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Items: 7

1.

Allele-Specific Mechanisms of Activation of MEK1 Mutants Determine Their Properties.

Gao Y, Chang MT, McKay D, Na N, Zhou B, Yaeger R, Torres NM, Muniz K, Drosten M, Barbacid M, Caponigro G, Stuart D, Moebitz H, Solit DB, Abdel-Wahab O, Taylor BS, Yao Z, Rosen N.

Cancer Discov. 2018 May;8(5):648-661. doi: 10.1158/2159-8290.CD-17-1452. Epub 2018 Feb 26.

PMID:
29483135
2.

Perspective on computational and structural aspects of kinase discovery from IPK2014.

Martin E, Knapp S, Engh RA, Moebitz H, Varin T, Roux B, Meiler J, Berdini V, Baumann A, Vieth M.

Biochim Biophys Acta. 2015 Oct;1854(10 Pt B):1595-604. doi: 10.1016/j.bbapap.2015.03.014. Epub 2015 Apr 7. Review.

3.

Ten things you should know about protein kinases: IUPHAR Review 14.

Fabbro D, Cowan-Jacob SW, Moebitz H.

Br J Pharmacol. 2015 Jun;172(11):2675-700. doi: 10.1111/bph.13096. Epub 2015 Mar 24. Review.

4.

The Substrate-Activity-Screening methodology applied to receptor tyrosine kinases: a proof-of-concept study.

Chapelat J, Berst F, Marzinzik AL, Moebitz H, Drueckes P, Trappe J, Fabbro D, Seebach D.

Eur J Med Chem. 2012 Nov;57:1-9. doi: 10.1016/j.ejmech.2012.08.038. Epub 2012 Sep 4.

PMID:
23041456
5.

Substrate profiling of IGF-1R and InsR: identification of a potent pentamer substrate.

Chapelat J, Berst F, Marzinzik AL, Moebitz H, Drueckes P, Fabbro D, Trappe J, Seebach D.

Bioorg Med Chem Lett. 2011 Dec 1;21(23):7030-3. doi: 10.1016/j.bmcl.2011.09.101. Epub 2011 Sep 29.

PMID:
22004721
6.

Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy.

Velcicky J, Feifel R, Hawtin S, Heng R, Huppertz C, Koch G, Kroemer M, Moebitz H, Revesz L, Scheufler C, Schlapbach A.

Bioorg Med Chem Lett. 2010 Feb 1;20(3):1293-7. doi: 10.1016/j.bmcl.2009.10.138. Epub 2009 Nov 3.

PMID:
20060294
7.

Pyrrolo-pyrimidones: a novel class of MK2 inhibitors with potent cellular activity.

Schlapbach A, Feifel R, Hawtin S, Heng R, Koch G, Moebitz H, Revesz L, Scheufler C, Velcicky J, Waelchli R, Huppertz C.

Bioorg Med Chem Lett. 2008 Dec 1;18(23):6142-6. doi: 10.1016/j.bmcl.2008.10.039. Epub 2008 Oct 11.

PMID:
18945615

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