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Items: 1 to 50 of 213

1.

Specific targeting of CD163+ TAMs mobilizes inflammatory monocytes and promotes T cell-mediated tumor regression.

Etzerodt A, Tsalkitzi K, Maniecki M, Damsky W, Delfini M, Baudoin E, Moulin M, Bosenberg M, Graversen JH, Auphan-Anezin N, Moestrup SK, Lawrence T.

J Exp Med. 2019 Aug 2. pii: jem.20182124. doi: 10.1084/jem.20182124. [Epub ahead of print]

PMID:
31375534
2.

The macrophage-related biomarkers sCD163 and sCD206 are released by different shedding mechanisms.

Nielsen MC, Andersen MN, Rittig N, Rødgaard-Hansen S, Grønbaek H, Moestrup SK, Møller HJ, Etzerodt A.

J Leukoc Biol. 2019 Jun 26. doi: 10.1002/JLB.3A1218-500R. [Epub ahead of print]

PMID:
31242338
3.

Using the hemoglobin-binding Staphylococcus aureus protein IsdH to enable plasma analysis of hemolyzed blood samples.

Sæderup KL, Revsholm J, Richardt PB, Christiansen SH, Hennig D, Moestrup SK, Graversen JH.

Clin Chem Lab Med. 2019 Jun 22. pii: /j/cclm.ahead-of-print/cclm-2019-0381/cclm-2019-0381.xml. doi: 10.1515/cclm-2019-0381. [Epub ahead of print]

PMID:
31228860
4.

Targeted lipid nanoparticle delivery of calcitriol to human monocyte-derived macrophages in vitro and in vivo: investigation of the anti-inflammatory effects of calcitriol.

Rafique A, Etzerodt A, Graversen JH, Moestrup SK, Dagnæs-Hansen F, Møller HJ.

Int J Nanomedicine. 2019 Apr 23;14:2829-2846. doi: 10.2147/IJN.S192113. eCollection 2019.

5.

STAT3 inhibition specifically in human monocytes and macrophages by CD163-targeted corosolic acid-containing liposomes.

Andersen MN, Etzerodt A, Graversen JH, Holthof LC, Moestrup SK, Hokland M, Møller HJ.

Cancer Immunol Immunother. 2019 Mar;68(3):489-502. doi: 10.1007/s00262-019-02301-3. Epub 2019 Jan 14.

PMID:
30637473
6.

Structural assembly of the megadalton-sized receptor for intestinal vitamin B12 uptake and kidney protein reabsorption.

Larsen C, Etzerodt A, Madsen M, Skjødt K, Moestrup SK, Andersen CBF.

Nat Commun. 2018 Dec 6;9(1):5204. doi: 10.1038/s41467-018-07468-4.

7.

Diet-Induced Abdominal Obesity, Metabolic Changes, and Atherosclerosis in Hypercholesterolemic Minipigs.

Al-Mashhadi AL, Poulsen CB, von Wachenfeldt K, Robertson AK, Bentzon JF, Nielsen LB, Thygesen J, Tolbod LP, Larsen JR, Moestrup SK, Frendéus B, Mortensen B, Drouet L, Al-Mashhadi RH, Falk E.

J Diabetes Res. 2018 Feb 25;2018:6823193. doi: 10.1155/2018/6823193. eCollection 2018.

8.

Decreased expression of megalin and cubilin and altered mitochondrial activity in tenofovir nephrotoxicity.

Cez A, Brocheriou I, Lescure FX, Adam C, Girard PM, Pialoux G, Moestrup SK, Fellahi S, Bastard JP, Ronco P, Plaisier E.

Hum Pathol. 2018 Mar;73:89-101. doi: 10.1016/j.humpath.2017.12.018. Epub 2018 Jan 5.

PMID:
29309806
9.

The class I scavenger receptor CD163 promotes internalization of ADAMTS13 by macrophages.

Verbij FC, Sorvillo N, Kaijen PHP, Hrdinova J, Peyron I, Fijnheer R, Ten Brinke A, Meijer AB, van Alphen FPJ, van den Berg TK, Graversen JJH, Moestrup SK, Voorberg J.

Blood Adv. 2017 Jan 16;1(5):293-305. doi: 10.1182/bloodadvances.2016001321. eCollection 2017 Jan 24.

10.

Extracellular Vesicles Transfer the Receptor Programmed Death-1 in Rheumatoid Arthritis.

