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Items: 1 to 50 of 164

1.

CAR T-cell bioengineering: Single variable domain of heavy chain antibody targeted CARs.

Rahbarizadeh F, Ahmadvand D, Moghimi SM.

Adv Drug Deliv Rev. 2019 Apr 17. pii: S0169-409X(19)30048-1. doi: 10.1016/j.addr.2019.04.006. [Epub ahead of print]

PMID:
31004624
2.

Complement therapeutics meets nanomedicine: overcoming human complement activation and leukocyte uptake of nanomedicines with soluble domains of CD55.

Gifford G, Vu VP, Banda NK, Holers VM, Wang G, Groman EV, Backos D, Scheinman R, Moghimi SM, Simberg D.

J Control Release. 2019 May 28;302:181-189. doi: 10.1016/j.jconrel.2019.04.009. Epub 2019 Apr 8.

PMID:
30974134
3.

The Interplay between Blood Proteins, Complement, and Macrophages on Nanomedicine Performance and Responses.

Moghimi SM, Simberg D, Skotland T, Yaghmur A, Hunter C.

J Pharmacol Exp Ther. 2019 Apr 2. pii: jpet.119.258012. doi: 10.1124/jpet.119.258012. [Epub ahead of print]

4.
5.

Combined Fluorimetric Caspase-3/7 Assay and Bradford Protein Determination for Assessment of Polycation-Mediated Cytotoxicity.

Larsen AK, Hall A, Lundsgart H, Moghimi SM.

Methods Mol Biol. 2019;1943:301-311. doi: 10.1007/978-1-4939-9092-4_19.

PMID:
30838624
6.

Lactate Dehydrogenase Assay for Assessment of Polycation Cytotoxicity.

Parhamifar L, Andersen H, Moghimi SM.

Methods Mol Biol. 2019;1943:291-299. doi: 10.1007/978-1-4939-9092-4_18.

PMID:
30838623
7.

Publisher Correction: Immunoglobulin deposition on biomolecule corona determines complement opsonization efficiency of preclinical and clinical nanoparticles.

Vu VP, Gifford GB, Chen F, Benasutti H, Wang G, Groman EV, Scheinman R, Saba L, Moghimi SM, Simberg D.

Nat Nanotechnol. 2019 Mar;14(3):298. doi: 10.1038/s41565-019-0379-0.

PMID:
30670872
8.

Immunoglobulin deposition on biomolecule corona determines complement opsonization efficiency of preclinical and clinical nanoparticles.

Vu VP, Gifford GB, Chen F, Benasutti H, Wang G, Groman EV, Scheinman R, Saba L, Moghimi SM, Simberg D.

Nat Nanotechnol. 2019 Mar;14(3):260-268. doi: 10.1038/s41565-018-0344-3. Epub 2019 Jan 14. Erratum in: Nat Nanotechnol. 2019 Jan 22;:.

PMID:
30643271
9.

Pharmacokinetic analysis reveals limitations and opportunities for nanomedicine targeting of endothelial and extravascular compartments of tumours.

Benchimol MJ, Bourne D, Moghimi SM, Simberg D.

J Drug Target. 2019 Jun - Jul;27(5-6):690-698. doi: 10.1080/1061186X.2019.1566339. Epub 2019 Feb 4.

PMID:
30614276
10.

Nanoparticle transport pathways into tumors.

Moghimi SM, Simberg D.

J Nanopart Res. 2018;20(6):169. doi: 10.1007/s11051-018-4273-8. Epub 2018 Jun 21.

11.

Multivalent targeting and killing of HER2 overexpressing breast carcinoma cells with methotrexate-encapsulated tetra-specific non-overlapping variable domain heavy chain anti-HER2 antibody-PEG-liposomes: In vitro proof-of-concept.

Khoshtinat Nikkhoi S, Rahbarizadeh F, Ahmadvand D, Moghimi SM.

