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Items: 1 to 50 of 71

1.

Constitutive androstane receptor 1 is constitutively bound to chromatin and 'primed' for transactivation in hepatocytes.

McMahon M, Ding S, Jimenez LA, Terranova R, Gerard MA, Vitobello A, Moggs J, Henderson CJ, Wolf CR.

Mol Pharmacol. 2019 Jan;95(1):97-105. doi: 10.1124/mol.118.113555. Epub 2018 Oct 25.

2.

Chromatin dynamics underlying latent responses to xenobiotics.

Moggs J, Terranova R.

Toxicol Res (Camb). 2018 Feb 28;7(4):606-617. doi: 10.1039/c7tx00317j. eCollection 2018 Jul 1. Review.

PMID:
30090610
3.

Defining baseline epigenetic landscapes in the rat liver.

Thomson JP, Ottaviano R, Buesen R, Moggs JG, Schwarz M, Meehan RR.

Epigenomics. 2017 Dec;9(12):1503-1527. doi: 10.2217/epi-2017-0029. Epub 2017 Nov 13.

4.

Human relevance of rodent liver tumors: Key insights from a Toxicology Forum workshop on nongenotoxic modes of action.

Felter SP, Foreman JE, Boobis A, Corton JC, Doi AM, Flowers L, Goodman J, Haber LT, Jacobs A, Klaunig JE, Lynch AM, Moggs J, Pandiri A.

Regul Toxicol Pharmacol. 2018 Feb;92:1-7. doi: 10.1016/j.yrtph.2017.11.003. Epub 2017 Nov 4. Review.

5.

Derisking Drug-Induced Carcinogenicity for Novel Therapeutics.

Moggs JG, MacLachlan T, Martus HJ, Bentley P.

Trends Cancer. 2016 Aug;2(8):398-408. doi: 10.1016/j.trecan.2016.07.003. Epub 2016 Jul 30. Review.

PMID:
28741493
6.

Xenobiotic CAR Activators Induce Dlk1-Dio3 Locus Noncoding RNA Expression in Mouse Liver.

Pouché L, Vitobello A, Römer M, Glogovac M, MacLeod AK, Ellinger-Ziegelbauer H, Westphal M, Dubost V, Stiehl DP, Dumotier B, Fekete A, Moulin P, Zell A, Schwarz M, Moreno R, Huang JTJ, Elcombe CR, Henderson CJ, Roland Wolf C, Moggs JG, Terranova R.

Toxicol Sci. 2017 Aug 1;158(2):367-378. doi: 10.1093/toxsci/kfx104.

PMID:
28541575
7.

Translational Safety Genetics.

Bhoumik P, Del Rio-Espinola A, Hahne F, Moggs J, Grenet O.

Toxicol Pathol. 2017 Jan;45(1):119-126. doi: 10.1177/0192623316675064. Epub 2016 Dec 8. Review.

PMID:
27932582
8.

A Synopsis of the "Influence of Epigenetics, Genetics, and Immunology" Session Part A at the 35th Annual Society of Toxicologic Pathology Symposium.

Harrill AH, Moggs JG, Adkins KK, Augustin HG, Johnson RC, Leach MW.

Toxicol Pathol. 2017 Jan;45(1):114-118. doi: 10.1177/0192623316670781. Epub 2016 Oct 5. Review.

PMID:
27708198
9.

Loss of Tet1-Associated 5-Hydroxymethylcytosine Is Concomitant with Aberrant Promoter Hypermethylation in Liver Cancer.

Thomson JP, Ottaviano R, Unterberger EB, Lempiäinen H, Muller A, Terranova R, Illingworth RS, Webb S, Kerr AR, Lyall MJ, Drake AJ, Wolf CR, Moggs JG, Schwarz M, Meehan RR.

Cancer Res. 2016 May 15;76(10):3097-108. doi: 10.1158/0008-5472.CAN-15-1910. Epub 2016 Apr 6.

10.

Reciprocal changes in DNA methylation and hydroxymethylation and a broad repressive epigenetic switch characterize FMR1 transcriptional silencing in fragile X syndrome.

