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International Society on Thrombosis and Haemostasis core curriculum project: core competencies in laboratory thrombosis and hemostasis.

Moffat KA, Kiencke V, Blanco AN, McLintock C, Peyvandi F, de Maat MPM, Adams MJ, Angchaisuksiri P, Nair S, Tsuda H, Haddad M, Renné T, Clark RC, Ross MT.

J Thromb Haemost. 2019 Aug 9. doi: 10.1111/jth.14601. [Epub ahead of print]


Perioperative Management of Patients With Atrial Fibrillation Receiving a Direct Oral Anticoagulant.

Douketis JD, Spyropoulos AC, Duncan J, Carrier M, Le Gal G, Tafur AJ, Vanassche T, Verhamme P, Shivakumar S, Gross PL, Lee AYY, Yeo E, Solymoss S, Kassis J, Le Templier G, Kowalski S, Blostein M, Shah V, MacKay E, Wu C, Clark NP, Bates SM, Spencer FA, Arnaoutoglou E, Coppens M, Arnold DM, Caprini JA, Li N, Moffat KA, Syed S, Schulman S.

JAMA Intern Med. 2019 Aug 5. doi: 10.1001/jamainternmed.2019.2431. [Epub ahead of print]


Understanding the motivations of patients: A co-designed project to understand the factors behind patient engagement.

McCarron TL, Noseworthy T, Moffat K, Wilkinson G, Zelinsky S, White D, Hassay D, Lorenzetti DL, Marlett NJ.

Health Expect. 2019 Aug 4. doi: 10.1111/hex.12942. [Epub ahead of print]


Distinct Conformations, Aggregation and Cellular Internalization of Different Tau Strains.

Karikari TK, Nagel DA, Grainger A, Clarke-Bland C, Crowe J, Hill EJ, Moffat KG.

Front Cell Neurosci. 2019 Jul 9;13:296. doi: 10.3389/fncel.2019.00296. eCollection 2019.


Imaging correlates of the Blood Brain Barrier disruption in HIV associated neurocognitive disorder and therapeutic implications.

Chaganti J, Marripudi K, Staub LP, Rae CD, Gates TM, Moffat KJ, Brew BJ.

AIDS. 2019 Jul 2. doi: 10.1097/QAD.0000000000002300. [Epub ahead of print]


Marek's Disease Virus-Encoded MicroRNA 155 Ortholog Critical for the Induction of Lymphomas Is Not Essential for the Proliferation of Transformed Cell Lines.

Zhang Y, Tang N, Luo J, Teng M, Moffat K, Shen Z, Watson M, Nair V, Yao Y.

J Virol. 2019 Aug 13;93(17). pii: e00713-19. doi: 10.1128/JVI.00713-19. Print 2019 Sep 1.


Factors associated with recruitment to randomised controlled trials in general practice: protocol for a systematic review.

Moffat KR, Cannon P, Shi W, Sullivan F.

Trials. 2019 May 10;20(1):266. doi: 10.1186/s13063-019-3354-z.


Update on diagnostic testing for platelet function disorders: What is practical and useful?

Hayward CPM, Moffat KA, Brunet J, Carlino SA, Plumhoff E, Meijer P, Zehnder JL.

Int J Lab Hematol. 2019 May;41 Suppl 1:26-32. doi: 10.1111/ijlh.12995. Review.


Laue diffraction and time-resolved crystallography: a personal history.

Moffat K.

Philos Trans A Math Phys Eng Sci. 2019 Jun 17;377(2147):20180243. doi: 10.1098/rsta.2018.0243.


Targeted Editing of the pp38 Gene in Marek's Disease Virus-Transformed Cell Lines Using CRISPR/Cas9 System.

Zhang Y, Luo J, Tang N, Teng M, Reddy VRAP, Moffat K, Shen Z, Nair V, Yao Y.

Viruses. 2019 Apr 26;11(5). pii: E391. doi: 10.3390/v11050391.


Understanding patient engagement in health system decision-making: a co-designed scoping review.

McCarron TL, Moffat K, Wilkinson G, Zelinsky S, Boyd JM, White D, Hassay D, Lorenzetti DL, Marlett NJ, Noseworthy T.

