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Items: 1 to 50 of 337

1.

Monitoring drug crystallization in percutaneous penetration using localized nano-thermal analysis and photothermal microspectroscopy.

Goh CF, Moffat JG, Craig DQM, Hadgraft J, Lane ME.

Mol Pharm. 2018 Dec 10. doi: 10.1021/acs.molpharmaceut.8b01027. [Epub ahead of print]

PMID:
30525649
2.

Eukaryotic Voltage-Gated Sodium Channels: On Their Origins, Asymmetries, Losses, Diversification and Adaptations.

Fux JE, Mehta A, Moffat J, Spafford JD.

Front Physiol. 2018 Nov 21;9:1406. doi: 10.3389/fphys.2018.01406. eCollection 2018.

3.

Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer.

Wu P, Sneeringer CJ, Pitts KE, Day ES, Chan BK, Wei B, Lehoux I, Mortara K, Li H, Wu J, Franke Y, Moffat JG, Grogan JL, Heffron TP, Wang W.

Structure. 2018 Nov 13. pii: S0969-2126(18)30386-1. doi: 10.1016/j.str.2018.10.025. [Epub ahead of print]

PMID:
30503777
4.

Using Bayesian network modelling to untangle farm management risk factors for bovine viral diarrhoea virus infection.

Han JH, Holter J, Moffat J, Weston JF, Heuer C, Gates MC.

Prev Vet Med. 2018 Dec 1;161:75-82. doi: 10.1016/j.prevetmed.2018.10.014. Epub 2018 Oct 28.

PMID:
30466661
5.

Protocadherin-1 is essential for cell entry by New World hantaviruses.

Jangra RK, Herbert AS, Li R, Jae LT, Kleinfelter LM, Slough MM, Barker SL, Guardado-Calvo P, Román-Sosa G, Dieterle ME, Kuehne AI, Muena NA, Wirchnianski AS, Nyakatura EK, Fels JM, Ng M, Mittler E, Pan J, Bharrhan S, Wec AZ, Lai JR, Sidhu SS, Tischler ND, Rey FA, Moffat J, Brummelkamp TR, Wang Z, Dye JM, Chandran K.

Nature. 2018 Nov;563(7732):559-563. doi: 10.1038/s41586-018-0702-1. Epub 2018 Nov 21.

PMID:
30464266
6.

Lung cancer screening - gaining consensus on next steps - proceedings of a closed workshop in the UK.

Moffat J, Hiom S, Kumar HS, Baldwin DR.

Lung Cancer. 2018 Nov;125:121-127. doi: 10.1016/j.lungcan.2018.07.029. Epub 2018 Jul 21. Review.

PMID:
30429009
7.

Genome-wide CRISPR-Cas9 Interrogation of Splicing Networks Reveals a Mechanism for Recognition of Autism-Misregulated Neuronal Microexons.

Gonatopoulos-Pournatzis T, Wu M, Braunschweig U, Roth J, Han H, Best AJ, Raj B, Aregger M, O'Hanlon D, Ellis JD, Calarco JA, Moffat J, Gingras AC, Blencowe BJ.

Mol Cell. 2018 Nov 1;72(3):510-524.e12. doi: 10.1016/j.molcel.2018.10.008.

PMID:
30388412
8.

Pooled Lentiviral CRISPR-Cas9 Screens for Functional Genomics in Mammalian Cells.

Aregger M, Chandrashekhar M, Tong AHY, Chan K, Moffat J.

Methods Mol Biol. 2019;1869:169-188. doi: 10.1007/978-1-4939-8805-1_15.

PMID:
30324523
9.

EPH Profiling of BTIC Populations in Glioblastoma Multiforme Using CyTOF.

Hu AX, Adams JJ, Vora P, Qazi M, Singh SK, Moffat J, Sidhu SS.

Methods Mol Biol. 2019;1869:155-168. doi: 10.1007/978-1-4939-8805-1_14.

PMID:
30324522
10.

A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor properties.

Pavlovic Z, Adams JJ, Blazer LL, Gakhal AK, Jarvik N, Steinhart Z, Robitaille M, Mascall K, Pan J, Angers S, Moffat J, Sidhu SS.

MAbs. 2018 Nov-Dec;10(8):1157-1167. doi: 10.1080/19420862.2018.1515565. Epub 2018 Sep 25.

PMID:
30183492
11.

Microscopic and Macroscopic Properties of Carbohydrate Solutions in the Ionic Liquid 1-Ethyl-3-methyl-imidazolium Acetate.

Ries ME, Radhi A, Green SM, Moffat J, Budtova T.

