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Items: 1 to 50 of 102

1.

Two-Step Activation Mechanism of the ClpB Disaggregase for Sequential Substrate Threading by the Main ATPase Motor.

Deville C, Franke K, Mogk A, Bukau B, Saibil HR.

Cell Rep. 2019 Jun 18;27(12):3433-3446.e4. doi: 10.1016/j.celrep.2019.05.075.

2.

Toxic Activation of an AAA+ Protease by the Antibacterial Drug Cyclomarin A.

Maurer M, Linder D, Franke KB, Jäger J, Taylor G, Gloge F, Gremer S, Le Breton L, Mayer MP, Weber-Ban E, Carroni M, Bukau B, Mogk A.

Cell Chem Biol. 2019 Aug 15;26(8):1169-1179.e4. doi: 10.1016/j.chembiol.2019.05.008. Epub 2019 Jun 13.

PMID:
31204287
3.

Cellular Functions and Mechanisms of Action of Small Heat Shock Proteins.

Mogk A, Ruger-Herreros C, Bukau B.

Annu Rev Microbiol. 2019 Sep 8;73:89-110. doi: 10.1146/annurev-micro-020518-115515. Epub 2019 May 15.

PMID:
31091419
4.

A Gatekeeper Residue of ClpS1 from Arabidopsis thaliana Chloroplasts Determines its Affinity Towards Substrates of the Bacterial N-End Rule.

Colombo CV, Rosano GL, Mogk A, Ceccarelli EA.

Plant Cell Physiol. 2018 Mar 1;59(3):624-636. doi: 10.1093/pcp/pcy016.

PMID:
29401302
5.

A prion-like domain in Hsp42 drives chaperone-facilitated aggregation of misfolded proteins.

Grousl T, Ungelenk S, Miller S, Ho CT, Khokhrina M, Mayer MP, Bukau B, Mogk A.

J Cell Biol. 2018 Apr 2;217(4):1269-1285. doi: 10.1083/jcb.201708116. Epub 2018 Jan 23.

6.

Cellular Handling of Protein Aggregates by Disaggregation Machines.

Mogk A, Bukau B, Kampinga HH.

Mol Cell. 2018 Jan 18;69(2):214-226. doi: 10.1016/j.molcel.2018.01.004. Review.

7.

Stand-alone ClpG disaggregase confers superior heat tolerance to bacteria.

Lee C, Franke KB, Kamal SM, Kim H, Lünsdorf H, Jäger J, Nimtz M, Trček J, Jänsch L, Bukau B, Mogk A, Römling U.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E273-E282. doi: 10.1073/pnas.1712051115. Epub 2017 Dec 20.

8.

Regulatory coiled-coil domains promote head-to-head assemblies of AAA+ chaperones essential for tunable activity control.

Carroni M, Franke KB, Maurer M, Jäger J, Hantke I, Gloge F, Linder D, Gremer S, Turgay K, Bukau B, Mogk A.

Elife. 2017 Nov 22;6. pii: e30120. doi: 10.7554/eLife.30120.

9.

Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase.

Deville C, Carroni M, Franke KB, Topf M, Bukau B, Mogk A, Saibil HR.

Sci Adv. 2017 Aug 4;3(8):e1701726. doi: 10.1126/sciadv.1701726. eCollection 2017 Aug.

10.

Mutant Analysis Reveals Allosteric Regulation of ClpB Disaggregase.

Franke KB, Bukau B, Mogk A.

Front Mol Biosci. 2017 Feb 22;4:6. doi: 10.3389/fmolb.2017.00006. eCollection 2017.

11.

Hsp70 displaces small heat shock proteins from aggregates to initiate protein refolding.

Żwirowski S, Kłosowska A, Obuchowski I, Nillegoda NB, Piróg A, Ziętkiewicz S, Bukau B, Mogk A, Liberek K.

EMBO J. 2017 Mar 15;36(6):783-796. doi: 10.15252/embj.201593378. Epub 2017 Feb 20.

12.

Role of sHsps in organizing cytosolic protein aggregation and disaggregation.

Mogk A, Bukau B.

Cell Stress Chaperones. 2017 Jul;22(4):493-502. doi: 10.1007/s12192-017-0762-4. Epub 2017 Jan 24. Review.

13.

Small heat shock proteins sequester misfolding proteins in near-native conformation for cellular protection and efficient refolding.