Brasa S, Mueller A, Jacquemont S, Hahne F, Rozenberg I, Peters T, He Y, McCormack C, Gasparini F, Chibout SD, Grenet O, Moggs J, Gomez-Mancilla B, Terranova R.

Clin Epigenetics. 2016 Feb 5;8:15. doi: 10.1186/s13148-016-0181-x. eCollection 2016.

11.

Evaluation of 5-methylcytosine and 5-hydroxymethylcytosine as potential biomarkers for characterisation of chemical allergens.

Chapman VL, Terranova R, Moggs JG, Kimber I, Dearman RJ.

Toxicology. 2016 Jan 18;340:17-26. doi: 10.1016/j.tox.2015.12.003. Epub 2015 Dec 28.

PMID:
26732893
12.

Importance of investigating epigenetic alterations for industry and regulators: An appraisal of current efforts by the Health and Environmental Sciences Institute.

Miousse IR, Currie R, Datta K, Ellinger-Ziegelbauer H, French JE, Harrill AH, Koturbash I, Lawton M, Mann D, Meehan RR, Moggs JG, O'Lone R, Rasoulpour RJ, Pera RA, Thompson K.

Toxicology. 2015 Sep 1;335:11-9. doi: 10.1016/j.tox.2015.06.009. Epub 2015 Jun 29.

13.

Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors.

Luisier R, Lempiäinen H, Scherbichler N, Braeuning A, Geissler M, Dubost V, Müller A, Scheer N, Chibout SD, Hara H, Picard F, Theil D, Couttet P, Vitobello A, Grenet O, Grasl-Kraupp B, Ellinger-Ziegelbauer H, Thomson JP, Meehan RR, Elcombe CR, Henderson CJ, Wolf CR, Schwarz M, Moulin P, Terranova R, Moggs JG.

Toxicol Sci. 2014 Jun;139(2):501-11. doi: 10.1093/toxsci/kfu038. Epub 2014 Apr 1.

PMID:
24690595
14.

Chemical allergen induced perturbations of the mouse lymph node DNA methylome.

Chapman VL, Zollinger T, Terranova R, Moggs J, Kimber I, Dearman RJ.

Toxicol Sci. 2014 Jun;139(2):350-61. doi: 10.1093/toxsci/kfu047. Epub 2014 Mar 27.

PMID:
24675093
15.

Retro-orbital blood acquisition facilitates circulating microRNA measurement in zebrafish with paracetamol hepatotoxicity.

Vliegenthart AD, Starkey Lewis P, Tucker CS, Del Pozo J, Rider S, Antoine DJ, Dubost V, Westphal M, Moulin P, Bailey MA, Moggs JG, Goldring CE, Park BK, Dear JW.

Zebrafish. 2014 Jun;11(3):219-26. doi: 10.1089/zeb.2013.0912. Epub 2014 Mar 13.

16.

Ha-ras and β-catenin oncoproteins orchestrate metabolic programs in mouse liver tumors.

Unterberger EB, Eichner J, Wrzodek C, Lempiäinen H, Luisier R, Terranova R, Metzger U, Plummer S, Knorpp T, Braeuning A, Moggs J, Templin MF, Honndorf V, Piotto M, Zell A, Schwarz M.

Int J Cancer. 2014 Oct 1;135(7):1574-85. doi: 10.1002/ijc.28798. Epub 2014 Mar 3.

17.

Computational modeling identifies key gene regulatory interactions underlying phenobarbital-mediated tumor promotion.

Luisier R, Unterberger EB, Goodman JI, Schwarz M, Moggs J, Terranova R, van Nimwegen E.

Nucleic Acids Res. 2014 Apr;42(7):4180-95. doi: 10.1093/nar/gkt1415. Epub 2014 Jan 23.

18.

Comparative analysis of affinity-based 5-hydroxymethylation enrichment techniques.

Thomson JP, Hunter JM, Nestor CE, Dunican DS, Terranova R, Moggs JG, Meehan RR.

