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Items: 1 to 50 of 74

1.

Brief isoflurane administration as a post-exposure treatment for organophosphate poisoning.

Krishnan JKS, Figueiredo TH, Moffett JR, Arun P, Appu AP, Puthillathu N, Braga MF, Flagg T, Namboodiri AM.

Neurotoxicology. 2017 Dec;63:84-89. doi: 10.1016/j.neuro.2017.09.009. Epub 2017 Sep 20.

PMID:
28939237
2.

Increasing N-acetylaspartate in the Brain during Postnatal Myelination Does Not Cause the CNS Pathologies of Canavan Disease.

Appu AP, Moffett JR, Arun P, Moran S, Nambiar V, Krishnan JKS, Puthillathu N, Namboodiri AMA.

Front Mol Neurosci. 2017 Jun 2;10:161. doi: 10.3389/fnmol.2017.00161. eCollection 2017.

3.

Effect of administration method, animal weight and age on the intranasal delivery of drugs to the brain.

Krishnan JKS, Arun P, Chembukave B, Appu AP, Vijayakumar N, Moffett JR, Puthillathu N, Namboodiri AMA.

J Neurosci Methods. 2017 Jul 15;286:16-21. doi: 10.1016/j.jneumeth.2017.05.012. Epub 2017 May 10.

4.

A role for the locus coeruleus in the analgesic efficacy of N-acetylaspartylglutamate peptidase (GCPII) inhibitors ZJ43 and 2-PMPA.

Nonaka T, Yamada T, Ishimura T, Zuo D, Moffett JR, Neale JH, Yamamoto T.

Mol Pain. 2017 Jan;13:1744806917697008. doi: 10.1177/1744806917697008.

5.

Efficacy of N-Acetylserotonin and Melatonin in the EAE Model of Multiple Sclerosis.

Wen J, Ariyannur PS, Ribeiro R, Tanaka M, Moffett JR, Kirmani BF, Namboodiri AM, Zhang Y.

J Neuroimmune Pharmacol. 2016 Dec;11(4):763-773. Epub 2016 Aug 25.

PMID:
27562847
6.

The end of the road for the tryptophan depletion concept in pregnancy and infection.

Badawy AA, Namboodiri AM, Moffett JR.

Clin Sci (Lond). 2016 Aug 1;130(15):1327-33. doi: 10.1042/CS20160153. Review.

7.

Intranasal delivery of obidoxime to the brain prevents mortality and CNS damage from organophosphate poisoning.

Krishnan JKS, Arun P, Appu AP, Vijayakumar N, Figueiredo TH, Braga MFM, Baskota S, Olsen CH, Farkas N, Dagata J, Frey WH 2nd, Moffett JR, Namboodiri AMA.

Neurotoxicology. 2016 Mar;53:64-73. doi: 10.1016/j.neuro.2015.12.020. Epub 2016 Jan 2.

8.

Rapid intranasal delivery of chloramphenicol acetyltransferase in the active form to different brain regions as a model for enzyme therapy in the CNS.

Appu AP, Arun P, Krishnan JKS, Moffett JR, Namboodiri AMA.

J Neurosci Methods. 2016 Feb 1;259:129-134. doi: 10.1016/j.jneumeth.2015.11.027. Epub 2015 Dec 10.

9.

Acetate as a Metabolic and Epigenetic Modifier of Cancer Therapy.

Jaworski DM, Namboodiri AM, Moffett JR.

J Cell Biochem. 2016 Mar;117(3):574-88. doi: 10.1002/jcb.25305. Review.

PMID:
26251955
10.

N-Acetylaspartate reductions in brain injury: impact on post-injury neuroenergetics, lipid synthesis, and protein acetylation.

Moffett JR, Arun P, Ariyannur PS, Namboodiri AM.

Front Neuroenergetics. 2013 Dec 26;5:11. doi: 10.3389/fnene.2013.00011. Review.

11.

Acetate supplementation induces growth arrest of NG2/PDGFRα-positive oligodendroglioma-derived tumor-initiating cells.

Long PM, Tighe SW, Driscoll HE, Moffett JR, Namboodiri AM, Viapiano MS, Lawler SE, Jaworski DM.

