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Items: 1 to 20 of 370

1.

IPO11 mediates βcatenin nuclear import in a subset of colorectal cancers.

Mis M, O'Brien S, Steinhart Z, Lin S, Hart T, Moffat J, Angers S.

J Cell Biol. 2020 Feb 3;219(2). pii: e201903017. doi: 10.1083/jcb.201903017.

PMID:
31881079
2.

Evaluation of a national lung cancer symptom awareness campaign in Wales.

McCutchan G, Smits S, Ironmonger L, Slyne C, Boughey A, Moffat J, Thomas R, Huws DW, Brain K.

Br J Cancer. 2019 Dec 16. doi: 10.1038/s41416-019-0676-2. [Epub ahead of print]

PMID:
31839675
3.

mTORC1 in the orbitofrontal cortex promotes habitual alcohol seeking.

Morisot N, Phamluong K, Ehinger Y, Berger AL, Moffat JJ, Ron D.

Elife. 2019 Dec 11;8. pii: e51333. doi: 10.7554/eLife.51333.

4.

A CD133-AKT-Wnt signaling axis drives glioblastoma brain tumor-initiating cells.

Manoranjan B, Chokshi C, Venugopal C, Subapanditha M, Savage N, Tatari N, Provias JP, Murty NK, Moffat J, Doble BW, Singh SK.

Oncogene. 2019 Nov 6. doi: 10.1038/s41388-019-1086-x. [Epub ahead of print]

PMID:
31695152
5.

Forward genetic screen in human podocytes identifies diphthamide biosynthesis genes as regulators of adhesion.

Cinà DP, Ketela T, Brown KR, Chandrashekhar M, Mero P, Li C, Onay T, Fu Y, Han Z, Saleem M, Moffat J, Quaggin SE.

Am J Physiol Renal Physiol. 2019 Dec 1;317(6):F1593-F1604. doi: 10.1152/ajprenal.00195.2019. Epub 2019 Sep 30.

PMID:
31566424
6.

High-throughput genome-wide phenotypic screening via immunomagnetic cell sorting.

Mair B, Aldridge PM, Atwal RS, Philpott D, Zhang M, Masud SN, Labib M, Tong AHY, Sargent EH, Angers S, Moffat J, Kelley SO.

Nat Biomed Eng. 2019 Oct;3(10):796-805. doi: 10.1038/s41551-019-0454-8. Epub 2019 Sep 23.

PMID:
31548591
7.

Pooled CRISPR-Based Genetic Screens in Mammalian Cells.

Chan K, Tong AHY, Brown KR, Mero P, Moffat J.

J Vis Exp. 2019 Sep 4;(151). doi: 10.3791/59780.

PMID:
31545321
8.

CRISPR screens are feasible in TP53 wild-type cells.

Brown KR, Mair B, Soste M, Moffat J.

Mol Syst Biol. 2019 Aug;15(8):e8679. doi: 10.15252/msb.20188679.

9.

Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice.

Tao Y, Mis M, Blazer L, Ustav M Jnr, Steinhart Z, Chidiac R, Kubarakos E, O'Brien S, Wang X, Jarvik N, Patel N, Adams J, Moffat J, Angers S, Sidhu SS.

Elife. 2019 Aug 27;8. pii: e46134. doi: 10.7554/eLife.46134.

10.

Identifying chemogenetic interactions from CRISPR screens with drugZ.

Colic M, Wang G, Zimmermann M, Mascall K, McLaughlin M, Bertolet L, Lenoir WF, Moffat J, Angers S, Durocher D, Hart T.

Genome Med. 2019 Aug 22;11(1):52. doi: 10.1186/s13073-019-0665-3.

11.

Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2.

Pegram LM, Liddle JC, Xiao Y, Hoh M, Rudolph J, Iverson DB, Vigers GP, Smith D, Zhang H, Wang W, Moffat JG, Ahn NG.

Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15463-15468. doi: 10.1073/pnas.1906824116. Epub 2019 Jul 16.

12.

Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma.

Bronner SM, Merrick KA, Murray J, Salphati L, Moffat JG, Pang J, Sneeringer CJ, Dompe N, Cyr P, Purkey H, Boenig GL, Li J, Kolesnikov A, Larouche-Gauthier R, Lai KW, Shen X, Aubert-Nicol S, Chen YC, Cheong J, Crawford JJ, Hafner M, Haghshenas P, Jakalian A, Leclerc JP, Lim NK, O'Brien T, Plise EG, Shalan H, Sturino C, Wai J, Xiao Y, Yin J, Zhao L, Gould S, Olivero A, Heffron TP.

Bioorg Med Chem Lett. 2019 Aug 15;29(16):2294-2301. doi: 10.1016/j.bmcl.2019.06.021. Epub 2019 Jun 26.

PMID:
31307887
13.

Establishing population-based surveillance of diagnostic timeliness using linked cancer registry and administrative data for patients with colorectal and lung cancer.

Pearson C, Fraser J, Peake M, Valori R, Poirier V, Coupland VH, Hiom S, McPhail S, Moffat J, Lyratzopoulos G, Shelton J.

Cancer Epidemiol. 2019 Aug;61:111-118. doi: 10.1016/j.canep.2019.05.010. Epub 2019 Jun 15.

14.

Bmi1 regulates human glioblastoma stem cells through activation of differential gene networks in CD133+ brain tumor initiating cells.

Vora P, Seyfrid M, Venugopal C, Qazi MA, Salim S, Isserlin R, Subapanditha M, O'Farrell E, Mahendram S, Singh M, Bakhshinyan D, Chokshi C, McFarlane N, Dvorkin-Gheva A, Brown KR, Murty N, Moffat J, Bader GD, Singh SK.

J Neurooncol. 2019 Jul;143(3):417-428. doi: 10.1007/s11060-019-03192-1. Epub 2019 May 21.

PMID:
31115870
15.
16.

Genetic interaction networks in cancer cells.

Mair B, Moffat J, Boone C, Andrews BJ.

Curr Opin Genet Dev. 2019 Feb;54:64-72. doi: 10.1016/j.gde.2019.03.002. Epub 2019 Apr 8. Review.

17.

Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies.

Mair B, Tomic J, Masud SN, Tonge P, Weiss A, Usaj M, Tong AHY, Kwan JJ, Brown KR, Titus E, Atkins M, Chan KSK, Munsie L, Habsid A, Han H, Kennedy M, Cohen B, Keller G, Moffat J.

Cell Rep. 2019 Apr 9;27(2):599-615.e12. doi: 10.1016/j.celrep.2019.02.041.

18.

Global Genetic Networks and the Genotype-to-Phenotype Relationship.

Costanzo M, Kuzmin E, van Leeuwen J, Mair B, Moffat J, Boone C, Andrews B.

Cell. 2019 Mar 21;177(1):85-100. doi: 10.1016/j.cell.2019.01.033. Review.

19.

Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies.

Raman S, Beilschmidt M, To M, Lin K, Lui F, Jmeian Y, Ng M, Fernandez M, Fu Y, Mascall K, Duque A, Wang X, Pan G, Angers S, Moffat J, Sidhu SS, Magram J, Sinclair AM, Fransson J, Julien JP.

Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6812-6817. doi: 10.1073/pnas.1817246116. Epub 2019 Mar 20.

20.

Early intervention programmes for infants at high risk of atypical neurodevelopmental outcome.

Hutchon B, Gibbs D, Harniess P, Jary S, Crossley SL, Moffat JV, Basu N, Basu AP.

Dev Med Child Neurol. 2019 Dec;61(12):1362-1367. doi: 10.1111/dmcn.14187. Epub 2019 Mar 4. Review.

PMID:
30828797

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