Greisen SR, Yan Y, Hansen AS, Venø MT, Nyengaard JR, Moestrup SK, Hvid M, Freeman GJ, Kjems J, Deleuran B.

Front Immunol. 2017 Jul 24;8:851. doi: 10.3389/fimmu.2017.00851. eCollection 2017.

11.

Cellular uptake of proMMP-2:TIMP-2 complexes by the endocytic receptor megalin/LRP-2.

Johanns M, Lemoine P, Janssens V, Grieco G, Moestrup SK, Nielsen R, Christensen EI, Courtoy PJ, Emonard H, Marbaix E, Henriet P.

Sci Rep. 2017 Jun 28;7(1):4328. doi: 10.1038/s41598-017-04648-y.

12.

A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease.

PrabhuDas MR, Baldwin CL, Bollyky PL, Bowdish DME, Drickamer K, Febbraio M, Herz J, Kobzik L, Krieger M, Loike J, McVicker B, Means TK, Moestrup SK, Post SR, Sawamura T, Silverstein S, Speth RC, Telfer JC, Thiele GM, Wang XY, Wright SD, El Khoury J.

J Immunol. 2017 May 15;198(10):3775-3789. doi: 10.4049/jimmunol.1700373.

13.

The absence of the CD163 receptor has distinct temporal influences on intracerebral hemorrhage outcomes.

Leclerc JL, Lampert AS, Loyola Amador C, Schlakman B, Vasilopoulos T, Svendsen P, Moestrup SK, Doré S.

J Cereb Blood Flow Metab. 2018 Feb;38(2):262-273. doi: 10.1177/0271678X17701459. Epub 2017 Mar 30.

14.

Antibody-Directed Glucocorticoid Targeting to CD163 in M2-type Macrophages Attenuates Fructose-Induced Liver Inflammatory Changes.

Svendsen P, Graversen JH, Etzerodt A, Hager H, Røge R, Grønbæk H, Christensen EI, Møller HJ, Vilstrup H, Moestrup SK.

Mol Ther Methods Clin Dev. 2016 Dec 24;4:50-61. doi: 10.1016/j.omtm.2016.11.004. eCollection 2017 Mar 17.

15.

High Plasma Lipid Levels Reduce Efficacy of Adenovirus-Mediated Gene Therapy.

Kivelä AM, Huusko J, Gurzeler E, Laine A, Dijkstra MH, Dragneva G, Andersen CB, Moestrup SK, Ylä-Herttuala S.

Sci Rep. 2017 Mar 24;7(1):386. doi: 10.1038/s41598-017-00376-5.

16.

Soluble CD163 predicts incident chronic lung, kidney and liver disease in HIV infection.

Kirkegaard-Klitbo DM, Mejer N, Knudsen TB, Møller HJ, Moestrup SK, Poulsen SD, Kronborg G, Benfield T.

AIDS. 2017 Apr 24;31(7):981-988. doi: 10.1097/QAD.0000000000001432. Erratum in: AIDS. 2018 Mar 13;32(5):679.

PMID:
28252527
17.

Soluble ectodomain CD163 and extracellular vesicle-associated CD163 are two differently regulated forms of 'soluble CD163' in plasma.

Etzerodt A, Berg RM, Plovsing RR, Andersen MN, Bebien M, Habbeddine M, Lawrence T, Møller HJ, Moestrup SK.

Sci Rep. 2017 Jan 13;7:40286. doi: 10.1038/srep40286.

18.

Untargeted Metabolomics Analysis of ABCC6-Deficient Mice Discloses an Altered Metabolic Liver Profile.

Rasmussen MR, Nielsen KL, Laursen MR, Nielsen CB, Svendsen P, Dimke H, Christensen EI, Johannsen M, Moestrup SK.

J Proteome Res. 2016 Dec 2;15(12):4591-4600. Epub 2016 Nov 3.

PMID:
27758107
19.

The Staphylococcus aureus Protein IsdH Inhibits Host Hemoglobin Scavenging to Promote Heme Acquisition by the Pathogen.

Sæderup KL, Stødkilde K, Graversen JH, Dickson CF, Etzerodt A, Hansen SW, Fago A, Gell D, Andersen CB, Moestrup SK.

J Biol Chem. 2016 Nov 11;291(46):23989-23998. Epub 2016 Sep 28.

20.

Haptoglobin.

