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Items: 1 to 50 of 56

1.

Inhibition of NR4A1 Promotes Ros Accumulation and IL24-Dependent Growth Arrest in Rhabdomyosarcoma.

Hedrick E, Mohankumar K, Lacey A, Safe S.

Mol Cancer Res. 2019 Aug 28. doi: 10.1158/1541-7786.MCR-19-0408. [Epub ahead of print]

PMID:
31462501
2.

Aryl Hydrocarbon Receptor (AhR) Ligands as Selective AhR Modulators: Genomic Studies.

Safe S, Han H, Goldsby J, Mohankumar K, Chapkin RS.

Curr Opin Toxicol. 2018 Oct-Dec;11-12:10-20. doi: 10.1016/j.cotox.2018.11.005. Epub 2018 Nov 22.

3.

A murine neonatal model of necrotizing enterocolitis caused by anemia and red blood cell transfusions.

MohanKumar K, Namachivayam K, Song T, Jake Cha B, Slate A, Hendrickson JE, Pan H, Wickline SA, Oh JY, Patel RP, He L, Torres BA, Maheshwari A.

Nat Commun. 2019 Aug 2;10(1):3494. doi: 10.1038/s41467-019-11199-5.

4.

Potent inhibition of breast cancer by bis-indole-derived nuclear receptor 4A1 (NR4A1) antagonists.

Hedrick E, Li X, Cheng Y, Lacey A, Mohankumar K, Zarei M, Safe S.

Breast Cancer Res Treat. 2019 Aug;177(1):29-40. doi: 10.1007/s10549-019-05279-9. Epub 2019 May 22.

PMID:
31119568
5.

Genetic Polymorphisms in the Open Reading Frame of the CCR5 gene From HIV-1 Seronegative and Seropositive Individuals From National Capital Regions of India.

Ronsard L, Sood V, Yousif AS, Ramesh J, Shankar V, Das J, Sumi N, Rai T, Mohankumar K, Sridharan S, Dorschel A, Ramachandran VG, Banerjea AC.

Sci Rep. 2019 May 20;9(1):7594. doi: 10.1038/s41598-019-44136-z.

6.

Nuclear receptor 4A1 (NR4A1) antagonists induce ROS-dependent inhibition of mTOR signaling in endometrial cancer.

Mohankumar K, Li X, Sridharan S, Karki K, Safe S.

Gynecol Oncol. 2019 Jul;154(1):218-227. doi: 10.1016/j.ygyno.2019.04.678. Epub 2019 Apr 30.

PMID:
31053403
7.

Reactive Oxygen Species (ROS)-Inducing Triterpenoid Inhibits Rhabdomyosarcoma Cell and Tumor Growth through Targeting Sp Transcription Factors.

Kasiappan R, Jutooru I, Mohankumar K, Karki K, Lacey A, Safe S.

Mol Cancer Res. 2019 Mar;17(3):794-805. doi: 10.1158/1541-7786.MCR-18-1071. Epub 2019 Jan 4.

PMID:
30610105
8.

Interleukin-24 (IL24) Is Suppressed by PAX3-FOXO1 and Is a Novel Therapy for Rhabdomyosarcoma.

Lacey A, Hedrick E, Cheng Y, Mohankumar K, Warren M, Safe S.

Mol Cancer Ther. 2018 Dec;17(12):2756-2766. doi: 10.1158/1535-7163.MCT-18-0118. Epub 2018 Sep 6.

PMID:
30190424
9.

TGFβ-Induced Lung Cancer Cell Migration Is NR4A1-Dependent.

Hedrick E, Mohankumar K, Safe S.

Mol Cancer Res. 2018 Dec;16(12):1991-2002. doi: 10.1158/1541-7786.MCR-18-0366. Epub 2018 Aug 2.

PMID:
30072581
10.

Bis-Indole-Derived NR4A1 Ligands and Metformin Exhibit NR4A1-Dependent Glucose Metabolism and Uptake in C2C12 Cells.

Mohankumar K, Lee J, Wu CS, Sun Y, Safe S.

Endocrinology. 2018 May 1;159(5):1950-1963. doi: 10.1210/en.2017-03049.

11.

Impact of Genetic Variations in HIV-1 Tat on LTR-Mediated Transcription via TAR RNA Interaction.

Ronsard L, Ganguli N, Singh VK, Mohankumar K, Rai T, Sridharan S, Pajaniradje S, Kumar B, Rai D, Chaudhuri S, Coumar MS, Ramachandran VG, Banerjea AC.