PLoS One. 2013 Nov 20;8(11):e80714. doi: 10.1371/journal.pone.0080714. eCollection 2013.

12.

N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) promote growth and inhibit differentiation of glioma stem-like cells.

Long PM, Moffett JR, Namboodiri AM, Viapiano MS, Lawler SE, Jaworski DM.

J Biol Chem. 2013 Sep 6;288(36):26188-200. doi: 10.1074/jbc.M113.487553. Epub 2013 Jul 24. Erratum in: J Biol Chem. 2013 Nov 1;288(44):31916-7.

13.

Do reductions in brain N-acetylaspartate levels contribute to the etiology of some neuropsychiatric disorders?

Ariyannur PS, Arun P, Barry ES, Andrews-Shigaki B, Bosomtwi A, Tang H, Selwyn R, Grunberg NE, Moffett JR, Namboodiri AM.

J Neurosci Res. 2013 Jul;91(7):934-42. doi: 10.1002/jnr.23234. Epub 2013 Apr 30.

PMID:
23633398
14.

NAAG peptidase inhibition in the periaqueductal gray and rostral ventromedial medulla reduces flinching in the formalin model of inflammation.

Yamada T, Zuo D, Yamamoto T, Olszewski RT, Bzdega T, Moffett JR, Neale JH.

Mol Pain. 2012 Sep 12;8:67. doi: 10.1186/1744-8069-8-67.

15.

Effects of N-acetylaspartylglutamate (NAAG) peptidase inhibition on release of glutamate and dopamine in prefrontal cortex and nucleus accumbens in phencyclidine model of schizophrenia.

Zuo D, Bzdega T, Olszewski RT, Moffett JR, Neale JH.

J Biol Chem. 2012 Jun 22;287(26):21773-82. doi: 10.1074/jbc.M112.363226. Epub 2012 May 8.

16.

Unified immune modulation by 4-1BB triggering leads to diverse effects on disease progression in vivo.

Choi BK, Kim YH, Choi JH, Kim CH, Kim KS, Sung YC, Lee YM, Moffett JR, Kwon BS.

Cytokine. 2011 Sep;55(3):420-8. doi: 10.1016/j.cyto.2011.05.015. Epub 2011 Jun 22.

PMID:
21700476
17.

Extensive aspartoacylase expression in the rat central nervous system.

Moffett JR, Arun P, Ariyannur PS, Garbern JY, Jacobowitz DM, Namboodiri AM.

Glia. 2011 Oct;59(10):1414-34. doi: 10.1002/glia.21186. Epub 2011 May 19.

18.

Miasmas, germs, homeopathy and hormesis: commentary on the relationship between homeopathy and hormesis.

Moffett JR.

Hum Exp Toxicol. 2010 Jul;29(7):539-43. doi: 10.1177/0960327110369855.

PMID:
20558603
19.

Nuclear-cytoplasmic localization of acetyl coenzyme a synthetase-1 in the rat brain.

Ariyannur PS, Moffett JR, Madhavarao CN, Arun P, Vishnu N, Jacobowitz DM, Hallows WC, Denu JM, Namboodiri AM.

J Comp Neurol. 2010 Aug 1;518(15):2952-77. doi: 10.1002/cne.22373.

20.

Metabolic acetate therapy improves phenotype in the tremor rat model of Canavan disease.

Arun P, Madhavarao CN, Moffett JR, Hamilton K, Grunberg NE, Ariyannur PS, Gahl WA, Anikster Y, Mog S, Hallows WC, Denu JM, Namboodiri AM.

J Inherit Metab Dis. 2010 Jun;33(3):195-210. doi: 10.1007/s10545-010-9100-z. Epub 2010 May 13.

21.

Riluzole decreases synthesis of N-acetylaspartate and N-acetylaspartylglutamate in SH-SY5Y human neuroblastoma cells.

Arun P, Moffett JR, Namboodiri AM.

Brain Res. 2010 Jun 2;1334:25-30. doi: 10.1016/j.brainres.2010.04.001. Epub 2010 Apr 13.

PMID:
20394738
22.

Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme: implications for specialized acetyl coenzyme A metabolism in the CNS.

Ariyannur PS, Moffett JR, Manickam P, Pattabiraman N, Arun P, Nitta A, Nabeshima T, Madhavarao CN, Namboodiri AM.