Andersen CBF, Stødkilde K, Sæderup KL, Kuhlee A, Raunser S, Graversen JH, Moestrup SK.

Antioxid Redox Signal. 2017 May 10;26(14):814-831. doi: 10.1089/ars.2016.6793. Epub 2016 Nov 8. Review.

PMID:
27650279
21.

Anti-Inflammatory Modulation of Microglia via CD163-Targeted Glucocorticoids Protects Dopaminergic Neurons in the 6-OHDA Parkinson's Disease Model.

Tentillier N, Etzerodt A, Olesen MN, Rizalar FS, Jacobsen J, Bender D, Moestrup SK, Romero-Ramos M.

J Neurosci. 2016 Sep 7;36(36):9375-90. doi: 10.1523/JNEUROSCI.1636-16.2016.

22.

Plasma Soluble CD163 Level Independently Predicts All-Cause Mortality in HIV-1-Infected Individuals.

Knudsen TB, Ertner G, Petersen J, Møller HJ, Moestrup SK, Eugen-Olsen J, Kronborg G, Benfield T.

J Infect Dis. 2016 Oct 15;214(8):1198-204. doi: 10.1093/infdis/jiw263. Epub 2016 Jun 28.

PMID:
27354366
23.

Anti-CD163-dexamethasone conjugate inhibits the acute phase response to lipopolysaccharide in rats.

Thomsen KL, Møller HJ, Graversen JH, Magnusson NE, Moestrup SK, Vilstrup H, Grønbæk H.

World J Hepatol. 2016 Jun 18;8(17):726-30. doi: 10.4254/wjh.v8.i17.726.

24.

A disintegrin and metalloprotease-17 and galectin-9 are important regulators of local 4-1BB activity and disease outcome in rheumatoid arthritis.

Nielsen MA, Andersen T, Etzerodt A, Kragstrup TW, Rasmussen TK, Stengaard-Pedersen K, Hetland ML, Hørslev-Petersen K, Junker P, Østergaard M, Hvid M, Moestrup SK, Deleuran B.

Rheumatology (Oxford). 2016 Oct;55(10):1871-9. doi: 10.1093/rheumatology/kew237. Epub 2016 Jun 21.

PMID:
27330157
25.

Treatment with a human recombinant monoclonal IgG antibody against oxidized LDL in atherosclerosis-prone pigs reduces cathepsin S in coronary lesions.

Poulsen CB, Al-Mashhadi AL, von Wachenfeldt K, Bentzon JF, Nielsen LB, Al-Mashhadi RH, Thygesen J, Tolbod L, Larsen JR, Frøkiær J, Tawakol A, Vucic E, Fredrickson J, Baruch A, Frendéus B, Robertson AK, Moestrup SK, Drouet L, Falk E.

Int J Cardiol. 2016 Jul 15;215:506-15. doi: 10.1016/j.ijcard.2016.03.222. Epub 2016 Apr 2.

PMID:
27135822
26.

Anti-inflammatory liposomes have no impact on liver regeneration in rats.

Jepsen BN, Andersen KJ, Knudsen AR, Nyengaard JR, Hamilton-Dutoit S, Svendsen P, Etzerodt A, Møller HJ, Moestrup SK, Graversen JH, Mortensen FV.

Ann Med Surg (Lond). 2015 Nov 2;4(4):452-61. doi: 10.1016/j.amsu.2015.10.018. eCollection 2015 Dec.

27.

Regulation of the Water Channel Aquaporin-2 via 14-3-3θ and -ζ.

Moeller HB, Slengerik-Hansen J, Aroankins T, Assentoft M, MacAulay N, Moestrup SK, Bhalla V, Fenton RA.

J Biol Chem. 2016 Jan 29;291(5):2469-84. doi: 10.1074/jbc.M115.691121. Epub 2015 Dec 8.

28.

Macrophage activation markers predict mortality in patients with liver cirrhosis without or with acute-on-chronic liver failure (ACLF).

Grønbæk H, Rødgaard-Hansen S, Aagaard NK, Arroyo V, Moestrup SK, Garcia E, Solà E, Domenicali M, Piano S, Vilstrup H, Møller HJ; CANONIC study investigators of the EASL-CLIF Consortium.

J Hepatol. 2016 Apr;64(4):813-22. doi: 10.1016/j.jhep.2015.11.021. Epub 2015 Nov 27.

PMID:
26639396
29.

Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation.