Ungelenk S, Moayed F, Ho CT, Grousl T, Scharf A, Mashaghi A, Tans S, Mayer MP, Mogk A, Bukau B.

Nat Commun. 2016 Nov 30;7:13673. doi: 10.1038/ncomms13673.

14.

Aggregation-induced changes in the chemical exchange saturation transfer (CEST) signals of proteins.

Goerke S, Milde KS, Bukowiecki R, Kunz P, Klika KD, Wiglenda T, Mogk A, Wanker EE, Bukau B, Ladd ME, Bachert P, Zaiss M.

NMR Biomed. 2017 Jan;30(1). doi: 10.1002/nbm.3665. Epub 2016 Nov 11.

PMID:
27859838
15.

Bacterial and Yeast AAA+ Disaggregases ClpB and Hsp104 Operate through Conserved Mechanism Involving Cooperation with Hsp70.

Kummer E, Szlachcic A, Franke KB, Ungelenk S, Bukau B, Mogk A.

J Mol Biol. 2016 Oct 23;428(21):4378-4391. doi: 10.1016/j.jmb.2016.09.003. Epub 2016 Sep 9.

PMID:
27616763
16.

The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation.

Yonashiro R, Tahara EB, Bengtson MH, Khokhrina M, Lorenz H, Chen KC, Kigoshi-Tansho Y, Savas JN, Yates JR, Kay SA, Craig EA, Mogk A, Bukau B, Joazeiro CA.

Elife. 2016 Mar 4;5:e11794. doi: 10.7554/eLife.11794.

17.

Characterization of ClpS2, an essential adaptor protein for the cyanobacterium Synechococcus elongatus.

Tryggvesson A, Ståhlberg FM, Töpel M, Tanabe N, Mogk A, Clarke AK.

FEBS Lett. 2015 Dec 21;589(24 Pt B):4039-46. doi: 10.1016/j.febslet.2015.11.026. Epub 2015 Nov 24.

18.

Incomplete proteasomal degradation of green fluorescent proteins in the context of tandem fluorescent protein timers.

Khmelinskii A, Meurer M, Ho CT, Besenbeck B, Füller J, Lemberg MK, Bukau B, Mogk A, Knop M.

Mol Biol Cell. 2016 Jan 15;27(2):360-70. doi: 10.1091/mbc.E15-07-0525. Epub 2015 Nov 25.

19.

Systemic control of protein synthesis through sequestration of translation and ribosome biogenesis factors during severe heat stress.

Cherkasov V, Grousl T, Theer P, Vainshtein Y, Glässer C, Mongis C, Kramer G, Stoecklin G, Knop M, Mogk A, Bukau B.

FEBS Lett. 2015 Nov 30;589(23):3654-64. doi: 10.1016/j.febslet.2015.10.010. Epub 2015 Oct 17.

20.

Human Hsp70 Disaggregase Reverses Parkinson's-Linked α-Synuclein Amyloid Fibrils.

Gao X, Carroni M, Nussbaum-Krammer C, Mogk A, Nillegoda NB, Szlachcic A, Guilbride DL, Saibil HR, Mayer MP, Bukau B.

Mol Cell. 2015 Sep 3;59(5):781-93. doi: 10.1016/j.molcel.2015.07.012. Epub 2015 Aug 20.

21.

Cooperation of Hsp70 and Hsp100 chaperone machines in protein disaggregation.

Mogk A, Kummer E, Bukau B.

Front Mol Biosci. 2015 May 19;2:22. doi: 10.3389/fmolb.2015.00022. eCollection 2015. Review.

22.

Signature of protein unfolding in chemical exchange saturation transfer imaging.

Goerke S, Zaiss M, Kunz P, Klika KD, Windschuh JD, Mogk A, Bukau B, Ladd ME, Bachert P.

NMR Biomed. 2015 Jul;28(7):906-13. doi: 10.1002/nbm.3317. Epub 2015 May 26.

PMID:
26010522
23.

Prolonged starvation drives reversible sequestration of lipid biosynthetic enzymes and organelle reorganization in Saccharomyces cerevisiae.

Suresh HG, da Silveira Dos Santos AX, Kukulski W, Tyedmers J, Riezman H, Bukau B, Mogk A.

Mol Biol Cell. 2015 May 1;26(9):1601-15. doi: 10.1091/mbc.E14-11-1559. Epub 2015 Mar 11.

24.

Spatially organized aggregation of misfolded proteins as cellular stress defense strategy.