J Phys Chem B. 2018 Sep 20;122(37):8763-8771. doi: 10.1021/acs.jpcb.8b06939. Epub 2018 Sep 6.

12.

The role of ARID1B, a BAF chromatin remodeling complex subunit, in neural development and behavior.

Moffat JJ, Jung EM, Ka M, Smith AL, Jeon BT, Santen GWE, Kim WY.

Prog Neuropsychopharmacol Biol Psychiatry. 2019 Mar 8;89:30-38. doi: 10.1016/j.pnpbp.2018.08.021. Epub 2018 Aug 24. Review.

PMID:
30149092
13.

Meeting report: 31st International Conference on Antiviral Research.

Bray M, Andrei G, Ballana E, Carter K, Durantel D, Gentry B, Janeba Z, Moffat J, Oomen CJ, Tarbet B, Riveira-Muñoz E, Esté JA; International Society for Antiviral Research.

Antiviral Res. 2018 Oct;158:88-102. doi: 10.1016/j.antiviral.2018.08.002. Epub 2018 Aug 4. Review.

PMID:
30086336
14.

The shieldin complex mediates 53BP1-dependent DNA repair.

Noordermeer SM, Adam S, Setiaputra D, Barazas M, Pettitt SJ, Ling AK, Olivieri M, Álvarez-Quilón A, Moatti N, Zimmermann M, Annunziato S, Krastev DB, Song F, Brandsma I, Frankum J, Brough R, Sherker A, Landry S, Szilard RK, Munro MM, McEwan A, Goullet de Rugy T, Lin ZY, Hart T, Moffat J, Gingras AC, Martin A, van Attikum H, Jonkers J, Lord CJ, Rottenberg S, Durocher D.

Nature. 2018 Aug;560(7716):117-121. doi: 10.1038/s41586-018-0340-7. Epub 2018 Jul 18.

PMID:
30022168
15.

Cellular Stress Response to Varicella-Zoster Virus Infection of Human Skin Includes Highly Elevated Interleukin-6 Expression.

Jarosinski KW, Carpenter JE, Buckingham EM, Jackson W, Knudtson K, Moffat JF, Kita H, Grose C.

Open Forum Infect Dis. 2018 May 22;5(6):ofy118. doi: 10.1093/ofid/ofy118. eCollection 2018 Jun.

16.

CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions.

Zimmermann M, Murina O, Reijns MAM, Agathanggelou A, Challis R, Tarnauskaitė Ž, Muir M, Fluteau A, Aregger M, McEwan A, Yuan W, Clarke M, Lambros MB, Paneesha S, Moss P, Chandrashekhar M, Angers S, Moffat J, Brunton VG, Hart T, de Bono J, Stankovic T, Jackson AP, Durocher D.

Nature. 2018 Jul;559(7713):285-289. doi: 10.1038/s41586-018-0291-z. Epub 2018 Jul 4.

PMID:
29973717
17.

Cotargeting Ephrin Receptor Tyrosine Kinases A2 and A3 in Cancer Stem Cells Reduces Growth of Recurrent Glioblastoma.

Qazi MA, Vora P, Venugopal C, Adams J, Singh M, Hu A, Gorelik M, Subapanditha MK, Savage N, Yang J, Chokshi C, London M, Gont A, Bobrowski D, Grinshtein N, Brown KR, Murty NK, Nilvebrant J, Kaplan D, Moffat J, Sidhu S, Singh SK.

Cancer Res. 2018 Sep 1;78(17):5023-5037. doi: 10.1158/0008-5472.CAN-18-0267. Epub 2018 Jun 26.

PMID:
29945963
18.

Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48.

Velimezi G, Robinson-Garcia L, Muñoz-Martínez F, Wiegant WW, Ferreira da Silva J, Owusu M, Moder M, Wiedner M, Rosenthal SB, Fisch KM, Moffat J, Menche J, van Attikum H, Jackson SP, Loizou JI.

Nat Commun. 2018 Jun 11;9(1):2280. doi: 10.1038/s41467-018-04649-z.

19.

A transcriptional MAPK Pathway Activity Score (MPAS) is a clinically relevant biomarker in multiple cancer types.

Wagle MC, Kirouac D, Klijn C, Liu B, Mahajan S, Junttila M, Moffat J, Merchant M, Huw L, Wongchenko M, Okrah K, Srinivasan S, Mounir Z, Sumiyoshi T, Haverty PM, Yauch RL, Yan Y, Kabbarah O, Hampton G, Amler L, Ramanujan S, Lackner MR, Huang SA.