Brain Res. 2010 Jun 4;1335:1-13. doi: 10.1016/j.brainres.2010.04.008. Epub 2010 Apr 10.

PMID:
20385109
23.

Enzyme stabilization by glass-derived silicates in glass-exposed aqueous solutions.

Ives JA, Moffett JR, Arun P, Lam D, Todorov TI, Brothers AB, Anick DJ, Centeno J, Namboodiri MA, Jonas WB.

Homeopathy. 2010 Jan;99(1):15-24. doi: 10.1016/j.homp.2009.11.006.

PMID:
20129173
24.

Metabolic acetate therapy for the treatment of traumatic brain injury.

Arun P, Ariyannur PS, Moffett JR, Xing G, Hamilton K, Grunberg NE, Ives JA, Namboodiri AM.

J Neurotrauma. 2010 Jan;27(1):293-8. doi: 10.1089/neu.2009.0994.

25.

Glyceryl triacetate for Canavan disease: a low-dose trial in infants and evaluation of a higher dose for toxicity in the tremor rat model.

Madhavarao CN, Arun P, Anikster Y, Mog SR, Staretz-Chacham O, Moffett JR, Grunberg NE, Gahl WA, Namboodiri AMA.

J Inherit Metab Dis. 2009 Oct;32(5):640. doi: 10.1007/s10545-009-1155-3. Epub 2009 Aug 15.

PMID:
19685155
26.

Evidence for mitochondrial and cytoplasmic N-acetylaspartate synthesis in SH-SY5Y neuroblastoma cells.

Arun P, Moffett JR, Namboodiri AM.

Neurochem Int. 2009 Sep;55(4):219-25. doi: 10.1016/j.neuint.2009.03.003. Epub 2009 Mar 17.

PMID:
19524112
27.

Antipsychotic drugs increase N-acetylaspartate and N-acetylaspartylglutamate in SH-SY5Y human neuroblastoma cells.

Arun P, Madhavarao CN, Moffett JR, Namboodiri AM.

J Neurochem. 2008 Aug;106(4):1669-80. doi: 10.1111/j.1471-4159.2008.05524.x. Epub 2008 Jun 28.

28.

IDO expands human CD4+CD25high regulatory T cells by promoting maturation of LPS-treated dendritic cells.

Hill M, Tanguy-Royer S, Royer P, Chauveau C, Asghar K, Tesson L, Lavainne F, Rémy S, Brion R, Hubert FX, Heslan M, Rimbert M, Berthelot L, Moffett JR, Josien R, Grégoire M, Anegon I.

Eur J Immunol. 2007 Nov;37(11):3054-62.

29.

Selective vulnerability of hippocampal NAAGergic neurons in experimental temporal lobe epilepsy.

Pacheco Otalora LF, Moffett JR, Garrido-Sanabria ER.

Brain Res. 2007 May 4;1144:219-30. Epub 2007 Feb 2.

PMID:
17346683
30.

N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology.

Moffett JR, Ross B, Arun P, Madhavarao CN, Namboodiri AM.

Prog Neurobiol. 2007 Feb;81(2):89-131. Epub 2007 Jan 5. Review.

31.

Laboratory research in homeopathy: con.

Moffett JR, Arun P, Namboodiri MA.

Integr Cancer Ther. 2006 Dec;5(4):333-42. Review.

PMID:
17101762
32.

Regulation of N-acetylaspartate and N-acetylaspartylglutamate biosynthesis by protein kinase activators.

Arun P, Madhavarao CN, Moffett JR, Namboodiri MA.

J Neurochem. 2006 Sep;98(6):2034-42.

33.

Aspartoacylase is a regulated nuclear-cytoplasmic enzyme.

Hershfield JR, Madhavarao CN, Moffett JR, Benjamins JA, Garbern JY, Namboodiri A.

FASEB J. 2006 Oct;20(12):2139-41. Epub 2006 Aug 25.

PMID:
16935940
34.

Defective myelin lipid synthesis as a pathogenic mechanism of Canavan disease.

Namboodiri AM, Moffett JR, Arun P, Mathew R, Namboodiri S, Potti A, Hershfield J, Kirmani B, Jacobowitz DM, Madhavarao CN.

