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Atrophic brain signatures of mild forms of neurocognitive impairment in virally suppressed HIV infection.

Nichols MJ, Gates TM, Soares JR, Moffat KJ, Rae CD, Brew BJ, Cysique LA.

AIDS. 2018 Oct 15. doi: 10.1097/QAD.0000000000002042. [Epub ahead of print]


Preparation of stable tau oligomers for cellular and biochemical studies.

Karikari TK, Nagel DA, Grainger A, Clarke-Bland C, Hill EJ, Moffat KG.

Anal Biochem. 2018 Oct 10. pii: S0003-2697(18)30524-4. doi: 10.1016/j.ab.2018.10.013. [Epub ahead of print]


Basic coagulation tests as surrogates of dabigatran levels in a pre-operative setting: Analysis of five activated partial thromboplastin time reagents and thrombin time.

Dubé C, Douketis JD, Moffat KA, Schulman S, Blais N.

Thromb Res. 2018 Sep 19;171:62-67. doi: 10.1016/j.thromres.2018.09.051. [Epub ahead of print]


Comparison of the immunogenicity and cross-lineage efficacy of live attenuated peste des petits ruminants virus vaccines PPRV/Nigeria/75/1 and PPRV/Sungri/96.

Hodgson S, Moffat K, Hill H, Flannery JT, Graham SP, Baron MD, Darpel KE.

J Virol. 2018 Sep 26. pii: JVI.01471-18. doi: 10.1128/JVI.01471-18. [Epub ahead of print]


Structural basis for light control of cell development revealed by crystal structures of a myxobacterial phytochrome.

Woitowich NC, Halavaty AS, Waltz P, Kupitz C, Valera J, Tracy G, Gallagher KD, Claesson E, Nakane T, Pandey S, Nelson G, Tanaka R, Nango E, Mizohata E, Owada S, Tono K, Joti Y, Nugent AC, Patel H, Mapara A, Hopkins J, Duong P, Bizhga D, Kovaleva SE, St Peter R, Hernandez CN, Ozarowski WB, Roy-Chowdhuri S, Yang JH, Edlund P, Takala H, Ihalainen J, Brayshaw J, Norwood T, Poudyal I, Fromme P, Spence JCH, Moffat K, Westenhoff S, Schmidt M, Stojković EA.

IUCrJ. 2018 Aug 29;5(Pt 5):619-634. doi: 10.1107/S2052252518010631. eCollection 2018 Sep 1.


Composite Cellularized Structures Created from an Interpenetrating Polymer Network Hydrogel Reinforced by a 3D Woven Scaffold.

Moffat KL, Goon K, Moutos FT, Estes BT, Oswald SJ, Zhao X, Guilak F.

Macromol Biosci. 2018 Oct;18(10):e1800140. doi: 10.1002/mabi.201800140. Epub 2018 Jul 24.


Femtosecond structural photobiology.

Moffat K.

Science. 2018 Jul 13;361(6398):127-128. doi: 10.1126/science.aau3200. No abstract available.


McMaster RARE-Bestpractices clinical practice guideline on diagnosis and management of the catastrophic antiphospholipid syndrome.

Legault K, Schunemann H, Hillis C, Yeung C, Akl EA, Carrier M, Cervera R, Crowther M, Dentali F, Erkan D, Espinosa G, Khamashta M, Meerpohl JJ, Moffat K, O'Brien S, Pengo V, Rand JH, Rodriguez Pinto I, Thom L, Iorio A.

J Thromb Haemost. 2018 Jun 7. doi: 10.1111/jth.14192. [Epub ahead of print]


Management of multimorbidity using a patient-centred care model: a pragmatic cluster-randomised trial of the 3D approach.

Salisbury C, Man MS, Bower P, Guthrie B, Chaplin K, Gaunt DM, Brookes S, Fitzpatrick B, Gardner C, Hollinghurst S, Lee V, McLeod J, Mann C, Moffat KR, Mercer SW.