NPJ Precis Oncol. 2018 Mar 7;2(1):7. doi: 10.1038/s41698-018-0051-4. eCollection 2018.

20.

Assessing the safety of magnetic resonance imaging in cardiac device carriers.

Gesu E, Colombo G, Moffat JV; Gruppo di Autoformazione Metodologica (GrAM).

Intern Emerg Med. 2018 May 15. doi: 10.1007/s11739-018-1876-0. [Epub ahead of print] No abstract available.

PMID:
29766404
21.

ERK Mutations and Amplification Confer Resistance to ERK-Inhibitor Therapy.

Jaiswal BS, Durinck S, Stawiski EW, Yin J, Wang W, Lin E, Moffat J, Martin SE, Modrusan Z, Seshagiri S.

Clin Cancer Res. 2018 Aug 15;24(16):4044-4055. doi: 10.1158/1078-0432.CCR-17-3674. Epub 2018 May 14.

PMID:
29760222
22.

The Inhibitory NKR-P1B:Clr-b Recognition Axis Facilitates Detection of Oncogenic Transformation and Cancer Immunosurveillance.

Tanaka M, Fine JH, Kirkham CL, Aguilar OA, Belcheva A, Martin A, Ketela T, Moffat J, Allan DSJ, Carlyle JR.

Cancer Res. 2018 Jul 1;78(13):3589-3603. doi: 10.1158/0008-5472.CAN-17-1688. Epub 2018 Apr 24.

PMID:
29691253
23.

Designing Peptide/Graphene Hybrid Hydrogels through Fine-Tuning of Molecular Interactions.

Wychowaniec JK, Iliut M, Zhou M, Moffat J, Elsawy MA, Pinheiro WA, Hoyland JA, Miller AF, Vijayaraghavan A, Saiani A.

Biomacromolecules. 2018 Jul 9;19(7):2731-2741. doi: 10.1021/acs.biomac.8b00333. Epub 2018 May 2.

24.

Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies.

Pollock SB, Hu A, Mou Y, Martinko AJ, Julien O, Hornsby M, Ploder L, Adams JJ, Geng H, Müschen M, Sidhu SS, Moffat J, Wells JA.

Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2836-2841. doi: 10.1073/pnas.1721899115. Epub 2018 Feb 23.

25.

Correction: Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors.

Merchant M, Moffat J, Schaefer G, Chan J, Wang X, Orr C, Cheng J, Hunsaker T, Shao L, Wang SJ, Wagle MC, Lin E, Haverty PM, Shahidi-Latham S, Ngu H, Solon M, Eastham-Anderson J, Koeppen H, Huang SA, Schwarz J, Belvin M, Kirouac D, Junttila MR.

PLoS One. 2018 Jan 25;13(1):e0192059. doi: 10.1371/journal.pone.0192059. eCollection 2018.

26.

Arid1b haploinsufficiency disrupts cortical interneuron development and mouse behavior.

Jung EM, Moffat JJ, Liu J, Dravid SM, Gurumurthy CB, Kim WY.

Nat Neurosci. 2017 Dec;20(12):1694-1707. doi: 10.1038/s41593-017-0013-0. Epub 2017 Nov 6.

27.

Publisher Correction: Time dependent decomposition of ammonia borane for the controlled production of 2D hexagonal boron nitride.

Babenko V, Lane G, Koos AA, Murdock AT, So K, Britton J, Meysami SS, Moffat J, Grobert N.

Sci Rep. 2017 Nov 22;7(1):16346. doi: 10.1038/s41598-017-16514-y.

28.

Corrigendum: Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors.

Steinhart Z, Pavlovic Z, Chandrashekhar M, Hart T, Wang X, Zhang X, Robitaille M, Brown KR, Jaksani S, Overmeer R, Boj SF, Adams J, Pan J, Clevers H, Sidhu S, Moffat J, Angers S.

Nat Med. 2017 Nov 7;23(11):1384. doi: 10.1038/nm1117-1384d.

PMID:
29117169
29.

Time dependent decomposition of ammonia borane for the controlled production of 2D hexagonal boron nitride.

Babenko V, Lane G, Koos AA, Murdock AT, So K, Britton J, Meysami SS, Moffat J, Grobert N.

Sci Rep. 2017 Oct 30;7(1):14297. doi: 10.1038/s41598-017-14663-8. Erratum in: Sci Rep. 2017 Nov 22;7(1):16346.

30.

Emerging and evolving concepts in gene essentiality.

Rancati G, Moffat J, Typas A, Pavelka N.

Nat Rev Genet. 2018 Jan;19(1):34-49. doi: 10.1038/nrg.2017.74. Epub 2017 Oct 16. Review.