Pilecki B, Holm AT, Schlosser A, Moeller JB, Wohl AP, Zuk AV, Heumüller SE, Wallis R, Moestrup SK, Sengle G, Holmskov U, Sorensen GL.

J Biol Chem. 2016 Jan 15;291(3):1103-14. doi: 10.1074/jbc.M115.681775. Epub 2015 Nov 24.

30.

Anti-CD163-dexamethasone protects against apoptosis after ischemia/reperfusion injuries in the rat liver.

Møller LN, Knudsen AR, Andersen KJ, Nyengaard JR, Hamilton-Dutoit S, Okholm Møller EM, Svendsen P, Møller HJ, Moestrup SK, Graversen JH, Mortensen FV.

Ann Med Surg (Lond). 2015 Sep 3;4(4):331-7. doi: 10.1016/j.amsu.2015.09.001. eCollection 2015 Dec.

31.

Drug Trafficking into Macrophages via the Endocytotic Receptor CD163.

Graversen JH, Moestrup SK.

Membranes (Basel). 2015 Jun 23;5(2):228-52. doi: 10.3390/membranes5020228. Review.

32.

Dexamethasone targeted directly to macrophages induces macrophage niches that promote erythroid expansion.

Falchi M, Varricchio L, Martelli F, Masiello F, Federici G, Zingariello M, Girelli G, Whitsett C, Petricoin EF 3rd, Moestrup SK, Zeuner A, Migliaccio AR.

Haematologica. 2015 Feb;100(2):178-87. doi: 10.3324/haematol.2014.114405. Epub 2014 Dec 22.

33.

Structural basis for trypanosomal haem acquisition and susceptibility to the host innate immune system.

Stødkilde K, Torvund-Jensen M, Moestrup SK, Andersen CB.

Nat Commun. 2014 Nov 20;5:5487. doi: 10.1038/ncomms6487.

PMID:
25410714
34.

Circular trimers of gelatinase B/matrix metalloproteinase-9 constitute a distinct population of functional enzyme molecules differentially regulated by tissue inhibitor of metalloproteinases-1.

Vandooren J, Born B, Solomonov I, Zajac E, Saldova R, Senske M, Ugarte-Berzal E, Martens E, Van den Steen PE, Van Damme J, Garcia-Pardo A, Froeyen M, Deryugina EI, Quigley JP, Moestrup SK, Rudd PM, Sagi I, Opdenakker G.

Biochem J. 2015 Jan 15;465(2):259-70. doi: 10.1042/BJ20140418.

35.

Biodistribution and PET imaging of a novel [68Ga]-anti-CD163-antibody conjugate in rats with collagen-induced arthritis and in controls.

Eichendorff S, Svendsen P, Bender D, Keiding S, Christensen EI, Deleuran B, Moestrup SK.

Mol Imaging Biol. 2015 Feb;17(1):87-93. doi: 10.1007/s11307-014-0768-6.

PMID:
25053229
36.

Standardizing scavenger receptor nomenclature.

Prabhudas M, Bowdish D, Drickamer K, Febbraio M, Herz J, Kobzik L, Krieger M, Loike J, Means TK, Moestrup SK, Post S, Sawamura T, Silverstein S, Wang XY, El Khoury J.

J Immunol. 2014 Mar 1;192(5):1997-2006. doi: 10.4049/jimmunol.1490003. Review.

37.

How calcium makes endocytic receptors attractive.

Andersen CB, Moestrup SK.

Trends Biochem Sci. 2014 Feb;39(2):82-90. doi: 10.1016/j.tibs.2013.12.003. Epub 2014 Jan 4. Review.

PMID:
24393667
38.

Structural basis for inflammation-driven shedding of CD163 ectodomain and tumor necrosis factor-α in macrophages.

Etzerodt A, Rasmussen MR, Svendsen P, Chalaris A, Schwarz J, Galea I, Møller HJ, Moestrup SK.

J Biol Chem. 2014 Jan 10;289(2):778-88. doi: 10.1074/jbc.M113.520213. Epub 2013 Nov 25.

39.

Obesity alters adipose tissue macrophage iron content and tissue iron distribution.

Orr JS, Kennedy A, Anderson-Baucum EK, Webb CD, Fordahl SC, Erikson KM, Zhang Y, Etzerodt A, Moestrup SK, Hasty AH.

Diabetes. 2014 Feb;63(2):421-32. doi: 10.2337/db13-0213. Epub 2013 Oct 15.

