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Items: 29

1.

Biophysical, bioinformatical, cellular, and molecular investigations on the effects of graphene oxide nanosheets on the hemoglobin structure and lymphocyte cell cytotoxicity.

Babadaei MMN, Moghaddam MF, Solhvand S, Alizadehmollayaghoob E, Attar F, Rajabbeigi E, Akhtari K, Sari S, Falahati M.

Int J Nanomedicine. 2018 Oct 26;13:6871-6884. doi: 10.2147/IJN.S174048. eCollection 2018.

2.

The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen.

Riggs JR, Nagy M, Elsner J, Erdman P, Cashion D, Robinson D, Harris R, Huang D, Tehrani L, Deyanat-Yazdi G, Narla RK, Peng X, Tran T, Barnes L, Miller T, Katz J, Tang Y, Chen M, Moghaddam MF, Bahmanyar S, Pagarigan B, Delker S, LeBrun L, Chamberlain PP, Calabrese A, Canan SS, Leftheris K, Zhu D, Boylan JF.

J Med Chem. 2017 Nov 9;60(21):8989-9002. doi: 10.1021/acs.jmedchem.7b01223. Epub 2017 Oct 27.

PMID:
28991472
3.

Effectiveness of methylphenidate and PUFA for the treatment of patients with ADHD: A double-blinded randomized clinical trial.

Moghaddam MF, Shamekhi M, Rakhshani T.

Electron Physician. 2017 May 25;9(5):4412-4418. doi: 10.19082/4412. eCollection 2017 May.

4.

A Systematic Analysis of Physicochemical and ADME Properties of All Small Molecule Kinase Inhibitors Approved by US FDA from January 2001 to October 2015.

O Brien Z, Moghaddam MF.

Curr Med Chem. 2017;24(29):3159-3184. doi: 10.2174/0929867324666170523124441. Review.

5.

Implementation of a novel ultra fast metabolic stability analysis method using exact mass TOF-MS.

Manna JD, Richardson SJ, Moghaddam MF.

Bioanalysis. 2017 Feb;9(4):359-368. doi: 10.4155/bio-2016-0187. Epub 2017 Jan 11.

6.

Formation of A Novel Purine Metabolite through CYP3A4 Bioactivation and Glutathione Conjugation.

Apuy JL, Xiang C, Franc S, Hegde SG, Hubbard R, Zhao J, Moghaddam MF.

Drug Metab Lett. 2016;10(2):144-50.

7.

Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability.

Richardson SJ, Bai A, Kulkarni AA, Moghaddam MF.

Drug Metab Lett. 2016;10(2):83-90.

8.

Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115.

Mortensen DS, Perrin-Ninkovic SM, Shevlin G, Elsner J, Zhao J, Whitefield B, Tehrani L, Sapienza J, Riggs JR, Parnes JS, Papa P, Packard G, Lee BG, Harris R, Correa M, Bahmanyar S, Richardson SJ, Peng SX, Leisten J, Khambatta G, Hickman M, Gamez JC, Bisonette RR, Apuy J, Cathers BE, Canan SS, Moghaddam MF, Raymon HK, Worland P, Narla RK, Fultz KE, Sankar S.

J Med Chem. 2015 Jul 23;58(14):5599-608. doi: 10.1021/acs.jmedchem.5b00627. Epub 2015 Jul 8.

PMID:
26102506
9.

Discovery of mammalian target of rapamycin (mTOR) kinase inhibitor CC-223.

Mortensen DS, Perrin-Ninkovic SM, Shevlin G, Zhao J, Packard G, Bahmanyar S, Correa M, Elsner J, Harris R, Lee BG, Papa P, Parnes JS, Riggs JR, Sapienza J, Tehrani L, Whitefield B, Apuy J, Bisonette RR, Gamez JC, Hickman M, Khambatta G, Leisten J, Peng SX, Richardson SJ, Cathers BE, Canan SS, Moghaddam MF, Raymon HK, Worland P, Narla RK, Fultz KE, Sankar S.

J Med Chem. 2015 Jul 9;58(13):5323-33. doi: 10.1021/acs.jmedchem.5b00626. Epub 2015 Jun 26.

PMID:
26083478
10.

CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization.

Mortensen DS, Fultz KE, Xu S, Xu W, Packard G, Khambatta G, Gamez JC, Leisten J, Zhao J, Apuy J, Ghoreishi K, Hickman M, Narla RK, Bissonette R, Richardson S, Peng SX, Perrin-Ninkovic S, Tran T, Shi T, Yang WQ, Tong Z, Cathers BE, Moghaddam MF, Canan SS, Worland P, Sankar S, Raymon HK.

Mol Cancer Ther. 2015 Jun;14(6):1295-305. doi: 10.1158/1535-7163.MCT-14-1052. Epub 2015 Apr 8.

11.

A proposed screening paradigm for discovery of covalent inhibitor drugs.