Lancet. 2018 Jul 7;392(10141):41-50. doi: 10.1016/S0140-6736(18)31308-4. Epub 2018 Jun 29.


Electron microscopy examination of platelet whole mount preparations to quantitate platelet dense granule numbers: Implications for diagnosing suspected platelet function disorders due to dense granule deficiency.

Brunet JG, Iyer JK, Badin MS, Graf L, Moffat KA, Timleck M, Spitzer E, Hayward CPM.

Int J Lab Hematol. 2018 Aug;40(4):400-407. doi: 10.1111/ijlh.12801. Epub 2018 Mar 6.


Covertly active and progressing neurochemical abnormalities in suppressed HIV infection.

Cysique LA, Jugé L, Gates T, Tobia M, Moffat K, Brew BJ, Rae C.

Neurol Neuroimmunol Neuroinflamm. 2018 Jan 3;5(1):e430. doi: 10.1212/NXI.0000000000000430. eCollection 2018 Jan.


A simple and rapid approach to develop recombinant avian herpesvirus vectored vaccines using CRISPR/Cas9 system.

Tang N, Zhang Y, Pedrera M, Chang P, Baigent S, Moffat K, Shen Z, Nair V, Yao Y.

Vaccine. 2018 Jan 29;36(5):716-722. doi: 10.1016/j.vaccine.2017.12.025. Epub 2018 Jan 2.


Comprehensive benchmarking and ensemble approaches for metagenomic classifiers.

McIntyre ABR, Ounit R, Afshinnekoo E, Prill RJ, Hénaff E, Alexander N, Minot SS, Danko D, Foox J, Ahsanuddin S, Tighe S, Hasan NA, Subramanian P, Moffat K, Levy S, Lonardi S, Greenfield N, Colwell RR, Rosen GL, Mason CE.

Genome Biol. 2017 Sep 21;18(1):182. doi: 10.1186/s13059-017-1299-7.


Small crystals, fast dynamics and noisy data are indeed beautiful.

Moffat K.

IUCrJ. 2017 Jun 30;4(Pt 4):303-305. doi: 10.1107/S2052252517009472. eCollection 2017 Jul 1.


An AMPK-dependent regulatory pathway in tau-mediated toxicity.

Galasso A, Cameron CS, Frenguelli BG, Moffat KG.

Biol Open. 2017 Oct 15;6(10):1434-1444. doi: 10.1242/bio.022863.


Erratum to: White matter measures are near normal in controlled HIV infection except in those with cognitive impairment and longer HIV duration.

Cysique LA, Soares JR, Geng G, Scarpetta M, Moffat K, Green M, Brew BJ, Henry RG, Rae C.

J Neurovirol. 2017 Aug;23(4):548-549. doi: 10.1007/s13365-017-0542-z. No abstract available.


Functional Connectivity in Virally Suppressed Patients with HIV-Associated Neurocognitive Disorder: A Resting-State Analysis.

Chaganti JR, Heinecke A, Gates TM, Moffat KJ, Brew BJ.

AJNR Am J Neuroradiol. 2017 Aug;38(8):1623-1629. doi: 10.3174/ajnr.A5246. Epub 2017 Jun 8.


White matter measures are near normal in controlled HIV infection except in those with cognitive impairment and longer HIV duration.

Cysique LA, Soares JR, Geng G, Scarpetta M, Moffat K, Green M, Brew BJ, Henry RG, Rae C.

J Neurovirol. 2017 Aug;23(4):539-547. doi: 10.1007/s13365-017-0524-1. Epub 2017 Mar 21. Erratum in: J Neurovirol. 2017 Jul 28;:.


Cooperative elastic switching vs. laser heating in [Fe(phen)2(NCS)2] spin-crossover crystals excited by a laser pulse.

Bertoni R, Lorenc M, Graber T, Henning R, Moffat K, Létard JF, Collet E.