Syst Rev. 2019 Apr 18;8(1):97. doi: 10.1186/s13643-019-0994-8.


Establishment of Systems to Enable Isolation of Porcine Monoclonal Antibodies Broadly Neutralizing the Porcine Reproductive and Respiratory Syndrome Virus.

Goldeck D, Perry DM, Hayes JWP, Johnson LPM, Young JE, Roychoudhury P, McLuskey EL, Moffat K, Bakker AQ, Kwakkenbos MJ, Frossard JP, Rowland RRR, Murtaugh MP, Graham SP.

Front Immunol. 2019 Mar 27;10:572. doi: 10.3389/fimmu.2019.00572. eCollection 2019.


Correction to: Comprehensive benchmarking and ensemble approaches for metagenomic classifiers.

McIntyre ABR, Ounit R, Afshinnekoo E, Prill RJ, Hénaff E, Alexander N, Minot SS, Danko D, Foox J, Ahsanuddin S, Tighe S, Hasan NA, Subramanian P, Moffat K, Levy S, Lonardi S, Greenfield N, Colwell RR, Rosen GL, Mason CE.

Genome Biol. 2019 Apr 5;20(1):72. doi: 10.1186/s13059-019-1687-2.


A low-passage insect-cell isolate of bluetongue virus uses a macropinocytosis-like entry pathway to infect natural target cells derived from the bovine host.

Stevens LM, Moffat K, Cooke L, Nomikou K, Mertens PPC, Jackson T, Darpel KE.

J Gen Virol. 2019 Apr;100(4):568-582. doi: 10.1099/jgv.0.001240. Epub 2019 Mar 7.


A patient-centred intervention to improve the management of multimorbidity in general practice: the 3D RCT.

Salisbury C, Man MS, Chaplin K, Mann C, Bower P, Brookes S, Duncan P, Fitzpatrick B, Gardner C, Gaunt DM, Guthrie B, Hollinghurst S, Kadir B, Lee V, McLeod J, Mercer SW, Moffat KR, Moody E, Rafi I, Robinson R, Shaw A, Thorn J.

Southampton (UK): NIHR Journals Library; 2019 Feb.


Generating Recombinant Avian Herpesvirus Vectors with CRISPR/Cas9 Gene Editing.

Tang N, Zhang Y, Pedrera M, Chang P, Baigent S, Moffat K, Shen Z, Nair V, Yao Y.

J Vis Exp. 2019 Jan 7;(143). doi: 10.3791/58193.


Native T1 Mapping in the Diagnosis of Cardiac Allograft Rejection: A Prospective Histologically Validated Study.

Imran M, Wang L, McCrohon J, Yu C, Holloway C, Otton J, Huang J, Stehning C, Moffat KJ, Ross J, Puntmann VO, Vassiliou VS, Prasad S, Kotlyar E, Keogh A, Hayward C, Macdonald P, Jabbour A.

JACC Cardiovasc Imaging. 2019 Aug;12(8 Pt 2):1618-1628. doi: 10.1016/j.jcmg.2018.10.027. Epub 2019 Jan 16.


Atrophic brain signatures of mild forms of neurocognitive impairment in virally suppressed HIV infection.

Nichols MJ, Gates TM, Soares JR, Moffat KJ, Rae CD, Brew BJ, Cysique LA.

AIDS. 2019 Jan 27;33(1):55-66. doi: 10.1097/QAD.0000000000002042.


Preparation of stable tau oligomers for cellular and biochemical studies.

Karikari TK, Nagel DA, Grainger A, Clarke-Bland C, Hill EJ, Moffat KG.

Anal Biochem. 2019 Feb 1;566:67-74. doi: 10.1016/j.ab.2018.10.013. Epub 2018 Oct 11.


Basic coagulation tests as surrogates of dabigatran levels in a pre-operative setting: Analysis of five activated partial thromboplastin time reagents and thrombin time.

Dubé C, Douketis JD, Moffat KA, Schulman S, Blais N.

Thromb Res. 2018 Nov;171:62-67. doi: 10.1016/j.thromres.2018.09.051. Epub 2018 Sep 19.


Comparison of the Immunogenicities and Cross-Lineage Efficacies of Live Attenuated Peste des Petits Ruminants Virus Vaccines PPRV/Nigeria/75/1 and PPRV/Sungri/96.