Front Microbiol. 2017 Apr 21;8:706. doi: 10.3389/fmicb.2017.00706. eCollection 2017.

12.

Diagnostic accuracy of salivary creatinine, urea, and potassium levels to assess dialysis need in renal failure patients.

Bagalad BS, Mohankumar KP, Madhushankari GS, Donoghue M, Kuberappa PH.

Dent Res J (Isfahan). 2017 Jan-Feb;14(1):13-18.

13.

Neonatal mice with necrotizing enterocolitis-like injury develop thrombocytopenia despite increased megakaryopoiesis.

Namachivayam K, MohanKumar K, Garg L, Torres BA, Maheshwari A.

Pediatr Res. 2017 May;81(5):817-824. doi: 10.1038/pr.2017.7. Epub 2017 Jan 13.

14.

Cytokines and growth factors in the developing intestine and during necrotizing enterocolitis.

MohanKumar K, Namachivayam K, Ho TT, Torres BA, Ohls RK, Maheshwari A.

Semin Perinatol. 2017 Feb;41(1):52-60. doi: 10.1053/j.semperi.2016.09.018. Epub 2016 Nov 7. Review.

15.

Trinitrobenzene sulfonic acid-induced intestinal injury in neonatal mice activates transcriptional networks similar to those seen in human necrotizing enterocolitis.

MohanKumar K, Namachivayam K, Cheng F, Jiang RH, Flores-Torres J, Torres BA, Maheshwari A.

Pediatr Res. 2017 Jan;81(1-1):99-112. doi: 10.1038/pr.2016.189. Epub 2016 Sep 22.

16.

Heavy Metal Contamination in Groundwater around Industrial Estate vs Residential Areas in Coimbatore, India.

Mohankumar K, Hariharan V, Rao NP.

J Clin Diagn Res. 2016 Apr;10(4):BC05-7. doi: 10.7860/JCDR/2016/15943.7527. Epub 2016 Apr 1.

17.

Anti-proliferative and apoptosis-triggering potential of disulfiram and disulfiram-loaded polysorbate 80-stabilized PLGA nanoparticles on hepatocellular carcinoma Hep3B cell line.

Hoda M, Pajaniradje S, Shakya G, Mohankumar K, Rajagopalan R.

Nanomedicine. 2016 Aug;12(6):1641-50. doi: 10.1016/j.nano.2016.02.013. Epub 2016 Mar 22.

PMID:
27013133
18.

Smad7 interrupts TGF-β signaling in intestinal macrophages and promotes inflammatory activation of these cells during necrotizing enterocolitis.

MohanKumar K, Namachivayam K, Chapalamadugu KC, Garzon SA, Premkumar MH, Tipparaju SM, Maheshwari A.

Pediatr Res. 2016 Jun;79(6):951-61. doi: 10.1038/pr.2016.18. Epub 2016 Feb 9.

19.

Neuroprotective effect of Valeriana wallichii rhizome extract against the neurotoxin MPTP in C57BL/6 mice.

Sridharan S, Mohankumar K, Jeepipalli SP, Sankaramourthy D, Ronsard L, Subramanian K, Thamilarasan M, Raja K, Chandra VK, Sadras SR.

Neurotoxicology. 2015 Dec;51:172-83. doi: 10.1016/j.neuro.2015.10.012. Epub 2015 Oct 30.

PMID:
26522450
20.

Genetic and functional characterization of HIV-1 Vif on APOBEC3G degradation: First report of emergence of B/C recombinants from North India.

Ronsard L, Raja R, Panwar V, Saini S, Mohankumar K, Sridharan S, Padmapriya R, Chaudhuri S, Ramachandran VG, Banerjea AC.

Sci Rep. 2015 Oct 23;5:15438. doi: 10.1038/srep15438.

21.

BDMC-A, an analog of curcumin, inhibits markers of invasion, angiogenesis, and metastasis in breast cancer cells via NF-κB pathway--A comparative study with curcumin.

Mohankumar K, Sridharan S, Pajaniradje S, Singh VK, Ronsard L, Banerjea AC, Somasundaram DB, Coumar MS, Periyasamy L, Rajagopalan R.

Biomed Pharmacother. 2015 Aug;74:178-86. doi: 10.1016/j.biopha.2015.07.024. Epub 2015 Aug 15.

PMID:
26349982
22.

All-Trans Retinoic Acid Induces TGF-β2 in Intestinal Epithelial Cells via RhoA- and p38α MAPK-Mediated Activation of the Transcription Factor ATF2.