PMID:
29033457
31.

Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors.

Merchant M, Moffat J, Schaefer G, Chan J, Wang X, Orr C, Cheng J, Hunsaker T, Shao L, Wang SJ, Wagle MC, Lin E, Haverty PM, Shahidi-Latham S, Ngu H, Solon M, Eastham-Anderson J, Koeppen H, Huang SA, Schwarz J, Belvin M, Kirouac D, Junttila MR.

PLoS One. 2017 Oct 5;12(10):e0185862. doi: 10.1371/journal.pone.0185862. eCollection 2017. Erratum in: PLoS One. 2018 Jan 25;13(1):e0192059.

32.

Targeting the alternative sigma factor RpoN to combat virulence in Pseudomonas aeruginosa.

Lloyd MG, Lundgren BR, Hall CW, Gagnon LB, Mah TF, Moffat JF, Nomura CT.

Sci Rep. 2017 Oct 3;7(1):12615. doi: 10.1038/s41598-017-12667-y.

33.

Erratum: Clinical responses to ERK inhibition in BRAFV600E-mutant colorectal cancer predicted using a computational model.

Kirouac DC, Schaefer G, Chan J, Merchant M, Orr C, Huang SA, Moffat J, Liu L, Gadkar K, Ramanujan S.

NPJ Syst Biol Appl. 2017 Sep 4;3:25. doi: 10.1038/s41540-017-0026-z. eCollection 2017.

34.

NMR and Rheological Study of Anion Size Influence on the Properties of Two Imidazolium-based Ionic Liquids.

Green SM, Ries ME, Moffat J, Budtova T.

Sci Rep. 2017 Aug 21;7(1):8968. doi: 10.1038/s41598-017-09509-2.

35.

RNAi screen identifies essential regulators of human brain metastasis-initiating cells.

Singh M, Venugopal C, Tokar T, Brown KR, McFarlane N, Bakhshinyan D, Vijayakumar T, Manoranjan B, Mahendram S, Vora P, Qazi M, Dhillon M, Tong A, Durrer K, Murty N, Hallet R, Hassell JA, Kaplan DR, Cutz JC, Jurisica I, Moffat J, Singh SK.

Acta Neuropathol. 2017 Dec;134(6):923-940. doi: 10.1007/s00401-017-1757-z. Epub 2017 Aug 1.

PMID:
28766011
36.

Opportunities and challenges in phenotypic drug discovery: an industry perspective.

Moffat JG, Vincent F, Lee JA, Eder J, Prunotto M.

Nat Rev Drug Discov. 2017 Aug;16(8):531-543. doi: 10.1038/nrd.2017.111. Epub 2017 Jul 7. Review.

PMID:
28685762
37.

Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens.

Hart T, Tong AHY, Chan K, Van Leeuwen J, Seetharaman A, Aregger M, Chandrashekhar M, Hustedt N, Seth S, Noonan A, Habsid A, Sizova O, Nedyalkova L, Climie R, Tworzyanski L, Lawson K, Sartori MA, Alibeh S, Tieu D, Masud S, Mero P, Weiss A, Brown KR, Usaj M, Billmann M, Rahman M, Constanzo M, Myers CL, Andrews BJ, Boone C, Durocher D, Moffat J.

G3 (Bethesda). 2017 Aug 7;7(8):2719-2727. doi: 10.1534/g3.117.041277.

38.

Clinical responses to ERK inhibition in BRAFV600E-mutant colorectal cancer predicted using a computational model.

Kirouac DC, Schaefer G, Chan J, Merchant M, Orr C, Huang SA, Moffat J, Liu L, Gadkar K, Ramanujan S.

NPJ Syst Biol Appl. 2017 Jun 2;3:14. doi: 10.1038/s41540-017-0016-1. eCollection 2017. Erratum in: NPJ Syst Biol Appl. 2017 Sep 4;3:25.

39.

Generation and Validation of Intracellular Ubiquitin Variant Inhibitors for USP7 and USP10.

Zhang W, Sartori MA, Makhnevych T, Federowicz KE, Dong X, Liu L, Nim S, Dong A, Yang J, Li Y, Haddad D, Ernst A, Heerding D, Tong Y, Moffat J, Sidhu SS.

J Mol Biol. 2017 Nov 10;429(22):3546-3560. doi: 10.1016/j.jmb.2017.05.025. Epub 2017 Jun 3.

PMID:
28587923
40.

The role of MACF1 in nervous system development and maintenance.

Moffat JJ, Ka M, Jung EM, Smith AL, Kim WY.