Hodgson S, Moffat K, Hill H, Flannery JT, Graham SP, Baron MD, Darpel KE.

J Virol. 2018 Nov 27;92(24). pii: e01471-18. doi: 10.1128/JVI.01471-18. Print 2018 Dec 15.


Structural basis for light control of cell development revealed by crystal structures of a myxobacterial phytochrome.

Woitowich NC, Halavaty AS, Waltz P, Kupitz C, Valera J, Tracy G, Gallagher KD, Claesson E, Nakane T, Pandey S, Nelson G, Tanaka R, Nango E, Mizohata E, Owada S, Tono K, Joti Y, Nugent AC, Patel H, Mapara A, Hopkins J, Duong P, Bizhga D, Kovaleva SE, St Peter R, Hernandez CN, Ozarowski WB, Roy-Chowdhuri S, Yang JH, Edlund P, Takala H, Ihalainen J, Brayshaw J, Norwood T, Poudyal I, Fromme P, Spence JCH, Moffat K, Westenhoff S, Schmidt M, Stojković EA.

IUCrJ. 2018 Aug 29;5(Pt 5):619-634. doi: 10.1107/S2052252518010631. eCollection 2018 Sep 1.


Composite Cellularized Structures Created from an Interpenetrating Polymer Network Hydrogel Reinforced by a 3D Woven Scaffold.

Moffat KL, Goon K, Moutos FT, Estes BT, Oswald SJ, Zhao X, Guilak F.

Macromol Biosci. 2018 Oct;18(10):e1800140. doi: 10.1002/mabi.201800140. Epub 2018 Jul 24.


Femtosecond structural photobiology.

Moffat K.

Science. 2018 Jul 13;361(6398):127-128. doi: 10.1126/science.aau3200. No abstract available.


McMaster RARE-Bestpractices clinical practice guideline on diagnosis and management of the catastrophic antiphospholipid syndrome.

Legault K, Schunemann H, Hillis C, Yeung C, Akl EA, Carrier M, Cervera R, Crowther M, Dentali F, Erkan D, Espinosa G, Khamashta M, Meerpohl JJ, Moffat K, O'Brien S, Pengo V, Rand JH, Rodriguez Pinto I, Thom L, Iorio A.

J Thromb Haemost. 2018 Jun 7. doi: 10.1111/jth.14192. [Epub ahead of print]


Management of multimorbidity using a patient-centred care model: a pragmatic cluster-randomised trial of the 3D approach.

Salisbury C, Man MS, Bower P, Guthrie B, Chaplin K, Gaunt DM, Brookes S, Fitzpatrick B, Gardner C, Hollinghurst S, Lee V, McLeod J, Mann C, Moffat KR, Mercer SW.

Lancet. 2018 Jul 7;392(10141):41-50. doi: 10.1016/S0140-6736(18)31308-4. Epub 2018 Jun 29.


Electron microscopy examination of platelet whole mount preparations to quantitate platelet dense granule numbers: Implications for diagnosing suspected platelet function disorders due to dense granule deficiency.

Brunet JG, Iyer JK, Badin MS, Graf L, Moffat KA, Timleck M, Spitzer E, Hayward CPM.

Int J Lab Hematol. 2018 Aug;40(4):400-407. doi: 10.1111/ijlh.12801. Epub 2018 Mar 6.


Covertly active and progressing neurochemical abnormalities in suppressed HIV infection.

Cysique LA, Jugé L, Gates T, Tobia M, Moffat K, Brew BJ, Rae C.

Neurol Neuroimmunol Neuroinflamm. 2018 Jan 3;5(1):e430. doi: 10.1212/NXI.0000000000000430. eCollection 2018 Jan.


A simple and rapid approach to develop recombinant avian herpesvirus vectored vaccines using CRISPR/Cas9 system.

Tang N, Zhang Y, Pedrera M, Chang P, Baigent S, Moffat K, Shen Z, Nair V, Yao Y.

Vaccine. 2018 Jan 29;36(5):716-722. doi: 10.1016/j.vaccine.2017.12.025. Epub 2018 Jan 2.


Comprehensive benchmarking and ensemble approaches for metagenomic classifiers.