Eur J Pharm Sci. 2018 Sep 15;122:42-50. doi: 10.1016/j.ejps.2018.06.019. Epub 2018 Jun 19.

PMID:
29933078
12.

Translational gaps in animal models of human infusion reactions to nanomedicines.

Moghimi SM, Simberg D.

Nanomedicine (Lond). 2018 May;13(9):973-975. doi: 10.2217/nnm-2018-0064. Epub 2018 May 23.

13.

Cisplatin Encapsulation Generates Morphologically Different Multicompartments in the Internal Nanostructures of Nonlamellar Liquid-Crystalline Self-Assemblies.

Azmi IDM, Østergaard J, Stürup S, Gammelgaard B, Urtti A, Moghimi SM, Yaghmur A.

Langmuir. 2018 Jun 5;34(22):6570-6581. doi: 10.1021/acs.langmuir.8b01149. Epub 2018 May 24.

PMID:
29768016
14.

C1q-Mediated Complement Activation and C3 Opsonization Trigger Recognition of Stealth Poly(2-methyl-2-oxazoline)-Coated Silica Nanoparticles by Human Phagocytes.

Tavano R, Gabrielli L, Lubian E, Fedeli C, Visentin S, Polverino De Laureto P, Arrigoni G, Geffner-Smith A, Chen F, Simberg D, Morgese G, Benetti EM, Wu L, Moghimi SM, Mancin F, Papini E.

ACS Nano. 2018 Jun 26;12(6):5834-5847. doi: 10.1021/acsnano.8b01806. Epub 2018 May 23.

PMID:
29750504
15.

Targeting Biological Barriers: Turning a Wall into a Therapeutic Springboard.

Moghimi SM, Howard KA.

Mol Ther. 2018 Apr 4;26(4):933-934. doi: 10.1016/j.ymthe.2018.03.008. Epub 2018 Mar 21. No abstract available.

16.

Complement activation turnover on surfaces of nanoparticles.

Moghimi SM, Simberg D.

Nano Today. 2017 Aug;15:8-10. doi: 10.1016/j.nantod.2017.03.001. Epub 2017 Apr 12.

17.

Nanomedicine safety in preclinical and clinical development: focus on idiosyncratic injection/infusion reactions.

Moghimi SM.

Drug Discov Today. 2018 May;23(5):1034-1042. doi: 10.1016/j.drudis.2017.11.006. Epub 2017 Nov 13. Review.

PMID:
29146517
18.

Revealing Dynamics of Accumulation of Systemically Injected Liposomes in the Skin by Intravital Microscopy.

Griffin JI, Wang G, Smith WJ, Vu VP, Scheinman R, Stitch D, Moldovan R, Moghimi SM, Simberg D.

ACS Nano. 2017 Nov 28;11(11):11584-11593. doi: 10.1021/acsnano.7b06524. Epub 2017 Oct 18.

19.

Nanoparticles and innate immunity: new perspectives on host defence.

Boraschi D, Italiani P, Palomba R, Decuzzi P, Duschl A, Fadeel B, Moghimi SM.

Semin Immunol. 2017 Dec;34:33-51. doi: 10.1016/j.smim.2017.08.013. Epub 2017 Aug 30. Review.

PMID:
28869063
20.

Interaction of extremophilic archaeal viruses with human and mouse complement system and viral biodistribution in mice.

Wu L, Uldahl KB, Chen F, Benasutti H, Logvinski D, Vu V, Banda NK, Peng X, Simberg D, Moghimi SM.

Mol Immunol. 2017 Oct;90:273-279. doi: 10.1016/j.molimm.2017.08.009. Epub 2017 Aug 30.

21.

Nanoparticle Technology: Having Impact, but Needing Further Optimization.

Moghimi SM, Wagner E.

Mol Ther. 2017 Jul 5;25(7):1461-1463. doi: 10.1016/j.ymthe.2017.06.007. Epub 2017 Jun 16. No abstract available.

22.

Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes.

