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Forward genetic screen in human podocytes identifies diphthamide biosynthesis genes as regulators of adhesion.

Cina DP, Ketela T, Brown KR, Chandrashekhar M, Mero P, Li C, Onay T, Fu Y, Han Z, Saleem MA, Moffat J, Quaggin SE.

Am J Physiol Renal Physiol. 2019 Sep 30. doi: 10.1152/ajprenal.00195.2019. [Epub ahead of print]


High-throughput genome-wide phenotypic screening via immunomagnetic cell sorting.

Mair B, Aldridge PM, Atwal RS, Philpott D, Zhang M, Masud SN, Labib M, Tong AHY, Sargent EH, Angers S, Moffat J, Kelley SO.

Nat Biomed Eng. 2019 Oct;3(10):796-805. doi: 10.1038/s41551-019-0454-8. Epub 2019 Sep 23.


Pooled CRISPR-Based Genetic Screens in Mammalian Cells.

Chan K, Tong AHY, Brown KR, Mero P, Moffat J.

J Vis Exp. 2019 Sep 4;(151). doi: 10.3791/59780.


CRISPR screens are feasible in TP53 wild-type cells.

Brown KR, Mair B, Soste M, Moffat J.

Mol Syst Biol. 2019 Aug;15(8):e8679. doi: 10.15252/msb.20188679.


Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice.

Tao Y, Mis M, Blazer L, Ustav M Jnr, Steinhart Z, Chidiac R, Kubarakos E, O'Brien S, Wang X, Jarvik N, Patel N, Adams J, Moffat J, Angers S, Sidhu SS.

Elife. 2019 Aug 27;8. pii: e46134. doi: 10.7554/eLife.46134.


Identifying chemogenetic interactions from CRISPR screens with drugZ.

Colic M, Wang G, Zimmermann M, Mascall K, McLaughlin M, Bertolet L, Lenoir WF, Moffat J, Angers S, Durocher D, Hart T.

Genome Med. 2019 Aug 22;11(1):52. doi: 10.1186/s13073-019-0665-3.


Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2.

Pegram LM, Liddle JC, Xiao Y, Hoh M, Rudolph J, Iverson DB, Vigers GP, Smith D, Zhang H, Wang W, Moffat JG, Ahn NG.

Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15463-15468. doi: 10.1073/pnas.1906824116. Epub 2019 Jul 16.


Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma.

Bronner SM, Merrick KA, Murray J, Salphati L, Moffat JG, Pang J, Sneeringer CJ, Dompe N, Cyr P, Purkey H, Boenig GL, Li J, Kolesnikov A, Larouche-Gauthier R, Lai KW, Shen X, Aubert-Nicol S, Chen YC, Cheong J, Crawford JJ, Hafner M, Haghshenas P, Jakalian A, Leclerc JP, Lim NK, O'Brien T, Plise EG, Shalan H, Sturino C, Wai J, Xiao Y, Yin J, Zhao L, Gould S, Olivero A, Heffron TP.

Bioorg Med Chem Lett. 2019 Aug 15;29(16):2294-2301. doi: 10.1016/j.bmcl.2019.06.021. Epub 2019 Jun 26.


Establishing population-based surveillance of diagnostic timeliness using linked cancer registry and administrative data for patients with colorectal and lung cancer.

Pearson C, Fraser J, Peake M, Valori R, Poirier V, Coupland VH, Hiom S, McPhail S, Moffat J, Lyratzopoulos G, Shelton J.

Cancer Epidemiol. 2019 Aug;61:111-118. doi: 10.1016/j.canep.2019.05.010. Epub 2019 Jun 15.


Bmi1 regulates human glioblastoma stem cells through activation of differential gene networks in CD133+ brain tumor initiating cells.

Vora P, Seyfrid M, Venugopal C, Qazi MA, Salim S, Isserlin R, Subapanditha M, O'Farrell E, Mahendram S, Singh M, Bakhshinyan D, Chokshi C, McFarlane N, Dvorkin-Gheva A, Brown KR, Murty N, Moffat J, Bader GD, Singh SK.

J Neurooncol. 2019 Jul;143(3):417-428. doi: 10.1007/s11060-019-03192-1. Epub 2019 May 21.


Genetic interaction networks in cancer cells.

Mair B, Moffat J, Boone C, Andrews BJ.

Curr Opin Genet Dev. 2019 Feb;54:64-72. doi: 10.1016/j.gde.2019.03.002. Epub 2019 Apr 8. Review.


Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies.

Mair B, Tomic J, Masud SN, Tonge P, Weiss A, Usaj M, Tong AHY, Kwan JJ, Brown KR, Titus E, Atkins M, Chan KSK, Munsie L, Habsid A, Han H, Kennedy M, Cohen B, Keller G, Moffat J.

Cell Rep. 2019 Apr 9;27(2):599-615.e12. doi: 10.1016/j.celrep.2019.02.041.


Global Genetic Networks and the Genotype-to-Phenotype Relationship.

Costanzo M, Kuzmin E, van Leeuwen J, Mair B, Moffat J, Boone C, Andrews B.

Cell. 2019 Mar 21;177(1):85-100. doi: 10.1016/j.cell.2019.01.033. Review.


Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies.

Raman S, Beilschmidt M, To M, Lin K, Lui F, Jmeian Y, Ng M, Fernandez M, Fu Y, Mascall K, Duque A, Wang X, Pan G, Angers S, Moffat J, Sidhu SS, Magram J, Sinclair AM, Fransson J, Julien JP.

Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6812-6817. doi: 10.1073/pnas.1817246116. Epub 2019 Mar 20.


Early intervention programmes for infants at high risk of atypical neurodevelopmental outcome.

Hutchon B, Gibbs D, Harniess P, Jary S, Crossley SL, Moffat JV, Basu N, Basu AP.

Dev Med Child Neurol. 2019 Mar 4. doi: 10.1111/dmcn.14187. [Epub ahead of print] Review.


Yeast Two-Hybrid Analysis for Ubiquitin Variant Inhibitors of Human Deubiquitinases.

Pascoe N, Seetharaman A, Teyra J, Manczyk N, Satori MA, Tjandra D, Makhnevych T, Schwerdtfeger C, Brasher BB, Moffat J, Costanzo M, Boone C, Sicheri F, Sidhu SS.

J Mol Biol. 2019 Mar 15;431(6):1160-1171. doi: 10.1016/j.jmb.2019.02.007. Epub 2019 Feb 11.


Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma.

Wang X, Blackaby W, Allen V, Chan GKY, Chang JH, Chiang PC, Diène C, Drummond J, Do S, Fan E, Harstad EB, Hodges A, Hu H, Jia W, Kofie W, Kolesnikov A, Lyssikatos JP, Ly J, Matteucci M, Moffat JG, Munugalavadla V, Murray J, Nash D, Noland CL, Del Rosario G, Ross L, Rouse C, Sharpe A, Slaga D, Sun M, Tsui V, Wallweber H, Yu SF, Ebens AJ.

J Med Chem. 2019 Feb 28;62(4):2140-2153. doi: 10.1021/acs.jmedchem.8b01857. Epub 2019 Feb 20.


Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.

Teyra J, Singer AU, Schmitges FW, Jaynes P, Kit Leng Lui S, Polyak MJ, Fodil N, Krieger JR, Tong J, Schwerdtfeger C, Brasher BB, Ceccarelli DFJ, Moffat J, Sicheri F, Moran MF, Gros P, Eichhorn PJA, Lenter M, Boehmelt G, Sidhu SS.

Structure. 2019 Apr 2;27(4):590-605.e5. doi: 10.1016/j.str.2019.01.002. Epub 2019 Jan 31.


The fate of cellulose nanocrystal stabilised emulsions after simulated gastrointestinal digestion and exposure to intestinal mucosa.

Mackie A, Gourcy S, Rigby N, Moffat J, Capron I, Bajka B.

Nanoscale. 2019 Feb 7;11(6):2991-2998. doi: 10.1039/c8nr05860a.


A rapid in vitro methodology for simultaneous target discovery and antibody generation against functional cell subpopulations.

Nixon AML, Duque A, Yelle N, McLaughlin M, Davoudi S, Pedley NM, Haynes J, Brown KR, Pan J, Hart T, Gilbert PM, Singh SK, O'Brien CA, Sidhu SS, Moffat J.

Sci Rep. 2019 Jan 29;9(1):842. doi: 10.1038/s41598-018-37462-1.


Effect of the Pulmonary Embolism Rule-Out Criteria on subsequent thromboembolic events among low-risk emergency department patients: the PROPER randomized clinical trial.

Malavolta D, Quatela V, Moffat J, Ottolini BB; GrAM (Gruppo di Autoformazione metodologica).