CrystEngComm. 2016 Oct 14;18(38):7269-7275. doi: 10.1039/C6CE00659K. Epub 2016 Apr 29.


Bacteriophytochrome Photoisomerization Proceeds Homogeneously Despite Heterogeneity in Ground State.

Wang C, Flanagan ML, McGillicuddy RD, Zheng H, Ginzburg AR, Yang X, Moffat K, Engel GS.

Biophys J. 2016 Nov 15;111(10):2125-2134. doi: 10.1016/j.bpj.2016.10.017.


Expression and purification of tau protein and its frontotemporal dementia variants using a cleavable histidine tag.

Karikari TK, Turner A, Stass R, Lee LC, Wilson B, Nagel DA, Hill EJ, Moffat KG.

Protein Expr Purif. 2017 Feb;130:44-54. doi: 10.1016/j.pep.2016.09.009. Epub 2016 Sep 20.


The room temperature crystal structure of a bacterial phytochrome determined by serial femtosecond crystallography.

Edlund P, Takala H, Claesson E, Henry L, Dods R, Lehtivuori H, Panman M, Pande K, White T, Nakane T, Berntsson O, Gustavsson E, Båth P, Modi V, Roy-Chowdhury S, Zook J, Berntsen P, Pandey S, Poudyal I, Tenboer J, Kupitz C, Barty A, Fromme P, Koralek JD, Tanaka T, Spence J, Liang M, Hunter MS, Boutet S, Nango E, Moffat K, Groenhof G, Ihalainen J, Stojković EA, Schmidt M, Westenhoff S.

Sci Rep. 2016 Oct 19;6:35279. doi: 10.1038/srep35279.


Laboratory Monitoring of Oral Vitamin K Anticoagulation.

Moffat KA, Lewis CW.

Semin Thromb Hemost. 2017 Apr;43(3):245-252. doi: 10.1055/s-0036-1587690. Epub 2016 Sep 27.


Variability in platelet dense granule adenosine triphosphate release findings amongst patients tested multiple times as part of an assessment for a bleeding disorder.

Badin MS, Graf L, Iyer JK, Moffat KA, Seecharan JL, Hayward CP.

Int J Lab Hematol. 2016 Dec;38(6):648-657. doi: 10.1111/ijlh.12553. Epub 2016 Aug 30.


Interactive digital interventions to promote self-management in adults with asthma: systematic review and meta-analysis.

McLean G, Murray E, Band R, Moffat KR, Hanlon P, Bruton A, Thomas M, Yardley L, Mair FS.

BMC Pulm Med. 2016 May 23;16(1):83. doi: 10.1186/s12890-016-0248-7. Review.


Report on the International Society for Laboratory Hematology Survey on guidelines to support clinical hematology laboratory practice.

Hayward CP, Moffat KA, George TI, Proytcheva M, Iorio A.

Int J Lab Hematol. 2016 May;38 Suppl 1:133-8. doi: 10.1111/ijlh.12501. Epub 2016 May 9.


Femtosecond structural dynamics drives the trans/cis isomerization in photoactive yellow protein.

Pande K, Hutchison CD, Groenhof G, Aquila A, Robinson JS, Tenboer J, Basu S, Boutet S, DePonte DP, Liang M, White TA, Zatsepin NA, Yefanov O, Morozov D, Oberthuer D, Gati C, Subramanian G, James D, Zhao Y, Koralek J, Brayshaw J, Kupitz C, Conrad C, Roy-Chowdhury S, Coe JD, Metz M, Xavier PL, Grant TD, Koglin JE, Ketawala G, Fromme R, Šrajer V, Henning R, Spence JC, Ourmazd A, Schwander P, Weierstall U, Frank M, Fromme P, Barty A, Chapman HN, Moffat K, van Thor JJ, Schmidt M.

Science. 2016 May 6;352(6286):725-9. doi: 10.1126/science.aad5081. Epub 2016 May 5.