Wibroe PP, Anselmo AC, Nilsson PH, Sarode A, Gupta V, Urbanics R, Szebeni J, Hunter AC, Mitragotri S, Mollnes TE, Moghimi SM.

Nat Nanotechnol. 2017 Jul;12(6):589-594. doi: 10.1038/nnano.2017.47. Epub 2017 Apr 10.

PMID:
28396605
23.

Polyplex Evolution: Understanding Biology, Optimizing Performance.

Hall A, Lächelt U, Bartek J, Wagner E, Moghimi SM.

Mol Ther. 2017 Jul 5;25(7):1476-1490. doi: 10.1016/j.ymthe.2017.01.024. Epub 2017 Mar 6. Review.

24.

In Vitro and In Vivo Differences in Murine Third Complement Component (C3) Opsonization and Macrophage/Leukocyte Responses to Antibody-Functionalized Iron Oxide Nanoworms.

Wang G, Griffin JI, Inturi S, Brenneman B, Banda NK, Holers VM, Moghimi SM, Simberg D.

Front Immunol. 2017 Feb 15;8:151. doi: 10.3389/fimmu.2017.00151. eCollection 2017.

25.

Peptide and nucleic acid-directed self-assembly of cationic nanovehicles through giant unilamellar vesicle modification: Targetable nanocomplexes for in vivo nucleic acid delivery.

Tagalakis AD, Maeshima R, Yu-Wai-Man C, Meng J, Syed F, Wu LP, Aldossary AM, McCarthy D, Moghimi SM, Hart SL.

Acta Biomater. 2017 Mar 15;51:351-362. doi: 10.1016/j.actbio.2017.01.048. Epub 2017 Jan 18.

PMID:
28110069
26.

Mechanisms and Barriers in Cancer Nanomedicine: Addressing Challenges, Looking for Solutions.

Anchordoquy TJ, Barenholz Y, Boraschi D, Chorny M, Decuzzi P, Dobrovolskaia MA, Farhangrazi ZS, Farrell D, Gabizon A, Ghandehari H, Godin B, La-Beck NM, Ljubimova J, Moghimi SM, Pagliaro L, Park JH, Peer D, Ruoslahti E, Serkova NJ, Simberg D.

ACS Nano. 2017 Jan 24;11(1):12-18. doi: 10.1021/acsnano.6b08244. Epub 2017 Jan 9.

27.

Poly-(amidoamine) dendrimers with a precisely core positioned sulforhodamine B molecule for comparative biological tracing and profiling.

Wu LP, Ficker M, Mejlsøe SL, Hall A, Paolucci V, Christensen JB, Trohopoulos PN, Moghimi SM.

J Control Release. 2017 Jan 28;246:88-97. doi: 10.1016/j.jconrel.2016.12.016. Epub 2016 Dec 30.

PMID:
28040639
28.

Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo.

Chen F, Wang G, Griffin JI, Brenneman B, Banda NK, Holers VM, Backos DS, Wu L, Moghimi SM, Simberg D.

Nat Nanotechnol. 2017 May;12(4):387-393. doi: 10.1038/nnano.2016.269. Epub 2016 Dec 19.

29.

Recognition of extremophilic archaeal viruses by eukaryotic cells: a promising nanoplatform from the third domain of life.

Uldahl KB, Wu L, Hall A, Papathanasiou P, Peng X, Moghimi SM.

Sci Rep. 2016 Nov 28;6:37966. doi: 10.1038/srep37966.

30.

AFM visualization of sub-50nm polyplex disposition to the nuclear pore complex without compromising the integrity of the nuclear envelope.

Andersen H, Parhamifar L, Hunter AC, Shahin V, Moghimi SM.

J Control Release. 2016 Dec 28;244(Pt A):24-29. doi: 10.1016/j.jconrel.2016.11.008. Epub 2016 Nov 11.

PMID:
27845193
31.