McIntyre ABR, Ounit R, Afshinnekoo E, Prill RJ, Hénaff E, Alexander N, Minot SS, Danko D, Foox J, Ahsanuddin S, Tighe S, Hasan NA, Subramanian P, Moffat K, Levy S, Lonardi S, Greenfield N, Colwell RR, Rosen GL, Mason CE.

Genome Biol. 2017 Sep 21;18(1):182. doi: 10.1186/s13059-017-1299-7. Erratum in: Genome Biol. 2019 Apr 5;20(1):72.


Small crystals, fast dynamics and noisy data are indeed beautiful.

Moffat K.

IUCrJ. 2017 Jun 30;4(Pt 4):303-305. doi: 10.1107/S2052252517009472. eCollection 2017 Jul 1.


An AMPK-dependent regulatory pathway in tau-mediated toxicity.

Galasso A, Cameron CS, Frenguelli BG, Moffat KG.

Biol Open. 2017 Oct 15;6(10):1434-1444. doi: 10.1242/bio.022863.


Erratum to: White matter measures are near normal in controlled HIV infection except in those with cognitive impairment and longer HIV duration.

Cysique LA, Soares JR, Geng G, Scarpetta M, Moffat K, Green M, Brew BJ, Henry RG, Rae C.

J Neurovirol. 2017 Aug;23(4):548-549. doi: 10.1007/s13365-017-0542-z. No abstract available.


Functional Connectivity in Virally Suppressed Patients with HIV-Associated Neurocognitive Disorder: A Resting-State Analysis.

Chaganti JR, Heinecke A, Gates TM, Moffat KJ, Brew BJ.

AJNR Am J Neuroradiol. 2017 Aug;38(8):1623-1629. doi: 10.3174/ajnr.A5246. Epub 2017 Jun 8.


White matter measures are near normal in controlled HIV infection except in those with cognitive impairment and longer HIV duration.

Cysique LA, Soares JR, Geng G, Scarpetta M, Moffat K, Green M, Brew BJ, Henry RG, Rae C.

J Neurovirol. 2017 Aug;23(4):539-547. doi: 10.1007/s13365-017-0524-1. Epub 2017 Mar 21. Erratum in: J Neurovirol. 2017 Jul 28;:.


Cooperative elastic switching vs. laser heating in [Fe(phen)2(NCS)2] spin-crossover crystals excited by a laser pulse.

Bertoni R, Lorenc M, Graber T, Henning R, Moffat K, Létard JF, Collet E.

CrystEngComm. 2016 Oct 14;18(38):7269-7275. doi: 10.1039/C6CE00659K. Epub 2016 Apr 29.


Bacteriophytochrome Photoisomerization Proceeds Homogeneously Despite Heterogeneity in Ground State.

Wang C, Flanagan ML, McGillicuddy RD, Zheng H, Ginzburg AR, Yang X, Moffat K, Engel GS.

Biophys J. 2016 Nov 15;111(10):2125-2134. doi: 10.1016/j.bpj.2016.10.017.


Expression and purification of tau protein and its frontotemporal dementia variants using a cleavable histidine tag.

Karikari TK, Turner A, Stass R, Lee LC, Wilson B, Nagel DA, Hill EJ, Moffat KG.

Protein Expr Purif. 2017 Feb;130:44-54. doi: 10.1016/j.pep.2016.09.009. Epub 2016 Sep 20.


The room temperature crystal structure of a bacterial phytochrome determined by serial femtosecond crystallography.

Edlund P, Takala H, Claesson E, Henry L, Dods R, Lehtivuori H, Panman M, Pande K, White T, Nakane T, Berntsson O, Gustavsson E, Båth P, Modi V, Roy-Chowdhury S, Zook J, Berntsen P, Pandey S, Poudyal I, Tenboer J, Kupitz C, Barty A, Fromme P, Koralek JD, Tanaka T, Spence J, Liang M, Hunter MS, Boutet S, Nango E, Moffat K, Groenhof G, Ihalainen J, Stojković EA, Schmidt M, Westenhoff S.

Sci Rep. 2016 Oct 19;6:35279. doi: 10.1038/srep35279.


Laboratory Monitoring of Oral Vitamin K Anticoagulation.