Namachivayam K, MohanKumar K, Arbach D, Jagadeeswaran R, Jain SK, Natarajan V, Mehta D, Jankov RP, Maheshwari A.

PLoS One. 2015 Jul 30;10(7):e0134003. doi: 10.1371/journal.pone.0134003. eCollection 2015.

23.

An in vivo screen identifies ependymoma oncogenes and tumor-suppressor genes.

Mohankumar KM, Currle DS, White E, Boulos N, Dapper J, Eden C, Nimmervoll B, Thiruvenkatam R, Connelly M, Kranenburg TA, Neale G, Olsen S, Wang YD, Finkelstein D, Wright K, Gupta K, Ellison DW, Thomas AO, Gilbertson RJ.

Nat Genet. 2015 Aug;47(8):878-87. doi: 10.1038/ng.3323. Epub 2015 Jun 15.

24.

Transforming growth factor-β2 is sequestered in preterm human milk by chondroitin sulfate proteoglycans.

Namachivayam K, Coffing HP, Sankaranarayanan NV, Jin Y, MohanKumar K, Frost BL, Blanco CL, Patel AL, Meier PP, Garzon SA, Desai UR, Maheshwari A.

Am J Physiol Gastrointest Liver Physiol. 2015 Aug 1;309(3):G171-80. doi: 10.1152/ajpgi.00126.2015. Epub 2015 Jun 4.

25.

Preclinical examination of clofarabine in pediatric ependymoma: intratumoral concentrations insufficient to warrant further study.

Patel YT, Jacus MO, Boulos N, Dapper JD, Davis AD, Vuppala PK, Freeman BB 3rd, Mohankumar KM, Throm SL, Gilbertson RJ, Stewart CF.

Cancer Chemother Pharmacol. 2015 May;75(5):897-906. doi: 10.1007/s00280-015-2713-z. Epub 2015 Feb 28.

26.

VEGF mRNA and protein concentrations in the developing human eye.

Ma IT, McConaghy S, Namachivayam K, Halloran BA, Kurundkar AR, MohanKumar K, Maheshwari A, Ohls RK.

Pediatr Res. 2015 Apr;77(4):500-5. doi: 10.1038/pr.2015.15. Epub 2015 Jan 14.

27.

Apoptosis induction by an analog of curcumin (BDMC-A) in human laryngeal carcinoma cells through intrinsic and extrinsic pathways.

Mohankumar K, Pajaniradje S, Sridharan S, Singh VK, Ronsard L, Banerjea AC, Selvanesan BC, Coumar MS, Periyasamy L, Rajagopalan R.

Cell Oncol (Dordr). 2014 Dec;37(6):439-54. doi: 10.1007/s13402-014-0207-3. Epub 2014 Dec 1.

PMID:
25433549
28.

Estimation of age by Kvaal's technique in sample Indian population to establish the need for local Indian-based formulae.

Patil SK, Mohankumar KP, Donoghue M.

J Forensic Dent Sci. 2014 Sep;6(3):166-70. doi: 10.4103/0975-1475.137050.

29.

Hypoglycaemic role of wheatgrass and its effect on carbohydrate metabolic enzymes in type II diabetic rats.

Shakya G, Randhi PK, Pajaniradje S, Mohankumar K, Rajagopalan R.

Toxicol Ind Health. 2016 Jun;32(6):1026-32. doi: 10.1177/0748233714545202. Epub 2014 Aug 12.

PMID:
25116122
30.

Antiproliferative and apoptotic effects of Sesbania grandiflora leaves in human cancer cells.

Pajaniradje S, Mohankumar K, Pamidimukkala R, Subramanian S, Rajagopalan R.

Biomed Res Int. 2014;2014:474953. doi: 10.1155/2014/474953. Epub 2014 May 15.

31.

C11orf95-RELA fusions drive oncogenic NF-κB signalling in ependymoma.

Parker M, Mohankumar KM, Punchihewa C, Weinlich R, Dalton JD, Li Y, Lee R, Tatevossian RG, Phoenix TN, Thiruvenkatam R, White E, Tang B, Orisme W, Gupta K, Rusch M, Chen X, Li Y, Nagahawhatte P, Hedlund E, Finkelstein D, Wu G, Shurtleff S, Easton J, Boggs K, Yergeau D, Vadodaria B, Mulder HL, Becksfort J, Gupta P, Huether R, Ma J, Song G, Gajjar A, Merchant T, Boop F, Smith AA, Ding L, Lu C, Ochoa K, Zhao D, Fulton RS, Fulton LL, Mardis ER, Wilson RK, Downing JR, Green DR, Zhang J, Ellison DW, Gilbertson RJ.