Semin Cell Dev Biol. 2017 Sep;69:9-17. doi: 10.1016/j.semcdb.2017.05.020. Epub 2017 Jun 1. Review.

41.

Turning the Light On in the Phenotypic Drug Discovery Black Box.

Moffat JG.

Cell Chem Biol. 2017 May 18;24(5):545-547. doi: 10.1016/j.chembiol.2017.05.005.

42.

Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability.

Wang X, Kolesnikov A, Tay S, Chan G, Chao Q, Do S, Drummond J, Ebens AJ, Liu N, Ly J, Harstad E, Hu H, Moffat J, Munugalavadla V, Murray J, Slaga D, Tsui V, Volgraf M, Wallweber H, Chang JH.

J Med Chem. 2017 May 25;60(10):4458-4473. doi: 10.1021/acs.jmedchem.7b00418. Epub 2017 May 5.

PMID:
28445037
43.

Intratumoral heterogeneity: pathways to treatment resistance and relapse in human glioblastoma.

Qazi MA, Vora P, Venugopal C, Sidhu SS, Moffat J, Swanton C, Singh SK.

Ann Oncol. 2017 Jul 1;28(7):1448-1456. doi: 10.1093/annonc/mdx169. Review.

PMID:
28407030
44.

Regulatory T cells promote myelin regeneration in the central nervous system.

Dombrowski Y, O'Hagan T, Dittmer M, Penalva R, Mayoral SR, Bankhead P, Fleville S, Eleftheriadis G, Zhao C, Naughton M, Hassan R, Moffat J, Falconer J, Boyd A, Hamilton P, Allen IV, Kissenpfennig A, Moynagh PN, Evergren E, Perbal B, Williams AC, Ingram RJ, Chan JR, Franklin RJM, Fitzgerald DC.

Nat Neurosci. 2017 May;20(5):674-680. doi: 10.1038/nn.4528. Epub 2017 Mar 13.

45.

SMYD2 lysine methyltransferase regulates leukemia cell growth and regeneration after genotoxic stress.

Zipin-Roitman A, Aqaqe N, Yassin M, Biechonski S, Amar M, van Delft MF, Gan OI, McDermott SP, Buzina A, Ketela T, Shlush L, Xie S, Voisin V, Moffat J, Minden MD, Dick JE, Milyavsky M.

Oncotarget. 2017 Mar 7;8(10):16712-16727. doi: 10.18632/oncotarget.15147.

46.

Multilayered Control of Alternative Splicing Regulatory Networks by Transcription Factors.

Han H, Braunschweig U, Gonatopoulos-Pournatzis T, Weatheritt RJ, Hirsch CL, Ha KCH, Radovani E, Nabeel-Shah S, Sterne-Weiler T, Wang J, O'Hanlon D, Pan Q, Ray D, Zheng H, Vizeacoumar F, Datti A, Magomedova L, Cummins CL, Hughes TR, Greenblatt JF, Wrana JL, Moffat J, Blencowe BJ.

Mol Cell. 2017 Feb 2;65(3):539-553.e7. doi: 10.1016/j.molcel.2017.01.011.

47.

Design and Experimental Validation of Small Activating RNAs Targeting an Exogenous Promoter in Human Cells.

Harris EA, Buzina A, Moffat J, McMillen DR.

ACS Synth Biol. 2017 Apr 21;6(4):628-637. doi: 10.1021/acssynbio.6b00125. Epub 2017 Jan 17.

PMID:
28033709
48.

Identifying anticipated barriers to help-seeking to promote earlier diagnosis of cancer in Great Britain.

Moffat J, Hinchliffe R, Ironmonger L, Osborne K.

Public Health. 2016 Dec;141:120-125. doi: 10.1016/j.puhe.2016.08.012. Epub 2016 Oct 13. No abstract available.

49.

Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors.

Steinhart Z, Pavlovic Z, Chandrashekhar M, Hart T, Wang X, Zhang X, Robitaille M, Brown KR, Jaksani S, Overmeer R, Boj SF, Adams J, Pan J, Clevers H, Sidhu S, Moffat J, Angers S.

Nat Med. 2017 Jan;23(1):60-68. doi: 10.1038/nm.4219. Epub 2016 Nov 21. Erratum in: Nat Med. 2017 Nov 7;23 (11):1384.

PMID:
27869803
50.

Kin17 facilitates multiple double-strand break repair pathways that govern B cell class switching.

Le MX, Haddad D, Ling AK, Li C, So CC, Chopra A, Hu R, Angulo JF, Moffat J, Martin A.

Sci Rep. 2016 Nov 17;6:37215. doi: 10.1038/srep37215.

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