Nucleic Acids Res. 2013 Dec;41(22):e206. doi: 10.1093/nar/gkt1080. Epub 2013 Nov 7. Erratum in: Nucleic Acids Res. . 2014 Apr;42(6):4142.

19.

Epigenetic profiles as defined signatures of xenobiotic exposure.

Thomson JP, Moggs JG, Wolf CR, Meehan RR.

Mutat Res Genet Toxicol Environ Mutagen. 2014 Apr;764-765:3-9. doi: 10.1016/j.mrgentox.2013.08.007. Epub 2013 Aug 31. Review.

PMID:
24001620
20.

Current challenges and opportunities in nonclinical safety testing of biologics.

Kronenberg S, Baumann A, de Haan L, Hinton HJ, Moggs J, Theil FP, Wakefield I, Singer T.

Drug Discov Today. 2013 Dec;18(23-24):1138-43. doi: 10.1016/j.drudis.2013.08.003. Epub 2013 Aug 11.

PMID:
23942260
21.

Dynamic changes in 5-hydroxymethylation signatures underpin early and late events in drug exposed liver.

Thomson JP, Hunter JM, Lempiäinen H, Müller A, Terranova R, Moggs JG, Meehan RR.

Nucleic Acids Res. 2013 Jun;41(11):5639-54. doi: 10.1093/nar/gkt232. Epub 2013 Apr 17.

22.

Challenges and approaches for the development of safer immunomodulatory biologics.

Sathish JG, Sethu S, Bielsky MC, de Haan L, French NS, Govindappa K, Green J, Griffiths CE, Holgate S, Jones D, Kimber I, Moggs J, Naisbitt DJ, Pirmohamed M, Reichmann G, Sims J, Subramanyam M, Todd MD, Van Der Laan JW, Weaver RJ, Park BK.

Nat Rev Drug Discov. 2013 Apr;12(4):306-24. doi: 10.1038/nrd3974. Review.

PMID:
23535934
23.

Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital.

Antoine DJ, Dear JW, Lewis PS, Platt V, Coyle J, Masson M, Thanacoody RH, Gray AJ, Webb DJ, Moggs JG, Bateman DN, Goldring CE, Park BK.

Hepatology. 2013 Aug;58(2):777-87. doi: 10.1002/hep.26294. Epub 2013 Jul 2.

24.

Heart structure-specific transcriptomic atlas reveals conserved microRNA-mRNA interactions.

Vacchi-Suzzi C, Hahne F, Scheubel P, Marcellin M, Dubost V, Westphal M, Boeglen C, Büchmann-Møller S, Cheung MS, Cordier A, De Benedetto C, Deurinck M, Frei M, Moulin P, Oakeley E, Grenet O, Grevot A, Stull R, Theil D, Moggs JG, Marrer E, Couttet P.

PLoS One. 2013;8(1):e52442. doi: 10.1371/journal.pone.0052442. Epub 2013 Jan 2.

25.

Identification of Dlk1-Dio3 imprinted gene cluster noncoding RNAs as novel candidate biomarkers for liver tumor promotion.

Lempiäinen H, Couttet P, Bolognani F, Müller A, Dubost V, Luisier R, Del Rio Espinola A, Vitry V, Unterberger EB, Thomson JP, Treindl F, Metzger U, Wrzodek C, Hahne F, Zollinger T, Brasa S, Kalteis M, Marcellin M, Giudicelli F, Braeuning A, Morawiec L, Zamurovic N, Längle U, Scheer N, Schübeler D, Goodman J, Chibout SD, Marlowe J, Theil D, Heard DJ, Grenet O, Zell A, Templin MF, Meehan RR, Wolf RC, Elcombe CR, Schwarz M, Moulin P, Terranova R, Moggs JG.

Toxicol Sci. 2013 Feb;131(2):375-86. doi: 10.1093/toxsci/kfs303. Epub 2012 Oct 22.

PMID:
23091169
26.

Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome.

Thomson JP, Lempiäinen H, Hackett JA, Nestor CE, Müller A, Bolognani F, Oakeley EJ, Schübeler D, Terranova R, Reinhardt D, Moggs JG, Meehan RR.