Intern Emerg Med. 2019 Mar;14(2):309-310. doi: 10.1007/s11739-019-02027-1. Epub 2019 Jan 16. No abstract available.


Targeting discriminatory SNPs in Salmonella enterica serovar Heidelberg genomes using RNase H2-dependent PCR.

Labbé G, Rankin MA, Robertson J, Moffat J, Giang E, Lee LK, Ziebell K, MacKinnon J, Laing CR, Parmley EJ, Agunos A, Daignault D, Bekal S, Chui L, MacDonald KA, Hoang L, Slavic D, Ramsay D, Pollari F, Nash JHE, Johnson RP.

J Microbiol Methods. 2019 Feb;157:81-87. doi: 10.1016/j.mimet.2018.12.021. Epub 2018 Dec 25.


Functional genomic characterization of a synthetic anti-HER3 antibody reveals a role for ubiquitination by RNF41 in the anti-proliferative response.

Turowec JP, Lau EWT, Wang X, Brown KR, Fellouse FA, Jawanda KK, Pan J, Moffat J, Sidhu SS.

J Biol Chem. 2019 Jan 25;294(4):1396-1409. doi: 10.1074/jbc.RA118.004420. Epub 2018 Dec 6.


Discovery of potent azaindazole leucine-rich repeat kinase 2 (LRRK2) inhibitors possessing a key intramolecular hydrogen bond - Part 2.

Shore DGM, Sweeney ZK, Beresford A, Chan BK, Chen H, Drummond J, Gill A, Kleinheinz T, Liu X, Medhurst AD, McIver EG, Moffat JG, Zhu H, Estrada AA.

Bioorg Med Chem Lett. 2019 Feb 15;29(4):674-680. doi: 10.1016/j.bmcl.2018.10.017. Epub 2018 Oct 12.


Monitoring Drug Crystallization in Percutaneous Penetration Using Localized Nanothermal Analysis and Photothermal Microspectroscopy.

Goh CF, Moffat JG, Craig DQM, Hadgraft J, Lane ME.

Mol Pharm. 2019 Jan 7;16(1):359-370. doi: 10.1021/acs.molpharmaceut.8b01027. Epub 2018 Dec 20.


Eukaryotic Voltage-Gated Sodium Channels: On Their Origins, Asymmetries, Losses, Diversification and Adaptations.

Fux JE, Mehta A, Moffat J, Spafford JD.

Front Physiol. 2018 Nov 21;9:1406. doi: 10.3389/fphys.2018.01406. eCollection 2018.


Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer.

Wu P, Sneeringer CJ, Pitts KE, Day ES, Chan BK, Wei B, Lehoux I, Mortara K, Li H, Wu J, Franke Y, Moffat JG, Grogan JL, Heffron TP, Wang W.

Structure. 2019 Jan 2;27(1):125-133.e4. doi: 10.1016/j.str.2018.10.025. Epub 2018 Nov 29.


Using Bayesian network modelling to untangle farm management risk factors for bovine viral diarrhoea virus infection.

Han JH, Holter J, Moffat J, Weston JF, Heuer C, Gates MC.

Prev Vet Med. 2018 Dec 1;161:75-82. doi: 10.1016/j.prevetmed.2018.10.014. Epub 2018 Oct 28.


Protocadherin-1 is essential for cell entry by New World hantaviruses.

Jangra RK, Herbert AS, Li R, Jae LT, Kleinfelter LM, Slough MM, Barker SL, Guardado-Calvo P, Román-Sosa G, Dieterle ME, Kuehne AI, Muena NA, Wirchnianski AS, Nyakatura EK, Fels JM, Ng M, Mittler E, Pan J, Bharrhan S, Wec AZ, Lai JR, Sidhu SS, Tischler ND, Rey FA, Moffat J, Brummelkamp TR, Wang Z, Dye JM, Chandran K.

Nature. 2018 Nov;563(7732):559-563. doi: 10.1038/s41586-018-0702-1. Epub 2018 Nov 21.


Lung cancer screening - gaining consensus on next steps - proceedings of a closed workshop in the UK.

Moffat J, Hiom S, Kumar HS, Baldwin DR.

Lung Cancer. 2018 Nov;125:121-127. doi: 10.1016/j.lungcan.2018.07.029. Epub 2018 Jul 21. Review.


