ, Nickerson DA, Muzny D, Perez MV, Psaty BM, Soliman EZ, Sotoodehnia N, Lunetta KL, Benjamin EJ, Heckbert SR, Arking DE, Ellinor PT, Lin H.

PLoS Genet. 2016 Sep 2;12(9):e1006284. doi: 10.1371/journal.pgen.1006284. eCollection 2016 Sep.

44.

Strategies for Risk Analysis and Disease Classification in Atrial Fibrillation.

Adelman S, Daoud G, Mohler PJ.

J Cardiovasc Electrophysiol. 2016 Nov;27(11):1271-1273. doi: 10.1111/jce.13081. Epub 2016 Sep 20. No abstract available. Erratum in: J Cardiovasc Electrophysiol. 2019 Aug;30(8):1399.

45.

Adenosine-Induced Atrial Fibrillation: Localized Reentrant Drivers in Lateral Right Atria due to Heterogeneous Expression of Adenosine A1 Receptors and GIRK4 Subunits in the Human Heart.

Li N, Csepe TA, Hansen BJ, Sul LV, Kalyanasundaram A, Zakharkin SO, Zhao J, Guha A, Van Wagoner DR, Kilic A, Mohler PJ, Janssen PM, Biesiadecki BJ, Hummel JD, Weiss R, Fedorov VV.

Circulation. 2016 Aug 9;134(6):486-98. doi: 10.1161/CIRCULATIONAHA.115.021165. Epub 2016 Jul 26.

46.

Common human ANK2 variant confers in vivo arrhythmia phenotypes.

Musa H, Murphy NP, Curran J, Higgins JD, Webb TR, Makara MA, Wright P, Lancione PJ, Lubbers ER, Healy JA, Smith SA, Bennett V, Hund TJ, Kline CF, Mohler PJ.

Heart Rhythm. 2016 Sep;13(9):1932-40. doi: 10.1016/j.hrthm.2016.06.012. Epub 2016 Jun 11.

PMID:
27298202
47.

Elevated local [Ca2+] and CaMKII promote spontaneous Ca2+ release in ankyrin-B-deficient hearts.

Popescu I, Galice S, Mohler PJ, Despa S.

Cardiovasc Res. 2016 Aug 1;111(3):287-94. doi: 10.1093/cvr/cvw093. Epub 2016 Apr 30.

48.

Dysfunction of the β2-spectrin-based pathway in human heart failure.

Smith SA, Hughes LD, Kline CF, Kempton AN, Dorn LE, Curran J, Makara M, Webb TR, Wright P, Voigt N, Binkley PF, Janssen PM, Kilic A, Carnes CA, Dobrev D, Rasband MN, Hund TJ, Mohler PJ.

Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1583-91. doi: 10.1152/ajpheart.00875.2015. Epub 2016 Apr 22.

49.

Two-Pore K+ Channel TREK-1 Regulates Sinoatrial Node Membrane Excitability.

Unudurthi SD, Wu X, Qian L, Amari F, Onal B, Li N, Makara MA, Smith SA, Snyder J, Fedorov VV, Coppola V, Anderson ME, Mohler PJ, Hund TJ.

J Am Heart Assoc. 2016 Apr 20;5(4):e002865. doi: 10.1161/JAHA.115.002865.

50.

The Effect of Sorafenib, Tadalafil and Macitentan Treatments on Thyroxin-Induced Hemodynamic Changes and Cardiac Abnormalities.

Saad NS, Floyd K, Ahmed AA, Mohler PJ, Janssen PM, Elnakish MT.

PLoS One. 2016 Apr 15;11(4):e0153694. doi: 10.1371/journal.pone.0153694. eCollection 2016.

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