Foot-and-mouth disease virus replicates independently of phosphatidylinositol 4-phosphate and type III phosphatidylinositol 4-kinases.

Berryman S, Moffat K, Harak C, Lohmann V, Jackson T.

J Gen Virol. 2016 Aug;97(8):1841-52. doi: 10.1099/jgv.0.000485. Epub 2016 Apr 19.


Using shared needles for subcutaneous inoculation can transmit bluetongue virus mechanically between ruminant hosts.

Darpel KE, Barber J, Hope A, Wilson AJ, Gubbins S, Henstock M, Frost L, Batten C, Veronesi E, Moffat K, Carpenter S, Oura C, Mellor PS, Mertens PP.

Sci Rep. 2016 Feb 8;6:20627. doi: 10.1038/srep20627.


Maraviroc-intensified combined antiretroviral therapy improves cognition in virally suppressed HIV-associated neurocognitive disorder.

Gates TM, Cysique LA, Siefried KJ, Chaganti J, Moffat KJ, Brew BJ.

AIDS. 2016 Feb 20;30(4):591-600. doi: 10.1097/QAD.0000000000000951.


Improving management of gout in primary care using a customised electronic records template.

Moffat K, McNab D.

BMJ Qual Improv Rep. 2015 Jun 12;4(1). pii: u204832.w2038. doi: 10.1136/bmjquality.u204832.w2038. eCollection 2015.


Effect of standardized perioperative dabigatran interruption on the residual anticoagulation effect at the time of surgery or procedure.

Douketis JD, Wang G, Chan N, Eikelboom JW, Syed S, Barty R, Moffat KA, Spencer FA, Blostein M, Schulman S.

J Thromb Haemost. 2016 Jan;14(1):89-97. doi: 10.1111/jth.13178. Epub 2016 Jan 4.


Challenges of managing people with multimorbidity in today's healthcare systems.

Moffat K, Mercer SW.

BMC Fam Pract. 2015 Oct 14;16:129. doi: 10.1186/s12875-015-0344-4.


Structure of the response regulator RPA3017 involved in red-light signaling in Rhodopseudomonas palustris.

Yang X, Zeng X, Moffat K, Yang X.

Acta Crystallogr F Struct Biol Commun. 2015 Oct;71(Pt 10):1215-22. doi: 10.1107/S2053230X15014661. Epub 2015 Sep 23.


Hemodialysis for the treatment of dabigatran-associated bleeding: a case report and systematic review.

Chai-Adisaksopha C, Hillis C, Lim W, Boonyawat K, Moffat K, Crowther M.

J Thromb Haemost. 2015 Oct;13(10):1790-8. doi: 10.1111/jth.13117. Epub 2015 Sep 29. Review.


The interaction of economic rewards and moral convictions in predicting attitudes toward resource use.

Bastian B, Zhang A, Moffat K.

PLoS One. 2015 Aug 12;10(8):e0134863. doi: 10.1371/journal.pone.0134863. eCollection 2015.


Internal Quality Control Practices in Coagulation Laboratories: recommendations based on a patterns-of-practice survey.

McFarlane A, Aslan B, Raby A, Moffat KA, Selby R, Padmore R.

Int J Lab Hematol. 2015 Dec;37(6):729-38. doi: 10.1111/ijlh.12397. Epub 2015 Jun 24.


Light Signaling Mechanism of Two Tandem Bacteriophytochromes.

Yang X, Stojković EA, Ozarowski WB, Kuk J, Davydova E, Moffat K.

Structure. 2015 Jul 7;23(7):1179-89. doi: 10.1016/j.str.2015.04.022. Epub 2015 Jun 18.


Assembly and evaluation of an inventory of guidelines that are available to support clinical hematology laboratory practice.

Hayward CP, Moffat KA, George TI, Proytcheva M.

Int J Lab Hematol. 2015 May;37 Suppl 1:36-45. doi: 10.1111/ijlh.12348.