40.

Mechanism of Trypanosoma brucei gambiense resistance to human serum.

Uzureau P, Uzureau S, Lecordier L, Fontaine F, Tebabi P, Homblé F, Grélard A, Zhendre V, Nolan DP, Lins L, Crowet JM, Pays A, Felu C, Poelvoorde P, Vanhollebeke B, Moestrup SK, Lyngsø J, Pedersen JS, Mottram JC, Dufourc EJ, Pérez-Morga D, Pays E.

Nature. 2013 Sep 19;501(7467):430-4. doi: 10.1038/nature12516. Epub 2013 Aug 21.

PMID:
23965626
41.

Targeting dexamethasone to macrophages in a porcine endotoxemic model.

Granfeldt A, Hvas CL, Graversen JH, Christensen PA, Petersen MD, Anton G, Svendsen P, Sølling C, Etzerodt A, Tønnesen E, Moestrup SK, Møller HJ.

Crit Care Med. 2013 Nov;41(11):e309-18. doi: 10.1097/CCM.0b013e31828a45ef.

PMID:
23928834
42.

The haptoglobin-CD163-heme oxygenase-1 pathway for hemoglobin scavenging.

Thomsen JH, Etzerodt A, Svendsen P, Moestrup SK.

Oxid Med Cell Longev. 2013;2013:523652. doi: 10.1155/2013/523652. Epub 2013 May 27. Review.

43.

CD163 binding to haptoglobin-hemoglobin complexes involves a dual-point electrostatic receptor-ligand pairing.

Nielsen MJ, Andersen CB, Moestrup SK.

J Biol Chem. 2013 Jun 28;288(26):18834-41. doi: 10.1074/jbc.M113.471060. Epub 2013 May 13.

44.

Is classical pseudoxanthoma elasticum a consequence of hepatic 'intoxication' due to ABCC6 substrate accumulation in the liver?

Rasmussen MR, Sommerlund M, Moestrup SK.

Expert Rev Endocrinol Metab. 2013 Jan;8(1):37-46. doi: 10.1586/eem.12.72.

PMID:
30731651
45.

Haptoglobin: the hemoglobin detoxifier in plasma.

Alayash AI, Andersen CB, Moestrup SK, Bülow L.

Trends Biotechnol. 2013 Jan;31(1):2-3. doi: 10.1016/j.tibtech.2012.10.003. Epub 2012 Nov 7.

PMID:
23140673
46.

Structure of the haptoglobin-haemoglobin complex.

Andersen CB, Torvund-Jensen M, Nielsen MJ, de Oliveira CL, Hersleth HP, Andersen NH, Pedersen JS, Andersen GR, Moestrup SK.

Nature. 2012 Sep 20;489(7416):456-9. doi: 10.1038/nature11369. Epub 2012 Aug 26.

PMID:
22922649
47.

CD163 and inflammation: biological, diagnostic, and therapeutic aspects.

Etzerodt A, Moestrup SK.

Antioxid Redox Signal. 2013 Jun 10;18(17):2352-63. doi: 10.1089/ars.2012.4834. Epub 2012 Oct 19. Review.

48.

Plasma clearance of hemoglobin and haptoglobin in mice and effect of CD163 gene targeting disruption.

Etzerodt A, Kjolby M, Nielsen MJ, Maniecki M, Svendsen P, Moestrup SK.

Antioxid Redox Signal. 2013 Jun 10;18(17):2254-63. doi: 10.1089/ars.2012.4605. Epub 2012 Aug 29.

PMID:
22793784
49.

Targeting the hemoglobin scavenger receptor CD163 in macrophages highly increases the anti-inflammatory potency of dexamethasone.

Graversen JH, Svendsen P, Dagnæs-Hansen F, Dal J, Anton G, Etzerodt A, Petersen MD, Christensen PA, Møller HJ, Moestrup SK.

Mol Ther. 2012 Aug;20(8):1550-8. doi: 10.1038/mt.2012.103. Epub 2012 May 29.

50.

Vitamin B12 transport from food to the body's cells--a sophisticated, multistep pathway.

Nielsen MJ, Rasmussen MR, Andersen CB, Nexø E, Moestrup SK.

Nat Rev Gastroenterol Hepatol. 2012 May 1;9(6):345-54. doi: 10.1038/nrgastro.2012.76. Review.

PMID:
22547309

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