Genome Biol. 2012 Oct 3;13(10):R93. doi: 10.1186/gb-2012-13-10-r93.

27.

Perturbation of microRNAs in rat heart during chronic doxorubicin treatment.

Vacchi-Suzzi C, Bauer Y, Berridge BR, Bongiovanni S, Gerrish K, Hamadeh HK, Letzkus M, Lyon J, Moggs J, Paules RS, Pognan F, Staedtler F, Vidgeon-Hart MP, Grenet O, Couttet P.

PLoS One. 2012;7(7):e40395. doi: 10.1371/journal.pone.0040395. Epub 2012 Jul 31.

28.

Serum microRNA biomarkers for drug-induced liver injury.

Starkey Lewis PJ, Merz M, Couttet P, Grenet O, Dear J, Antoine DJ, Goldring C, Park BK, Moggs JG.

Clin Pharmacol Ther. 2012 Sep;92(3):291-3. doi: 10.1038/clpt.2012.101. Epub 2012 Jul 25. Review.

PMID:
22828715
29.

Investigative safety science as a competitive advantage for Pharma.

Moggs J, Moulin P, Pognan F, Brees D, Leonard M, Busch S, Cordier A, Heard DJ, Kammüller M, Merz M, Bouchard P, Chibout SD.

Expert Opin Drug Metab Toxicol. 2012 Sep;8(9):1071-82. doi: 10.1517/17425255.2012.693914. Epub 2012 Jul 7. Review.

PMID:
22769724
30.

Regulation of allergic responses to chemicals and drugs: possible roles of epigenetic mechanisms.

Moggs JG, Terranova R, Kammüller ME, Chibout SD, Chapman V, Dearman RJ, Kimber I.

Toxicol Sci. 2012 Nov;130(1):60-9. doi: 10.1093/toxsci/kfs207. Epub 2012 Jun 15. Review.

PMID:
22705809
31.

Circulating microRNAs as potential markers of human drug-induced liver injury.

Starkey Lewis PJ, Dear J, Platt V, Simpson KJ, Craig DG, Antoine DJ, French NS, Dhaun N, Webb DJ, Costello EM, Neoptolemos JP, Moggs J, Goldring CE, Park BK.

Hepatology. 2011 Nov;54(5):1767-76. doi: 10.1002/hep.24538.

PMID:
22045675
32.

Phenobarbital mediates an epigenetic switch at the constitutive androstane receptor (CAR) target gene Cyp2b10 in the liver of B6C3F1 mice.

Lempiäinen H, Müller A, Brasa S, Teo SS, Roloff TC, Morawiec L, Zamurovic N, Vicart A, Funhoff E, Couttet P, Schübeler D, Grenet O, Marlowe J, Moggs J, Terranova R.

PLoS One. 2011 Mar 24;6(3):e18216. doi: 10.1371/journal.pone.0018216.

33.

Mapping the epigenome--impact for toxicology.

Marlowe J, Teo SS, Chibout SD, Pognan F, Moggs J.

EXS. 2009;99:259-88. Review.

PMID:
19157065
34.

Linking molecular and population stress responses in Daphnia magna exposed to cadmium.

Connon R, Hooper HL, Sibly RM, Lim FL, Heckmann LH, Moore DJ, Watanabe H, Soetaert A, Cook K, Maund SJ, Hutchinson TH, Moggs J, De Coen W, Iguchi T, Callaghan A.

Environ Sci Technol. 2008 Mar 15;42(6):2181-8.

PMID:
18409656
35.

Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor.

Peffer RC, Moggs JG, Pastoor T, Currie RA, Wright J, Milburn G, Waechter F, Rusyn I.

Toxicol Sci. 2007 Sep;99(1):315-25. Epub 2007 Jun 8.

PMID:
17557908
36.

Emerging evidence for the interrelationship of xenobiotic exposure and circadian rhythms: a review.

Lim FL, Currie RA, Orphanides G, Moggs JG.

Xenobiotica. 2006 Oct-Nov;36(10-11):1140-51. Review.

PMID:
17118921
37.

Identification of early molecular pathways affected by paraquat in rat lung.