Out-of-equilibrium dynamics of photoexcited spin-state concentration waves.

Marino A, Buron-Le Cointe M, Lorenc M, Toupet L, Henning R, DiChiara AD, Moffat K, Bréfuel N, Collet E.

Faraday Discuss. 2015;177:363-79. doi: 10.1039/c4fd00164h.


Time-resolved serial crystallography captures high-resolution intermediates of photoactive yellow protein.

Tenboer J, Basu S, Zatsepin N, Pande K, Milathianaki D, Frank M, Hunter M, Boutet S, Williams GJ, Koglin JE, Oberthuer D, Heymann M, Kupitz C, Conrad C, Coe J, Roy-Chowdhury S, Weierstall U, James D, Wang D, Grant T, Barty A, Yefanov O, Scales J, Gati C, Seuring C, Srajer V, Henning R, Schwander P, Fromme R, Ourmazd A, Moffat K, Van Thor JJ, Spence JC, Fromme P, Chapman HN, Schmidt M.

Science. 2014 Dec 5;346(6214):1242-6. doi: 10.1126/science.1259357.


Signal to noise considerations for single crystal femtosecond time resolved crystallography of the Photoactive Yellow Protein.

van Thor JJ, Warren MM, Lincoln CN, Chollet M, Lemke HT, Fritz DM, Schmidt M, Tenboer J, Ren Z, Srajer V, Moffat K, Graber T.

Faraday Discuss. 2014;171:439-55. doi: 10.1039/c4fd00011k. Epub 2014 Jul 30.


FTIR Spectroscopy Revealing Light-Dependent Refolding of the Conserved Tongue Region of Bacteriophytochrome.

Stojković EA, Toh KC, Alexandre MT, Baclayon M, Moffat K, Kennis JT.

J Phys Chem Lett. 2014 Aug 7;5(15):2512-2515. Epub 2014 Jul 7.


Monitoring the anticoagulant effect after a massive rivaroxaban overdose.

Linkins LA, Moffat K.

J Thromb Haemost. 2014 Sep;12(9):1570-1. doi: 10.1111/jth.12669. Epub 2014 Aug 11.


Time-resolved crystallography and protein design: signalling photoreceptors and optogenetics.

Moffat K.

Philos Trans R Soc Lond B Biol Sci. 2014 Jul 17;369(1647):20130568. doi: 10.1098/rstb.2013.0568. Review.


Evaluation of an automated method for measuring von Willebrand factor activity in clinical samples without ristocetin.

Graf L, Moffat KA, Carlino SA, Chan AK, Iorio A, Giulivi A, Hayward CP.

Int J Lab Hematol. 2014 Jun;36(3):341-51. doi: 10.1111/ijlh.12218.


Technological advances in diagnostic testing for von Willebrand disease: new approaches and challenges.

Hayward CP, Moffat KA, Graf L.

Int J Lab Hematol. 2014 Jun;36(3):334-40. doi: 10.1111/ijlh.12220. Review.


Reply to 'contradictions in X-ray structures of intermediates in the photocycle of photoactive yellow protein'.

Jung YO, Lee JH, Kim J, Schmidt M, Moffat K, Šrajer V, Ihee H.

Nat Chem. 2014 Apr;6(4):259-60. doi: 10.1038/nchem.1897. No abstract available.


Coiled-coil dimerization of the LOV2 domain of the blue-light photoreceptor phototropin 1 from Arabidopsis thaliana.

Halavaty AS, Moffat K.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Dec;69(Pt 12):1316-21. doi: 10.1107/S1744309113029199. Epub 2013 Nov 28.


Pigment-protein interactions in phytochromes probed by fluorescence line narrowing spectroscopy.

Nieder JB, Stojković EA, Moffat K, Forest KT, Lamparter T, Bittl R, Kennis JT.

J Phys Chem B. 2013 Dec 5;117(48):14940-50. doi: 10.1021/jp409110q. Epub 2013 Nov 22.


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