Genome-wide CRISPR-Cas9 Interrogation of Splicing Networks Reveals a Mechanism for Recognition of Autism-Misregulated Neuronal Microexons.

Gonatopoulos-Pournatzis T, Wu M, Braunschweig U, Roth J, Han H, Best AJ, Raj B, Aregger M, O'Hanlon D, Ellis JD, Calarco JA, Moffat J, Gingras AC, Blencowe BJ.

Mol Cell. 2018 Nov 1;72(3):510-524.e12. doi: 10.1016/j.molcel.2018.10.008.


Pooled Lentiviral CRISPR-Cas9 Screens for Functional Genomics in Mammalian Cells.

Aregger M, Chandrashekhar M, Tong AHY, Chan K, Moffat J.

Methods Mol Biol. 2019;1869:169-188. doi: 10.1007/978-1-4939-8805-1_15.


EPH Profiling of BTIC Populations in Glioblastoma Multiforme Using CyTOF.

Hu AX, Adams JJ, Vora P, Qazi M, Singh SK, Moffat J, Sidhu SS.

Methods Mol Biol. 2019;1869:155-168. doi: 10.1007/978-1-4939-8805-1_14.


A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor properties.

Pavlovic Z, Adams JJ, Blazer LL, Gakhal AK, Jarvik N, Steinhart Z, Robitaille M, Mascall K, Pan J, Angers S, Moffat J, Sidhu SS.

MAbs. 2018 Nov-Dec;10(8):1157-1167. doi: 10.1080/19420862.2018.1515565. Epub 2018 Sep 25.


Microscopic and Macroscopic Properties of Carbohydrate Solutions in the Ionic Liquid 1-Ethyl-3-methyl-imidazolium Acetate.

Ries ME, Radhi A, Green SM, Moffat J, Budtova T.

J Phys Chem B. 2018 Sep 20;122(37):8763-8771. doi: 10.1021/acs.jpcb.8b06939. Epub 2018 Sep 6.


The role of ARID1B, a BAF chromatin remodeling complex subunit, in neural development and behavior.

Moffat JJ, Jung EM, Ka M, Smith AL, Jeon BT, Santen GWE, Kim WY.

Prog Neuropsychopharmacol Biol Psychiatry. 2019 Mar 8;89:30-38. doi: 10.1016/j.pnpbp.2018.08.021. Epub 2018 Aug 24. Review.


Meeting report: 31st International Conference on Antiviral Research.

Bray M, Andrei G, Ballana E, Carter K, Durantel D, Gentry B, Janeba Z, Moffat J, Oomen CJ, Tarbet B, Riveira-Muñoz E, Esté JA; International Society for Antiviral Research.

Antiviral Res. 2018 Oct;158:88-102. doi: 10.1016/j.antiviral.2018.08.002. Epub 2018 Aug 4.


The shieldin complex mediates 53BP1-dependent DNA repair.

Noordermeer SM, Adam S, Setiaputra D, Barazas M, Pettitt SJ, Ling AK, Olivieri M, Álvarez-Quilón A, Moatti N, Zimmermann M, Annunziato S, Krastev DB, Song F, Brandsma I, Frankum J, Brough R, Sherker A, Landry S, Szilard RK, Munro MM, McEwan A, Goullet de Rugy T, Lin ZY, Hart T, Moffat J, Gingras AC, Martin A, van Attikum H, Jonkers J, Lord CJ, Rottenberg S, Durocher D.

Nature. 2018 Aug;560(7716):117-121. doi: 10.1038/s41586-018-0340-7. Epub 2018 Jul 18.


Cellular Stress Response to Varicella-Zoster Virus Infection of Human Skin Includes Highly Elevated Interleukin-6 Expression.

Jarosinski KW, Carpenter JE, Buckingham EM, Jackson W, Knudtson K, Moffat JF, Kita H, Grose C.

Open Forum Infect Dis. 2018 May 22;5(6):ofy118. doi: 10.1093/ofid/ofy118. eCollection 2018 Jun.


CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions.

Zimmermann M, Murina O, Reijns MAM, Agathanggelou A, Challis R, Tarnauskaitė Ž, Muir M, Fluteau A, Aregger M, McEwan A, Yuan W, Clarke M, Lambros MB, Paneesha S, Moss P, Chandrashekhar M, Angers S, Moffat J, Brunton VG, Hart T, de Bono J, Stankovic T, Jackson AP, Durocher D.