Mainwaring G, Lim FL, Antrobus K, Swain C, Clapp M, Kimber I, Orphanides G, Moggs JG.

Toxicology. 2006 Aug 15;225(2-3):157-72. Epub 2006 Jun 6.

PMID:
16854511
38.

Induction of iron homeostasis genes during estrogen-induced uterine growth and differentiation.

Stuckey R, Aldridge T, Lim FL, Moore DJ, Tinwell H, Doherty N, Davies R, Smith AG, Kimber I, Ashby J, Orphanides G, Moggs JG.

Mol Cell Endocrinol. 2006 Jul 11;253(1-2):22-9. Epub 2006 May 8.

PMID:
16684588
39.

Proteomic analysis of suction blister fluid isolated from human skin.

Macdonald N, Cumberbatch M, Singh M, Moggs JG, Orphanides G, Dearman RJ, Griffiths CE, Kimber I.

Clin Exp Dermatol. 2006 May;31(3):445-8.

PMID:
16681597
40.

Analysis of DNA repair and chromatin assembly in vitro using immobilized damaged DNA substrates.

Mello JA, Moggs JG, Almouzni G.

Methods Mol Biol. 2006;314:477-87.

PMID:
16673900
41.

Assaying for the dual incisions of nucleotide excision repair using DNA with a lesion at a specific site.

Shivji MK, Moggs JG, Kuraoka I, Wood RD.

Methods Mol Biol. 2006;314:435-56.

PMID:
16673898
42.

Gene regulation by IL-1beta independent of IL-1R1 in the mouse brain.

Andre R, Moggs JG, Kimber I, Rothwell NJ, Pinteaux E.

Glia. 2006 Apr 1;53(5):477-83.

PMID:
16358337
43.

Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3.

Macdonald N, Welburn JP, Noble ME, Nguyen A, Yaffe MB, Clynes D, Moggs JG, Orphanides G, Thomson S, Edmunds JW, Clayton AL, Endicott JA, Mahadevan LC.

Mol Cell. 2005 Oct 28;20(2):199-211.

44.
45.

Mapping molecular responses to xenoestrogens through Gene Ontology and pathway analysis of toxicogenomic data.

Currie RA, Orphanides G, Moggs JG.

Reprod Toxicol. 2005 Sep-Oct;20(3):433-40.

PMID:
15964738
46.

Gene ontology mapping as an unbiased method for identifying molecular pathways and processes affected by toxicant exposure: application to acute effects caused by the rodent non-genotoxic carcinogen diethylhexylphthalate.

Currie RA, Bombail V, Oliver JD, Moore DJ, Lim FL, Gwilliam V, Kimber I, Chipman K, Moggs JG, Orphanides G.

Toxicol Sci. 2005 Aug;86(2):453-69. Epub 2005 May 18.

PMID:
15901911
47.

Anti-proliferative effect of estrogen in breast cancer cells that re-express ERalpha is mediated by aberrant regulation of cell cycle genes.

Moggs JG, Murphy TC, Lim FL, Moore DJ, Stuckey R, Antrobus K, Kimber I, Orphanides G.

J Mol Endocrinol. 2005 Apr;34(2):535-51.

PMID:
15821115
48.

Phenotypic anchoring of gene expression changes during estrogen-induced uterine growth.

Moggs JG, Tinwell H, Spurway T, Chang HS, Pate I, Lim FL, Moore DJ, Soames A, Stuckey R, Currie R, Zhu T, Kimber I, Ashby J, Orphanides G.

Environ Health Perspect. 2004 Nov;112(16):1589-606.

49.

The need to decide if all estrogens are intrinsically similar.

Moggs JG, Ashby J, Tinwell H, Lim FL, Moore DJ, Kimber I, Orphanides G.

Environ Health Perspect. 2004 Aug;112(11):1137-42.

50.

Analysis of DNA repair and chromatin assembly in vitro using immobilized damaged DNA substrates.

Mello JA, Moggs JG, Almouzni G.

Methods Mol Biol. 2004;281:271-81.

PMID:
15220536

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