Moffat KA, Lewis CW.

Semin Thromb Hemost. 2017 Apr;43(3):245-252. doi: 10.1055/s-0036-1587690. Epub 2016 Sep 27.


Variability in platelet dense granule adenosine triphosphate release findings amongst patients tested multiple times as part of an assessment for a bleeding disorder.

Badin MS, Graf L, Iyer JK, Moffat KA, Seecharan JL, Hayward CP.

Int J Lab Hematol. 2016 Dec;38(6):648-657. doi: 10.1111/ijlh.12553. Epub 2016 Aug 30.


Interactive digital interventions to promote self-management in adults with asthma: systematic review and meta-analysis.

McLean G, Murray E, Band R, Moffat KR, Hanlon P, Bruton A, Thomas M, Yardley L, Mair FS.

BMC Pulm Med. 2016 May 23;16(1):83. doi: 10.1186/s12890-016-0248-7. Review.


Report on the International Society for Laboratory Hematology Survey on guidelines to support clinical hematology laboratory practice.

Hayward CP, Moffat KA, George TI, Proytcheva M, Iorio A.

Int J Lab Hematol. 2016 May;38 Suppl 1:133-8. doi: 10.1111/ijlh.12501. Epub 2016 May 9.


Femtosecond structural dynamics drives the trans/cis isomerization in photoactive yellow protein.

Pande K, Hutchison CD, Groenhof G, Aquila A, Robinson JS, Tenboer J, Basu S, Boutet S, DePonte DP, Liang M, White TA, Zatsepin NA, Yefanov O, Morozov D, Oberthuer D, Gati C, Subramanian G, James D, Zhao Y, Koralek J, Brayshaw J, Kupitz C, Conrad C, Roy-Chowdhury S, Coe JD, Metz M, Xavier PL, Grant TD, Koglin JE, Ketawala G, Fromme R, Šrajer V, Henning R, Spence JC, Ourmazd A, Schwander P, Weierstall U, Frank M, Fromme P, Barty A, Chapman HN, Moffat K, van Thor JJ, Schmidt M.

Science. 2016 May 6;352(6286):725-9. doi: 10.1126/science.aad5081. Epub 2016 May 5.


Foot-and-mouth disease virus replicates independently of phosphatidylinositol 4-phosphate and type III phosphatidylinositol 4-kinases.

Berryman S, Moffat K, Harak C, Lohmann V, Jackson T.

J Gen Virol. 2016 Aug;97(8):1841-52. doi: 10.1099/jgv.0.000485. Epub 2016 Apr 19.


Using shared needles for subcutaneous inoculation can transmit bluetongue virus mechanically between ruminant hosts.

Darpel KE, Barber J, Hope A, Wilson AJ, Gubbins S, Henstock M, Frost L, Batten C, Veronesi E, Moffat K, Carpenter S, Oura C, Mellor PS, Mertens PP.

Sci Rep. 2016 Feb 8;6:20627. doi: 10.1038/srep20627.


Maraviroc-intensified combined antiretroviral therapy improves cognition in virally suppressed HIV-associated neurocognitive disorder.

Gates TM, Cysique LA, Siefried KJ, Chaganti J, Moffat KJ, Brew BJ.

AIDS. 2016 Feb 20;30(4):591-600. doi: 10.1097/QAD.0000000000000951.


Improving management of gout in primary care using a customised electronic records template.

Moffat K, McNab D.

BMJ Qual Improv Rep. 2015 Jun 12;4(1). pii: u204832.w2038. doi: 10.1136/bmjquality.u204832.w2038. eCollection 2015.


Effect of standardized perioperative dabigatran interruption on the residual anticoagulation effect at the time of surgery or procedure.

Douketis JD, Wang G, Chan N, Eikelboom JW, Syed S, Barty R, Moffat KA, Spencer FA, Blostein M, Schulman S.

J Thromb Haemost. 2016 Jan;14(1):89-97. doi: 10.1111/jth.13178. Epub 2016 Jan 4.


Challenges of managing people with multimorbidity in today's healthcare systems.

Moffat K, Mercer SW.

BMC Fam Pract. 2015 Oct 14;16:129. doi: 10.1186/s12875-015-0344-4.

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