Moghaddam MF, Tang Y, O'Brien Z, Richardson SJ, Bacolod M, Chaturedi P, Apuy J, Kulkarni A.

Drug Metab Lett. 2014;8(1):19-30.

PMID:
24628405
12.

Proposing advancement criteria for efficient DMPK triage of new chemical entities.

Kulkarni A, Riggs J, Phan C, Bai A, Calabrese A, Shi T, Moghaddam MF.

Future Med Chem. 2014 Feb;6(2):131-9. doi: 10.4155/fmc.13.190.

PMID:
24467240
13.

Pomalidomide shows significant therapeutic activity against CNS lymphoma with a major impact on the tumor microenvironment in murine models.

Li Z, Qiu Y, Personett D, Huang P, Edenfield B, Katz J, Babusis D, Tang Y, Shirely MA, Moghaddam MF, Copland JA, Tun HW.

PLoS One. 2013 Aug 5;8(8):e71754. doi: 10.1371/journal.pone.0071754. Print 2013.

14.
15.

Isosteric analogs of lenalidomide and pomalidomide: synthesis and biological activity.

Ruchelman AL, Man HW, Zhang W, Chen R, Capone L, Kang J, Parton A, Corral L, Schafer PH, Babusis D, Moghaddam MF, Tang Y, Shirley MA, Muller GW.

Bioorg Med Chem Lett. 2013 Jan 1;23(1):360-5. doi: 10.1016/j.bmcl.2012.10.071. Epub 2012 Oct 27.

PMID:
23168019
16.

Metabolite interference in pharmacokinetic studies.

Moghaddam MF, Fan JH, Tang Y, Khatsenko O, Katz JC, Shirley MA.

Drug Metab Lett. 2007 Dec;1(4):272-5.

PMID:
19356054
17.

Comparison of glutathione S-transferase-Pi expression at mRNA levels in oesophageal mucosa using RT-PCR-ELISA in individuals with reflux diseases, adenocarcinoma and squamous cell carcinoma.

Rasmi Y, Allameh A, Nasseri-Moghaddam S, Gill P, Moghaddam MF, Hedayati M.

Clin Biochem. 2006 Oct;39(10):997-1001. Epub 2006 Jul 21.

PMID:
16979613
18.

Plasma pharmacokinetics and tissue distribution of a N-pyrrolo-[1,2-c]imidazolylphenyl sulfonamide in rats.

Moghaddam MF, Bogdanffy MS, Brown A, Ford K, Shalaby L.

Drug Metab Dispos. 2002 Jan;30(1):47-54.

PMID:
11744611
19.

Biotransformation, excretion kinetics, and tissue distribution of an N-pyrrolo[1,2-c]imidazolylphenyl sulfonamide herbicide in rats.

Moghaddam MF, Brown A, Budevska BO, Lam Z, Payne WG.

Drug Metab Dispos. 2001 Aug;29(8):1162-70.

PMID:
11454736
20.

An LC/MS/MS method for improved quantitation of the bound residues in the tissues of animals orally dosed with [(14)C]Benomyl.

Moghaddam MF, Trubey RK, Anderson JJ.

J Agric Food Chem. 2000 Nov;48(11):5195-9.

PMID:
11087458
21.

Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase.

Moghaddam MF, Grant DF, Cheek JM, Greene JF, Williamson KC, Hammock BD.

Nat Med. 1997 May;3(5):562-6.

PMID:
9142128
22.

Development of an in situ toxicity assay system using recombinant baculoviruses.

Grant DF, Greene JF, Pinot F, Borhan B, Moghaddam MF, Hammock BD, McCutchen B, Ohkawa H, Luo G, Guenthner TM.

Biochem Pharmacol. 1996 Feb 23;51(4):503-15.

PMID:
8619897
23.

Properties of enzymes hydrating epoxides in human epidermis and liver.

Winder BS, Nourooz-Zadeh J, Isseroff RR, Moghaddam MF, Hammock BD.

Int J Biochem. 1993 Sep;25(9):1291-301.

PMID:
8224376
24.

Unique metabolites of eicosapentaenoic acid interfere with corpus luteum function in the ewe.

Orwig KE, Leers-Sucheta S, Moghaddam MF, Jiang ZD, Gerwick WR, Stormshak F.

Prostaglandins. 1992 Dec;44(6):519-30.

PMID:
1335585
26.
28.

Effects of dietary pyrrolizidine (Senecio) alkaloids on vitamin A metabolism in rats.

Moghaddam MF, Cheeke PR.

Toxicol Lett. 1989 Feb;45(2-3):149-56.

PMID:
2919395
29.

Discovery of 12-(S)-hydroxy-5,8,10,14-icosatetraenoic acid [12-(S)-HETE] in the tropical red alga Platysiphonia miniata.

Moghaddam MF, Gerwick WH, Ballantine DL.

Prostaglandins. 1989 Feb;37(2):303-8.

PMID:
2727309

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