Miller SB, Mogk A, Bukau B.

J Mol Biol. 2015 Apr 10;427(7):1564-74. doi: 10.1016/j.jmb.2015.02.006. Epub 2015 Feb 11. Review.

PMID:
25681695
25.

Compartment-specific aggregases direct distinct nuclear and cytoplasmic aggregate deposition.

Miller SB, Ho CT, Winkler J, Khokhrina M, Neuner A, Mohamed MY, Guilbride DL, Richter K, Lisby M, Schiebel E, Mogk A, Bukau B.

EMBO J. 2015 Mar 12;34(6):778-97. doi: 10.15252/embj.201489524. Epub 2015 Feb 11.

26.

Mitochondria tether protein trash to rejuvenate cellular environments.

Mogk A, Bukau B.

Cell. 2014 Oct 23;159(3):471-2. doi: 10.1016/j.cell.2014.10.007.

27.

Type VI secretion system helps find a niche.

Kapitein N, Mogk A.

Cell Host Microbe. 2014 Jul 9;16(1):5-6. doi: 10.1016/j.chom.2014.06.012.

28.

Structure of the VipA/B type VI secretion complex suggests a contraction-state-specific recycling mechanism.

Kube S, Kapitein N, Zimniak T, Herzog F, Mogk A, Wendler P.

Cell Rep. 2014 Jul 10;8(1):20-30. doi: 10.1016/j.celrep.2014.05.034. Epub 2014 Jun 19.

29.

Monitoring protein misfolding by site-specific labeling of proteins in vivo.

Hsieh TY, Nillegoda NB, Tyedmers J, Bukau B, Mogk A, Kramer G.

PLoS One. 2014 Jun 10;9(6):e99395. doi: 10.1371/journal.pone.0099395. eCollection 2014.

30.

Head-to-tail interactions of the coiled-coil domains regulate ClpB activity and cooperation with Hsp70 in protein disaggregation.

Carroni M, Kummer E, Oguchi Y, Wendler P, Clare DK, Sinning I, Kopp J, Mogk A, Bukau B, Saibil HR.

Elife. 2014 Apr 30;3:e02481. doi: 10.7554/eLife.02481.

31.

Coordination of translational control and protein homeostasis during severe heat stress.

Cherkasov V, Hofmann S, Druffel-Augustin S, Mogk A, Tyedmers J, Stoecklin G, Bukau B.

Curr Biol. 2013 Dec 16;23(24):2452-62. doi: 10.1016/j.cub.2013.09.058. Epub 2013 Nov 27.

32.

Mechanism of Hsp104/ClpB inhibition by prion curing Guanidinium hydrochloride.

Kummer E, Oguchi Y, Seyffer F, Bukau B, Mogk A.

FEBS Lett. 2013 Mar 18;587(6):810-7. doi: 10.1016/j.febslet.2013.02.011. Epub 2013 Feb 14.

33.

Deadly syringes: type VI secretion system activities in pathogenicity and interbacterial competition.

Kapitein N, Mogk A.

Curr Opin Microbiol. 2013 Feb;16(1):52-8. doi: 10.1016/j.mib.2012.11.009. Epub 2013 Jan 2. Review.

PMID:
23290191
34.

ClpV recycles VipA/VipB tubules and prevents non-productive tubule formation to ensure efficient type VI protein secretion.

Kapitein N, Bönemann G, Pietrosiuk A, Seyffer F, Hausser I, Locker JK, Mogk A.

Mol Microbiol. 2013 Mar;87(5):1013-28. doi: 10.1111/mmi.12147. Epub 2013 Feb 3.

35.

A tightly regulated molecular toggle controls AAA+ disaggregase.

Oguchi Y, Kummer E, Seyffer F, Berynskyy M, Anstett B, Zahn R, Wade RC, Mogk A, Bukau B.

Nat Struct Mol Biol. 2012 Dec;19(12):1338-46. doi: 10.1038/nsmb.2441. Epub 2012 Nov 18.

PMID:
23160353
36.

Hsp70 proteins bind Hsp100 regulatory M domains to activate AAA+ disaggregase at aggregate surfaces.

Seyffer F, Kummer E, Oguchi Y, Winkler J, Kumar M, Zahn R, Sourjik V, Bukau B, Mogk A.

Nat Struct Mol Biol. 2012 Dec;19(12):1347-55. doi: 10.1038/nsmb.2442. Epub 2012 Nov 18.