Activation of Human Complement System by Dextran-Coated Iron Oxide Nanoparticles Is Not Affected by Dextran/Fe Ratio, Hydroxyl Modifications, and Crosslinking.

Wang G, Chen F, Banda NK, Holers VM, Wu L, Moghimi SM, Simberg D.

Front Immunol. 2016 Oct 10;7:418. eCollection 2016.

32.

ImmunoPEGliposome-mediated reduction of blood and brain amyloid levels in a mouse model of Alzheimer's disease is restricted to aged animals.

Ordóñez-Gutiérrez L, Posado-Fernández A, Ahmadvand D, Lettiero B, Wu L, Antón M, Flores O, Moghimi SM, Wandosell F.

Biomaterials. 2017 Jan;112:141-152. doi: 10.1016/j.biomaterials.2016.07.027. Epub 2016 Aug 2.

PMID:
27760398
33.

A structurally diverse library of safe-by-design citrem-phospholipid lamellar and non-lamellar liquid crystalline nano-assemblies.

Azmi ID, Wibroe PP, Wu LP, Kazem AI, Amenitsch H, Moghimi SM, Yaghmur A.

J Control Release. 2016 Oct 10;239:1-9. doi: 10.1016/j.jconrel.2016.08.011. Epub 2016 Aug 12.

PMID:
27524284
34.

Complement Propriety and Conspiracy in Nanomedicine: Perspective and a Hypothesis.

Moghimi SM.

Nucleic Acid Ther. 2016 Apr;26(2):67-72. doi: 10.1089/nat.2015.0587. Epub 2015 Dec 31.

PMID:
26720796
35.

Nanoparticle patterning for biomedicine.

Moghimi SM.

Bioimpacts. 2016;6(4):183-185. doi: 10.15171/bi.2016.24. Epub 2016 Dec 28.

36.

Tumour exosomes display differential mechanical and complement activation properties dependent on malignant state: implications in endothelial leakiness.

Whitehead B, Wu L, Hvam ML, Aslan H, Dong M, Dyrskjøt L, Ostenfeld MS, Moghimi SM, Howard KA.

J Extracell Vesicles. 2015 Dec 28;4:29685. doi: 10.3402/jev.v4.29685. eCollection 2015.

37.

Cubosomes and hexosomes as versatile platforms for drug delivery.

Azmi ID, Moghimi SM, Yaghmur A.

Ther Deliv. 2015;6(12):1347-64. doi: 10.4155/tde.15.81. Review.

PMID:
26652281
38.

Soluble and immobilized graphene oxide activates complement system differently dependent on surface oxidation state.

Wibroe PP, Petersen SV, Bovet N, Laursen BW, Moghimi SM.

Biomaterials. 2016 Feb;78:20-6. doi: 10.1016/j.biomaterials.2015.11.028. Epub 2015 Nov 19.

PMID:
26646624
39.

An integrated assessment of morphology, size, and complement activation of the PEGylated liposomal doxorubicin products Doxil®, Caelyx®, DOXOrubicin, and SinaDoxosome.

Wibroe PP, Ahmadvand D, Oghabian MA, Yaghmur A, Moghimi SM.

J Control Release. 2016 Jan 10;221:1-8. doi: 10.1016/j.jconrel.2015.11.021. Epub 2015 Nov 26.

PMID:
26608877
40.

Modulatory Role of Surface Coating of Superparamagnetic Iron Oxide Nanoworms in Complement Opsonization and Leukocyte Uptake.

Inturi S, Wang G, Chen F, Banda NK, Holers VM, Wu L, Moghimi SM, Simberg D.

ACS Nano. 2015 Nov 24;9(11):10758-68. doi: 10.1021/acsnano.5b05061. Epub 2015 Oct 21.

41.

Platelet mimicry: The emperor's new clothes?

Moghimi SM, Hunter AC, Peer D.

Nanomedicine. 2016 Jan;12(1):245-8. doi: 10.1016/j.nano.2015.09.005. Epub 2015 Sep 25.