Nature. 2018 Jul;559(7713):285-289. doi: 10.1038/s41586-018-0291-z. Epub 2018 Jul 4.


Cotargeting Ephrin Receptor Tyrosine Kinases A2 and A3 in Cancer Stem Cells Reduces Growth of Recurrent Glioblastoma.

Qazi MA, Vora P, Venugopal C, Adams J, Singh M, Hu A, Gorelik M, Subapanditha MK, Savage N, Yang J, Chokshi C, London M, Gont A, Bobrowski D, Grinshtein N, Brown KR, Murty NK, Nilvebrant J, Kaplan D, Moffat J, Sidhu S, Singh SK.

Cancer Res. 2018 Sep 1;78(17):5023-5037. doi: 10.1158/0008-5472.CAN-18-0267. Epub 2018 Jun 26.


Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48.

Velimezi G, Robinson-Garcia L, Muñoz-Martínez F, Wiegant WW, Ferreira da Silva J, Owusu M, Moder M, Wiedner M, Rosenthal SB, Fisch KM, Moffat J, Menche J, van Attikum H, Jackson SP, Loizou JI.

Nat Commun. 2018 Jun 11;9(1):2280. doi: 10.1038/s41467-018-04649-z.


A transcriptional MAPK Pathway Activity Score (MPAS) is a clinically relevant biomarker in multiple cancer types.

Wagle MC, Kirouac D, Klijn C, Liu B, Mahajan S, Junttila M, Moffat J, Merchant M, Huw L, Wongchenko M, Okrah K, Srinivasan S, Mounir Z, Sumiyoshi T, Haverty PM, Yauch RL, Yan Y, Kabbarah O, Hampton G, Amler L, Ramanujan S, Lackner MR, Huang SA.

NPJ Precis Oncol. 2018 Mar 7;2(1):7. doi: 10.1038/s41698-018-0051-4. eCollection 2018.


Assessing the safety of magnetic resonance imaging in cardiac device carriers.

Gesu E, Colombo G, Moffat JV; Gruppo di Autoformazione Metodologica (GrAM).

Intern Emerg Med. 2018 Sep;13(6):933-935. doi: 10.1007/s11739-018-1876-0. Epub 2018 May 15. No abstract available.


ERK Mutations and Amplification Confer Resistance to ERK-Inhibitor Therapy.

Jaiswal BS, Durinck S, Stawiski EW, Yin J, Wang W, Lin E, Moffat J, Martin SE, Modrusan Z, Seshagiri S.

Clin Cancer Res. 2018 Aug 15;24(16):4044-4055. doi: 10.1158/1078-0432.CCR-17-3674. Epub 2018 May 14.


The Inhibitory NKR-P1B:Clr-b Recognition Axis Facilitates Detection of Oncogenic Transformation and Cancer Immunosurveillance.

Tanaka M, Fine JH, Kirkham CL, Aguilar OA, Belcheva A, Martin A, Ketela T, Moffat J, Allan DSJ, Carlyle JR.

Cancer Res. 2018 Jul 1;78(13):3589-3603. doi: 10.1158/0008-5472.CAN-17-1688. Epub 2018 Apr 24.


Designing Peptide/Graphene Hybrid Hydrogels through Fine-Tuning of Molecular Interactions.

Wychowaniec JK, Iliut M, Zhou M, Moffat J, Elsawy MA, Pinheiro WA, Hoyland JA, Miller AF, Vijayaraghavan A, Saiani A.

Biomacromolecules. 2018 Jul 9;19(7):2731-2741. doi: 10.1021/acs.biomac.8b00333. Epub 2018 May 2.


Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies.

Pollock SB, Hu A, Mou Y, Martinko AJ, Julien O, Hornsby M, Ploder L, Adams JJ, Geng H, Müschen M, Sidhu SS, Moffat J, Wells JA.

Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2836-2841. doi: 10.1073/pnas.1721899115. Epub 2018 Feb 23.


Correction: Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors.

Merchant M, Moffat J, Schaefer G, Chan J, Wang X, Orr C, Cheng J, Hunsaker T, Shao L, Wang SJ, Wagle MC, Lin E, Haverty PM, Shahidi-Latham S, Ngu H, Solon M, Eastham-Anderson J, Koeppen H, Huang SA, Schwarz J, Belvin M, Kirouac D, Junttila MR.

PLoS One. 2018 Jan 25;13(1):e0192059. doi: 10.1371/journal.pone.0192059. eCollection 2018.

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