Nature. 2014 Feb 27;506(7489):451-5. doi: 10.1038/nature13109. Epub 2014 Feb 19. Erratum in: Nature. 2014 Apr 24;508(7497):554. Becksford, Jared [corrected to Becksfort, Jared].

32.

Amniotic fluid-borne hepatocyte growth factor protects rat pups against experimental necrotizing enterocolitis.

Jain SK, Baggerman EW, Mohankumar K, Namachivayam K, Jagadeeswaran R, Reyes VE, Maheshwari A.

Am J Physiol Gastrointest Liver Physiol. 2014 Mar 1;306(5):G361-9. doi: 10.1152/ajpgi.00272.2013. Epub 2014 Jan 9.

33.

Intestinal epithelial apoptosis initiates gut mucosal injury during extracorporeal membrane oxygenation in the newborn piglet.

MohanKumar K, Killingsworth CR, McIlwain RB, Timpa JG, Jagadeeswaran R, Namachivayam K, Kurundkar AR, Kelly DR, Garzon SA, Maheshwari A.

Lab Invest. 2014 Feb;94(2):150-60. doi: 10.1038/labinvest.2013.149. Epub 2013 Dec 23.

34.

Mechanism of apoptotic induction in human breast cancer cell, MCF-7, by an analog of curcumin in comparison with curcumin--an in vitro and in silico approach.

Mohankumar K, Pajaniradje S, Sridharan S, Singh VK, Ronsard L, Banerjea AC, Benson CS, Coumar MS, Rajagopalan R.

Chem Biol Interact. 2014 Mar 5;210:51-63. doi: 10.1016/j.cbi.2013.12.006. Epub 2013 Dec 21.

PMID:
24365254
35.

Preterm human milk contains a large pool of latent TGF-β, which can be activated by exogenous neuraminidase.

Namachivayam K, Blanco CL, Frost BL, Reeves AA, Jagadeeswaran R, MohanKumar K, Safarulla A, Mandal P, Garzon SA, Raj JU, Maheshwari A.

Am J Physiol Gastrointest Liver Physiol. 2013 Jun 15;304(12):G1055-65. doi: 10.1152/ajpgi.00039.2013. Epub 2013 Apr 4.

36.

Smad7 inhibits autocrine expression of TGF-β2 in intestinal epithelial cells in baboon necrotizing enterocolitis.

Namachivayam K, Blanco CL, MohanKumar K, Jagadeeswaran R, Vasquez M, McGill-Vargas L, Garzon SA, Jain SK, Gill RK, Freitag NE, Weitkamp JH, Seidner SR, Maheshwari A.

Am J Physiol Gastrointest Liver Physiol. 2013 Jan 15;304(2):G167-80. doi: 10.1152/ajpgi.00141.2012. Epub 2012 Nov 15.

37.

The prolactin receptor mediates HOXA1-stimulated oncogenicity in mammary carcinoma cells.

Hou L, Xu B, Mohankumar KM, Goffin V, Perry JK, Lobie PE, Liu DX.

Int J Oncol. 2012 Dec;41(6):2285-95. doi: 10.3892/ijo.2012.1660. Epub 2012 Oct 15.

PMID:
23064471
38.

Gut mucosal injury in neonates is marked by macrophage infiltration in contrast to pleomorphic infiltrates in adult: evidence from an animal model.

MohanKumar K, Kaza N, Jagadeeswaran R, Garzon SA, Bansal A, Kurundkar AR, Namachivayam K, Remon JI, Bandepalli CR, Feng X, Weitkamp JH, Maheshwari A.

Am J Physiol Gastrointest Liver Physiol. 2012 Jul;303(1):G93-102. doi: 10.1152/ajpgi.00016.2012. Epub 2012 Apr 26.

39.

An integrated in vitro and in vivo high-throughput screen identifies treatment leads for ependymoma.

Atkinson JM, Shelat AA, Carcaboso AM, Kranenburg TA, Arnold LA, Boulos N, Wright K, Johnson RA, Poppleton H, Mohankumar KM, Féau C, Phoenix T, Gibson P, Zhu L, Tong Y, Eden C, Ellison DW, Priebe W, Koul D, Yung WK, Gajjar A, Stewart CF, Guy RK, Gilbertson RJ.