PMID:
26409192
42.

Citrem modulates internal nanostructure of glyceryl monooleate dispersions and bypasses complement activation: Towards development of safe tunable intravenous lipid nanocarriers.

Wibroe PP, Mat Azmi ID, Nilsson C, Yaghmur A, Moghimi SM.

Nanomedicine. 2015 Nov;11(8):1909-14. doi: 10.1016/j.nano.2015.08.003. Epub 2015 Sep 5.

PMID:
26348655
43.

Differential Modulation of Cellular Bioenergetics by Poly(L-lysine)s of Different Molecular Weights.

Hall A, Wu LP, Parhamifar L, Moghimi SM.

Biomacromolecules. 2015 Jul 13;16(7):2119-26. doi: 10.1021/acs.biomac.5b00533. Epub 2015 Jun 22.

PMID:
26053306
44.

Modulatory effect of human plasma on the internal nanostructure and size characteristics of liquid-crystalline nanocarriers.

Azmi ID, Wu L, Wibroe PP, Nilsson C, Østergaard J, Stürup S, Gammelgaard B, Urtti A, Moghimi SM, Yaghmur A.

Langmuir. 2015 May 12;31(18):5042-9. doi: 10.1021/acs.langmuir.5b00830. Epub 2015 Apr 30.

PMID:
25884233
45.

Dendrimers in Medicine: Therapeutic Concepts and Pharmaceutical Challenges.

Wu LP, Ficker M, Christensen JB, Trohopoulos PN, Moghimi SM.

Bioconjug Chem. 2015 Jul 15;26(7):1198-211. doi: 10.1021/acs.bioconjchem.5b00031. Epub 2015 Feb 13. Review.

PMID:
25654320
46.

New platforms for multi-functional ocular lenses: engineering double-sided functionalized nano-coatings.

Mehta P, Justo L, Walsh S, Arshad MS, Wilson CG, O'Sullivan CK, Moghimi SM, Vizirianakis IS, Avgoustakis K, Fatouros DG, Ahmad Z.

J Drug Target. 2015 May;23(4):305-10. doi: 10.3109/1061186X.2014.1001395. Epub 2015 Jan 13.

PMID:
25582133
47.

Polyethylenimine architecture-dependent metabolic imprints and perturbation of cellular redox homeostasis.

Hall A, Parhamifar L, Lange MK, Meyle KD, Sanderhoff M, Andersen H, Roursgaard M, Larsen AK, Jensen PB, Christensen C, Bartek J, Moghimi SM.

Biochim Biophys Acta. 2015 Mar;1847(3):328-342. doi: 10.1016/j.bbabio.2014.12.002. Epub 2014 Dec 5.

48.

Repeated intraperitoneal injections of liposomes containing phosphatidic acid and cardiolipin reduce amyloid-β levels in APP/PS1 transgenic mice.

Ordóñez-Gutiérrez L, Re F, Bereczki E, Ioja E, Gregori M, Andersen AJ, Antón M, Moghimi SM, Pei JJ, Masserini M, Wandosell F.

Nanomedicine. 2015 Feb;11(2):421-30. doi: 10.1016/j.nano.2014.09.015. Epub 2014 Nov 14.

49.

Mechanisms of complement activation by dextran-coated superparamagnetic iron oxide (SPIO) nanoworms in mouse versus human serum.

Banda NK, Mehta G, Chao Y, Wang G, Inturi S, Fossati-Jimack L, Botto M, Wu L, Moghimi SM, Simberg D.

Part Fibre Toxicol. 2014 Nov 26;11:64. doi: 10.1186/s12989-014-0064-2.

50.

Polycation-mediated integrated cell death processes.

Parhamifar L, Andersen H, Wu L, Hall A, Hudzech D, Moghimi SM.

Adv Genet. 2014;88:353-98. doi: 10.1016/B978-0-12-800148-6.00012-2. Review.

PMID:
25409612

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