PMID:
23160352
37.

Hsp70 targets Hsp100 chaperones to substrates for protein disaggregation and prion fragmentation.

Winkler J, Tyedmers J, Bukau B, Mogk A.

J Cell Biol. 2012 Aug 6;198(3):387-404. doi: 10.1083/jcb.201201074.

38.

Interaction specificity between the chaperone and proteolytic components of the cyanobacterial Clp protease.

Tryggvesson A, Ståhlberg FM, Mogk A, Zeth K, Clarke AK.

Biochem J. 2012 Sep 1;446(2):311-20. doi: 10.1042/BJ20120649.

PMID:
22657732
39.

Chaperone networks in protein disaggregation and prion propagation.

Winkler J, Tyedmers J, Bukau B, Mogk A.

J Struct Biol. 2012 Aug;179(2):152-60. doi: 10.1016/j.jsb.2012.05.002. Epub 2012 May 10. Review.

PMID:
22580344
40.

Hsp42 is required for sequestration of protein aggregates into deposition sites in Saccharomyces cerevisiae.

Specht S, Miller SB, Mogk A, Bukau B.

J Cell Biol. 2011 Nov 14;195(4):617-29. doi: 10.1083/jcb.201106037. Epub 2011 Nov 7.

41.

Molecular basis for the unique role of the AAA+ chaperone ClpV in type VI protein secretion.

Pietrosiuk A, Lenherr ED, Falk S, Bönemann G, Kopp J, Zentgraf H, Sinning I, Mogk A.

J Biol Chem. 2011 Aug 26;286(34):30010-21. doi: 10.1074/jbc.M111.253377. Epub 2011 Jul 5.

42.

Cooperative and independent activities of Sgt2 and Get5 in the targeting of tail-anchored proteins.

Kohl C, Tessarz P, von der Malsburg K, Zahn R, Bukau B, Mogk A.

Biol Chem. 2011 Jul;392(7):601-8. doi: 10.1515/BC.2011.066. Epub 2011 May 28.

PMID:
21619481
43.

Integrating protein homeostasis strategies in prokaryotes.

Mogk A, Huber D, Bukau B.

Cold Spring Harb Perspect Biol. 2011 Apr 1;3(4). pii: a004366. doi: 10.1101/cshperspect.a004366. Review.

44.

Cellular strategies for controlling protein aggregation.

Tyedmers J, Mogk A, Bukau B.

Nat Rev Mol Cell Biol. 2010 Nov;11(11):777-88. doi: 10.1038/nrm2993. Epub 2010 Oct 14. Review.

PMID:
20944667
45.

Tubules and donuts: a type VI secretion story.

Bönemann G, Pietrosiuk A, Mogk A.

Mol Microbiol. 2010 May;76(4):815-21. doi: 10.1111/j.1365-2958.2010.07171.x. Epub 2010 Apr 23. Review.

46.

Cell biology. When the beginning marks the end.

Mogk A, Bukau B.

Science. 2010 Feb 19;327(5968):966-7. doi: 10.1126/science.1187274. No abstract available.

PMID:
20167776
47.

Towards a unifying mechanism for ClpB/Hsp104-mediated protein disaggregation and prion propagation.

Haslberger T, Bukau B, Mogk A.

Biochem Cell Biol. 2010 Feb;88(1):63-75. doi: 10.1139/o09-118. Review.

PMID:
20130680
48.

Quantitative and spatio-temporal features of protein aggregation in Escherichia coli and consequences on protein quality control and cellular ageing.

Winkler J, Seybert A, König L, Pruggnaller S, Haselmann U, Sourjik V, Weiss M, Frangakis AS, Mogk A, Bukau B.

EMBO J. 2010 Mar 3;29(5):910-23. doi: 10.1038/emboj.2009.412. Epub 2010 Jan 21.

49.

The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease.

Kirstein J, Hoffmann A, Lilie H, Schmidt R, Rübsamen-Waigmann H, Brötz-Oesterhelt H, Mogk A, Turgay K.

EMBO Mol Med. 2009 Apr;1(1):37-49. doi: 10.1002/emmm.200900002.

50.

Principles of general and regulatory proteolysis by AAA+ proteases in Escherichia coli.

Schmidt R, Bukau B, Mogk A.

Res Microbiol. 2009 Nov;160(9):629-36. doi: 10.1016/j.resmic.2009.08.018. Epub 2009 Sep 22. Review.

PMID:
19781640

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