Cancer Cell. 2011 Sep 13;20(3):384-99. doi: 10.1016/j.ccr.2011.08.013.

40.

Trefoil factor 3 is oncogenic and mediates anti-estrogen resistance in human mammary carcinoma.

Kannan N, Kang J, Kong X, Tang J, Perry JK, Mohankumar KM, Miller LD, Liu ET, Mertani HC, Zhu T, Grandison PM, Liu DX, Lobie PE.

Neoplasia. 2010 Dec;12(12):1041-53.

41.

Chlorine gas exposure causes systemic endothelial dysfunction by inhibiting endothelial nitric oxide synthase-dependent signaling.

Honavar J, Samal AA, Bradley KM, Brandon A, Balanay J, Squadrito GL, MohanKumar K, Maheshwari A, Postlethwait EM, Matalon S, Patel RP.

Am J Respir Cell Mol Biol. 2011 Aug;45(2):419-25. doi: 10.1165/rcmb.2010-0151OC. Epub 2010 Dec 3.

42.

Cross-species genomics matches driver mutations and cell compartments to model ependymoma.

Johnson RA, Wright KD, Poppleton H, Mohankumar KM, Finkelstein D, Pounds SB, Rand V, Leary SE, White E, Eden C, Hogg T, Northcott P, Mack S, Neale G, Wang YD, Coyle B, Atkinson J, DeWire M, Kranenburg TA, Gillespie Y, Allen JC, Merchant T, Boop FA, Sanford RA, Gajjar A, Ellison DW, Taylor MD, Grundy RG, Gilbertson RJ.

Nature. 2010 Jul 29;466(7306):632-6. doi: 10.1038/nature09173. Epub 2010 Jul 18.

43.

Autocrine human growth hormone stimulates oncogenicity of endometrial carcinoma cells.

Pandey V, Perry JK, Mohankumar KM, Kong XJ, Liu SM, Wu ZS, Mitchell MD, Zhu T, Lobie PE.

Endocrinology. 2008 Aug;149(8):3909-19. doi: 10.1210/en.2008-0286. Epub 2008 May 1.

44.

Transcriptional activation of signal transducer and activator of transcription (STAT) 3 and STAT5B partially mediate homeobox A1-stimulated oncogenic transformation of the immortalized human mammary epithelial cell.

Mohankumar KM, Perry JK, Kannan N, Kohno K, Gluckman PD, Emerald BS, Lobie PE.

Endocrinology. 2008 May;149(5):2219-29. doi: 10.1210/en.2007-1320. Epub 2008 Feb 14.

PMID:
18276758
45.

The contribution of growth hormone to mammary neoplasia.

Perry JK, Mohankumar KM, Emerald BS, Mertani HC, Lobie PE.

J Mammary Gland Biol Neoplasia. 2008 Mar;13(1):131-45. doi: 10.1007/s10911-008-9070-z. Epub 2008 Feb 7. Review.

46.

The ABC transporter BCRP/ABCG2 is a placental survival factor, and its expression is reduced in idiopathic human fetal growth restriction.

Evseenko DA, Murthi P, Paxton JW, Reid G, Emerald BS, Mohankumar KM, Lobie PE, Brennecke SP, Kalionis B, Keelan JA.

FASEB J. 2007 Nov;21(13):3592-605. Epub 2007 Jun 26.

PMID:
17595345
47.

HOXA1-stimulated oncogenicity is mediated by selective upregulation of components of the p44/42 MAP kinase pathway in human mammary carcinoma cells.

Mohankumar KM, Xu XQ, Zhu T, Kannan N, Miller LD, Liu ET, Gluckman PD, Sukumar S, Emerald BS, Lobie PE.

Oncogene. 2007 Jun 7;26(27):3998-4008. Epub 2007 Jan 8.

PMID:
17213808
48.
49.

HOXA1 is required for E-cadherin-dependent anchorage-independent survival of human mammary carcinoma cells.

Zhang X, Emerald BS, Mukhina S, Mohankumar KM, Kraemer A, Yap AS, Gluckman PD, Lee KO, Lobie PE.

J Biol Chem. 2006 Mar 10;281(10):6471-81. Epub 2005 Dec 22.

50.

White spot syndrome virus infection decreases the activity of antioxidant enzymes in Fenneropenaeus indicus.

Mohankumar K, Ramasamy P.

Virus Res. 2006 Jan;115(1):69-75. Epub 2005 Sep 1.

PMID:
16139913

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