Adv Exp Med Biol. 2006;576:145-63; discussion 361-3. Review. No abstract available.

PMID:
16802710
35.

Expression of N-acetylaspartate and N-acetylaspartylglutamate in the nervous system.

Moffett JR, Namboodiri AM.

Adv Exp Med Biol. 2006;576:7-26; discussion 361-3. No abstract available.

PMID:
16802702
36.

Preface: a brief review of N-acetylaspartate.

Moffett JR, Namboodiri AM.

Adv Exp Med Biol. 2006;576:vii-xiii. Review. No abstract available.

PMID:
16802700
37.

Canavan disease and the role of N-acetylaspartate in myelin synthesis.

Namboodiri AM, Peethambaran A, Mathew R, Sambhu PA, Hershfield J, Moffett JR, Madhavarao CN.

Mol Cell Endocrinol. 2006 Jun 27;252(1-2):216-23. Epub 2006 May 2. Review.

PMID:
16647192
38.

Progress toward acetate supplementation therapy for Canavan disease: glyceryl triacetate administration increases acetate, but not N-acetylaspartate, levels in brain.

Mathew R, Arun P, Madhavarao CN, Moffett JR, Namboodiri MA.

J Pharmacol Exp Ther. 2005 Oct;315(1):297-303. Epub 2005 Jul 7.

PMID:
16002461
39.

Rapid sodium cyanide depletion in cell culture media: outgassing of hydrogen cyanide at physiological pH.

Arun P, Moffett JR, Ives JA, Todorov TI, Centeno JA, Namboodiri MA, Jonas WB.

Anal Biochem. 2005 Apr 15;339(2):282-9.

PMID:
15797569
40.

Defective N-acetylaspartate catabolism reduces brain acetate levels and myelin lipid synthesis in Canavan's disease.

Madhavarao CN, Arun P, Moffett JR, Szucs S, Surendran S, Matalon R, Garbern J, Hristova D, Johnson A, Jiang W, Namboodiri MA.

Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5221-6. Epub 2005 Mar 22.

41.

SH-SY5Y neuroblastoma cells: a model system for studying biosynthesis of NAAG.

Arun P, Madhavarao CN, Hershfield JR, Moffett JR, Namboodiri MA.

Neuroreport. 2004 May 19;15(7):1167-70.

PMID:
15129167
42.

Immunohistochemical localization of aspartoacylase in the rat central nervous system.

Madhavarao CN, Moffett JR, Moore RA, Viola RE, Namboodiri MA, Jacobowitz DM.

J Comp Neurol. 2004 May 3;472(3):318-29.

PMID:
15065127
43.

Effect of the proteasome inhibitor MLN519 on the expression of inflammatory molecules following middle cerebral artery occlusion and reperfusion in the rat.

Berti R, Williams AJ, Velarde LC, Moffett JR, Elliott PJ, Adams J, Yao C, Dave JR, Tortella FC.

Neurotox Res. 2003;5(7):505-14.

PMID:
14715434
44.

DNA fragmentation in leukocytes following subacute low-dose nerve agent exposure.

Moffett JR, Price RA, Anderson SM, Sipos ML, Moran AV, Tortella FC, Dave JR.

Cell Mol Life Sci. 2003 Oct;60(10):2266-71.

PMID:
14618272
45.

Treatment with the snail peptide CGX-1007 reduces DNA damage and alters gene expression of c-fos and bcl-2 following focal ischemic brain injury in rats.

Williams AJ, Ling G, Berti R, Moffett JR, Yao C, Lu XM, Dave JR, Tortella FC.

Exp Brain Res. 2003 Nov;153(1):16-26. Epub 2003 Aug 29.

PMID:
12955387
46.

Tryptophan and the immune response.

Moffett JR, Namboodiri MA.

Immunol Cell Biol. 2003 Aug;81(4):247-65. Review.

PMID:
12848846
47.
48.

Studies on neuronal apoptosis in primary forebrain cultures: neuroprotective/anti-apoptotic action of NR2B NMDA antagonists.

Dave JR, Williams AJ, Moffett JR, Koenig ML, Tortella FC.

Neurotox Res. 2003;5(4):255-64.

PMID:
12835117

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